JP6174684B2 - カルシウム系抗菌材料 - Google Patents

カルシウム系抗菌材料 Download PDF

Info

Publication number
JP6174684B2
JP6174684B2 JP2015511567A JP2015511567A JP6174684B2 JP 6174684 B2 JP6174684 B2 JP 6174684B2 JP 2015511567 A JP2015511567 A JP 2015511567A JP 2015511567 A JP2015511567 A JP 2015511567A JP 6174684 B2 JP6174684 B2 JP 6174684B2
Authority
JP
Japan
Prior art keywords
lithium
calcium
compound
ttcp
phosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2015511567A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015520148A (ja
JP2015520148A5 (enExample
Inventor
リン,ジン−フェイ,チャン
ジュ,チェン−ピン
チェン,チャン−ケン
ヤン,ビン−チェン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2015520148A publication Critical patent/JP2015520148A/ja
Publication of JP2015520148A5 publication Critical patent/JP2015520148A5/ja
Application granted granted Critical
Publication of JP6174684B2 publication Critical patent/JP6174684B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02Inorganic materials
    • A61L27/04Metals or alloys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/14Alkali metal chlorides; Alkaline earth metal chlorides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/42Phosphorus; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0015Medicaments; Biocides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02Inorganic materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02Inorganic materials
    • A61L27/12Phosphorus-containing materials, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/16Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/02Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/12Materials or treatment for tissue regeneration for dental implants or prostheses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Materials Engineering (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015511567A 2012-05-07 2013-05-06 カルシウム系抗菌材料 Active JP6174684B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261643500P 2012-05-07 2012-05-07
US61/643,500 2012-05-07
PCT/US2013/039661 WO2013169633A1 (en) 2012-05-07 2013-05-06 Antibacterial calcium-based materials

Publications (3)

Publication Number Publication Date
JP2015520148A JP2015520148A (ja) 2015-07-16
JP2015520148A5 JP2015520148A5 (enExample) 2016-06-16
JP6174684B2 true JP6174684B2 (ja) 2017-08-02

Family

ID=49512698

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015511567A Active JP6174684B2 (ja) 2012-05-07 2013-05-06 カルシウム系抗菌材料

Country Status (7)

Country Link
US (2) US10207023B2 (enExample)
EP (1) EP2846811B1 (enExample)
JP (1) JP6174684B2 (enExample)
KR (3) KR20200050477A (enExample)
CN (2) CN104302300B (enExample)
TW (1) TWI630003B (enExample)
WO (1) WO2013169633A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI651103B (zh) 2013-12-13 2019-02-21 萊特醫技股份有限公司 多相骨移植替代材料
CN110558311A (zh) * 2019-09-17 2019-12-13 海南医学院第一附属医院 一种创战伤中保存离体骨的医用材料及其制备方法
KR102284280B1 (ko) * 2019-12-13 2021-08-02 가톨릭대학교 산학협력단 착색방지기능을 가지는 코팅 조성물 및 이를 이용한 임시 치관
CN117339026B (zh) * 2023-11-09 2024-05-14 广州医科大学附属口腔医院(广州医科大学羊城医院) 用于植入人体牙槽骨中的可吸收支架的制备及应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6117409A (ja) * 1984-07-02 1986-01-25 Meishin Toryo Kk 非晶質リン酸カルシウムの製法およびこれを主成分とする生体適応性組成物
US5705273A (en) * 1995-03-08 1998-01-06 The Ohio State University Method for strengthening dental restorative materials
US6071528A (en) * 1997-02-19 2000-06-06 Ultradent Products, Inc. Adhesive antimicrobial and/or reparative dentin stimulating dental compositions and methods for forming and using such compositions
JP2000313817A (ja) * 1999-04-30 2000-11-14 Ishizuka Glass Co Ltd 樹脂添加剤
SE0201052D0 (sv) * 2002-04-04 2002-04-04 Cerbio Tech Ab Biocompatible cement compositions and method of manufacturing
CN1475279B (zh) * 2002-08-13 2010-04-14 中国科学院福建物质结构研究所 一种羟基磷灰石骨水泥人工骨的制备方法
US6930144B2 (en) * 2003-06-24 2005-08-16 Hewlett-Packard Development Company, L.P. Cement system including a binder for use in freeform fabrication
DE102004026432A1 (de) * 2004-05-29 2005-12-22 Schott Ag Glaszusammensetzungen als antimikrobieller Zusatz für Dentalmaterialien und deren Verwendung
JP4764685B2 (ja) * 2005-09-20 2011-09-07 旭ファイバーグラス株式会社 抗菌剤、それを含む樹脂組成物及び成形材料
WO2008102214A2 (en) * 2007-02-22 2008-08-28 Ghassemian Pour Bavandi, Madjid Endodontic filling material
EP2014259A1 (en) * 2007-07-09 2009-01-14 Astra Tech AB A bone tissue implant comprising lithium ions
WO2009029734A2 (en) * 2007-08-28 2009-03-05 Pioneer Surgical Technology, Inc. Cement products and methods of making and using the same
US8052787B2 (en) * 2007-09-28 2011-11-08 National Taiwan University Bio-material and method of preparation thereof
KR100957543B1 (ko) * 2008-01-28 2010-05-11 연세대학교 산학협력단 비정질 칼슘 포스페이트를 함유하는 골대체용 조성물
EP2252338B1 (en) * 2008-02-20 2014-01-01 Augma Biomaterials Ltd. Bone graft material and uses thereof
WO2009105614A2 (en) * 2008-02-22 2009-08-27 Dermal Technologies, Llc Compositions for tissue augmentation
WO2009111307A2 (en) * 2008-02-29 2009-09-11 Smith & Nephew, Inc. Coating and coating method
WO2011040851A1 (en) * 2009-10-02 2011-04-07 Doxa Ab Calcium aluminate based paste for stabilizing dental implants and restoring tissue attachment after surgery and methods therefor
US8778378B2 (en) * 2009-12-21 2014-07-15 Orthovita, Inc. Bioactive antibacterial bone graft materials
AU2011296343B2 (en) * 2010-08-30 2015-12-10 Pulmatrix Operating Company, Inc. Dry powder formulations and methods for treating pulmonary diseases
WO2012046667A1 (ja) * 2010-10-06 2012-04-12 クラレメディカル株式会社 象牙細管封鎖剤及びその製造方法
US8784551B2 (en) * 2010-10-19 2014-07-22 National Cheng Kung University Bone cement formula and bioresorbable hardened bone cement composites prepared with the same

