JP6225114B2 - クラスタ検出に関する装置 - Google Patents

クラスタ検出に関する装置 Download PDF

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Publication number
JP6225114B2
JP6225114B2 JP2014540600A JP2014540600A JP6225114B2 JP 6225114 B2 JP6225114 B2 JP 6225114B2 JP 2014540600 A JP2014540600 A JP 2014540600A JP 2014540600 A JP2014540600 A JP 2014540600A JP 6225114 B2 JP6225114 B2 JP 6225114B2
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sample chamber
light
cartridge
excitation light
photodetector
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Japanese (ja)
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JP2014535060A5 (enExample
JP2014535060A (ja
Inventor
ヨハネス ヨセフ フベルティナ バーバラ スレイペン
ヨハネス ヨセフ フベルティナ バーバラ スレイペン
メンノ ウィレム ヨセ プリンス
メンノ ウィレム ヨセ プリンス
アンドレア ランゾーニ
アンドレア ランゾーニ
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Koninklijke Philips NV
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Koninklijke Philips NV
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/1717—Systems in which incident light is modified in accordance with the properties of the material investigated with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
    • G01N2021/1727—Magnetomodulation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
JP2014540600A 2011-11-14 2012-11-06 クラスタ検出に関する装置 Active JP6225114B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161559307P 2011-11-14 2011-11-14
US61/559,307 2011-11-14
PCT/IB2012/056186 WO2013072806A1 (en) 2011-11-14 2012-11-06 Apparatus for cluster detection

Publications (3)

Publication Number Publication Date
JP2014535060A JP2014535060A (ja) 2014-12-25
JP2014535060A5 JP2014535060A5 (enExample) 2015-12-24
JP6225114B2 true JP6225114B2 (ja) 2017-11-01

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JP2014540600A Active JP6225114B2 (ja) 2011-11-14 2012-11-06 クラスタ検出に関する装置

Country Status (7)

Country Link
US (1) US9863863B2 (enExample)
EP (1) EP2780692A1 (enExample)
JP (1) JP6225114B2 (enExample)
CN (1) CN103930765B (enExample)
BR (1) BR112014011259A2 (enExample)
IN (1) IN2014CN03614A (enExample)
WO (1) WO2013072806A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI582408B (zh) 2011-08-29 2017-05-11 安美基公司 用於非破壞性檢測－流體中未溶解粒子之方法及裝置
JP6517193B2 (ja) * 2013-06-07 2019-05-22 マルバーン インストゥルメンツ リミテッド アレイベースの試料特性評価
JP7028454B2 (ja) * 2016-11-30 2022-03-02 国立研究開発法人産業技術総合研究所 標的物質検出装置及び標的物質検出方法
WO2018100780A1 (ja) * 2016-11-30 2018-06-07 国立研究開発法人産業技術総合研究所 標的物質検出装置及び標的物質検出方法
US10088660B2 (en) 2017-02-10 2018-10-02 Amgen Inc. Imaging system for counting and sizing particles in fluid-filled vessels
FI3580550T3 (fi) * 2017-02-10 2024-07-30 Amgen Inc Kuvausjärjestelmä fluidilla täytetyissä astioissa olevien hiukkasten lukumäärän ja koon määrittämiseksi
CN107121649B (zh) * 2017-03-29 2023-10-10 金华职业技术学院 一种使用磁强计测量磁性分子团簇磁矩的方法
GB2566995B (en) * 2017-09-29 2023-01-18 Cotton Mouton Diagnostics Ltd A method of detection
TWI776251B (zh) * 2020-10-08 2022-09-01 中原大學 基於目標分子吸附之磁控量測系統
KR102856352B1 (ko) * 2020-10-16 2025-09-04 삼성전자주식회사 다채널 액체 파티클 계수기
CN116121051B (zh) * 2023-03-14 2023-09-01 鲲鹏(徐州)科学仪器有限公司 一种光学检测装置

