JP6171014B2 - オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン - Google Patents

オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン Download PDF

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JP6171014B2
JP6171014B2 JP2015528568A JP2015528568A JP6171014B2 JP 6171014 B2 JP6171014 B2 JP 6171014B2 JP 2015528568 A JP2015528568 A JP 2015528568A JP 2015528568 A JP2015528568 A JP 2015528568A JP 6171014 B2 JP6171014 B2 JP 6171014B2
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group
compound
methyl
hapten
nhc
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Japanese (ja)
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JP2015532645A5 (OSRAM
JP2015532645A (ja
Inventor
ドナエ，マシュー，ギャレット
ゴング，ヨン
サルター，ライズ
リョホレンコ，エリック
デコリー，トーマス，アール．
レメリー，バート，エム．
サンカラン，バヌマティ
Original Assignee
ヤンセン ファーマシューティカ エヌ．ベー．
ヤンセン ファーマシューティカ エヌ．ベー．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/77—Ovalbumin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2015528568A 2012-08-21 2013-08-20 オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン Active JP6171014B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261691454P 2012-08-21 2012-08-21
US61/691,454 2012-08-21
PCT/US2013/055700 WO2014031587A1 (en) 2012-08-21 2013-08-20 Haptens of olanzipine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017130471A Division JP6423490B2 (ja) 2012-08-21 2017-07-03 オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン

Publications (3)

Publication Number Publication Date
JP2015532645A JP2015532645A (ja) 2015-11-12
JP2015532645A5 JP2015532645A5 (OSRAM) 2016-05-26
JP6171014B2 true JP6171014B2 (ja) 2017-07-26

Family

ID=49081007

Family Applications (3)

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JP2015528568A Active JP6171014B2 (ja) 2012-08-21 2013-08-20 オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン
JP2017130471A Active JP6423490B2 (ja) 2012-08-21 2017-07-03 オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン
JP2018196525A Active JP6763000B2 (ja) 2012-08-21 2018-10-18 オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン

Family Applications After (2)

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JP2017130471A Active JP6423490B2 (ja) 2012-08-21 2017-07-03 オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン
JP2018196525A Active JP6763000B2 (ja) 2012-08-21 2018-10-18 オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン

Country Status (11)

