JP6126004B2 - 血小板の生成のための組成物および方法、およびそれらの使用の方法 - Google Patents

血小板の生成のための組成物および方法、およびそれらの使用の方法 Download PDF

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JP6126004B2
JP6126004B2 JP2013535151A JP2013535151A JP6126004B2 JP 6126004 B2 JP6126004 B2 JP 6126004B2 JP 2013535151 A JP2013535151 A JP 2013535151A JP 2013535151 A JP2013535151 A JP 2013535151A JP 6126004 B2 JP6126004 B2 JP 6126004B2
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gata
cells
platelets
megakaryocytes
cell
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JP2014511118A5 (https=
JP2014511118A (ja
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ポンチ、モーティマー
ワイス、ミッチェル
ガデュー、ポール
フレンチ、デボラ
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Childrens Hospital of Philadelphia CHOP
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/19Platelets; Megacaryocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2501/60Transcription factors
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    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Developmental Biology & Embryology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2013535151A 2010-10-25 2011-10-25 血小板の生成のための組成物および方法、およびそれらの使用の方法 Expired - Fee Related JP6126004B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40651410P 2010-10-25 2010-10-25
US61/406,514 2010-10-25
PCT/US2011/057716 WO2012061146A1 (en) 2010-10-25 2011-10-25 Compositions and methods for the generation of platelets and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2014511118A JP2014511118A (ja) 2014-05-08
JP2014511118A5 JP2014511118A5 (https=) 2014-12-11
JP6126004B2 true JP6126004B2 (ja) 2017-05-10

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JP2013535151A Expired - Fee Related JP6126004B2 (ja) 2010-10-25 2011-10-25 血小板の生成のための組成物および方法、およびそれらの使用の方法

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US (1) US9259443B2 (https=)
EP (1) EP2633047A4 (https=)
JP (1) JP6126004B2 (https=)
AU (1) AU2011323729B2 (https=)
CA (1) CA2815426A1 (https=)
WO (1) WO2012061146A1 (https=)

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CA3177929A1 (en) 2012-12-21 2014-06-26 Astellas Institute For Regenerative Medicine Methods for production of platelets from pluripotent stem cells and compositions thereof
WO2014138485A1 (en) * 2013-03-08 2014-09-12 Irm Llc Ex vivo production of platelets from hematopoietic stem cells and the product thereof
EP3322800A4 (en) * 2015-07-13 2019-05-01 University of Utah Research Foundation PROCESS FOR THE PRODUCTION OF RED BLOOD BODIES AND BLOOD PLATES IN VITRO AND USES THEREOF
WO2018053288A1 (en) * 2016-09-16 2018-03-22 The Children's Hospital Of Philadelphia Methods and compositions for identification and enrichment of platelet-producing megakaryocytes (mks)
JP2021509812A (ja) 2018-01-05 2021-04-08 プレートレット バイオジェネシス, インコーポレイテッド 巨核球を産生するための組成物および方法
AU2019291955A1 (en) 2018-06-29 2021-02-18 Platelet Biogenesis, Inc. Compositions for drug delivery and methods of use thereof
JP2022512622A (ja) * 2018-10-05 2022-02-07 ユニヴァーシティー オブ ユタ リサーチ ファウンデーション 改変受容体を含む血小板の作製方法及びその使用法

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Publication number Publication date
US9259443B2 (en) 2016-02-16
AU2011323729B2 (en) 2016-08-04
WO2012061146A1 (en) 2012-05-10
EP2633047A4 (en) 2014-04-02
EP2633047A1 (en) 2013-09-04
US20140086883A1 (en) 2014-03-27
AU2011323729A1 (en) 2013-05-30
JP2014511118A (ja) 2014-05-08
CA2815426A1 (en) 2012-05-10

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