JP6240610B2 - 電解質下剤 - Google Patents
電解質下剤 Download PDFInfo
- Publication number
- JP6240610B2 JP6240610B2 JP2014537428A JP2014537428A JP6240610B2 JP 6240610 B2 JP6240610 B2 JP 6240610B2 JP 2014537428 A JP2014537428 A JP 2014537428A JP 2014537428 A JP2014537428 A JP 2014537428A JP 6240610 B2 JP6240610 B2 JP 6240610B2
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- JP
- Japan
- Prior art keywords
- composition
- formulation
- sodium
- pharmaceutical composition
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000008141 laxative Substances 0.000 title claims description 64
- 230000002475 laxative effect Effects 0.000 title claims description 55
- 239000000203 mixture Substances 0.000 claims description 245
- 238000009472 formulation Methods 0.000 claims description 81
- 239000008194 pharmaceutical composition Substances 0.000 claims description 79
- BPKUDUSVDVLOPY-UHFFFAOYSA-N bisoxatin Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C(=O)NC2=CC=CC=C2O1 BPKUDUSVDVLOPY-UHFFFAOYSA-N 0.000 claims description 39
- 229960002875 bisoxatin Drugs 0.000 claims description 36
- 235000002639 sodium chloride Nutrition 0.000 claims description 25
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 24
- 239000002775 capsule Substances 0.000 claims description 24
- ZCBJDQBSLZREAA-UHFFFAOYSA-N Bisoxatin acetate Chemical compound C1=CC(OC(=O)C)=CC=C1C1(C=2C=CC(OC(C)=O)=CC=2)C(=O)NC2=CC=CC=C2O1 ZCBJDQBSLZREAA-UHFFFAOYSA-N 0.000 claims description 23
- GOZDTZWAMGHLDY-UHFFFAOYSA-L sodium picosulfate Chemical compound [Na+].[Na+].C1=CC(OS(=O)(=O)[O-])=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OS([O-])(=O)=O)C=C1 GOZDTZWAMGHLDY-UHFFFAOYSA-L 0.000 claims description 22
- 159000000000 sodium salts Chemical class 0.000 claims description 22
- 239000012530 fluid Substances 0.000 claims description 19
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 19
- YVPYQUNUQOZFHG-UHFFFAOYSA-N amidotrizoic acid Chemical compound CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I YVPYQUNUQOZFHG-UHFFFAOYSA-N 0.000 claims description 16
- 210000001072 colon Anatomy 0.000 claims description 15
- 229960005223 diatrizoic acid Drugs 0.000 claims description 15
- 159000000003 magnesium salts Chemical class 0.000 claims description 15
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 14
- 239000003826 tablet Substances 0.000 claims description 14
- 229950009290 bisoxatin acetate Drugs 0.000 claims description 13
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 12
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 12
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 12
- 229960003390 magnesium sulfate Drugs 0.000 claims description 12
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 12
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 12
- 235000011152 sodium sulphate Nutrition 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 11
- KHOITXIGCFIULA-UHFFFAOYSA-N Alophen Chemical compound C1=CC(OC(=O)C)=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OC(C)=O)C=C1 KHOITXIGCFIULA-UHFFFAOYSA-N 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 9
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims description 9
- 229910052939 potassium sulfate Inorganic materials 0.000 claims description 9
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- 239000002872 contrast media Substances 0.000 claims description 8
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- 125000000129 anionic group Chemical group 0.000 claims description 6
