JP6218870B2 - ジンセノサイドf2を含む非アルコール性肝疾患又はインスリン抵抗性の予防若しくは治療用組成物 - Google Patents
ジンセノサイドf2を含む非アルコール性肝疾患又はインスリン抵抗性の予防若しくは治療用組成物 Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
Description
朝鮮人参、花旗参、竹節参などを含むその他の高麗人参の葉及び根に20倍の体積の80%エタノールを加えて2回以上抽出し、乾燥させて粗サポニンを得る。前記粗サポニンを水に再び溶解させてHP−20樹脂に吸着させ、その後100%水で洗浄して糖を除去し、次いで40%エタノールで一次洗浄してプロトパナキサトリオール(protopanaxatriol)系のジンセノサイドRe、Rg1を優先的に除去する。その後、80%エタノールで洗浄するとプロトパナキサジオール(protopanaxadiol)系のジンセノサイドRb1、Rb2、Rc、Rdが溶出して出てくるので、これを乾燥させて得る。前記プロトパナキサジオールジンセノサイド混合物を基質として用いて、特許文献2に記載の方法で反応させることにより、70%以上のジンセノサイドF2を得た。次いで、試料用に用いるジンセノサイドF2は、ODS樹脂を用いて吸着させ、その後適正濃度のエタノールを濃度勾配により連続して流出させると95%以上の高純度のジンセノサイドF2分画を得ることができ、これを乾燥させて用いた。
ジンセノサイドF2の脂肪肝の緩和効果を確認するために、高脂肪食餌マウスモデルを用いた。8週齢の雄性マウス(体重25−28g)に高脂肪食餌を12週間 と、50mg/kgのジンセノサイドF2を週5日経口給与した。その結果、ジンセノサイドF2を給与したグループは、対照群と比較し、肝臓の大きさ(図1a)及び肝臓の重量(図1b)の差が顕著に減少することを確認した。前記結果によりジンセノサイドF2は高脂肪食餌を給与したにもかかわらず、脂肪肝の生成を抑制する効果があることが分かった。
肝組織の変化を観察するために、H&E(Hematoxylin and eosin)染色を行い、オイルレッドO(Oil-red O)染色で肝細胞の中性脂質を染色し、前記の結果を×100の倍率で示した(図2a)。その結果、ジンセノサイドF2の投与により、肝細胞における脂肪蓄積が減少したことを再度確認することができた。
11週齢のマウスでグルコースとインスリンを投与した後、経時的に血糖値をチェックした。その結果、ジンセノサイドF2グループで時間が経過するにつれて、対照群に比べて糖数値が下がり、初期血糖値に比べて血糖値を下げる効果が優れていることが確認できた(図3)。結論としてジンセノサイドF2は、高脂肪食餌を与えたマウスにおいてインスリン敏感度を向上させる効果を有することが分かった。
高脂肪食餌とジンセノサイドF2を与えたマウスにおいて、ジンセノサイドF2は、各種の炎症性サイトカイン(TNF−α、IL−1β、及びIL−6)の発現を抑制させ、クッパー細胞においてもそれと同様の結果を示した(図4)。
肝星細胞にTNF−αを処理した後、ジンセノサイドF2を10、20、及び30μM処理し、24時間培養した。培養された肝星細胞で発現レベルの差を確認した結果、ジンセノサイドF2は、エンドカンナビノイドの一種である2−AGを合成するのに重要な酵素であるDAGLα及びDAGLβの発現を抑制し、それ以外にも、肝臓損傷に関連する因子であるNAPE−PLD、FAAHの発現を抑制することが確認することができた(図5)。
Claims (8)
- ジンセノサイドF2を含む非アルコール性肝疾患又はインスリン抵抗性の予防若しくは治療用医薬組成物。
- 前記非アルコール性肝疾患は、非アルコール性脂肪肝、非アルコール性肝炎、又は非アルコール性肝硬変である、請求項1に記載の医薬組成物。
- 前記ジンセノサイドF2は、肝臓における脂肪形成又は脂肪の蓄積を抑制するものである、請求項1に記載の医薬組成物。
- ジンセノサイドF2を含む非アルコール性肝疾患又はインスリン抵抗性の予防若しくは改善用健康機能食品。
- 前記健康機能食品は、粉末、顆粒、錠剤、カプセル、又は飲料形態である、請求項4に記載の健康機能食品。
- ジンセノサイドF2を含む非アルコール性肝疾患又はインスリン抵抗性の予防若しくは改善用飼料組成物。
- 請求項1〜3のいずれかの組成物を、ヒトを除く非アルコール性肝疾患又はインスリン抵抗性の疑いのある個体に投与するステップを含む、非アルコール性肝疾患又はインスリン抵抗性の予防若しくは治療方法。
- 非アルコール性肝疾患又はインスリン抵抗性を予防若しくは治療するための医薬の製造におけるジンセノサイドF2の使用。
Applications Claiming Priority (2)
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KR1020150030031A KR101695848B1 (ko) | 2015-03-03 | 2015-03-03 | 진세노사이드 f2를 포함하는 비알코올성 간 질환 또는 인슐린 저항성의 예방 또는 치료용 조성물 |
KR10-2015-0030031 | 2015-03-03 |
