UA114345C2 - 6-((s)-1-{1-[5-(2-гідроксіетокси)піридин-2-іл]-1h-піразол-3-іл}етил)-3h-1,3-бензотіазол-2-он як антагоніст tarp-гамма 8-залежного рецептора ampa - Google Patents

6-((s)-1-{1-[5-(2-гідроксіетокси)піридин-2-іл]-1h-піразол-3-іл}етил)-3h-1,3-бензотіазол-2-он як антагоніст tarp-гамма 8-залежного рецептора ampa

Info

Publication number
UA114345C2
UA114345C2 UAA201504865A UAA201504865A UA114345C2 UA 114345 C2 UA114345 C2 UA 114345C2 UA A201504865 A UAA201504865 A UA A201504865A UA A201504865 A UAA201504865 A UA A201504865A UA 114345 C2 UA114345 C2 UA 114345C2
Authority
UA
Ukraine
Prior art keywords
tarp
receptor antagonist
benzothiazol
pyrazol
pyridin
Prior art date
Application number
UAA201504865A
Other languages
English (en)
Inventor
Джон Кевін Ріл
Джон Кэвин Рил
Уоррен Джей Портер
Уоррэн Джэй Портэр
Джеффрі Майкл Уіткін
Джэффри Майкл Уиткин
Original Assignee
Елі Ліллі Енд Компані
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Елі Ліллі Енд Компані, Эли Лилли Энд Компани filed Critical Елі Ліллі Енд Компані
Publication of UA114345C2 publication Critical patent/UA114345C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Описаний антагоніст TARP γ8-залежних рецепторів АМРА формули (I) або фармацевтично прийнятна соль, застосування і способи його одержання. (І)
UAA201504865A 2012-11-27 2013-11-20 6-((s)-1-{1-[5-(2-гідроксіетокси)піридин-2-іл]-1h-піразол-3-іл}етил)-3h-1,3-бензотіазол-2-он як антагоніст tarp-гамма 8-залежного рецептора ampa UA114345C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261730273P 2012-11-27 2012-11-27
PCT/US2013/070885 WO2014085153A1 (en) 2012-11-27 2013-11-20 6-((s)-1-{1-[5-(2-hydroxy-ethoxy)-pyridin-2-yl]-1h-pyrazol-3-yl}- ethyl)-3h-1,3-benzothiazol-2-one as a tarp-gamma 8 dependent ampa receptor antagonist

Publications (1)

Publication Number Publication Date
UA114345C2 true UA114345C2 (uk) 2017-05-25

Family

ID=49753484

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201504865A UA114345C2 (uk) 2012-11-27 2013-11-20 6-((s)-1-{1-[5-(2-гідроксіетокси)піридин-2-іл]-1h-піразол-3-іл}етил)-3h-1,3-бензотіазол-2-он як антагоніст tarp-гамма 8-залежного рецептора ampa

Country Status (36)

Country Link
US (1) US8765960B2 (uk)
EP (1) EP2925754B1 (uk)
JP (1) JP6246227B2 (uk)
KR (1) KR101693133B1 (uk)
CN (1) CN104797578B (uk)
AP (1) AP2015008489A0 (uk)
AR (1) AR093527A1 (uk)
AU (1) AU2013352594B2 (uk)
BR (1) BR112015011200A2 (uk)
CA (1) CA2889243C (uk)
CL (1) CL2015001419A1 (uk)
CR (1) CR20150267A (uk)
CY (1) CY1118657T1 (uk)
DK (1) DK2925754T3 (uk)
DO (1) DOP2015000113A (uk)
EA (1) EA026686B1 (uk)
ES (1) ES2618260T3 (uk)
HK (1) HK1209116A1 (uk)
HR (1) HRP20170274T1 (uk)
HU (1) HUE033447T2 (uk)
IL (1) IL238831B (uk)
JO (1) JO3225B1 (uk)
MA (1) MA38126B1 (uk)
MX (1) MX356478B (uk)
MY (1) MY177721A (uk)
PE (1) PE20151728A1 (uk)
PH (1) PH12015501154A1 (uk)
PL (1) PL2925754T3 (uk)
PT (1) PT2925754T (uk)
SG (1) SG11201504164VA (uk)
SI (1) SI2925754T1 (uk)
TN (1) TN2015000200A1 (uk)
TW (2) TW201825484A (uk)
UA (1) UA114345C2 (uk)
WO (1) WO2014085153A1 (uk)
ZA (1) ZA201503733B (uk)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201609719A (zh) * 2014-05-28 2016-03-16 美國禮來大藥廠 作為ＴＡＲＰ－γ８依賴性ＡＭＰＡ受體拮抗劑之６－經取代－３Ｈ－１，３－苯并噻唑－２－酮化合物
JP6804469B2 (ja) 2015-04-29 2020-12-23 ヤンセン ファーマシューティカ エヌ．ベー． ベンゾイミダゾロン及びベンゾチアゾロン化合物並びにａｍｐａ受容体調節因子としてのそれらの使用
CN107750250B (zh) 2015-04-29 2021-09-07 詹森药业有限公司 吲哚酮化合物及其作为ampa受体调节剂的用途
CN107567452B (zh) 2015-04-29 2020-07-07 詹森药业有限公司 咪唑并哌嗪和吡唑并嘧啶以及它们作为ampa受体调节剂的用途
KR20240017991A (ko) * 2015-04-29 2024-02-08 라포 테라퓨틱스, 인크. 아자벤즈이미다졸 및 ampa 수용체 조절제로서의 이의 용도
EA036903B1 (ru) * 2016-10-26 2021-01-13 Янссен Фармацевтика Нв Соединения конденсированных бициклических пиридинов и их применение в качестве модуляторов ampa-рецептора
RU2650523C1 (ru) * 2017-07-24 2018-04-16 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Производное пиридоксина для лечения эпилепсии
RU2703286C1 (ru) * 2019-06-18 2019-10-16 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Соли (5-гидрокси-3,4-бис(гидроксиметил)-6-метилпиридин-2-ил)метансульфокислоты и способ их получения

