TWI630003B - 抗菌製劑及使用其製作一骨頭植入物的方法 - Google Patents
抗菌製劑及使用其製作一骨頭植入物的方法 Download PDFInfo
- Publication number
- TWI630003B TWI630003B TW102116122A TW102116122A TWI630003B TW I630003 B TWI630003 B TW I630003B TW 102116122 A TW102116122 A TW 102116122A TW 102116122 A TW102116122 A TW 102116122A TW I630003 B TWI630003 B TW I630003B
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- Prior art keywords
- lithium
- calcium
- ttcp
- antibacterial
- item
- Prior art date
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 121
- 239000007943 implant Substances 0.000 title claims abstract description 24
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 11
- 238000002360 preparation method Methods 0.000 title claims description 43
- 238000000034 method Methods 0.000 title claims description 23
- 239000000203 mixture Substances 0.000 claims abstract description 42
- 150000002642 lithium compounds Chemical class 0.000 claims abstract description 22
- 229940043430 calcium compound Drugs 0.000 claims abstract description 14
- 150000001674 calcium compounds Chemical class 0.000 claims abstract description 14
- 239000007787 solid Substances 0.000 claims abstract description 14
- 238000009472 formulation Methods 0.000 claims abstract description 12
- 229920002125 Sokalan® Polymers 0.000 claims description 90
- 239000000243 solution Substances 0.000 claims description 88
- 239000000843 powder Substances 0.000 claims description 80
- 239000007788 liquid Substances 0.000 claims description 40
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 27
- -1 lithium ammonium amine Chemical class 0.000 claims description 25
- 239000002245 particle Substances 0.000 claims description 23
- 238000002156 mixing Methods 0.000 claims description 22
- 229910052744 lithium Inorganic materials 0.000 claims description 19
- 239000001506 calcium phosphate Substances 0.000 claims description 16
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 15
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 claims description 15
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 15
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 15
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 14
- 239000003242 anti bacterial agent Substances 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 12
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 12
- 235000011010 calcium phosphates Nutrition 0.000 claims description 12
- 239000011734 sodium Substances 0.000 claims description 12
- PQXKHYXIUOZZFA-UHFFFAOYSA-M lithium fluoride Chemical compound [Li+].[F-] PQXKHYXIUOZZFA-UHFFFAOYSA-M 0.000 claims description 9
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims description 8
- IIPYXGDZVMZOAP-UHFFFAOYSA-N lithium nitrate Chemical compound [Li+].[O-][N+]([O-])=O IIPYXGDZVMZOAP-UHFFFAOYSA-N 0.000 claims description 8
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 7
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims description 7
- 239000000292 calcium oxide Substances 0.000 claims description 7
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 7
- 239000012981 Hank's balanced salt solution Substances 0.000 claims description 6
- 239000002639 bone cement Substances 0.000 claims description 6
- KMQAPZBMEMMKSS-UHFFFAOYSA-K calcium;magnesium;phosphate Chemical compound [Mg+2].[Ca+2].[O-]P([O-])([O-])=O KMQAPZBMEMMKSS-UHFFFAOYSA-K 0.000 claims description 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 6
- 239000000194 fatty acid Substances 0.000 claims description 6
- 229930195729 fatty acid Natural products 0.000 claims description 6
- AMXOYNBUYSYVKV-UHFFFAOYSA-M lithium bromide Chemical compound [Li+].[Br-] AMXOYNBUYSYVKV-UHFFFAOYSA-M 0.000 claims description 6
- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 claims description 6
- 229910052808 lithium carbonate Inorganic materials 0.000 claims description 6
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 claims description 6
