JP2015520148A5 - - Google Patents
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- Publication number
- JP2015520148A5 JP2015520148A5 JP2015511567A JP2015511567A JP2015520148A5 JP 2015520148 A5 JP2015520148 A5 JP 2015520148A5 JP 2015511567 A JP2015511567 A JP 2015511567A JP 2015511567 A JP2015511567 A JP 2015511567A JP 2015520148 A5 JP2015520148 A5 JP 2015520148A5
- Authority
- JP
- Japan
- Prior art keywords
- lithium
- calcium
- antibacterial agent
- compound
- phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003242 anti bacterial agent Substances 0.000 claims 20
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims 16
- 229940043430 calcium compound Drugs 0.000 claims 10
- 150000001674 calcium compounds Chemical class 0.000 claims 10
- 239000001506 calcium phosphate Substances 0.000 claims 9
- 150000002642 lithium compounds Chemical class 0.000 claims 9
- 229940095672 calcium sulfate Drugs 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 239000007787 solid Substances 0.000 claims 7
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 4
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 4
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 4
- 235000011010 calcium phosphates Nutrition 0.000 claims 4
- 229910052744 lithium Inorganic materials 0.000 claims 4
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims 3
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 claims 3
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims 3
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims 3
- 229940038472 dicalcium phosphate Drugs 0.000 claims 3
- 239000008187 granular material Substances 0.000 claims 3
- 239000000843 powder Substances 0.000 claims 3
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 claims 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
- 229920002125 Sokalan® Polymers 0.000 claims 2
- 230000000844 anti-bacterial effect Effects 0.000 claims 2
- 239000004599 antimicrobial Substances 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 2
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims 2
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims 2
- 239000000292 calcium oxide Substances 0.000 claims 2
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims 2
- ZOMBKNNSYQHRCA-UHFFFAOYSA-J calcium sulfate hemihydrate Chemical compound O.[Ca+2].[Ca+2].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O ZOMBKNNSYQHRCA-UHFFFAOYSA-J 0.000 claims 2
- KMQAPZBMEMMKSS-UHFFFAOYSA-K calcium;magnesium;phosphate Chemical compound [Mg+2].[Ca+2].[O-]P([O-])([O-])=O KMQAPZBMEMMKSS-UHFFFAOYSA-K 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- AMXOYNBUYSYVKV-UHFFFAOYSA-M lithium bromide Chemical compound [Li+].[Br-] AMXOYNBUYSYVKV-UHFFFAOYSA-M 0.000 claims 2
- PQXKHYXIUOZZFA-UHFFFAOYSA-M lithium fluoride Chemical compound [Li+].[F-] PQXKHYXIUOZZFA-UHFFFAOYSA-M 0.000 claims 2
- HSZCZNFXUDYRKD-UHFFFAOYSA-M lithium iodide Chemical compound [Li+].[I-] HSZCZNFXUDYRKD-UHFFFAOYSA-M 0.000 claims 2
- IIPYXGDZVMZOAP-UHFFFAOYSA-N lithium nitrate Chemical compound [Li+].[O-][N+]([O-])=O IIPYXGDZVMZOAP-UHFFFAOYSA-N 0.000 claims 2
- FUJCRWPEOMXPAD-UHFFFAOYSA-N lithium oxide Chemical compound [Li+].[Li+].[O-2] FUJCRWPEOMXPAD-UHFFFAOYSA-N 0.000 claims 2
- 229910001947 lithium oxide Inorganic materials 0.000 claims 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 1
- 239000012981 Hank's balanced salt solution Substances 0.000 claims 1
- 229940095564 anhydrous calcium sulfate Drugs 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 claims 1
- 239000001110 calcium chloride Substances 0.000 claims 1
- 229910001628 calcium chloride Inorganic materials 0.000 claims 1
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims 1
- 239000001354 calcium citrate Substances 0.000 claims 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims 1