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- 239000001103 potassium chloride Substances 0.000 claims description 6
- 235000011164 potassium chloride Nutrition 0.000 claims description 6
- 229910001415 sodium ion Inorganic materials 0.000 claims description 6
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 claims description 5
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims description 5
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims description 5
- 229960004308 acetylcysteine Drugs 0.000 claims description 5
- 229910052788 barium Inorganic materials 0.000 claims description 5
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 5
- 229910001425 magnesium ion Inorganic materials 0.000 claims description 5
- 239000001509 sodium citrate Substances 0.000 claims description 5
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 5
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- 229940005574 sodium gluconate Drugs 0.000 claims description 5
- WTWSHHITWMVLBX-DKWTVANSSA-M sodium;(2s)-2-aminobutanedioate;hydron Chemical compound [Na+].[O-]C(=O)[C@@H](N)CC(O)=O WTWSHHITWMVLBX-DKWTVANSSA-M 0.000 claims description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 4
- 239000004386 Erythritol Substances 0.000 claims description 4
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 4
- 230000000996 additive effect Effects 0.000 claims description 4
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- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 4
- 229940009714 erythritol Drugs 0.000 claims description 4
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- 235000011194 food seasoning agent Nutrition 0.000 claims description 4
- 239000004337 magnesium citrate Substances 0.000 claims description 4
- 229960005336 magnesium citrate Drugs 0.000 claims description 4
- 235000002538 magnesium citrate Nutrition 0.000 claims description 4
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 claims description 4
- 239000004137 magnesium phosphate Substances 0.000 claims description 4
- 229960002261 magnesium phosphate Drugs 0.000 claims description 4
- 229910000157 magnesium phosphate Inorganic materials 0.000 claims description 4
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- 239000011573 trace mineral Substances 0.000 claims description 4
- 235000013619 trace mineral Nutrition 0.000 claims description 4
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 claims description 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 239000007897 gelcap Substances 0.000 claims description 3
- 239000011630 iodine Substances 0.000 claims description 3
- 229910052740 iodine Inorganic materials 0.000 claims description 3
- NBQNWMBBSKPBAY-UHFFFAOYSA-N iodixanol Chemical compound IC=1C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C(I)C=1N(C(=O)C)CC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NBQNWMBBSKPBAY-UHFFFAOYSA-N 0.000 claims description 3
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 claims description 3
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 claims description 3
- 235000015097 nutrients Nutrition 0.000 claims description 3
- AVTYONGGKAJVTE-OLXYHTOASA-L potassium L-tartrate Chemical compound [K+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O AVTYONGGKAJVTE-OLXYHTOASA-L 0.000 claims description 3
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Detergent Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US201261717599P | 2012-10-23 | 2012-10-23 | |
| US61/717,599 | 2012-10-23 | ||
| PCT/AU2012/001315 WO2013059881A1 (en) | 2011-10-27 | 2012-10-27 | Electrolyte purgatives |
