JP6206926B2 - 異常なプロテインキナーゼｃのチエノピリミジン阻害剤 - Google Patents

異常なプロテインキナーゼｃのチエノピリミジン阻害剤 Download PDF

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JP6206926B2
JP6206926B2 JP2014543517A JP2014543517A JP6206926B2 JP 6206926 B2 JP6206926 B2 JP 6206926B2 JP 2014543517 A JP2014543517 A JP 2014543517A JP 2014543517 A JP2014543517 A JP 2014543517A JP 6206926 B2 JP6206926 B2 JP 6206926B2
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amino
cycloalkyl
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JP2014533728A (ja
JP2014533728A5 (https=
Inventor
ディー． ドーシー、ブルース
ディー． ドーシー、ブルース
エス． ラーン、キース
エス． ラーン、キース
エル． モリス、エマ
エル． モリス、エマ
アール． オット、グレゴリー
アール． オット、グレゴリー
アール． ルーフェイ、ジョナサン
アール． ルーフェイ、ジョナサン
エヌ． サウディ、クリステル
エヌ． サウディ、クリステル
シー． ワーグナー、ジェイソン
シー． ワーグナー、ジェイソン
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Cancer Research Technology Ltd
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Cancer Research Technology Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014543517A 2011-11-23 2012-11-19 異常なプロテインキナーゼｃのチエノピリミジン阻害剤 Active JP6206926B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161563310P 2011-11-23 2011-11-23
US61/563,310 2011-11-23
PCT/US2012/065831 WO2013078126A1 (en) 2011-11-23 2012-11-19 Thienopyrimidine inhibitors of atypical protein kinase c

Publications (3)

Publication Number Publication Date
JP2014533728A JP2014533728A (ja) 2014-12-15
JP2014533728A5 JP2014533728A5 (https=) 2016-01-14
JP6206926B2 true JP6206926B2 (ja) 2017-10-04

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JP2014543517A Active JP6206926B2 (ja) 2011-11-23 2012-11-19 異常なプロテインキナーゼｃのチエノピリミジン阻害剤

Country Status (11)

Country Link
US (3) US9604994B2 (https=)
EP (2) EP2782917B1 (https=)
JP (1) JP6206926B2 (https=)
CN (1) CN104053661B (https=)
AU (2) AU2012340869B2 (https=)
CA (1) CA2855446C (https=)
ES (1) ES2575143T3 (https=)
IL (1) IL232559B (https=)
IN (1) IN2014CN04558A (https=)
MX (1) MX355088B (https=)
WO (1) WO2013078126A1 (https=)

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TWI675836B (zh) * 2014-03-25 2019-11-01 美商伊格尼塔公司 非典型蛋白質激酶ｃ之氮雜喹唑啉抑制劑
JP7114076B2 (ja) * 2015-12-22 2022-08-08 シャイ・セラピューティクス・エルエルシー がん及び炎症性疾患の処置のための化合物
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
KR20180075228A (ko) * 2016-12-26 2018-07-04 한미약품 주식회사 싸이에노피리미딘 화합물의 신규 제조방법 및 중간체
JP7514005B2 (ja) 2017-06-21 2024-07-10 シャイ・セラピューティクス・エルエルシー がん、炎症性疾患、ラソパシー、及び線維性疾患の治療のためのｒａｓスーパーファミリーと相互作用する化合物
WO2019119206A1 (en) * 2017-12-18 2019-06-27 Merck Sharp & Dohme Corp. Purine inhibitors of human phosphatidylinositol 3-kinase delta
CN108658999B (zh) * 2018-04-24 2021-02-05 温州大学 2-苯基杂环并[2,3-d]嘧啶-4(3H)-酮类化合物的合成方法
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JP7629200B2 (ja) * 2018-11-20 2025-02-13 ジョージタウン ユニバーシティ 神経変性、筋変性及びリソソーム蓄積障害を治療するための組成物及び方法
JP7407461B2 (ja) 2018-12-19 2024-01-04 シャイ・セラピューティクス・エルエルシー がん、炎症性疾患、ｒａｓ病、及び線維性疾患の処置のためのｒａｓスーパーファミリーと相互作用する化合物
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Publication number Publication date
EP2782917B1 (en) 2016-03-02
IN2014CN04558A (https=) 2015-09-18
US20140323435A1 (en) 2014-10-30
EP2782917A1 (en) 2014-10-01
AU2017203725B2 (en) 2019-02-28
IL232559B (en) 2018-04-30
AU2017203725A1 (en) 2017-06-22
ES2575143T3 (es) 2016-06-24
NZ625447A (en) 2015-09-25
US9604994B2 (en) 2017-03-28
HK1202529A1 (zh) 2015-10-02
US10183950B2 (en) 2019-01-22
CA2855446A1 (en) 2013-05-30
US20170158706A1 (en) 2017-06-08
EP3048106A1 (en) 2016-07-27
JP2014533728A (ja) 2014-12-15
MX2014006233A (es) 2014-10-17
CA2855446C (en) 2021-04-20
WO2013078126A1 (en) 2013-05-30
US20190106433A1 (en) 2019-04-11
CN104053661A (zh) 2014-09-17
AU2012340869B2 (en) 2017-03-02
IL232559A0 (en) 2014-06-30
MX355088B (es) 2018-04-04
AU2012340869A1 (en) 2014-06-19
CN104053661B (zh) 2018-06-19
EP3048106B1 (en) 2019-11-06
US10954251B2 (en) 2021-03-23

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