JP6206926B2 - 異常なプロテインキナーゼｃのチエノピリミジン阻害剤 - Google Patents

異常なプロテインキナーゼｃのチエノピリミジン阻害剤 Download PDF

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JP6206926B2
JP6206926B2 JP2014543517A JP2014543517A JP6206926B2 JP 6206926 B2 JP6206926 B2 JP 6206926B2 JP 2014543517 A JP2014543517 A JP 2014543517A JP 2014543517 A JP2014543517 A JP 2014543517A JP 6206926 B2 JP6206926 B2 JP 6206926B2
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alkyl
amino
cycloalkyl
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JP2014533728A (ja
JP2014533728A5 (enExample
Inventor
ディー． ドーシー、ブルース
ディー． ドーシー、ブルース
エス． ラーン、キース
エス． ラーン、キース
エル． モリス、エマ
エル． モリス、エマ
アール． オット、グレゴリー
アール． オット、グレゴリー
アール． ルーフェイ、ジョナサン
アール． ルーフェイ、ジョナサン
エヌ． サウディ、クリステル
エヌ． サウディ、クリステル
シー． ワーグナー、ジェイソン
シー． ワーグナー、ジェイソン
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Cancer Research Technology Ltd
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Cancer Research Technology Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014543517A 2011-11-23 2012-11-19 異常なプロテインキナーゼｃのチエノピリミジン阻害剤 Active JP6206926B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161563310P 2011-11-23 2011-11-23
US61/563,310 2011-11-23
PCT/US2012/065831 WO2013078126A1 (en) 2011-11-23 2012-11-19 Thienopyrimidine inhibitors of atypical protein kinase c

Publications (3)

Publication Number Publication Date
JP2014533728A JP2014533728A (ja) 2014-12-15
JP2014533728A5 JP2014533728A5 (enExample) 2016-01-14
JP6206926B2 true JP6206926B2 (ja) 2017-10-04

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JP2014543517A Active JP6206926B2 (ja) 2011-11-23 2012-11-19 異常なプロテインキナーゼｃのチエノピリミジン阻害剤

Country Status (11)

Country Link
US (3) US9604994B2 (enExample)
EP (2) EP2782917B1 (enExample)
JP (1) JP6206926B2 (enExample)
CN (1) CN104053661B (enExample)
AU (2) AU2012340869B2 (enExample)
CA (1) CA2855446C (enExample)
ES (1) ES2575143T3 (enExample)
IL (1) IL232559B (enExample)
IN (1) IN2014CN04558A (enExample)
MX (1) MX355088B (enExample)
WO (1) WO2013078126A1 (enExample)

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HK1210732A1 (en) 2012-07-11 2016-05-06 Nimbus Iris, Inc. Irak inhibitors and uses thereof
EP2872144A4 (en) 2012-07-11 2015-12-02 Nimbus Iris Inc IRAQ INHIBITOR AND USES THEREOF
WO2014110114A1 (en) 2013-01-10 2014-07-17 Nimbus Iris, Inc. Irak inhibitors and uses thereof
EP3049086A4 (en) 2013-09-27 2017-02-22 Nimbus Iris, Inc. Irak inhibitors and uses thereof
TWI675836B (zh) 2014-03-25 2019-11-01 美商伊格尼塔公司 非典型蛋白質激酶ｃ之氮雜喹唑啉抑制劑
WO2017112777A1 (en) 2015-12-22 2017-06-29 SHY Therapeutics LLC Compounds for the treatment of cancer and inflammatory disease
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TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
KR20180075228A (ko) * 2016-12-26 2018-07-04 한미약품 주식회사 싸이에노피리미딘 화합물의 신규 제조방법 및 중간체
KR102736865B1 (ko) * 2017-06-21 2024-12-03 샤이 테라퓨틱스 엘엘씨 암, 염증성 질환, 신경발달질환 및 섬유증 질환의 치료를 위하여 Ras 수퍼패밀리와 상호작용하는 화합물
WO2019119206A1 (en) * 2017-12-18 2019-06-27 Merck Sharp & Dohme Corp. Purine inhibitors of human phosphatidylinositol 3-kinase delta
CN108658999B (zh) * 2018-04-24 2021-02-05 温州大学 2-苯基杂环并[2,3-d]嘧啶-4(3H)-酮类化合物的合成方法
EP3632908A1 (en) 2018-10-02 2020-04-08 Inventiva Inhibitors of the yap/taz-tead interaction and their use in the treatment of cancer
CN120040470A (zh) 2018-11-20 2025-05-27 乔治敦大学 用于治疗神经退行性、肌退行性和溶酶体贮积病症的组合物和方法
JP7407461B2 (ja) 2018-12-19 2024-01-04 シャイ・セラピューティクス・エルエルシー がん、炎症性疾患、ｒａｓ病、及び線維性疾患の処置のためのｒａｓスーパーファミリーと相互作用する化合物
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JP2014533728A (ja) 2014-12-15
AU2012340869A1 (en) 2014-06-19
US10183950B2 (en) 2019-01-22
MX2014006233A (es) 2014-10-17
CN104053661B (zh) 2018-06-19
IL232559A0 (en) 2014-06-30
IL232559B (en) 2018-04-30
CN104053661A (zh) 2014-09-17
EP2782917B1 (en) 2016-03-02
EP3048106B1 (en) 2019-11-06
AU2017203725A1 (en) 2017-06-22
HK1202529A1 (zh) 2015-10-02
US10954251B2 (en) 2021-03-23
WO2013078126A1 (en) 2013-05-30
US20170158706A1 (en) 2017-06-08
EP2782917A1 (en) 2014-10-01
CA2855446C (en) 2021-04-20
EP3048106A1 (en) 2016-07-27
CA2855446A1 (en) 2013-05-30
IN2014CN04558A (enExample) 2015-09-18
AU2017203725B2 (en) 2019-02-28
US20190106433A1 (en) 2019-04-11
US20140323435A1 (en) 2014-10-30
AU2012340869B2 (en) 2017-03-02
ES2575143T3 (es) 2016-06-24
NZ625447A (en) 2015-09-25
US9604994B2 (en) 2017-03-28
MX355088B (es) 2018-04-04

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