- HSZCZNFXUDYRKD-UHFFFAOYSA-M lithium iodide Chemical compound [Li+].[I-] HSZCZNFXUDYRKD-UHFFFAOYSA-M 0.000 claims description 6
- FUJCRWPEOMXPAD-UHFFFAOYSA-N lithium oxide Chemical compound [Li+].[Li+].[O-2] FUJCRWPEOMXPAD-UHFFFAOYSA-N 0.000 claims description 6
- 229910001947 lithium oxide Inorganic materials 0.000 claims description 6
- 229910001386 lithium phosphate Inorganic materials 0.000 claims description 6
- 229910052700 potassium Inorganic materials 0.000 claims description 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 239000011780 sodium chloride Substances 0.000 claims description 6
- TWQULNDIKKJZPH-UHFFFAOYSA-K trilithium;phosphate Chemical compound [Li+].[Li+].[Li+].[O-]P([O-])([O-])=O TWQULNDIKKJZPH-UHFFFAOYSA-K 0.000 claims description 6
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 5
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 4
- 239000001110 calcium chloride Substances 0.000 claims description 4
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 4
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims description 4
- 239000001354 calcium citrate Substances 0.000 claims description 4
- 239000000920 calcium hydroxide Substances 0.000 claims description 4
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 4
- 150000004676 glycans Chemical class 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 4
- INHCSSUBVCNVSK-UHFFFAOYSA-L lithium sulfate Inorganic materials [Li+].[Li+].[O-]S([O-])(=O)=O INHCSSUBVCNVSK-UHFFFAOYSA-L 0.000 claims description 4
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 4
- 229920001282 polysaccharide Polymers 0.000 claims description 4
- 239000005017 polysaccharide Substances 0.000 claims description 4
- 229960003975 potassium Drugs 0.000 claims description 4
- 239000011591 potassium Substances 0.000 claims description 4
- RBTVSNLYYIMMKS-UHFFFAOYSA-N tert-butyl 3-aminoazetidine-1-carboxylate;hydrochloride Chemical compound Cl.CC(C)(C)OC(=O)N1CC(N)C1 RBTVSNLYYIMMKS-UHFFFAOYSA-N 0.000 claims description 4
- 235000013337 tricalcium citrate Nutrition 0.000 claims description 4
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- 229930195725 Mannitol Natural products 0.000 claims description 3
- 241000872931 Myoporum sandwicense Species 0.000 claims description 3
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
- PSHMSSXLYVAENJ-UHFFFAOYSA-N dilithium;[oxido(oxoboranyloxy)boranyl]oxy-oxoboranyloxyborinate Chemical compound [Li+].[Li+].O=BOB([O-])OB([O-])OB=O PSHMSSXLYVAENJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
- XIXADJRWDQXREU-UHFFFAOYSA-M lithium acetate Chemical compound [Li+].CC([O-])=O XIXADJRWDQXREU-UHFFFAOYSA-M 0.000 claims description 3
- NMHMDUCCVHOJQI-UHFFFAOYSA-N lithium molybdate Chemical compound [Li+].[Li+].[O-][Mo]([O-])(=O)=O NMHMDUCCVHOJQI-UHFFFAOYSA-N 0.000 claims description 3
- 229910003002 lithium salt Inorganic materials 0.000 claims description 3
- 159000000002 lithium salts Chemical class 0.000 claims description 3
- HGPXWXLYXNVULB-UHFFFAOYSA-M lithium stearate Chemical compound [Li+].CCCCCCCCCCCCCCCCCC([O-])=O HGPXWXLYXNVULB-UHFFFAOYSA-M 0.000 claims description 3
- WNCZOFYWLAPNSS-UHFFFAOYSA-M lithium;3-carboxy-3,5-dihydroxy-5-oxopentanoate Chemical compound [Li+].OC(=O)CC(O)(C(O)=O)CC([O-])=O WNCZOFYWLAPNSS-UHFFFAOYSA-M 0.000 claims description 3
- 239000000594 mannitol Substances 0.000 claims description 3
- 235000010355 mannitol Nutrition 0.000 claims description 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 3
- 235000016337 monopotassium tartrate Nutrition 0.000 claims description 3
- KYKNRZGSIGMXFH-ZVGUSBNCSA-M potassium bitartrate Chemical compound [K+].OC(=O)[C@H](O)[C@@H](O)C([O-])=O KYKNRZGSIGMXFH-ZVGUSBNCSA-M 0.000 claims description 3
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 3
- 229940086065 potassium hydrogentartrate Drugs 0.000 claims description 3
- LJCNRYVRMXRIQR-OLXYHTOASA-L potassium sodium L-tartrate Chemical compound [Na+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O LJCNRYVRMXRIQR-OLXYHTOASA-L 0.000 claims description 3