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JP2016166185A JP2016166185A (ja) | 2016-09-15 |
JP6218870B2 true JP6218870B2 (ja) | 2017-10-25 |
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Country Status (5)
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US (2) | US20160256477A1 (ja) |
EP (1) | EP3064209B1 (ja) |
JP (1) | JP6218870B2 (ja) |
KR (1) | KR101695848B1 (ja) |
CN (1) | CN105935364B (ja) |
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TWI717559B (zh) | 2017-05-18 | 2021-02-01 | 王子製藥股份有限公司 | 包含葫蘆巴萃取物之組合物用於製備預防非酒精性脂肪肝之醫藥組合物的用途 |
CA3075711A1 (en) * | 2017-09-13 | 2019-03-21 | Novartis Ag | Use of il-1 b binding antibodies for the treatment of alcoholic hepatitis |
KR102091528B1 (ko) | 2018-12-21 | 2020-03-24 | 재단법인 금산국제인삼약초연구소 | 인삼 농축액을 포함하는 간질환 개선용 조성물 |
BR112021023218A2 (pt) * | 2019-05-22 | 2022-02-08 | Demetrix Inc | Polipeptídeos sintase de canabinoide otimizados |
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CN1240390C (zh) * | 2002-01-30 | 2006-02-08 | 株式会社一和 | 生物转化人参组合物及其制备方法 |
KR100479803B1 (ko) * | 2002-04-08 | 2005-03-30 | 홍림통산(주) | 약효가 증가된 특수가공처리 인삼 추출물을 함유하는뇌졸증의 예방 및 치료를 위한 조성물 |
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CN100378117C (zh) * | 2006-03-17 | 2008-04-02 | 中国科学院长春应用化学研究所 | 一种从人参根中获得二醇型人参皂苷f2含量较高的人参皂苷粗提物的方法 |
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KR101433661B1 (ko) | 2012-05-31 | 2014-08-26 | 한국과학기술원 | 신규한 진세노사이드 글리코시다제를 이용한 진세노사이드 f2의 제조방법 |
KR101877801B1 (ko) * | 2012-07-05 | 2018-07-13 | (주)아모레퍼시픽 | 수경재배 인삼 유래 진세노사이드 f2를 함유하는 피부 외용제 조성물 |
KR101460569B1 (ko) * | 2012-07-27 | 2014-11-12 | 강원대학교산학협력단 | 진세노사이드 f2를 유효 성분으로 포함하는 주름개선, 피부미백 및 여드름 개선용 화장료 조성물 |
KR101343857B1 (ko) * | 2012-09-12 | 2013-12-20 | 재단법인 금산국제인삼약초연구소 | 발효 홍삼 유래의 진세노사이드 f2를 유효성분으로 하는 발모촉진용 또는 탈모방지용 외용제 조성물 |
KR101621356B1 (ko) * | 2014-09-05 | 2016-05-17 | 한국과학기술원 | 진세노사이드 f2의 간 질환 예방 또는 치료 용도 |
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KR101695848B1 (ko) | 2017-01-13 |
EP3064209B1 (en) | 2019-11-06 |
US20160256477A1 (en) | 2016-09-08 |
CN105935364B (zh) | 2020-02-11 |
CN105935364A (zh) | 2016-09-14 |
EP3064209A1 (en) | 2016-09-07 |
US20210008088A1 (en) | 2021-01-14 |
KR20160107420A (ko) | 2016-09-19 |
JP2016166185A (ja) | 2016-09-15 |
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