MX355758B - Analogos constreñidos en el anillo como inhibidores de arginasa. - Google Patents
Analogos constreñidos en el anillo como inhibidores de arginasa.Info
- Publication number
- MX355758B MX355758B MX2014012606A MX2014012606A MX355758B MX 355758 B MX355758 B MX 355758B MX 2014012606 A MX2014012606 A MX 2014012606A MX 2014012606 A MX2014012606 A MX 2014012606A MX 355758 B MX355758 B MX 355758B
- Authority
- MX
- Mexico
- Prior art keywords
- arginase
- arginase inhibitors
- constrained analogs
- ring constrained
- activity
- Prior art date
Links
- 102000004452 Arginase Human genes 0.000 title abstract 3
- 108700024123 Arginases Proteins 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 102100030356 Arginase-2, mitochondrial Human genes 0.000 abstract 1
- 101710186578 Arginase-2, mitochondrial Proteins 0.000 abstract 1
- 150000001642 boronic acid derivatives Chemical class 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
Abstract
Los análogos inventivos de ácido borónico son potentes inhibidores de la actividad de arginasa I y II. Estos compuestos son terapéuticos candidatos para tratar una enfermedad o trastorno asociado con un desequilibrio en la actividad o concentración de las enzimas celulares de arginasa 1 y arginasa II. La invención también proporciona las composiciones farmacéuticas de los compuestos inventivos y los métodos para utilizar las composiciones para terapia.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261625814P | 2012-04-18 | 2012-04-18 | |
| PCT/US2013/030930 WO2013158262A1 (en) | 2012-04-18 | 2013-03-13 | Ring constrained analogs as arginase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014012606A MX2014012606A (es) | 2015-01-19 |
| MX355758B true MX355758B (es) | 2018-04-27 |
Family
ID=47997937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014012606A MX355758B (es) | 2012-04-18 | 2013-03-13 | Analogos constreñidos en el anillo como inhibidores de arginasa. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9200011B2 (es) |
| EP (1) | EP2852598B3 (es) |
| JP (1) | JP6152167B2 (es) |
| CN (1) | CN104540836B (es) |
| AU (1) | AU2013249790B2 (es) |
| BR (1) | BR112014026057B1 (es) |
| CA (1) | CA2870526C (es) |
| IL (1) | IL235155B (es) |
| IN (1) | IN2014DN09678A (es) |
| MX (1) | MX355758B (es) |
| WO (1) | WO2013158262A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5898177B2 (ja) | 2010-04-22 | 2016-04-06 | マーズ インコーポレイテッド | アルギナーゼ阻害剤およびそれらの治療用途 |
| HUE027317T2 (en) | 2010-10-26 | 2016-10-28 | Mars Inc | Boronates as arginase inhibitors |
| PL410665A1 (pl) | 2014-12-29 | 2016-07-04 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
| MX385315B (es) | 2015-06-23 | 2025-03-14 | Calithera Biosciences Inc | Composiciones y metodos para inhibir actividad de arginasa. |
| PT3368541T (pt) | 2015-10-30 | 2020-07-06 | Calithera Biosciences Inc | Composições e métodos para inibição da atividade da arginase |
| WO2017085947A1 (ja) * | 2015-11-18 | 2017-05-26 | 東京応化工業株式会社 | アルギナーゼ活性の測定方法、アルギナーゼ活性の検出キット及びアルギナーゼ関連疾患検出キット |
| EP3379248B1 (en) * | 2015-11-18 | 2020-09-23 | Tokyo Ohka Kogyo Co., Ltd. | Arginase activity measurement method, arginase activity detection kit, arginase-related disease detection kit, and arginase inhibitor or active agent screening method |
| WO2017086421A1 (ja) * | 2015-11-18 | 2017-05-26 | 東京応化工業株式会社 | アルギナーゼ活性の測定方法、アルギナーゼ活性の検出キット、アルギナーゼ関連疾患検出キット、及びアルギナーゼの阻害剤又は活性剤のスクリーニング方法 |
| PL417066A1 (pl) * | 2016-05-04 | 2017-11-06 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
| CA3042878A1 (en) | 2016-11-08 | 2018-05-17 | Calithera Biosciences, Inc. | Arginase inhibitor combination therapies |