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims description 3
- 229910052939 potassium sulfate Inorganic materials 0.000 claims description 3
- 235000011151 potassium sulphates Nutrition 0.000 claims description 3
- 239000001540 sodium lactate Substances 0.000 claims description 3
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- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 238000011049 filling Methods 0.000 claims description 2
- IDNHOWMYUQKKTI-UHFFFAOYSA-M lithium nitrite Chemical compound [Li+].[O-]N=O IDNHOWMYUQKKTI-UHFFFAOYSA-M 0.000 claims description 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 2
- 229940074439 potassium sodium tartrate Drugs 0.000 claims description 2
- CRQZBQZASKQJAN-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;potassium Chemical compound [K].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O CRQZBQZASKQJAN-BTVCFUMJSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000004575 stone Substances 0.000 claims 1
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical group [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 description 163
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
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- A61L24/0015—Medicaments; Biocides
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- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
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- A—HUMAN NECESSITIES
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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- A—HUMAN NECESSITIES
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
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- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
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- Surgery (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Materials Engineering (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US201261643500P | 2012-05-07 | 2012-05-07 | |
| US61/643,500 | 2012-05-07 |
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| TW201345570A TW201345570A (zh) | 2013-11-16 |
| TWI630003B true TWI630003B (zh) | 2018-07-21 |
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| EP (1) | EP2846811B1 (enExample) |
| JP (1) | JP6174684B2 (enExample) |
| KR (3) | KR20200050477A (enExample) |
| CN (2) | CN104302300B (enExample) |
| TW (1) | TWI630003B (enExample) |
| WO (1) | WO2013169633A1 (enExample) |
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| TWI651103B (zh) | 2013-12-13 | 2019-02-21 | 萊特醫技股份有限公司 | 多相骨移植替代材料 |
| CN110558311A (zh) * | 2019-09-17 | 2019-12-13 | 海南医学院第一附属医院 | 一种创战伤中保存离体骨的医用材料及其制备方法 |
| KR102284280B1 (ko) * | 2019-12-13 | 2021-08-02 | 가톨릭대학교 산학협력단 | 착색방지기능을 가지는 코팅 조성물 및 이를 이용한 임시 치관 |
| CN117339026B (zh) * | 2023-11-09 | 2024-05-14 | 广州医科大学附属口腔医院（广州医科大学羊城医院） | 用于植入人体牙槽骨中的可吸收支架的制备及应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5705273A (en) * | 1995-03-08 | 1998-01-06 | The Ohio State University | Method for strengthening dental restorative materials |
| US6071528A (en) * | 1997-02-19 | 2000-06-06 | Ultradent Products, Inc. | Adhesive antimicrobial and/or reparative dentin stimulating dental compositions and methods for forming and using such compositions |
| TW200914070A (en) * | 2007-09-28 | 2009-04-01 | Univ Nat Taiwan | Porous bio-material and method of preparation thereof |
| US20110038938A1 (en) * | 2008-02-22 | 2011-02-17 | Ison Ira C | Compositions for tissue augmentation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6117409A (ja) * | 1984-07-02 | 1986-01-25 | Meishin Toryo Kk | 非晶質リン酸カルシウムの製法およびこれを主成分とする生体適応性組成物 |
| JP2000313817A (ja) * | 1999-04-30 | 2000-11-14 | Ishizuka Glass Co Ltd | 樹脂添加剤 |
| SE0201052D0 (sv) * | 2002-04-04 | 2002-04-04 | Cerbio Tech Ab | Biocompatible cement compositions and method of manufacturing |