- 239000000920 calcium hydroxide Substances 0.000 claims 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims 1
- 230000001934 delay Effects 0.000 claims 1
- PSHMSSXLYVAENJ-UHFFFAOYSA-N dilithium;[oxido(oxoboranyloxy)boranyl]oxy-oxoboranyloxyborinate Chemical compound [Li+].[Li+].O=BOB([O-])OB([O-])OB=O PSHMSSXLYVAENJ-UHFFFAOYSA-N 0.000 claims 1
- 150000004820 halides Chemical class 0.000 claims 1
- -1 hydroxyapitite Substances 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- XIXADJRWDQXREU-UHFFFAOYSA-M lithium acetate Chemical compound [Li+].CC([O-])=O XIXADJRWDQXREU-UHFFFAOYSA-M 0.000 claims 1
- AFRJJFRNGGLMDW-UHFFFAOYSA-N lithium amide Chemical compound [Li+].[NH2-] AFRJJFRNGGLMDW-UHFFFAOYSA-N 0.000 claims 1
- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 claims 1
- 229910052808 lithium carbonate Inorganic materials 0.000 claims 1
- NMHMDUCCVHOJQI-UHFFFAOYSA-N lithium molybdate Chemical compound [Li+].[Li+].[O-][Mo]([O-])(=O)=O NMHMDUCCVHOJQI-UHFFFAOYSA-N 0.000 claims 1
- IDNHOWMYUQKKTI-UHFFFAOYSA-M lithium nitrite Chemical compound [Li+].[O-]N=O IDNHOWMYUQKKTI-UHFFFAOYSA-M 0.000 claims 1
- 229910001386 lithium phosphate Inorganic materials 0.000 claims 1
- 229910003002 lithium salt Inorganic materials 0.000 claims 1
- 159000000002 lithium salts Chemical class 0.000 claims 1
- HGPXWXLYXNVULB-UHFFFAOYSA-M lithium stearate Chemical compound [Li+].CCCCCCCCCCCCCCCCCC([O-])=O HGPXWXLYXNVULB-UHFFFAOYSA-M 0.000 claims 1
- INHCSSUBVCNVSK-UHFFFAOYSA-L lithium sulfate Inorganic materials [Li+].[Li+].[O-]S([O-])(=O)=O INHCSSUBVCNVSK-UHFFFAOYSA-L 0.000 claims 1
- WNCZOFYWLAPNSS-UHFFFAOYSA-M lithium;3-carboxy-3,5-dihydroxy-5-oxopentanoate Chemical compound [Li+].OC(=O)CC(O)(C(O)=O)CC([O-])=O WNCZOFYWLAPNSS-UHFFFAOYSA-M 0.000 claims 1
- 229910000150 monocalcium phosphate Inorganic materials 0.000 claims 1
- 235000019691 monocalcium phosphate Nutrition 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 239000003340 retarding agent Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- RBTVSNLYYIMMKS-UHFFFAOYSA-N tert-butyl 3-aminoazetidine-1-carboxylate;hydrochloride Chemical compound Cl.CC(C)(C)OC(=O)N1CC(N)C1 RBTVSNLYYIMMKS-UHFFFAOYSA-N 0.000 claims 1
- 235000013337 tricalcium citrate Nutrition 0.000 claims 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims 1
- 235000019731 tricalcium phosphate Nutrition 0.000 claims 1
- 229940078499 tricalcium phosphate Drugs 0.000 claims 1
- TWQULNDIKKJZPH-UHFFFAOYSA-K trilithium;phosphate Chemical compound [Li+].[Li+].[Li+].[O-]P([O-])([O-])=O TWQULNDIKKJZPH-UHFFFAOYSA-K 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261643500P | 2012-05-07 | 2012-05-07 | |
| US61/643,500 | 2012-05-07 | ||
| PCT/US2013/039661 WO2013169633A1 (en) | 2012-05-07 | 2013-05-06 | Antibacterial calcium-based materials |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015520148A JP2015520148A (ja) | 2015-07-16 |
| JP2015520148A5 true JP2015520148A5 (enExample) | 2016-06-16 |
| JP6174684B2 JP6174684B2 (ja) | 2017-08-02 |
Family
ID=49512698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511567A Active JP6174684B2 (ja) | 2012-05-07 | 2013-05-06 | カルシウム系抗菌材料 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10207023B2 (enExample) |
| EP (1) | EP2846811B1 (enExample) |
| JP (1) | JP6174684B2 (enExample) |
| KR (3) | KR20150004826A (enExample) |
| CN (2) | CN104302300B (enExample) |
| TW (1) | TWI630003B (enExample) |
| WO (1) | WO2013169633A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI651103B (zh) | 2013-12-13 | 2019-02-21 | 萊特醫技股份有限公司 | 多相骨移植替代材料 |
| CN110558311A (zh) * | 2019-09-17 | 2019-12-13 | 海南医学院第一附属医院 | 一种创战伤中保存离体骨的医用材料及其制备方法 |
| KR102284280B1 (ko) * | 2019-12-13 | 2021-08-02 | 가톨릭대학교 산학협력단 | 착색방지기능을 가지는 코팅 조성물 및 이를 이용한 임시 치관 |
| US20250073263A1 (en) * | 2023-08-29 | 2025-03-06 | Joy Medical Devices Corporation | Method for killing osteosarcoma cells with a bone cement preparation comprising calcium and lithium |