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2807777B2 (ja) * 1994-09-09 1998-10-08 工業技術院長 スラブ光導波路を利用した光吸収スペクトル測定装置
JPH10332698A (ja) * 1997-06-03 1998-12-18 Hitachi Ltd 特異的結合反応の判定方法
DE19825518C2 (de) * 1998-06-08 2001-10-04 Fresenius Ag Vorrichtung zur Messung von Parameteränderungen an lichtdurchlässigen Objekten
CA2401511A1 (en) * 2000-03-13 2001-09-20 Genospectra, Inc. Fiber optic scanner
JP3695340B2 (ja) * 2001-03-30 2005-09-14 株式会社日立製作所 Ｄｎａ検査方法及びその装置並びに蛍光検出方法
DE10137665A1 (de) * 2001-05-09 2002-11-14 Kilian Hennes Vorrichtung und Verfahren zum Erfassen und Klassifizieren von biologischen Partikeln oder Molekülen
JP2009058523A (ja) * 2001-05-10 2009-03-19 Yokogawa Electric Corp バイオチップ読取装置
DE10130727C2 (de) * 2001-06-21 2003-09-18 Mediquant Gmbh Verfahren und Vorrichtung zur Messung von Mikroviskositätsveränderungen als Immuntest
US7149396B2 (en) * 2003-06-16 2006-12-12 The Regents Of The University Of California Apparatus for optical measurements on low-index non-solid materials based on arrow waveguides
JP2005070031A (ja) * 2003-08-01 2005-03-17 Shimadzu Corp マイクロチップを用いた成分分析装置
JP4401897B2 (ja) * 2004-08-19 2010-01-20 独立行政法人理化学研究所 レシオイメージング装置
US7248361B2 (en) * 2005-12-22 2007-07-24 Palo Alto Research Center Incorporated Fluorescence reader based on anti-resonant waveguide excitation
SE529474C2 (sv) * 2006-04-19 2007-08-21 Imego Ab Detekteringsanordning och förfarande
WO2008075285A1 (en) 2006-12-19 2008-06-26 Koninklijke Philips Electronics N.V. Measuring agglutination parameters
DE602007007243D1 (de) * 2007-02-23 2010-07-29 Koninkl Philips Electronics Nv Sensorvorrichtung und verfahren zum detektieren magnetischer partikel
US9068977B2 (en) * 2007-03-09 2015-06-30 The Regents Of The University Of Michigan Non-linear rotation rates of remotely driven particles and uses thereof
EP1972927A1 (en) * 2007-03-14 2008-09-24 Koninklijke Philips Electronics N.V. Microelectronic sensor device for detecting label particles
US20100322824A1 (en) 2007-11-05 2010-12-23 Koninklijke Philips Electronics N.V. Biosensor cartridge
WO2009066236A1 (en) 2007-11-22 2009-05-28 Koninklijke Philips Electronics N.V. Methods and systems for coupling a bio-cartridge with an optical reader
WO2009074933A1 (en) 2007-12-13 2009-06-18 Koninklijke Philips Electronics N. V. Biosensor based on frustrated total internal reflection
EP2103974A1 (en) 2008-03-21 2009-09-23 Nitto Denko Corporation Optical waveguide having grating and method of forming the same
JP5816083B2 (ja) * 2008-06-24 2015-11-17 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． マイクロアレイ評価システム及び方法
JP5685537B2 (ja) * 2008-09-05 2015-03-18 コーニンクレッカ フィリップス エヌ ヴェ クラスター・アッセイにおける改善した検出のための回転磁場
CN102187242B (zh) 2008-10-16 2015-08-19 皇家飞利浦电子股份有限公司 具有四极磁性驱动系统的生物传感器
CN102292634B (zh) * 2009-01-22 2016-08-03 皇家飞利浦电子股份有限公司 用于磁性生物传感器设备的混合致动协议
WO2010148252A1 (en) * 2009-06-17 2010-12-23 Jody Vykoukal Method and apparatus for quantitative microimaging
WO2011021142A1 (en) * 2009-08-19 2011-02-24 Koninklijke Philips Electronics N.V. Detection of different target components by cluster formation
KR101258878B1 (ko) 2009-08-28 2013-04-30 한국전자통신연구원 광 주사 바이오 센서 칩 및 바이오 센서 칩의 구동 방법
JPWO2011049044A1 (ja) * 2009-10-19 2013-03-14 国立大学法人東京工業大学 磁性微粒子を用いるバイオセンサ
US20120003750A1 (en) 2010-07-02 2012-01-05 Koninklijke Philips Electronics N.V. Detection of actuated clusters by scattering
EP2591334A1 (en) 2010-07-09 2013-05-15 Koninklijke Philips Electronics N.V. Cartridge with large-scale manufacturing design
EP2541250A1 (en) 2011-06-30 2013-01-02 Koninklijke Philips Electronics N.V. Molecular architecture on magnetic particles for affinity assays with low non-specific binding
EP2541230A1 (en) * 2011-06-30 2013-01-02 Koninklijke Philips Electronics N.V. Detection of clusters of magnetic particles

Also Published As

Publication number Publication date
US9863863B2 (en) 2018-01-09
IN2014CN03614A (enExample) 2015-10-09
BR112014011259A2 (pt) 2017-04-25
CN103930765A (zh) 2014-07-16
EP2780692A1 (en) 2014-09-24
WO2013072806A1 (en) 2013-05-23
JP2014535060A (ja) 2014-12-25
US20140302619A1 (en) 2014-10-09
CN103930765B (zh) 2017-10-13

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