Country Link
US (1) US9303041B2 (OSRAM)
EP (2) EP3492473B1 (OSRAM)
JP (3) JP6171014B2 (OSRAM)
CN (1) CN104854110B (OSRAM)
AU (1) AU2013306018B2 (OSRAM)
CA (1) CA2882454C (OSRAM)
ES (2) ES2701062T3 (OSRAM)
PL (1) PL2888269T3 (OSRAM)
PT (1) PT2888269T (OSRAM)
TR (1) TR201816378T4 (OSRAM)
WO (1) WO2014031587A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017222671A (ja) * 2012-08-21 2017-12-21 ヤンセン ファーマシューティカ エヌ．ベー． オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2888277A4 (en) 2012-08-21 2016-05-18 Ortho Clinical Diagnostics Inc ANTIBODIES AGAINST PALIPERIDONE AND USE THEREOF
JP6270845B2 (ja) 2012-08-21 2018-01-31 ヤンセン ファーマシューティカ エヌ．ベー． アリピプラゾールに対する抗体及びその使用
PL2888592T3 (pl) 2012-08-21 2018-03-30 Janssen Pharmaceutica Nv Przeciwciała względem kwetiapiny i ich zastosowania
PL2888234T3 (pl) 2012-08-21 2018-07-31 Janssen Pharmaceutica Nv Hapteny arypiprazolu i ich zastosowanie w testach immunologicznych
AU2013305887B2 (en) 2012-08-21 2018-02-22 Saladax Biomedical Inc. Antibodies to risperidone and use thereof
AU2013305895B2 (en) 2012-08-21 2017-10-19 Saladax Biomedical Inc. Antibodies to olanzapine haptens and use thereof
AU2013305970B2 (en) 2012-08-21 2017-08-17 Saladax Biomedical Inc. Antibodies to aripiprazole haptens and use thereof
ES2926662T3 (es) 2012-08-21 2022-10-27 Janssen Pharmaceutica Nv Anticuerpos contra haptenos de risperidona y uso de los mismos
CN104736566A (zh) 2012-08-21 2015-06-24 奥索临床诊断有限公司 帕潘立酮半抗原的抗体及其用途
WO2014031665A1 (en) 2012-08-21 2014-02-27 Ortho-Clinical Diagnostics, Inc Antibodies to quetiapine haptens and use thereof
CN104755928B (zh) 2012-08-21 2017-05-10 詹森药业有限公司 奥氮平的抗体及其用途
CN108368180B (zh) 2015-12-17 2022-07-26 詹森药业有限公司 喹硫平的抗体及其用途
WO2017106501A1 (en) 2015-12-17 2017-06-22 Janssen Pharmaceutica Nv Antibodies to risperidone and use thereof
CN110938082A (zh) * 2019-10-30 2020-03-31 杭州博拓生物科技股份有限公司 一种奥氮平人工抗原及其制备方法
CN110950808A (zh) * 2019-10-30 2020-04-03 杭州博拓生物科技股份有限公司 一种氯氮平人工抗原及其制备方法
US20240024496A1 (en) * 2020-12-22 2024-01-25 Intervet Inc. Conjugated zearalenone to protect against mycotoxicosis
CN114685477B (zh) * 2020-12-25 2023-11-17 长沙博源医疗科技有限公司 一种利奈唑胺衍生物、免疫原、抗利奈唑胺特异性抗体及其制备方法与应用
CN114685527B (zh) * 2020-12-25 2024-03-05 长沙博源医疗科技有限公司 一种奥氮平衍生物、免疫原、抗奥氮平特异性抗体及其制备方法与应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022780A (en) 1973-03-06 1977-05-10 Imperial Chemical Industries Limited Process for the manufacture of indole derivatives
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
DK0582368T3 (da) * 1992-05-29 2001-02-05 Lilly Co Eli Thienobenzodiazepinderivater til behandling af forstyrrelser i centralnervesystemet
US6034078A (en) 1992-05-29 2000-03-07 Eli Lilly And Company Limited Thienobenzodiazepine compounds
EP0576095B1 (en) * 1992-06-26 1999-01-27 Johnson & Johnson Clinical Diagnostics, Inc. Immunoassays with labeled thyronine hapten analogues
US5395933A (en) * 1992-08-07 1995-03-07 Eastman Kodak Company Carbamazepine hapten analogues
UA76708C2 (uk) * 1999-12-08 2006-09-15 Сінгента Патисипейшонс Аг Антитіло, яке застосовується в імунологічному аналізі зразка для визначення неонікотиноїдного інсектициду, білковий кон'югат для одержання антитіла, спосіб визначення концентрації неонікотиноїдного інсектициду в зразку та набір для визначення кількості неонікотиноїдного інсектициду
US6958156B2 (en) 2000-12-15 2005-10-25 Vyrex Corporation Isoflavone derivatives
WO2003082877A1 (en) 2002-03-28 2003-10-09 Eli Lilly And Company Piperazine substituted aryl benzodiazepines and their use as dopamine receptor antagonists for the treatment of psychotic disorders
WO2004014895A1 (en) 2002-08-05 2004-02-19 Eli Lilly And Company Piperazine substituted aryl benzodiazepines
ATE452882T1 (de) * 2003-09-23 2010-01-15 Fermion Oy Herstellung von quetiapin
TW200616604A (en) * 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
EP2266622A3 (en) * 2004-08-26 2012-06-20 Piramal Life Sciences Limited Prodrugs containing novel bio-cleavable linkers
CN101809447A (zh) * 2007-09-27 2010-08-18 诺瓦提斯公司 药物监测方法
US20100069356A1 (en) 2008-09-17 2010-03-18 Auspex Pharmaceuticals, Inc. Dibenzothiazepine modulators of dopamine, alpha adrenergic, and serotonin receptors
CN102245605B (zh) 2008-10-14 2016-01-27 阿斯利康(瑞典)有限公司 用于治疗细菌感染的稠合、螺环杂芳族化合物
EP2194048A1 (en) 2008-12-02 2010-06-09 Dirk Sartor Nitrate esters for the treatment of vascular and metabolic diseases
CN107714703A (zh) 2009-12-31 2018-02-23 凯姆制药公司 喹硫平的氨基酸缀合物、其制备和使用方法
WO2011112657A1 (en) 2010-03-11 2011-09-15 Kempharm, Inc. Fatty acid conjugates of quetiapine, process for making and using the same
US8088594B2 (en) 2010-03-16 2012-01-03 Saladax Biomedical Inc. Risperidone immunoassay
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
US8623324B2 (en) 2010-07-21 2014-01-07 Aat Bioquest Inc. Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates
JP5757497B2 (ja) * 2010-10-06 2015-07-29 公立大学法人大阪府立大学 シガトキシン類ｃｔｘ１ｂおよび５４−デオキシ−ｃｔｘ１ｂを認識するモノクローナル抗体およびそれを用いるシガトキシン類検出キット
JP5952912B2 (ja) * 2011-12-15 2016-07-13 アルカーメス ファーマ アイルランド リミテッド 二級アミン化合物のプロドラッグ
EP3492473B1 (en) * 2012-08-21 2025-07-30 Janssen Pharmaceutica NV Haptens of olanzapine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017222671A (ja) * 2012-08-21 2017-12-21 ヤンセン ファーマシューティカ エヌ．ベー． オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン
JP2019034955A (ja) * 2012-08-21 2019-03-07 ヤンセン ファーマシューティカ エヌ．ベー． オランザピン（Ｏｌａｎｚｉｐｉｎｅ）のハプテン

Also Published As

Publication number Publication date
JP6763000B2 (ja) 2020-09-30
AU2013306018B2 (en) 2017-08-10
PT2888269T (pt) 2019-01-17
CA2882454C (en) 2020-08-11
EP3492473B1 (en) 2025-07-30
EP2888269A1 (en) 2015-07-01
CN104854110B (zh) 2016-12-28
EP3492473A1 (en) 2019-06-05
PL2888269T3 (pl) 2019-06-28
CA2882454A1 (en) 2014-02-27
TR201816378T4 (tr) 2018-11-21
US9303041B2 (en) 2016-04-05
JP2015532645A (ja) 2015-11-12
JP2019034955A (ja) 2019-03-07
ES3043017T3 (en) 2025-11-24
WO2014031587A1 (en) 2014-02-27
CN104854110A (zh) 2015-08-19
ES2701062T3 (es) 2019-02-20
JP2017222671A (ja) 2017-12-21
AU2013306018A1 (en) 2015-03-12
HK1211933A1 (en) 2016-06-03
JP6423490B2 (ja) 2018-11-14
US20140213766A1 (en) 2014-07-31
EP2888269B1 (en) 2018-10-24

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