| CN117339026B (zh) * | 2023-11-09 | 2024-05-14 | 广州医科大学附属口腔医院（广州医科大学羊城医院） | 用于植入人体牙槽骨中的可吸收支架的制备及应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6117409A (ja) * | 1984-07-02 | 1986-01-25 | Meishin Toryo Kk | 非晶質リン酸カルシウムの製法およびこれを主成分とする生体適応性組成物 |
| US5705273A (en) * | 1995-03-08 | 1998-01-06 | The Ohio State University | Method for strengthening dental restorative materials |
| US6071528A (en) * | 1997-02-19 | 2000-06-06 | Ultradent Products, Inc. | Adhesive antimicrobial and/or reparative dentin stimulating dental compositions and methods for forming and using such compositions |
| JP2000313817A (ja) * | 1999-04-30 | 2000-11-14 | Ishizuka Glass Co Ltd | 樹脂添加剤 |
| SE0201052D0 (sv) * | 2002-04-04 | 2002-04-04 | Cerbio Tech Ab | Biocompatible cement compositions and method of manufacturing |
| CN1475279B (zh) * | 2002-08-13 | 2010-04-14 | 中国科学院福建物质结构研究所 | 一种羟基磷灰石骨水泥人工骨的制备方法 |
| US6930144B2 (en) * | 2003-06-24 | 2005-08-16 | Hewlett-Packard Development Company, L.P. | Cement system including a binder for use in freeform fabrication |
| DE102004026432A1 (de) * | 2004-05-29 | 2005-12-22 | Schott Ag | Glaszusammensetzungen als antimikrobieller Zusatz für Dentalmaterialien und deren Verwendung |
| JP4764685B2 (ja) * | 2005-09-20 | 2011-09-07 | 旭ファイバーグラス株式会社 | 抗菌剤、それを含む樹脂組成物及び成形材料 |
| WO2008102214A2 (en) * | 2007-02-22 | 2008-08-28 | Ghassemian Pour Bavandi, Madjid | Endodontic filling material |
| EP2014259A1 (en) * | 2007-07-09 | 2009-01-14 | Astra Tech AB | A bone tissue implant comprising lithium ions |
| WO2009029734A2 (en) * | 2007-08-28 | 2009-03-05 | Pioneer Surgical Technology, Inc. | Cement products and methods of making and using the same |
| US8052787B2 (en) * | 2007-09-28 | 2011-11-08 | National Taiwan University | Bio-material and method of preparation thereof |
| KR100957543B1 (ko) * | 2008-01-28 | 2010-05-11 | 연세대학교 산학협력단 | 비정질 칼슘 포스페이트를 함유하는 골대체용 조성물 |
| EP2252338B1 (en) * | 2008-02-20 | 2014-01-01 | Augma Biomaterials Ltd. | Bone graft material and uses thereof |
| WO2009105614A2 (en) * | 2008-02-22 | 2009-08-27 | Dermal Technologies, Llc | Compositions for tissue augmentation |
| EP2268327B1 (en) * | 2008-02-29 | 2019-05-29 | Smith & Nephew, Inc. | Coating and coating method |
| US20120189983A1 (en) * | 2009-10-02 | 2012-07-26 | Doxa Ab | Calcium aluminate based paste for stabilizing dental implants and restoring tissue attachment after surgery and methods therefore |
| US8778378B2 (en) * | 2009-12-21 | 2014-07-15 | Orthovita, Inc. | Bioactive antibacterial bone graft materials |
| WO2012030664A1 (en) * | 2010-08-30 | 2012-03-08 | Pulmatrix, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| EP2626058B1 (en) * | 2010-10-06 | 2019-05-01 | Kuraray Noritake Dental Inc. | Dentinal tubule sealant and method for producing the same |
| US8784551B2 (en) * | 2010-10-19 | 2014-07-22 | National Cheng Kung University | Bone cement formula and bioresorbable hardened bone cement composites prepared with the same |
-
2013
- 2013-05-06 US US13/887,416 patent/US10207023B2/en active Active
- 2013-05-06 EP EP13787118.2A patent/EP2846811B1/en active Active
- 2013-05-06 JP JP2015511567A patent/JP6174684B2/ja active Active
- 2013-05-06 CN CN201380023551.3A patent/CN104302300B/zh active Active
- 2013-05-06 WO PCT/US2013/039661 patent/WO2013169633A1/en not_active Ceased
- 2013-05-06 KR KR1020147031072A patent/KR20150004826A/ko not_active Ceased
- 2013-05-06 KR KR1020207015455A patent/KR102214257B1/ko active Active
- 2013-05-06 TW TW102116122A patent/TWI630003B/zh active
- 2013-05-06 CN CN201711401529.4A patent/CN107982574B/zh active Active
- 2013-05-06 KR KR1020207012751A patent/KR20200050477A/ko not_active Ceased
-
2018
- 2018-12-18 US US16/223,773 patent/US20190117826A1/en not_active Abandoned
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