JP6195830B2 - 適応光学系を有する顕微鏡検査法 - Google Patents
適応光学系を有する顕微鏡検査法 Download PDFInfo
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- JP6195830B2 JP6195830B2 JP2014520398A JP2014520398A JP6195830B2 JP 6195830 B2 JP6195830 B2 JP 6195830B2 JP 2014520398 A JP2014520398 A JP 2014520398A JP 2014520398 A JP2014520398 A JP 2014520398A JP 6195830 B2 JP6195830 B2 JP 6195830B2
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- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/06—Means for illuminating specimens
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
- G02B26/06—Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the phase of light
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161507906P | 2011-07-14 | 2011-07-14 | |
| US61/507,906 | 2011-07-14 | ||
| PCT/US2012/046815 WO2013010151A1 (en) | 2011-07-14 | 2012-07-13 | Microscopy with adaptive optics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014521122A JP2014521122A (ja) | 2014-08-25 |
| JP2014521122A5 JP2014521122A5 (enExample) | 2015-09-17 |
| JP6195830B2 true JP6195830B2 (ja) | 2017-09-13 |
Family
ID=46679291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014520398A Active JP6195830B2 (ja) | 2011-07-14 | 2012-07-13 | 適応光学系を有する顕微鏡検査法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8629413B2 (enExample) |
| EP (1) | EP2732326B1 (enExample) |
| JP (1) | JP6195830B2 (enExample) |
| WO (1) | WO2013010151A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012503798A (ja) * | 2008-09-25 | 2012-02-09 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | 構造物の光刺激およびイメージングを提供するためのデバイス、装置、および方法 |
| EP3657228A1 (en) | 2009-07-09 | 2020-05-27 | Howard Hughes Medical Institute | Microscopy with adaptive optics |
| WO2013010151A1 (en) | 2011-07-14 | 2013-01-17 | Howard Hughes Medical Institute | Microscopy with adaptive optics |
| JP5854680B2 (ja) * | 2011-07-25 | 2016-02-09 | キヤノン株式会社 | 撮像装置 |
| US20150062320A1 (en) * | 2013-09-05 | 2015-03-05 | Board Of Regents, The University Of Texas System | Diffuse reflectance hyperspectral imaging system |
| DE102013015933A1 (de) * | 2013-09-19 | 2015-03-19 | Carl Zeiss Microscopy Gmbh | Hochauflösende Scanning-Mikroskopie |
| DE102013112595B4 (de) * | 2013-11-15 | 2024-08-01 | Carl Zeiss Microscopy Gmbh | Anordnung zur Lichtblattmikroskopie |
| WO2015108846A1 (en) | 2014-01-14 | 2015-07-23 | Applied Scientific Instrumentation, Inc. | Light sheet generator |
| DE102014203348A1 (de) * | 2014-02-25 | 2015-08-27 | Carl Zeiss Smt Gmbh | Bündelverteilungsoptik, Beleuchtungsoptik mit einer derartigen Bündelverteilungsoptik, optisches System mit einer derartigen Beleuchtungsoptik sowie Projektionsbelichtungsanlage mit einem derartigen optischen System |
| KR20150102180A (ko) * | 2014-02-27 | 2015-09-07 | 삼성디스플레이 주식회사 | 레이저 빔 조사 장치 및 이를 이용한 유기 발광 디스플레이 장치의 제조 방법 |
| JP6518041B2 (ja) * | 2014-05-21 | 2019-05-22 | 浜松ホトニクス株式会社 | 光刺激装置及び光刺激方法 |
| DE102014112199B4 (de) * | 2014-08-26 | 2024-10-10 | Carl Zeiss Microscopy Gmbh | Mikroskopisches Abbildungssystem |
| WO2016047225A1 (ja) * | 2014-09-25 | 2016-03-31 | シチズンホールディングス株式会社 | 位相変調デバイス及びレーザ顕微鏡 |
| DE102014017003B4 (de) | 2014-11-12 | 2025-09-04 | Carl Zeiss Ag | Scaneinrichtung für konfokale scannende Bildgebungssysteme |
| WO2016141339A1 (en) | 2015-03-04 | 2016-09-09 | Aramco Services Company | Adaptive optics for imaging through highly scattering media in oil reservoir applications |
| DE102015103802A1 (de) | 2015-03-16 | 2016-09-22 | Carl Zeiss Microscopy Gmbh | Verfahren und Anordnung zur lichtblattmikroskopischen Untersuchung einer Probe |
| JP6402677B2 (ja) * | 2015-04-23 | 2018-10-10 | 横河電機株式会社 | 光音響波検出装置、光音響イメージング装置 |
| US10520712B2 (en) * | 2015-07-01 | 2019-12-31 | The Trustees Of Columbia University In The City Of New York | System, method and computer-accessible medium for multi-plane imaging of neural circuits |
| US10481092B2 (en) * | 2015-07-21 | 2019-11-19 | Queen's University At Kingston | Multiplexed excitation emission matrix spectroscopy |
