JP6121595B2 - イソフムロン類を含む自律神経調節剤 - Google Patents
イソフムロン類を含む自律神経調節剤 Download PDFInfo
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- JP6121595B2 JP6121595B2 JP2016104574A JP2016104574A JP6121595B2 JP 6121595 B2 JP6121595 B2 JP 6121595B2 JP 2016104574 A JP2016104574 A JP 2016104574A JP 2016104574 A JP2016104574 A JP 2016104574A JP 6121595 B2 JP6121595 B2 JP 6121595B2
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Description
この2種類の自律神経系は、気温や心的ストレスのような外部環境変化や栄養状態などの内部環境変化に対応して、それぞれが拮抗的に働き、それらの変化に身体を対応させている。このとき過度なストレスにさらされ続けると、自律神経バランスが崩れ、交感神経が過剰に活動上昇することにより緊張状態が継続し、不眠のような体調不良に代表される自律神経失調症が引き起こされるとされている。ストレスを感じることが多い現代社会では、自律神経バランスを正常に保ち、過度な交感神経の興奮を抑制できる安全で簡便な方法の提供が望まれている。
得られた抽出液は、必要に応じてろ過または遠心分離によって固形物を除去した後、使用の態様により、そのまま用いるか、または溶媒を留去して一部濃縮若しくは乾燥して用いてもよい。また濃縮乃至は乾燥後、さらに非溶解性溶媒で洗浄して精製して用いても、またこれを更に適当な溶剤に溶解もしくは懸濁して用いることもできる。更に、上記のようにして得られた溶媒抽出液を、減圧乾燥、凍結乾燥等の通常の手段により乾燥させて得られたホップ抽出エキス乾燥物を使用してもよい。
異性化処理の方法は公知であり、いずれの方法を用いてもよいが、典型的には、ホップエキスをpH8〜9の弱アルカリ条件下で、あるいは酸化マグネシウム存在下で加熱することで実施することができる。ホップエキスをそのまま異性化処理に付してもよいが、異性化処理に先立って、ホップエキスを加温アルカリ水に添加し(ホップエキス添加後にpH8〜9)、溶解したα酸と不溶のβ酸を分離し、得られたα酸画分を異性化処理に付してもよい。
実験には、12時間毎の明暗周期(8時〜20時まで点灯)下に24℃の恒温動物室にて1週間以上飼育した体重約300gのWistar系雄ラット(約9週齢)を使用した。実験当日は、3時間絶食させた後にウレタン麻酔し、胃内投与用のカニューレを挿入し、その後、副腎交感神経遠心枝を銀電極で吊り上げ、(Shen J, et al. Neurosci. Lett. 383188-193, 2005;Tanida M, et al., Neurosci. Lett. 389: 109-114, 2005)に記載の方法に準じてそれら神経の電気活動を測定した。
Claims (10)
- イソフムロン類、またはその薬理学的に許容される塩もしくは溶媒和物を有効成分として含んでなる、自律神経調節剤。
- ホップの植物体またはホップエキスを含んでなる、請求項1に記載の自律神経調節剤。
- ホップエキスが異性化ホップエキスである、請求項2に記載の自律神経調節剤。
- 副腎交感神経活動の抑制に用いるための、請求項1〜3のいずれか一項に記載の自律神経調節剤。
- 食品添加剤として用いるための、請求項1〜4のいずれか一項に記載の自律神経調節剤。
- イソフムロン類、またはその薬理学的に許容される塩もしくは溶媒和物を有効成分として含んでなる、自律神経調節用の組成物。
- ホップの植物体またはホップエキスを含んでなる、請求項6に記載の組成物。
- ホップエキスが異性化ホップエキスである、請求項7に記載の組成物。
- 副腎交感神経活動の抑制に用いるための、請求項6〜8のいずれか一項に記載の組成物。
- 食品組成物である、請求項6〜9のいずれか一項に記載の組成物。
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