JP6129412B2 - シアル酸誘導体の製造方法 - Google Patents
シアル酸誘導体の製造方法 Download PDFInfo
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- JP6129412B2 JP6129412B2 JP2016516451A JP2016516451A JP6129412B2 JP 6129412 B2 JP6129412 B2 JP 6129412B2 JP 2016516451 A JP2016516451 A JP 2016516451A JP 2016516451 A JP2016516451 A JP 2016516451A JP 6129412 B2 JP6129412 B2 JP 6129412B2
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- cmp
- sialyltransferase
- amino acid
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
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- C—CHEMISTRY; METALLURGY
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
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- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020130062733A KR101525230B1 (ko) | 2013-05-31 | 2013-05-31 | 시알산 유도체의 제조방법 |
| KR10-2013-0062733 | 2013-05-31 | ||
| PCT/KR2014/004823 WO2014193183A1 (ko) | 2013-05-31 | 2014-05-30 | 시알산 유도체의 제조방법 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016519952A JP2016519952A (ja) | 2016-07-11 |
| JP2016519952A5 JP2016519952A5 (enExample) | 2016-08-18 |
| JP6129412B2 true JP6129412B2 (ja) | 2017-05-17 |
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| CN (1) | CN105473728A (enExample) |
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| ES2708759T3 (es) | 2013-05-13 | 2019-04-11 | Momenta Pharmaceuticals Inc | Procedimientos para el tratamiento de la neurodegeneración |
| WO2015057622A1 (en) | 2013-10-16 | 2015-04-23 | Momenta Pharmaceuticals, Inc. | Sialylated glycoproteins |
| WO2016045704A1 (en) | 2014-09-23 | 2016-03-31 | Huawei Technologies Co.,Ltd | Transmitter, receiver and methods for transmitting/ receiving synchronisation signals |
| CN106520864A (zh) * | 2016-09-28 | 2017-03-22 | 南京农业大学 | 一种酶法合成唾液酸类似物的方法及其应用 |
| WO2019020707A1 (en) * | 2017-07-26 | 2019-01-31 | Jennewein Biotechnologie Gmbh | SIALYL-TRANSFERASES AND THEIR USE IN THE PRODUCTION OF SIALYLATED OLIGOSACCHARIDES |
| JP6559763B2 (ja) * | 2017-12-14 | 2019-08-14 | ホアウェイ・テクノロジーズ・カンパニー・リミテッド | 送信機、受信機、および同期信号を送信／受信するための方法 |
| AU2018386217A1 (en) * | 2017-12-15 | 2020-07-02 | Glycosyn LLC | Sialyltransferases and uses thereof |
| CN110227164B (zh) | 2018-03-06 | 2021-11-23 | 江苏吉贝尔药业股份有限公司 | 含酮羰基的疏水性抗肿瘤药物及其缀合物、含有缀合物的纳米制剂及其制备方法及应用 |
| CN108409810A (zh) * | 2018-03-30 | 2018-08-17 | 广州中医药大学(广州中医药研究院) | 紫杉烷类化合物糖基化衍生物及其制备方法和应用 |
| GB2573539A (en) | 2018-05-09 | 2019-11-13 | Mjn Us Holdings Llc | Wellbeing supplement for postpartum maternal nutrition |
| US20220089631A1 (en) * | 2018-08-23 | 2022-03-24 | Genechem Inc. | Compound comprising multivalent sialyloligosaccharide residues, and composition for preventing or treating viral infection diseases, containing same as active ingredient |
| CN111248289B (zh) * | 2018-11-30 | 2023-04-07 | 内蒙古伊利实业集团股份有限公司 | 一种组合物、其制备方法及用途 |