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| EP (1) | EP2782581A4 (enExample) |
| JP (2) | JP6240610B2 (enExample) |
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| CN (1) | CN104010642B (enExample) |
| AU (2) | AU2012327212B2 (enExample) |
| BR (1) | BR112014009946A2 (enExample) |
| CA (1) | CA2853520C (enExample) |
| IL (1) | IL232218B (enExample) |
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| MX (1) | MX352891B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2821196C (en) | 2010-12-13 | 2022-11-22 | Thomas Julius Borody | Gastric and colonic formulations and methods for making and using them |
| TWI535461B (zh) | 2011-03-11 | 2016-06-01 | 諾金私人有限公司 | 結腸清潔溶液、用於製備該溶液之組成物、包含該組成物或溶液之套組、與製備該溶液之方法 |
| PT2877163T (pt) | 2012-07-27 | 2019-05-24 | Redhill Biopharma Ltd | Formulações e métodos de fabrico de formulações para utilização na evacuação colónica |
| KR20170098980A (ko) | 2012-09-11 | 2017-08-30 | 노어긴 비.브이. | Peg 및 아스코르베이트를 포함하는 조성물 |
| EP3563838A1 (en) | 2013-03-15 | 2019-11-06 | Braintree Laboratories, Inc. | Dual use oral pharmaceutical composition tablets of suflate salts and methods of use thereof |
| CN103585173B (zh) * | 2013-10-28 | 2016-06-29 | 王显著 | 含硫酸钠和匹可硫酸的药物组合物 |
| EP3191105A4 (en) * | 2014-09-12 | 2018-05-02 | Braintree Laboratories, Inc. | Sulfate salt solution laxative compositions and methods of use thereof |
| FR3049464B1 (fr) * | 2016-03-29 | 2021-08-06 | Marc Girard | Preparations coliques |
| US10143656B1 (en) | 2017-08-04 | 2018-12-04 | Braintree Laboratories, Inc. | Solid oral sulfate salt formulations for cleaning a colon and methods of using same |
| KR102127003B1 (ko) * | 2017-10-12 | 2020-06-25 | 주식회사 한국팜비오 | 황산염을 포함하는 대장 하제 조성물 |
| CN108244627A (zh) * | 2018-01-16 | 2018-07-06 | 广西天昌投资有限公司 | 一种具有润肠功能的香蕉口服液及其制备方法 |
| KR102111094B1 (ko) * | 2018-06-18 | 2020-05-14 | 주식회사 한국팜비오 | 무수황산나트륨, 황산칼륨, 무수황산마그네슘 및 시메티콘을 포함하는 장관하제 경구투여용 고형제제 조성물 |
| WO2020006389A1 (en) * | 2018-06-29 | 2020-01-02 | Viktor Veniaminovich Tets | Compositions for modulating gut microbiota |
| RU2699222C1 (ru) * | 2019-04-29 | 2019-09-04 | Алексей Владимирович Воронов | Солевой электролитный раствор для проведения энтеральных инфузий |
| RU2709495C1 (ru) * | 2019-08-01 | 2019-12-18 | Общество с ограниченной ответственностью "Гелеспон" | Способ очищения кишечника и набор для его осуществления |
| WO2021133017A1 (ko) * | 2019-12-23 | 2021-07-01 | 주식회사 비보존 | 대장 하제 조성물 |
| KR20220033810A (ko) * | 2020-09-10 | 2022-03-17 | 강윤식 | 장 정결용 보조 음료 |
| WO2024256873A1 (en) | 2023-06-15 | 2024-12-19 | Sebela Ireland Limited | Methods of administering safe colon cleansing compositions |
| KR20250176963A (ko) * | 2024-06-13 | 2025-12-22 | 주식회사태준제약 | 장정결을 위한 고형제제 |
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| US6162464A (en) * | 1997-03-31 | 2000-12-19 | Inkine Pharmaceutical, Inc. | Non-aqueous colonic purgative formulations |
| JP2000060487A (ja) * | 1998-08-27 | 2000-02-29 | Kao Corp | 便秘改善剤 |
| EE04580B1 (et) * | 2001-06-29 | 2006-02-15 | Tartu �likool | Mikroorganismi tüvi Lactobacillus fermentum ME-3 kui antimikroobne ja antioksüdantne probiootikum |
| US7101573B2 (en) * | 2001-09-28 | 2006-09-05 | Mcneil-Pcc, Inc. | Simethicone solid oral dosage form |
| AUPS088702A0 (en) * | 2002-03-04 | 2002-03-28 | Borody, Thomas Julius | Electrolyte purgative |
| JP4458761B2 (ja) * | 2003-03-27 | 2010-04-28 | ロート製薬株式会社 | 瀉下用製剤 |
| US7687075B2 (en) * | 2003-11-19 | 2010-03-30 | Salix Pharmaceuticals, Ltd. | Colonic purgative composition with soluble binding agent |