| CN1475279B (zh) * | 2002-08-13 | 2010-04-14 | 中国科学院福建物质结构研究所 | 一种羟基磷灰石骨水泥人工骨的制备方法 |
| US6930144B2 (en) * | 2003-06-24 | 2005-08-16 | Hewlett-Packard Development Company, L.P. | Cement system including a binder for use in freeform fabrication |
| DE102004026432A1 (de) * | 2004-05-29 | 2005-12-22 | Schott Ag | Glaszusammensetzungen als antimikrobieller Zusatz für Dentalmaterialien und deren Verwendung |
| JP4764685B2 (ja) * | 2005-09-20 | 2011-09-07 | 旭ファイバーグラス株式会社 | 抗菌剤、それを含む樹脂組成物及び成形材料 |
| WO2008102214A2 (en) * | 2007-02-22 | 2008-08-28 | Ghassemian Pour Bavandi, Madjid | Endodontic filling material |
| EP2014259A1 (en) * | 2007-07-09 | 2009-01-14 | Astra Tech AB | A bone tissue implant comprising lithium ions |
| WO2009029734A2 (en) * | 2007-08-28 | 2009-03-05 | Pioneer Surgical Technology, Inc. | Cement products and methods of making and using the same |
| KR100957543B1 (ko) * | 2008-01-28 | 2010-05-11 | 연세대학교 산학협력단 | 비정질 칼슘 포스페이트를 함유하는 골대체용 조성물 |
| EP2252338B1 (en) * | 2008-02-20 | 2014-01-01 | Augma Biomaterials Ltd. | Bone graft material and uses thereof |
| WO2009111307A2 (en) * | 2008-02-29 | 2009-09-11 | Smith & Nephew, Inc. | Coating and coating method |
| WO2011040851A1 (en) * | 2009-10-02 | 2011-04-07 | Doxa Ab | Calcium aluminate based paste for stabilizing dental implants and restoring tissue attachment after surgery and methods therefor |
| US8778378B2 (en) * | 2009-12-21 | 2014-07-15 | Orthovita, Inc. | Bioactive antibacterial bone graft materials |
| AU2011296343B2 (en) * | 2010-08-30 | 2015-12-10 | Pulmatrix Operating Company, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| WO2012046667A1 (ja) * | 2010-10-06 | 2012-04-12 | クラレメディカル株式会社 | 象牙細管封鎖剤及びその製造方法 |
| US8784551B2 (en) * | 2010-10-19 | 2014-07-22 | National Cheng Kung University | Bone cement formula and bioresorbable hardened bone cement composites prepared with the same |
-
2013
- 2013-05-06 WO PCT/US2013/039661 patent/WO2013169633A1/en not_active Ceased
- 2013-05-06 US US13/887,416 patent/US10207023B2/en active Active
- 2013-05-06 KR KR1020207012751A patent/KR20200050477A/ko not_active Ceased
- 2013-05-06 JP JP2015511567A patent/JP6174684B2/ja active Active
- 2013-05-06 KR KR1020147031072A patent/KR20150004826A/ko not_active Ceased
- 2013-05-06 CN CN201380023551.3A patent/CN104302300B/zh active Active
- 2013-05-06 EP EP13787118.2A patent/EP2846811B1/en active Active
- 2013-05-06 KR KR1020207015455A patent/KR102214257B1/ko active Active
- 2013-05-06 TW TW102116122A patent/TWI630003B/zh active
- 2013-05-06 CN CN201711401529.4A patent/CN107982574B/zh active Active
-
2018
- 2018-12-18 US US16/223,773 patent/US20190117826A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5705273A (en) * | 1995-03-08 | 1998-01-06 | The Ohio State University | Method for strengthening dental restorative materials |
| US6071528A (en) * | 1997-02-19 | 2000-06-06 | Ultradent Products, Inc. | Adhesive antimicrobial and/or reparative dentin stimulating dental compositions and methods for forming and using such compositions |
| TW200914070A (en) * | 2007-09-28 | 2009-04-01 | Univ Nat Taiwan | Porous bio-material and method of preparation thereof |
| US20110038938A1 (en) * | 2008-02-22 | 2011-02-17 | Ison Ira C | Compositions for tissue augmentation |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013169633A1 (en) | 2013-11-14 |
| KR20200065099A (ko) | 2020-06-08 |
| TW201345570A (zh) | 2013-11-16 |
| CN104302300B (zh) | 2018-09-14 |
| US10207023B2 (en) | 2019-02-19 |
| KR102214257B1 (ko) | 2021-02-09 |
| KR20200050477A (ko) | 2020-05-11 |
| JP2015520148A (ja) | 2015-07-16 |
| EP2846811A1 (en) | 2015-03-18 |
| CN107982574B (zh) | 2021-01-01 |
| US20130295193A1 (en) | 2013-11-07 |
| US20190117826A1 (en) | 2019-04-25 |
| EP2846811B1 (en) | 2018-03-14 |
| CN107982574A (zh) | 2018-05-04 |
| CN104302300A (zh) | 2015-01-21 |
| KR20150004826A (ko) | 2015-01-13 |
| EP2846811A4 (en) | 2015-05-06 |
| JP6174684B2 (ja) | 2017-08-02 |
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