| KR102245274B1 (ko) | 2019-01-28 | 2021-04-27 | 재단법인 지능형 바이오 시스템 설계 및 합성 연구단 | 최소 유전체를 갖는 신규 미생물 및 이의 제조 방법 |
| CN110396532A (zh) * | 2019-08-23 | 2019-11-01 | 中国科学院合肥物质科学研究院 | 一种制备唾液酸乳糖的方法 |
| CN111233949A (zh) * | 2020-02-10 | 2020-06-05 | 天津科技大学 | 一种神经节苷脂gm3和/或其类似物、合成方法和应用 |
| CN111249444B (zh) * | 2020-03-10 | 2023-04-07 | 西北大学 | 一种用于抑制白色念珠菌的制剂 |
| CN111394292B (zh) * | 2020-03-30 | 2022-08-09 | 江南大学 | 一种多途径复合产神经氨酸枯草芽孢杆菌及其应用 |
| EP3892731A1 (en) | 2020-04-08 | 2021-10-13 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Enzymatic method for preparation of cmp-neu5ac |
| KR20230099676A (ko) * | 2021-12-27 | 2023-07-04 | 주식회사 진켐 | 시알릴락토스를 이용한 혈뇌장벽 투과용 약물 전달체 |
| CN114736884B (zh) * | 2022-05-11 | 2023-10-20 | 中国科学院合肥物质科学研究院 | 一种胞苷单磷酸激酶突变体及其基因和应用 |
| CN119351382A (zh) * | 2023-11-28 | 2025-01-24 | 深圳瑞德林生物技术有限公司 | 酶组合物及其在制备唾液酸乳糖中的应用 |
| CN119662773A (zh) * | 2024-11-12 | 2025-03-21 | 深圳瑞德林生物技术有限公司 | 高通量平板筛选3-唾液酸转移酶突变体的试剂和方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3937891A1 (de) | 1989-11-15 | 1991-05-16 | Forschungszentrum Juelich Gmbh | Enzymatisches verfahren zur herstellung von n-acetylneuraminsaeure |
| JP3131655B2 (ja) | 1992-02-03 | 2001-02-05 | マルキン忠勇株式会社 | Ｎ−アセチルノイラミン酸の製造法 |
| WO1995026399A1 (fr) | 1994-03-25 | 1995-10-05 | Marukin Shoyu Co., Ltd. | Epimerase |
| ATE222294T1 (de) * | 1995-04-11 | 2002-08-15 | Neose Technologies Inc | Verbesserte verfahren zur enzymatischen synthese von oligosacchariden |
| JP3944866B2 (ja) | 1996-06-18 | 2007-07-18 | マルキンバイオ株式会社 | Ｎ−アセチルノイラミン酸シンターゼ、及びこれを用いるｎ−アセチルノイラミン酸の製造方法 |
| US6846656B1 (en) | 1999-08-30 | 2005-01-25 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing N-acetylneuraminic acid |
| CN1301330C (zh) | 2002-07-18 | 2007-02-21 | 雅玛山酱油株式会社 | Cmp－n－乙酰神经氨酸的制造方法 |
| KR100888513B1 (ko) * | 2006-12-15 | 2009-03-12 | 주식회사 진켐 | 신규 ｎ―아세틸글루코사민―２―에피머라아제 및 이를이용한 ｃｍｐ―ｎ―아세틸뉴라민산의 제조방법 |
| CN103108956A (zh) * | 2010-07-16 | 2013-05-15 | 格力康公司 | 新型唾液酸寡糖衍生物的合成 |
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2013
- 2013-05-31 KR KR1020130062733A patent/KR101525230B1/ko active Active
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2014
- 2014-05-30 CN CN201480042946.2A patent/CN105473728A/zh active Pending
- 2014-05-30 WO PCT/KR2014/004823 patent/WO2014193183A1/ko not_active Ceased
- 2014-05-30 EP EP14803659.3A patent/EP3009516A4/en not_active Withdrawn
- 2014-05-30 JP JP2016516451A patent/JP6129412B2/ja active Active
- 2014-05-30 US US14/894,757 patent/US9637768B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9637768B2 (en) | 2017-05-02 |
| JP2016519952A (ja) | 2016-07-11 |
| EP3009516A4 (en) | 2017-02-15 |
| KR20140141228A (ko) | 2014-12-10 |
| CN105473728A (zh) | 2016-04-06 |
| EP3009516A1 (en) | 2016-04-20 |
| WO2014193183A1 (ko) | 2014-12-04 |
| US20160130621A1 (en) | 2016-05-12 |
| KR101525230B1 (ko) | 2015-06-01 |
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