BR112014009946A2 - "composição, composição farmacêutica ou formulação purgativas e uso das mesmas" - Google Patents

"composição, composição farmacêutica ou formulação purgativas e uso das mesmas"

Info

Publication number
BR112014009946A2
BR112014009946A2 BR112014009946A BR112014009946A BR112014009946A2 BR 112014009946 A2 BR112014009946 A2 BR 112014009946A2 BR 112014009946 A BR112014009946 A BR 112014009946A BR 112014009946 A BR112014009946 A BR 112014009946A BR 112014009946 A2 BR112014009946 A2 BR 112014009946A2
Authority
BR
Brazil
Prior art keywords
compositions
water
soluble
purgatives
purgative
Prior art date
Application number
BR112014009946A
Other languages
English (en)
Inventor
Wettstein Antony
Saxon John
Ramrakha Sanjay
Julius Borody Thomas
Original Assignee
Salix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salix Pharmaceuticals Inc filed Critical Salix Pharmaceuticals Inc
Publication of BR112014009946A2 publication Critical patent/BR112014009946A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

electrolyte purgatives the invention provides compositions for use in purgatives, for use as purgatives, and to methods for inducing purgation of the colon. in alternative embodiments, the invention provides compositions, e.g., a purgative, comprising: a water-soluble sodium salt (especially sodium sulphate), a water-soluble potassium salt (especially potassium sulphate), and a water-soluble magnesium salt (especially magnesium sulphate); and, compositions further comprising: a bisoxatin, or a detergent stool softening agent (such as sodium picosulphate) and/or a water-soluble sugar (such as xylose or equivalent); or, compositions having these ingredients at different amounts, but at equivalent proportions. in alternative embodiments, the invention provides purgative compositions comprising electrolytes, salts, sugars, bisoxatin, dyes and biofilm disruptors. ****************************** tradução do resumo resumo patente de invenção: "purgativos de eletrólitos". a invenção apresenta composições para o uso em purgativos, para o uso como purgativos, e os métodos para a indução de purgação do cólon. em modalidades alternativas, a invenção apresenta composições, por exemplo, um purgativo, o qual compreende: um sal de sódio solúvel em água (especialmente o sulfato de sódio), um sal de potássio solúvel em água (especialmente o sulfato de potássio), e um sal de sódio solúvel em água (especialmente o sulfato de magnésio); e composições, que também compreendem: uma bisoxatina, ou um agente amaciante de fezes detergente (tal como o picosulfato de sódio) e/ou um açúcar solúvel em água (tal como a xilose ou algo equivalente); ou composições que têm esses ingredientes em quantidades diferentes, mas em proporções equivalentes. em modalidades alternativas, a invenção apresenta composições purgativas que compreendem eletrólitos, sais, açúcares, bisoxatina, corantes e rompedores de biopelícula. 21111474v1 1/1 21111474v1
BR112014009946A 2011-10-27 2012-10-27 "composição, composição farmacêutica ou formulação purgativas e uso das mesmas" BR112014009946A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161552431P 2011-10-27 2011-10-27
US201261717599P 2012-10-23 2012-10-23
PCT/AU2012/001315 WO2013059881A1 (en) 2011-10-27 2012-10-27 Electrolyte purgatives

Publications (1)

Publication Number Publication Date
BR112014009946A2 true BR112014009946A2 (pt) 2017-04-25

Family

ID=48166953

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014009946A BR112014009946A2 (pt) 2011-10-27 2012-10-27 "composição, composição farmacêutica ou formulação purgativas e uso das mesmas"

Country Status (13)

Country Link
US (1) US20150056140A1 (pt)
EP (1) EP2782581A4 (pt)
JP (2) JP6240610B2 (pt)
KR (1) KR20140090217A (pt)
CN (1) CN104010642B (pt)
AU (2) AU2012327212B2 (pt)
BR (1) BR112014009946A2 (pt)
CA (1) CA2853520C (pt)
IL (1) IL232218B (pt)
IN (1) IN2014DN03373A (pt)
MX (1) MX352891B (pt)
RU (1) RU2640920C2 (pt)
WO (1) WO2013059881A1 (pt)

Families Citing this family (16)