| CN105242397B (zh) * | 2015-09-30 | 2017-10-27 | 深圳大学 | 一种相干自适应光学像差校正系统 |
| US10386300B2 (en) | 2015-12-21 | 2019-08-20 | Verily Life Sciences Llc | Spectrally and spatially multiplexed fluorescent probes for in situ cell labeling |
| WO2017145348A1 (ja) * | 2016-02-26 | 2017-08-31 | 株式会社日立製作所 | 撮像装置 |
| US20170255012A1 (en) * | 2016-03-04 | 2017-09-07 | Sharp Kabushiki Kaisha | Head mounted display using spatial light modulator to move the viewing zone |
| WO2017153133A1 (en) | 2016-03-08 | 2017-09-14 | Asml Netherlands B.V. | Inspection apparatus and method, lithographic apparatus, method of manufacturing devices and computer program |
| US10551604B2 (en) | 2016-05-27 | 2020-02-04 | Verily Life Sciences Llc | Spatial light modulator based hyperspectral confocal microscopes and methods of use |
| US10760956B2 (en) | 2016-07-05 | 2020-09-01 | Canon Kabushiki Kaisha | Wavefront control apparatus, wavefront control method, information acquiring apparatus, and storage medium |
| JP6423841B2 (ja) | 2016-10-11 | 2018-11-14 | 浜松ホトニクス株式会社 | 試料観察装置及び試料観察方法 |
| US9946066B1 (en) | 2017-01-20 | 2018-04-17 | AdlOptica Optical Systems GmbH | Optics for diffraction limited focusing inside transparent media |
| US11237109B2 (en) | 2017-01-26 | 2022-02-01 | President And Fellows Of Harvard College | Widefield, high-speed optical sectioning |
| US10578849B2 (en) * | 2017-02-09 | 2020-03-03 | Howard Hughes Medical Institute | Video-rate volumetric functional imaging of the brain at synaptic resolution |
| US11237371B2 (en) | 2017-02-09 | 2022-02-01 | Howard Hughes Medical Institute | Video-rate volumetric functional imaging of the brain at synaptic resolution |
| EP3611549B1 (en) * | 2017-04-14 | 2024-05-29 | Hamamatsu Photonics K.K. | Aberration correction method and optical device |
| CN107144955A (zh) * | 2017-05-15 | 2017-09-08 | 清华大学 | 基于线扫描时空聚焦的结构光显微成像系统 |
| US11226479B2 (en) * | 2018-05-15 | 2022-01-18 | The Regents Of The University Of Colorado | Electrowetting prism for scanning in high resolution fluorescence microscopy |
| JP6754408B2 (ja) * | 2018-10-19 | 2020-09-09 | 浜松ホトニクス株式会社 | 試料観察装置及び試料観察方法 |
| US10520437B1 (en) * | 2019-05-24 | 2019-12-31 | Raytheon Company | High sensitivity sensor utilizing ultra-fast laser pulse excitation and time delayed detector |
| DE102019007066A1 (de) * | 2019-10-11 | 2021-04-15 | Abberior Instruments Gmbh | Verfahren und Vorrichtung zur Aberrationskorrektur in der Fluoreszenzmikroskopie |
| US20230027700A1 (en) * | 2019-12-24 | 2023-01-26 | The Australian National University, Innovation ANU | Laser scanning system |
| WO2021178041A1 (en) * | 2020-03-02 | 2021-09-10 | Massachusetts Institute Of Technology | Phase cancellation microscopy |
| JP7554064B2 (ja) * | 2020-06-30 | 2024-09-19 | 株式会社ヴィーネックス | 異物・欠陥検査装置、異物・欠陥検査における画像生成装置、及び異物・欠陥検査方法 |
| DE102020122726A1 (de) | 2020-08-31 | 2022-03-03 | Carl Zeiss Microscopy Gmbh | Verfahren und vorrichtung zur lichtblatt-mikroskopie sowie verfahren und vorrichtung zum variieren einer intensität von beleuchtungslicht |
| KR20220033682A (ko) * | 2020-09-10 | 2022-03-17 | 울산과학기술원 | 근접장 광학 현미경 시스템 및 이의 제어방법 |
| DE102021205727A1 (de) * | 2021-06-07 | 2022-12-08 | Carl Zeiss Meditec Ag | Verfahren zum Betreiben eines Mikroskopiesystems, Mikroskopiesystem und Kalibierverfahren für ein Mikroskopiesystem |
| US20230221178A1 (en) * | 2022-01-11 | 2023-07-13 | Modulight Corporation | Apparatus and a method for fluorescence imaging |
| CN115236043B (zh) * | 2022-07-01 | 2025-11-11 | 浙江大学 | 一种可见光双光梳高分辨超快显微成像装置及方法 |
| CN115480514B (zh) * | 2022-09-28 | 2024-07-26 | 山东大学 | 一种基于fpga的集成光强反馈及光阱量化的系统 |
| CN116338945B (zh) * | 2023-03-07 | 2025-11-04 | 清华大学 | 用于多光子成像的数字自适应光学方法及装置 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5394268A (en) * | 1993-02-05 | 1995-02-28 | Carnegie Mellon University | Field synthesis and optical subsectioning for standing wave microscopy |