| GB0409104D0 (en) * | 2004-04-23 | 2004-05-26 | Norgine Europe Bv | Compressed pharmaceutical compositions |
| US9125833B2 (en) * | 2005-11-02 | 2015-09-08 | Relmada Therapeutics, Inc. | Multimodal abuse resistant and extended release opioid formulations |
| WO2007057924A1 (en) * | 2005-11-21 | 2007-05-24 | Panacea Biotec Ltd | Laxative composition on the basis of triphala |
| WO2008021394A2 (en) * | 2006-08-15 | 2008-02-21 | Theraquest Biosciences, Llc | Pharmaceutical formulations of cannabinoids and method of use |
| JP2008115085A (ja) * | 2006-11-01 | 2008-05-22 | Tendou Seiyaku Kk | 緩下剤 |
| US20090155363A1 (en) * | 2007-12-14 | 2009-06-18 | Todd Maibach | Methods for oral administration of active drugs |
| US20090258090A1 (en) * | 2008-04-11 | 2009-10-15 | Braintree Laboratories, Inc. | Colon cleansing solution |
| WO2011047178A1 (en) * | 2009-10-14 | 2011-04-21 | Gi Innovation, Pllc | Colon cleansing of residual stool and secretions during colonoscopy |
| JP2011135936A (ja) * | 2009-12-25 | 2011-07-14 | Toshiba Corp | 画像処理装置、医用画像診断装置および画像処理プログラム |
| CA2821196C (en) * | 2010-12-13 | 2022-11-22 | Thomas Julius Borody | Gastric and colonic formulations and methods for making and using them |
| BR112013019360A2 (pt) * | 2011-01-28 | 2017-03-28 | A Shaver William | ingredientes, componente seco de formulação oral de baixo teor de cloreto farmaceuticamente aceitável para limpeza de cólon, solução de base de reposição de eletrólito aquosa para uso em lavagem colônica, métodos para limpar os intestinos de paciente, para preparar solução aquosa para limpeza do cólon e para aumentar substancialmente o paladar de limpador de cólon e kits para evacuação do cólon. |
-
2012
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- 2012-10-27 WO PCT/AU2012/001315 patent/WO2013059881A1/en not_active Ceased
- 2012-10-27 CN CN201280058877.5A patent/CN104010642B/zh not_active Expired - Fee Related
- 2012-10-27 KR KR1020147013786A patent/KR20140090217A/ko not_active Ceased
- 2012-10-27 CA CA2853520A patent/CA2853520C/en active Active
- 2012-10-27 RU RU2014121255A patent/RU2640920C2/ru not_active IP Right Cessation
- 2012-10-27 PH PH1/2014/500927A patent/PH12014500927B1/en unknown
- 2012-10-27 JP JP2014537428A patent/JP6240610B2/ja not_active Expired - Fee Related
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- 2012-10-27 IN IN3373DEN2014 patent/IN2014DN03373A/en unknown
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2014
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2016
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|---|---|
| EP2782581A4 (en) | 2015-05-20 |
| JP2018008997A (ja) | 2018-01-18 |
| NZ723576A (en) | 2018-07-27 |
| WO2013059881A1 (en) | 2013-05-02 |
| KR20140090217A (ko) | 2014-07-16 |
| BR112014009946A2 (pt) | 2017-04-25 |
| CA2853520A1 (en) | 2013-05-02 |
| AU2016213892A1 (en) | 2016-09-01 |
| IL232218B (en) | 2018-10-31 |
| IL232218A0 (en) | 2014-06-30 |
| AU2012327212A1 (en) | 2013-05-23 |
| EP2782581A1 (en) | 2014-10-01 |
| AU2012327212B2 (en) | 2016-05-12 |
| IN2014DN03373A (enExample) | 2015-06-05 |
| PH12014500927A1 (en) | 2014-06-16 |
| JP2015510491A (ja) | 2015-04-09 |
| MX352891B (es) | 2017-12-13 |
| CA2853520C (en) | 2021-11-16 |
| AU2016213892B2 (en) | 2018-04-05 |
| CN104010642A (zh) | 2014-08-27 |
| RU2640920C2 (ru) | 2018-01-12 |
| MX2014004962A (es) | 2015-01-16 |
| CN104010642B (zh) | 2018-08-17 |
| NZ624088A (en) | 2016-09-30 |
| PH12014500927B1 (en) | 2017-09-06 |
| US20150056140A1 (en) | 2015-02-26 |
| RU2014121255A (ru) | 2015-12-10 |
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