| WO2018090151A1 (es) * | 2016-11-18 | 2018-05-24 | Pontificia Universidad Catolica De Chile | Combinación farmacéutica para el tratamiento y prevención de la hipertensión arterial y disfunción vascular |
| ES2970715T3 (es) | 2016-12-22 | 2024-05-30 | Prec Pharmaceuticals Inc | Composiciones y métodos para inhibir la actividad de la arginasa |
| CN108794517B (zh) * | 2017-04-27 | 2021-03-30 | 南京谷睿生物科技有限公司 | 一种精氨酸酶抑制剂及其制备方法与用途 |
| WO2018209290A1 (en) | 2017-05-12 | 2018-11-15 | Calithera Biosciences, Inc. | Method of preparing (3r,4s)-3-acetamido-4-allyl-n-(tert-butyl)pyrrolidine-3-carboxamide |
| JP6925163B2 (ja) * | 2017-05-16 | 2021-08-25 | 東京応化工業株式会社 | 尿素の測定方法及び尿素検出キット |
| US11655260B2 (en) | 2017-12-22 | 2023-05-23 | Guangdong Newopp Biopharmaceuticals Co., Ltd. | Heterocyclic compounds as arginase inhibitors |
| JOP20200197A1 (ar) | 2018-02-17 | 2020-08-16 | Astrazeneca Ab | مثبطات أرجيناز وطرق لاستخدامها |
| SG11202008113RA (en) | 2018-03-05 | 2020-09-29 | Arcus Biosciences Inc | Arginase inhibitors |
| AU2019246728A1 (en) | 2018-03-29 | 2020-08-27 | Oncoarendi Therapeutics S.A. | Dipeptide piperidine derivatives |
| KR102718333B1 (ko) * | 2018-11-16 | 2024-10-17 | 아르커스 바이오사이언시즈 인코포레이티드 | Arg1 및/또는 arg2의 억제제 |
| CN112110944B (zh) * | 2019-06-21 | 2022-02-11 | 南京谷睿生物科技有限公司 | 一种化合物及其制备方法和应用 |
| TW202228720A (zh) | 2020-12-22 | 2022-08-01 | 波蘭商昂科艾倫迪治療法股份公司 | 精胺酸酶抑制劑及其使用方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1049660A1 (en) | 1997-10-10 | 2000-11-08 | The Trustees Of The University Of Pennsylvania | Compositions and methods for inhibiting arginase activity |
| EP1915143A4 (en) | 2005-07-01 | 2009-11-11 | Univ Johns Hopkins | ARGINASE II: TARGET TREATMENT FOR THE AGING HEART AND HEART FAILURE |
| EP2389352B1 (en) | 2009-01-26 | 2019-05-08 | The Trustees Of The University Of Pennsylvania | Arginase inhibitors and methods of use |
| JP5898177B2 (ja) * | 2010-04-22 | 2016-04-06 | マーズ インコーポレイテッド | アルギナーゼ阻害剤およびそれらの治療用途 |
| HUE027317T2 (en) * | 2010-10-26 | 2016-10-28 | Mars Inc | Boronates as arginase inhibitors |
-
2013
- 2013-03-13 JP JP2015506997A patent/JP6152167B2/ja active Active
- 2013-03-13 CA CA2870526A patent/CA2870526C/en active Active
- 2013-03-13 US US14/391,901 patent/US9200011B2/en active Active
- 2013-03-13 EP EP13712088.7A patent/EP2852598B3/en active Active
- 2013-03-13 IN IN9678DEN2014 patent/IN2014DN09678A/en unknown
- 2013-03-13 WO PCT/US2013/030930 patent/WO2013158262A1/en not_active Ceased
- 2013-03-13 AU AU2013249790A patent/AU2013249790B2/en not_active Ceased
- 2013-03-13 CN CN201380028496.7A patent/CN104540836B/zh active Active
- 2013-03-13 MX MX2014012606A patent/MX355758B/es active IP Right Grant
- 2013-03-13 BR BR112014026057-5A patent/BR112014026057B1/pt active IP Right Grant
-
2014
- 2014-10-19 IL IL235155A patent/IL235155B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2870526C (en) | 2020-05-05 |
| MX2014012606A (es) | 2015-01-19 |
| HK1209126A1 (en) | 2016-03-24 |
| IN2014DN09678A (es) | 2015-07-31 |
| EP2852598B1 (en) | 2016-05-11 |
| CN104540836B (zh) | 2016-11-09 |
| AU2013249790A1 (en) | 2014-12-04 |
| WO2013158262A1 (en) | 2013-10-24 |
| US20150080341A1 (en) | 2015-03-19 |
| BR112014026057B1 (pt) | 2020-10-13 |
| EP2852598A1 (en) | 2015-04-01 |
| AU2013249790B2 (en) | 2018-01-25 |
| US9200011B2 (en) | 2015-12-01 |
| CA2870526A1 (en) | 2013-10-24 |
| EP2852598B3 (en) | 2016-10-19 |
| BR112014026057A2 (pt) | 2017-06-27 |
| CN104540836A (zh) | 2015-04-22 |
| JP2015516397A (ja) | 2015-06-11 |
| IL235155B (en) | 2018-06-28 |
| JP6152167B2 (ja) | 2017-06-21 |
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