JP6229174B2 - 診断キット及びその使用方法 - Google Patents
診断キット及びその使用方法 Download PDFInfo
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- JP6229174B2 JP6229174B2 JP2016051761A JP2016051761A JP6229174B2 JP 6229174 B2 JP6229174 B2 JP 6229174B2 JP 2016051761 A JP2016051761 A JP 2016051761A JP 2016051761 A JP2016051761 A JP 2016051761A JP 6229174 B2 JP6229174 B2 JP 6229174B2
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- blood cells
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Classifications
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- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
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Description
、生体試料を計測位置に過剰に展開してしまうことによって、各測定に濃度差が生じることにより誤判定し、精度が悪くなる場合がある。
図1は、本実施の形態における診断キット100の上面図である。診断キット100は、基材プレート100bと、基材プレート100bに設けられた複数の診断プレート101とを備える。基材プレート100bは、中心軸100cを中心とする円環形状を有する。複数の診断プレート101は中心軸100cから遠ざかる所定の方向100aに延び、中心軸100cを中心に等角度間隔で放射状に配列されている。複数の診断プレート101により、診断キット100は複数の生体試料を一度に測定(検査)出来る。
続されたチャンバー105が設けられている。チャンバー105は複数の診断プレート101の全てと接続されている。流路103は一端103aから他端103bまで所定の方向100aに延びる。
、毛細管現象によりサンプル溶液がチャンバー102から流路103内に自発的に浸入する場合がある。一方、貫通孔107の疎水部が約120°以上の接触角を有すると撥水性が高過ぎるので、診断キット100に対して最高回転速度で遠心力を印加した場合であっても、生体試料がチャンバー102から流路103に浸入しない場合がある。
含まれていることが好ましい。
複数の個所で対象物通過部108を設けることにより、より効率的に、サンプル溶液から白血球を捕捉させることが可能となる。
光を遮断し、645nm以上の光を遮断せずに通過させることが望ましい。
ができる。
(実施の形態2)
図9は実施の形態2における診断キット200の断面図である。図9において、図1から図8に示す実施の形態1における診断キット100と同時部分には同じ参照番号を付す。実施の形態2における診断キット200は、実施の形態1における診断キット100の診断プレート101と検査プレート104の代わりに、診断プレート201と検査プレート204を備える。検査プレート204は、実施の形態1における検査プレート104の複数のキャビティ115の代わりに、複数のキャビティ115と形状の異なる複数のキャビティ215が形成されている。
(実施の形態3)
図15は実施の形態3における診断キット300の診断プレート301の断面図である。図15において、図1から図8に示す実施の形態1における診断キット100と同じ部分には同じ参照符号を付す。診断キット300は実施の形態1における診断キット100の診断プレート101の代わりに診断プレート301を備える。実施の形態3における診断キット300では検査プレート104にて血液や生体由来の成分から白血球を抽出して分析できる。
(実施の形態4)
図16は実施の形態4における診断キット400の診断プレート401の断面図である。図16において、図1から図8に示す実施の形態1における診断キット100と同じ部分には同じ参照符号を付す。診断キット400は実施の形態1における診断キット100の診断プレート101の代わりに診断プレート401を備える。実施の形態4における診断キット400は血液や生体由来の成分から血しょうを抽出して分析する。
成されている。生体試料に含まれる溶質のうち、赤血球、白血球などの血球成分や、その最大直径が繊維状物質440a間の空隙よりも大きいものが捕捉物として繊維状物質440aにより捕捉される。また、繊維状物質440a間の空隙を通過可能である血しょうが繊維状物質440a間を通過していくことにより、非対象物捕捉構造物440は血しょうを通過させて抽出することが可能である。
(実施の形態5)
図17は実施の形態5における検出装置1001の概略図である。図17において、図1から図16に示す実施の形態1〜4における診断キット100〜400と同じ部分には同じ参照符号を付す。検出装置1001は、検査プレート104(204、204a、204b、404)から出される蛍光を検出するカメラ551を備える。
る。
うでないものかを区別することができる。例えば、実施の形態1で説明したような非対象物捕捉構造物を有さない診断キットを用いて検体として赤血球中の外来生物の有無を検出する場合、白血球や検査プレートに付着していたゴミなどの検体でないものが蛍光を発する場合がある。しかし、赤血球と白血球とゴミとはそれぞれ大きさ、明度、形状などが異なるため画像処理を施すことでそれらを区別できる。
(実施の形態6)
図18と図19はそれぞれ実施の形態6における検査プレート104の上面図と要部拡大図である。図18と図19において、図1から図17に示す実施の形態1〜5における診断キット100〜400と検出装置1001と同じ部分には同じ参照番号を付す。実施の形態6における検出装置では、実施の形態5における検出装置1001と同様に、複数のキャビティ115を有する検査プレート104からの蛍光をカメラ551で検出した際に、検査プレート104でのキャビティ115の位置を検出することができる。
100b 基材プレート
101 診断プレート
102 チャンバー(第一のチャンバー)
103 流路
104 検査プレート
105 チャンバー(第二のチャンバー)
108 対象物通過部
109 非対象物捕捉構造物
109a 繊維状物質
110 非対象物捕捉プローブ
111 貫通板
112 スリット
115 キャビティ
117 フォトディテクタ
118 蛍光フィルタ
215 キャビティ
216 キャビティ
Claims (5)
- 赤血球を含有する生体試料と、核酸を染色することができる染色液とを用いて前記赤血球中の外来生物の有無を検出するために用いられる診断キットであって、
前記染色液を貯留して前記染色液に前記生体試料が注入されるように構成された第一のチャンバーと、
前記第一のチャンバーに接続された一端と、前記一端の反対側の他端とを有し、前記生体試料と前記染色液から前記赤血球を抽出するよう構成された流路と、
前記流路の前記他端に接続された、前記抽出した赤血球が配置されるように構成された検査プレートと、
を備えた診断キット。 - 前記流路に設けられる非対象物捕捉構造物を、さらに備える、
請求項1に記載の診断キット。 - 前記非対象物捕捉構造物は、複数の繊維状物質からなり、
前記複数の繊維状物質は、互いに絡み合う、
請求項2に記載の診断キット。 - 前記非対象物捕捉構造物は、前記生体試料に含まれる白血球を捕捉し、赤血球を通過させる、
請求項3に記載の診断キット。 - 前記複数の繊維状物質は、酸化珪素を主成分とする、
請求項3に記載の診断キット。
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- 2012-04-05 WO PCT/JP2012/002383 patent/WO2012137506A1/ja active Application Filing
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2013
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US20140004527A1 (en) | 2014-01-02 |
WO2012137506A1 (ja) | 2012-10-11 |
JPWO2012137506A1 (ja) | 2014-07-28 |
SG194064A1 (en) | 2013-11-29 |
JP2016136158A (ja) | 2016-07-28 |
JP5934921B2 (ja) | 2016-06-15 |
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