Also Published As

Publication number Publication date
WO2013169633A1 (en) 2013-11-14
KR20200065099A (ko) 2020-06-08
TW201345570A (zh) 2013-11-16
CN104302300B (zh) 2018-09-14
US10207023B2 (en) 2019-02-19
KR102214257B1 (ko) 2021-02-09
KR20200050477A (ko) 2020-05-11
JP2015520148A (ja) 2015-07-16
EP2846811A1 (en) 2015-03-18
CN107982574B (zh) 2021-01-01
US20130295193A1 (en) 2013-11-07
US20190117826A1 (en) 2019-04-25
EP2846811B1 (en) 2018-03-14
CN107982574A (zh) 2018-05-04
TWI630003B (zh) 2018-07-21
CN104302300A (zh) 2015-01-21
KR20150004826A (ko) 2015-01-13
EP2846811A4 (en) 2015-05-06

Similar Documents

Publication Publication Date Title
US8784551B2 (en) Bone cement formula and bioresorbable hardened bone cement composites prepared with the same
Siek et al. Evaluation of antibacterial activity and cytocompatibility of α-TCP based bone cements with silver-doped hydroxyapatite and CaCO3
Mouriño et al. Preparation and characterization of gallium releasing 3‐D alginate coated 45S5 Bioglass® based scaffolds for bone tissue engineering
US20190117826A1 (en) Antibacterial calcium-based materials
CN111840652B (zh) 骨修复材料及其制备方法
CN111888521A (zh) 骨修复材料及其制备方法
Chen et al. An antibacterial and injectable calcium phosphate scaffold delivering human periodontal ligament stem cells for bone tissue engineering
KR20160042064A (ko) 골 재생 재료 키트, 페이스트상 골 재생 재료, 골 재생 재료 및 골 접합재
Czechowska et al. The importance of chitosan and nano-TiHA in cement-type composites on the basis of calcium sulfate
Li et al. Lithium doped calcium phosphate cement maintains physical mechanical properties and promotes osteoblast proliferation and differentiation
Dong et al. Silk fibroin hydrogels induced and reinforced by acidic calcium phosphate–A simple way of producing bioactive and drug-loadable composites for biomedical applications
Kim et al. Octacalcium phosphate, a promising bone substitute material: a narrative review
Feng et al. N-Acetyl cysteine (NAC)-mediated reinforcement of alpha-tricalcium phosphate/silk fibroin (α-TCP/SF) cement
KR101654600B1 (ko) 주입형 자가-경화 인회석 시멘트를 포함하는 조성물
TWI388348B (zh) 含有聚合物或寡聚物之矽酸鈣系骨水泥及其製法
CN103920193B (zh) 一种载生物活性因子的类骨陶瓷复合材料的制备方法
CN102247599A (zh) 一种硼酸盐生物玻璃载抗生素缓释系统及其制备方法
KR20110043610A (ko) 칼슘 포스페이트를 함유하는 생체재료
CN105536059B (zh) 一种自修复可注射骨水泥及制备方法
EP2450064B1 (en) Bone Cement Formula and Bioresorbable Hardened Bone Cement Composites Prepared with the Same
Yang et al. An injectable bioactive poly (γ‐glutamic acid) modified magnesium phosphate bone cement for bone regeneration
CN103948964B (zh) 一种用脂联素包被的植骨材料的制备方法
Czechowska et al. Chemically bonded, calcium phosphate based bioceramics with addition of calcium sulphate
WO2012054010A1 (en) Bone cement formula and bioresorbable hardened bone cement composites prepared with the same

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160418

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160418

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170321

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170515

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20170627

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170706

R150 Certificate of patent or registration of utility model

Ref document number: 6174684

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250