| GB9603639D0 (en) * | 1996-02-21 | 1996-04-17 | Milner Peter J | A light-diverting optical component |
| DE19733193B4 (de) * | 1997-08-01 | 2005-09-08 | Carl Zeiss Jena Gmbh | Mikroskop mit adaptiver Optik |
| US6771417B1 (en) * | 1997-08-01 | 2004-08-03 | Carl Zeiss Jena Gmbh | Applications of adaptive optics in microscopy |
| ATE220465T1 (de) | 1997-10-29 | 2002-07-15 | Calum E Macaulay | Gerät und verfahren zur mikroskopie unter verwendung räumlich modulierten lichtes |
| GB9906011D0 (en) * | 1999-03-16 | 1999-05-12 | Whiley Foils Ltd | Fluorescent materials |
| EP1290485B1 (de) * | 2000-06-14 | 2007-01-03 | Deutsches Zentrum für Luft- und Raumfahrt e.V. | Verfahren zur quantitativen optischen messung der topographie einer oberfläche |
| US6995810B2 (en) | 2000-11-30 | 2006-02-07 | Texas Instruments Incorporated | Method and system for automated convergence and focus verification of projected images |
| US6561648B2 (en) | 2001-05-23 | 2003-05-13 | David E. Thomas | System and method for reconstruction of aberrated wavefronts |
| US6750457B2 (en) * | 2001-08-29 | 2004-06-15 | Becton Dickinson And Company | System for high throughput analysis |
| WO2003105678A2 (en) * | 2002-06-12 | 2003-12-24 | Advanced Research And Technology Institute, Inc. | Method and apparatus for improving both lateral and axial resolution in ophthalmoscopy |
| DE10227120A1 (de) * | 2002-06-15 | 2004-03-04 | Carl Zeiss Jena Gmbh | Mikroskop, insbesondere Laserscanningmikroskop mit adaptiver optischer Einrichtung |
| US6863406B2 (en) * | 2002-08-01 | 2005-03-08 | The University Of Chicago | Apparatus and method for fabricating, sorting, and integrating materials with holographic optical traps |
| JP2004239660A (ja) * | 2003-02-04 | 2004-08-26 | Japan Science & Technology Agency | 顕微鏡 |
| JP2004309702A (ja) | 2003-04-04 | 2004-11-04 | Olympus Corp | 顕微鏡 |
| JP4468684B2 (ja) | 2003-12-05 | 2010-05-26 | オリンパス株式会社 | 走査型共焦点顕微鏡装置 |
| JP4645113B2 (ja) | 2004-09-21 | 2011-03-09 | 日本電気株式会社 | 光検査方法及び光検査装置並びに光検査システム |
| US7473890B2 (en) * | 2004-11-23 | 2009-01-06 | New York University | Manipulation of objects in potential energy landscapes |
| WO2006058187A2 (en) * | 2004-11-23 | 2006-06-01 | Robert Eric Betzig | Optical lattice microscopy |
| DE102005056235B4 (de) | 2005-11-25 | 2008-04-10 | Leica Microsystems (Schweiz) Ag | Stereomikroskop |
| US7460248B2 (en) | 2006-05-15 | 2008-12-02 | Carestream Health, Inc. | Tissue imaging system |
| US8217992B2 (en) * | 2007-01-11 | 2012-07-10 | The Jackson Laboratory | Microscopic imaging techniques |
| JP4694538B2 (ja) * | 2007-07-23 | 2011-06-08 | オリンパス株式会社 | 走査型光学顕微鏡 |
| EP2053447B1 (de) * | 2007-10-22 | 2010-11-24 | Tecan Trading AG | Laser Scanner-Gerät für Fluoreszenzmessungen |
| US9395534B2 (en) * | 2007-11-27 | 2016-07-19 | Wisconsin Alumni Research Foundation | Optical system for correction of tissue induced aberration |
| US8184279B2 (en) * | 2008-06-16 | 2012-05-22 | The Regents Of The University Of Colorado, A Body Corporate | Fourier domain sensing |
| US7902525B2 (en) * | 2008-10-24 | 2011-03-08 | Landauer, Inc. | Method of luminescent solid state dosimetry of mixed radiations |
| EP3657228A1 (en) * | 2009-07-09 | 2020-05-27 | Howard Hughes Medical Institute | Microscopy with adaptive optics |
| WO2013010151A1 (en) | 2011-07-14 | 2013-01-17 | Howard Hughes Medical Institute | Microscopy with adaptive optics |
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- 2012-07-13 WO PCT/US2012/046815 patent/WO2013010151A1/en not_active Ceased
- 2012-07-13 JP JP2014520398A patent/JP6195830B2/ja active Active
- 2012-07-13 EP EP12747954.1A patent/EP2732326B1/en active Active
- 2012-07-16 US US13/550,250 patent/US8629413B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2732326B1 (en) | 2020-11-18 |
| US8629413B2 (en) | 2014-01-14 |
| JP2014521122A (ja) | 2014-08-25 |
| US20130181143A1 (en) | 2013-07-18 |
| WO2013010151A1 (en) | 2013-01-17 |
| EP2732326A1 (en) | 2014-05-21 |
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