AP2015008489A0 - 6-((S)-1-{1-[5-(2-hydroxy-ethoxy)-pyridin-2-yl]-1H-pyrazol-3-yl}-ethyl)-3H-1,3-benzothiazol-2-one asa tarp-gamma 8 dependent ampa receptor antagonist - Google Patents

6-((S)-1-{1-[5-(2-hydroxy-ethoxy)-pyridin-2-yl]-1H-pyrazol-3-yl}-ethyl)-3H-1,3-benzothiazol-2-one asa tarp-gamma 8 dependent ampa receptor antagonist

Info

Publication number
AP2015008489A0
AP2015008489A0 AP2015008489A AP2015008489A AP2015008489A0 AP 2015008489 A0 AP2015008489 A0 AP 2015008489A0 AP 2015008489 A AP2015008489 A AP 2015008489A AP 2015008489 A AP2015008489 A AP 2015008489A AP 2015008489 A0 AP2015008489 A0 AP 2015008489A0
Authority
AP
ARIPO
Prior art keywords
tarp
benzothiazol
asa
pyrazol
pyridin
Prior art date
Application number
AP2015008489A
Other languages
English (en)
Inventor
Jeffrey Michael Witkin
Warren Jaye Porter
Jon Kevin Reel
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AP2015008489A0 publication Critical patent/AP2015008489A0/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AP2015008489A 2012-11-27 2013-11-20 6-((S)-1-{1-[5-(2-hydroxy-ethoxy)-pyridin-2-yl]-1H-pyrazol-3-yl}-ethyl)-3H-1,3-benzothiazol-2-one asa tarp-gamma 8 dependent ampa receptor antagonist AP2015008489A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261730273P 2012-11-27 2012-11-27
PCT/US2013/070885 WO2014085153A1 (en) 2012-11-27 2013-11-20 6-((s)-1-{1-[5-(2-hydroxy-ethoxy)-pyridin-2-yl]-1h-pyrazol-3-yl}- ethyl)-3h-1,3-benzothiazol-2-one as a tarp-gamma 8 dependent ampa receptor antagonist

Publications (1)

Publication Number Publication Date
AP2015008489A0 true AP2015008489A0 (en) 2015-05-31

Family

ID=49753484

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2015008489A AP2015008489A0 (en) 2012-11-27 2013-11-20 6-((S)-1-{1-[5-(2-hydroxy-ethoxy)-pyridin-2-yl]-1H-pyrazol-3-yl}-ethyl)-3H-1,3-benzothiazol-2-one asa tarp-gamma 8 dependent ampa receptor antagonist

Country Status (36)

Country Link
US (1) US8765960B2 (xx)
EP (1) EP2925754B1 (xx)
JP (1) JP6246227B2 (xx)
KR (1) KR101693133B1 (xx)
CN (1) CN104797578B (xx)
AP (1) AP2015008489A0 (xx)
AR (1) AR093527A1 (xx)
AU (1) AU2013352594B2 (xx)
BR (1) BR112015011200A2 (xx)
CA (1) CA2889243C (xx)
CL (1) CL2015001419A1 (xx)
CR (1) CR20150267A (xx)
CY (1) CY1118657T1 (xx)
DK (1) DK2925754T3 (xx)
DO (1) DOP2015000113A (xx)
EA (1) EA026686B1 (xx)
ES (1) ES2618260T3 (xx)
HK (1) HK1209116A1 (xx)
HR (1) HRP20170274T1 (xx)
HU (1) HUE033447T2 (xx)
IL (1) IL238831B (xx)
JO (1) JO3225B1 (xx)
MA (1) MA38126B1 (xx)
MX (1) MX356478B (xx)
MY (1) MY177721A (xx)
PE (1) PE20151728A1 (xx)
PH (1) PH12015501154B1 (xx)
PL (1) PL2925754T3 (xx)
PT (1) PT2925754T (xx)
SG (1) SG11201504164VA (xx)
SI (1) SI2925754T1 (xx)
TN (1) TN2015000200A1 (xx)
TW (2) TW201825484A (xx)
UA (1) UA114345C2 (xx)
WO (1) WO2014085153A1 (xx)
ZA (1) ZA201503733B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201609719A (zh) * 2014-05-28 2016-03-16 美國禮來大藥廠 作為ＴＡＲＰ－γ８依賴性ＡＭＰＡ受體拮抗劑之６－經取代－３Ｈ－１，３－苯并噻唑－２－酮化合物
EP4144736A1 (en) 2015-04-29 2023-03-08 JANSSEN Pharmaceutica NV Azabenzimidazoles and their use as ampa receptor modulators
EP3288945B1 (en) 2015-04-29 2019-09-18 Janssen Pharmaceutica NV Imidazopyrazines and pyrazolopyrimidines and their use as ampa receptor modulators
JP6811187B2 (ja) 2015-04-29 2021-01-13 ヤンセン ファーマシューティカ エヌ．ベー． インドロン化合物、及びａｍｐａ受容体調節因子としてのそれらの使用
KR20170141767A (ko) * 2015-04-29 2017-12-26 얀센 파마슈티카 엔.브이. 벤즈이미다졸론 및 벤조티아졸론 화합물 및 ampa 수용체 조절제로서의 이들의 용도
EA036903B1 (ru) * 2016-10-26 2021-01-13 Янссен Фармацевтика Нв Соединения конденсированных бициклических пиридинов и их применение в качестве модуляторов ampa-рецептора
RU2650523C1 (ru) * 2017-07-24 2018-04-16 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Производное пиридоксина для лечения эпилепсии
RU2703286C1 (ru) * 2019-06-18 2019-10-16 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Соли (5-гидрокси-3,4-бис(гидроксиметил)-6-метилпиридин-2-ил)метансульфокислоты и способ их получения