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MY132385A (en) * 1995-08-31 2007-10-31 Novartis Ag 2,3-dioxo-1,2,3,4-tetrahydro-quinoxalinyl derivatives
JP2000281676A (ja) * 1999-01-25 2000-10-10 Yamanouchi Pharmaceut Co Ltd Ａｍｐａ拮抗化合物の新規製造法
ES2320973T3 (es) * 2000-06-12 2009-06-01 EISAI R&D MANAGEMENT CO., LTD. Compuestos de 1,2-dihidropiridina, procedimiento para su preparacion y uso de los mismos.
US8995993B2 (en) * 2000-10-11 2015-03-31 Gogo Llc System for managing mobile internet protocol addresses in an airborne wireless cellular network
WO2006066173A2 (en) * 2004-12-17 2006-06-22 Eli Lilly And Company Novel mch receptor antagonists
WO2007076161A2 (en) 2005-12-27 2007-07-05 Myriad Genetics, Inc Compounds with therapeutic activity
TW200817385A (en) * 2006-07-04 2008-04-16 Organon Nv Heterocyclic derivatives
EP2356099A1 (en) * 2008-10-08 2011-08-17 Pfizer Inc. Tetrahydrofuranyl sulfonamides for use as ampa modulators in the treatment of cns disorders
GEP20135992B (en) * 2009-01-12 2013-12-25 Icagen Inc Sulfonamide derivatives
US8513291B2 (en) * 2010-06-01 2013-08-20 Angion Biomedica Corp. Cytochrome P450 inhibitors and uses thereof
JP5976011B2 (ja) * 2011-04-05 2016-08-23 武田薬品工業株式会社 スルホンアミド誘導体およびその用途
TW201609719A (zh) * 2014-05-28 2016-03-16 美國禮來大藥廠 作為ＴＡＲＰ－γ８依賴性ＡＭＰＡ受體拮抗劑之６－經取代－３Ｈ－１，３－苯并噻唑－２－酮化合物

Also Published As

Publication number Publication date
MA38126A1 (fr) 2017-03-31
US20140148441A1 (en) 2014-05-29
TWI618705B (zh) 2018-03-21
CN104797578A (zh) 2015-07-22
EP2925754B1 (en) 2016-12-28
TW201434834A (zh) 2014-09-16
IL238831B (en) 2018-08-30
AU2013352594A1 (en) 2015-06-04
SI2925754T1 (sl) 2017-02-28
JP6246227B2 (ja) 2017-12-13
CY1118657T1 (el) 2017-07-12
EA201590823A1 (ru) 2015-08-31
AU2013352594B2 (en) 2016-02-18
HK1209116A1 (en) 2016-03-24
KR101693133B1 (ko) 2017-01-04
JO3225B1 (ar) 2018-03-08
ZA201503733B (en) 2017-09-27
AP2015008489A0 (en) 2015-05-31
PH12015501154B1 (en) 2015-08-10
WO2014085153A8 (en) 2014-07-31
DOP2015000113A (es) 2015-06-15
PT2925754T (pt) 2017-02-27
CA2889243A1 (en) 2014-06-05
DK2925754T3 (en) 2017-02-20
ES2618260T3 (es) 2017-06-21
CL2015001419A1 (es) 2015-10-02
MX2015006697A (es) 2015-08-05
EA026686B1 (ru) 2017-05-31
CN104797578B (zh) 2016-11-23
MA38126B1 (fr) 2017-11-30
US8765960B2 (en) 2014-07-01
KR20150070401A (ko) 2015-06-24
BR112015011200A2 (pt) 2017-07-11
PH12015501154A1 (en) 2015-08-10
HRP20170274T1 (hr) 2017-04-07
HUE033447T2 (en) 2017-11-28
JP2016501219A (ja) 2016-01-18
MX356478B (es) 2018-05-30
EP2925754A1 (en) 2015-10-07
CR20150267A (es) 2015-09-16
TW201825484A (zh) 2018-07-16
CA2889243C (en) 2017-06-13
AR093527A1 (es) 2015-06-10
PE20151728A1 (es) 2015-12-02
WO2014085153A1 (en) 2014-06-05
PL2925754T3 (pl) 2017-07-31
TN2015000200A1 (en) 2016-10-03
SG11201504164VA (en) 2015-07-30
MY177721A (en) 2020-09-23
IL238831A0 (en) 2015-06-30

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