JP6152167B2 - アルギナーゼ阻害剤としての環拘束性類似体 - Google Patents

アルギナーゼ阻害剤としての環拘束性類似体 Download PDF

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JP6152167B2
JP6152167B2 JP2015506997A JP2015506997A JP6152167B2 JP 6152167 B2 JP6152167 B2 JP 6152167B2 JP 2015506997 A JP2015506997 A JP 2015506997A JP 2015506997 A JP2015506997 A JP 2015506997A JP 6152167 B2 JP6152167 B2 JP 6152167B2
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disease
arginase
pharmaceutical composition
condition
composition according
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JP2015516397A (ja
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ザント マイケル ヴァン
ザント マイケル ヴァン
ジュニア グンナー エリック ジャグドマン
ジュニア グンナー エリック ジャグドマン
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Mars Inc
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
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  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
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  • Hospice & Palliative Care (AREA)
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JP2015506997A 2012-04-18 2013-03-13 アルギナーゼ阻害剤としての環拘束性類似体 Active JP6152167B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261625814P 2012-04-18 2012-04-18
US61/625,814 2012-04-18
PCT/US2013/030930 WO2013158262A1 (en) 2012-04-18 2013-03-13 Ring constrained analogs as arginase inhibitors

Publications (2)

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JP2015516397A JP2015516397A (ja) 2015-06-11
JP6152167B2 true JP6152167B2 (ja) 2017-06-21

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JP2015506997A Active JP6152167B2 (ja) 2012-04-18 2013-03-13 アルギナーゼ阻害剤としての環拘束性類似体

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US (1) US9200011B2 (Direct)
EP (1) EP2852598B3 (Direct)
JP (1) JP6152167B2 (Direct)
CN (1) CN104540836B (Direct)
AU (1) AU2013249790B2 (Direct)
BR (1) BR112014026057B1 (Direct)
CA (1) CA2870526C (Direct)
IL (1) IL235155B (Direct)
IN (1) IN2014DN09678A (Direct)
MX (1) MX355758B (Direct)
WO (1) WO2013158262A1 (Direct)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012027034B1 (pt) 2010-04-22 2020-10-13 Mars, Incorporated compostos inibidores de arginase, composição farmacêutica compreendendo o referido composto, método in vitro para inibição de arginase i e ii e uso do referido composto
RS54750B1 (sr) 2010-10-26 2016-10-31 Mars Inc Borati kao inhibitori arginaze
PL410665A1 (pl) 2014-12-29 2016-07-04 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Inhibitory arginazy oraz ich zastosowania terapeutyczne
WO2016210106A1 (en) 2015-06-23 2016-12-29 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
DK3368541T3 (da) 2015-10-30 2020-06-29 Calithera Biosciences Inc Sammensætninger og metoder til inhibiering af arginaseaktivitet
WO2017085947A1 (ja) * 2015-11-18 2017-05-26 東京応化工業株式会社 アルギナーゼ活性の測定方法、アルギナーゼ活性の検出キット及びアルギナーゼ関連疾患検出キット
JP6884705B2 (ja) * 2015-11-18 2021-06-09 東京応化工業株式会社 アルギナーゼ活性の測定方法、アルギナーゼ活性の検出キット、アルギナーゼ関連疾患検出キット、及びアルギナーゼの阻害剤又は活性剤のスクリーニング方法
PL417066A1 (pl) * 2016-05-04 2017-11-06 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Inhibitory arginazy oraz ich zastosowania terapeutyczne
US11291674B2 (en) 2016-11-08 2022-04-05 Calithera Biosciences, Inc. Arginase inhibitor combination therapies
WO2018090151A1 (es) * 2016-11-18 2018-05-24 Pontificia Universidad Catolica De Chile Combinación farmacéutica para el tratamiento y prevención de la hipertensión arterial y disfunción vascular
EP3842442B1 (en) 2016-12-22 2023-11-01 Precision Pharmaceuticals, Inc. Compositions and methods for inhibiting arginase activity
CN108794517B (zh) * 2017-04-27 2021-03-30 南京谷睿生物科技有限公司 一种精氨酸酶抑制剂及其制备方法与用途
US10494339B2 (en) 2017-05-12 2019-12-03 Calithera Biosciences, Inc. Method of preparing (3R,4S)-3-acetamido-4-allyl-N-(tert-butyl)pyrrolidine-3-carboxamide
JP6925163B2 (ja) * 2017-05-16 2021-08-25 東京応化工業株式会社 尿素の測定方法及び尿素検出キット
US11655260B2 (en) 2017-12-22 2023-05-23 Guangdong Newopp Biopharmaceuticals Co., Ltd. Heterocyclic compounds as arginase inhibitors
CN117186134A (zh) 2018-02-17 2023-12-08 阿斯利康(瑞典)有限公司 精氨酸酶抑制剂及其使用方法
US12054500B2 (en) 2018-03-05 2024-08-06 Arcus Biosciences, Inc. Arginase inhibitors
WO2019186497A1 (en) 2018-03-29 2019-10-03 Oncoarendi Therapeutics S.A. Dipeptide piperidine derivatives
WO2020102646A2 (en) 2018-11-16 2020-05-22 Arcus Biosciences, Inc. Inhibitors of arg1 and/or arg2
CN112110944B (zh) * 2019-06-21 2022-02-11 南京谷睿生物科技有限公司 一种化合物及其制备方法和应用
TW202228720A (zh) 2020-12-22 2022-08-01 波蘭商昂科艾倫迪治療法股份公司 精胺酸酶抑制劑及其使用方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9797998A (en) 1997-10-10 1999-05-03 Trustees Of The University Of Pennsylvania, The Compositions and methods for inhibiting arginase activity
EP1915143A4 (en) 2005-07-01 2009-11-11 Univ Johns Hopkins ARGINASE II: TARGET TREATMENT FOR THE AGING HEART AND HEART FAILURE
TR201910726T4 (tr) 2009-01-26 2019-08-21 Astrazeneca Uk Ltd Arginaz inhibitörleri ve kullanım yöntemleri.
BR112012027034B1 (pt) * 2010-04-22 2020-10-13 Mars, Incorporated compostos inibidores de arginase, composição farmacêutica compreendendo o referido composto, método in vitro para inibição de arginase i e ii e uso do referido composto
RS54750B1 (sr) 2010-10-26 2016-10-31 Mars Inc Borati kao inhibitori arginaze

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Publication number Publication date
MX355758B (es) 2018-04-27
HK1209126A1 (en) 2016-03-24
BR112014026057A2 (pt) 2017-06-27
EP2852598B1 (en) 2016-05-11
EP2852598A1 (en) 2015-04-01
US9200011B2 (en) 2015-12-01
CA2870526A1 (en) 2013-10-24
US20150080341A1 (en) 2015-03-19
AU2013249790A1 (en) 2014-12-04
IL235155B (en) 2018-06-28
CN104540836A (zh) 2015-04-22
BR112014026057B1 (pt) 2020-10-13
WO2013158262A1 (en) 2013-10-24
JP2015516397A (ja) 2015-06-11
IN2014DN09678A (Direct) 2015-07-31
CN104540836B (zh) 2016-11-09
EP2852598B3 (en) 2016-10-19
CA2870526C (en) 2020-05-05
AU2013249790B2 (en) 2018-01-25
MX2014012606A (es) 2015-01-19

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