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
MY132385A (en) * 1995-08-31 2007-10-31 Novartis Ag 2,3-dioxo-1,2,3,4-tetrahydro-quinoxalinyl derivatives
JP2000281676A (ja) * 1999-01-25 2000-10-10 Yamanouchi Pharmaceut Co Ltd Ａｍｐａ拮抗化合物の新規製造法
DE60137426D1 (de) * 2000-06-12 2009-03-05 Eisai R&D Man Co Ltd 1,2-dihydropyridinverbindungen, verfahren zu deren herstellung und deren verwendung
US8995993B2 (en) * 2000-10-11 2015-03-31 Gogo Llc System for managing mobile internet protocol addresses in an airborne wireless cellular network
DE602005009021D1 (de) * 2004-12-17 2008-09-25 Lilly Co Eli Neue mch-rezeptorantagonisten
WO2007076161A2 (en) 2005-12-27 2007-07-05 Myriad Genetics, Inc Compounds with therapeutic activity
TW200817385A (en) * 2006-07-04 2008-04-16 Organon Nv Heterocyclic derivatives
EP2356099A1 (en) * 2008-10-08 2011-08-17 Pfizer Inc. Tetrahydrofuranyl sulfonamides for use as ampa modulators in the treatment of cns disorders
RS53941B1 (en) * 2009-01-12 2015-08-31 Pfizer Limited SULFONAMID DERIVATIVES
JP6088425B2 (ja) * 2010-06-01 2017-03-01 アンジオン バイオメディカ コーポレーション チトクロームｐ４５０阻害剤およびその使用
JP5976011B2 (ja) * 2011-04-05 2016-08-23 武田薬品工業株式会社 スルホンアミド誘導体およびその用途
TW201609719A (zh) 2014-05-28 2016-03-16 美國禮來大藥廠 作為ＴＡＲＰ－γ８依賴性ＡＭＰＡ受體拮抗劑之６－經取代－３Ｈ－１，３－苯并噻唑－２－酮化合物

Also Published As

Publication number Publication date
WO2014085153A1 (en) 2014-06-05
ZA201503733B (en) 2017-09-27
IL238831A0 (en) 2015-06-30
EA026686B1 (ru) 2017-05-31
CR20150267A (es) 2015-09-16
EP2925754B1 (en) 2016-12-28
PE20151728A1 (es) 2015-12-02
CA2889243A1 (en) 2014-06-05
BR112015011200A2 (pt) 2017-07-11
MX2015006697A (es) 2015-08-05
JP6246227B2 (ja) 2017-12-13
MA38126B1 (fr) 2017-11-30
US8765960B2 (en) 2014-07-01
WO2014085153A8 (en) 2014-07-31
PH12015501154A1 (en) 2015-08-10
HK1209116A1 (en) 2016-03-24
PL2925754T3 (pl) 2017-07-31
TN2015000200A1 (en) 2016-10-03
JP2016501219A (ja) 2016-01-18
HUE033447T2 (en) 2017-11-28
IL238831B (en) 2018-08-30
UA114345C2 (uk) 2017-05-25
PH12015501154B1 (en) 2015-08-10
MX356478B (es) 2018-05-30
EP2925754A1 (en) 2015-10-07
TW201434834A (zh) 2014-09-16
MY177721A (en) 2020-09-23
PT2925754T (pt) 2017-02-27
CN104797578B (zh) 2016-11-23
DK2925754T3 (en) 2017-02-20
AR093527A1 (es) 2015-06-10
HRP20170274T1 (hr) 2017-04-07
AU2013352594B2 (en) 2016-02-18
CA2889243C (en) 2017-06-13
TW201825484A (zh) 2018-07-16
KR20150070401A (ko) 2015-06-24
CY1118657T1 (el) 2017-07-12
KR101693133B1 (ko) 2017-01-04
SG11201504164VA (en) 2015-07-30
SI2925754T1 (sl) 2017-02-28
DOP2015000113A (es) 2015-06-15
AU2013352594A1 (en) 2015-06-04
CN104797578A (zh) 2015-07-22
CL2015001419A1 (es) 2015-10-02
EA201590823A1 (ru) 2015-08-31
JO3225B1 (ar) 2018-03-08
US20140148441A1 (en) 2014-05-29
ES2618260T3 (es) 2017-06-21
TWI618705B (zh) 2018-03-21
MA38126A1 (fr) 2017-03-31

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