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NZ611868A (en) 2010-12-13 2015-11-27 Salix Pharmaceuticals Inc Gastric and colonic formulations and methods for making and using them
TWI535461B (zh) 2011-03-11 2016-06-01 諾金私人有限公司 結腸清潔溶液、用於製備該溶液之組成物、包含該組成物或溶液之套組、與製備該溶液之方法
PT2877163T (pt) 2012-07-27 2019-05-24 Redhill Biopharma Ltd Formulações e métodos de fabrico de formulações para utilização na evacuação colónica
ES2909386T3 (es) 2012-09-11 2022-05-06 Norgine Bv Composiciones que comprenden polietilenglicol y sulfatos de metales alcalinos o alcalinotérreos para su uso como composiciones de limpieza de colon
RS59667B1 (sr) 2013-03-15 2020-01-31 Braintree Laboratories Inc Oralna farmaceutska kompozicija sulfatnih soli u obliku tableta dvostruke primene i postupci njihove upotrebe
CN103585173B (zh) * 2013-10-28 2016-06-29 王显著 含硫酸钠和匹可硫酸的药物组合物
WO2016040733A1 (en) * 2014-09-12 2016-03-17 Braintree Laboratories, Inc. Sulfate salt solution laxative compositions and methods of use thereof
FR3049464B1 (fr) * 2016-03-29 2021-08-06 Marc Girard Preparations coliques
US10143656B1 (en) 2017-08-04 2018-12-04 Braintree Laboratories, Inc. Solid oral sulfate salt formulations for cleaning a colon and methods of using same
KR102127003B1 (ko) * 2017-10-12 2020-06-25 주식회사 한국팜비오 황산염을 포함하는 대장 하제 조성물
CN108244627A (zh) * 2018-01-16 2018-07-06 广西天昌投资有限公司 一种具有润肠功能的香蕉口服液及其制备方法
KR102111094B1 (ko) * 2018-06-18 2020-05-14 주식회사 한국팜비오 무수황산나트륨, 황산칼륨, 무수황산마그네슘 및 시메티콘을 포함하는 장관하제 경구투여용 고형제제 조성물
RU2699222C1 (ru) * 2019-04-29 2019-09-04 Алексей Владимирович Воронов Солевой электролитный раствор для проведения энтеральных инфузий
RU2709495C1 (ru) * 2019-08-01 2019-12-18 Общество с ограниченной ответственностью "Гелеспон" Способ очищения кишечника и набор для его осуществления
KR20220122613A (ko) * 2019-12-23 2022-09-02 주식회사 비보존 대장 하제 조성물
KR20220033810A (ko) * 2020-09-10 2022-03-17 강윤식 장 정결용 보조 음료

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US6162464A (en) * 1997-03-31 2000-12-19 Inkine Pharmaceutical, Inc. Non-aqueous colonic purgative formulations
JP2000060487A (ja) * 1998-08-27 2000-02-29 Kao Corp 便秘改善剤
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Also Published As

Publication number Publication date
JP2018008997A (ja) 2018-01-18
MX352891B (es) 2017-12-13
EP2782581A4 (en) 2015-05-20
IL232218A0 (en) 2014-06-30
KR20140090217A (ko) 2014-07-16
US20150056140A1 (en) 2015-02-26
AU2016213892A1 (en) 2016-09-01
AU2012327212A1 (en) 2013-05-23
WO2013059881A1 (en) 2013-05-02
JP2015510491A (ja) 2015-04-09
NZ723576A (en) 2018-07-27
AU2016213892B2 (en) 2018-04-05
CA2853520C (en) 2021-11-16
NZ624088A (en) 2016-09-30
CN104010642A (zh) 2014-08-27
IN2014DN03373A (pt) 2015-06-05
EP2782581A1 (en) 2014-10-01
CA2853520A1 (en) 2013-05-02
JP6240610B2 (ja) 2017-11-29
IL232218B (en) 2018-10-31
MX2014004962A (es) 2015-01-16
AU2012327212B2 (en) 2016-05-12
RU2014121255A (ru) 2015-12-10
RU2640920C2 (ru) 2018-01-12
CN104010642B (zh) 2018-08-17

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