JP6118817B2 - ５−（ジフルオロメチル）ピラジン−２−カルボン酸の製造方法およびその製造中間体 - Google Patents

５−（ジフルオロメチル）ピラジン−２−カルボン酸の製造方法およびその製造中間体 Download PDF

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Publication number
JP6118817B2
JP6118817B2 JP2014547207A JP2014547207A JP6118817B2 JP 6118817 B2 JP6118817 B2 JP 6118817B2 JP 2014547207 A JP2014547207 A JP 2014547207A JP 2014547207 A JP2014547207 A JP 2014547207A JP 6118817 B2 JP6118817 B2 JP 6118817B2
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formula
salt
pyrazine
group
compound
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JP2014547207A
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Japanese (ja)
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JP2015514676A (ja
Inventor
一洋 吉澤
一洋 吉澤
雅之 大森
雅之 大森
雄造 渡部
雄造 渡部
永井　光雄
光雄 永井
高橋　正史
正史 高橋
フランク ジー． ファン
フランク ジー． ファン
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2014547207A 2012-04-27 2013-04-25 ５−（ジフルオロメチル）ピラジン−２−カルボン酸の製造方法およびその製造中間体 Expired - Fee Related JP6118817B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261639362P 2012-04-27 2012-04-27
US61/639,362 2012-04-27
PCT/JP2013/062863 WO2013162065A1 (en) 2012-04-27 2013-04-25 Method for producing 5-(difluoromethyl)pyrazine-2-carboxilic acid and production intermediate thereof

Publications (2)

Publication Number Publication Date
JP2015514676A JP2015514676A (ja) 2015-05-21
JP6118817B2 true JP6118817B2 (ja) 2017-04-19

Family

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JP2014547207A Expired - Fee Related JP6118817B2 (ja) 2012-04-27 2013-04-25 ５−（ジフルオロメチル）ピラジン−２−カルボン酸の製造方法およびその製造中間体

Country Status (14)

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US (1) US9227942B2 (enExample)
EP (1) EP2841423B1 (enExample)
JP (1) JP6118817B2 (enExample)
CN (1) CN104245680B (enExample)
BR (1) BR112014026474A2 (enExample)
CA (1) CA2871264A1 (enExample)
ES (1) ES2615304T3 (enExample)
HU (1) HUE030534T2 (enExample)
IL (1) IL235161A0 (enExample)
IN (1) IN2014DN08922A (enExample)
MX (1) MX2014012683A (enExample)
RU (1) RU2014142545A (enExample)
SG (1) SG11201406589PA (enExample)
WO (1) WO2013162065A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI639607B (zh) 2013-06-18 2018-11-01 美國禮來大藥廠 Ｂａｃｅ抑制劑
JP7605139B2 (ja) * 2020-02-06 2024-12-24 Ａｇｃ株式会社 芳香族複素環置換ジフルオロ酢酸誘導体の製造方法
CN112645890B (zh) * 2020-12-25 2022-08-12 江苏广域化学有限公司 2-吡嗪羧酸酯类化合物的合成方法
CN117897377A (zh) * 2021-08-11 2024-04-16 Ａｇｃ株式会社 使用四氟乙烯进行的杂环的二氟甲基化反应

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007087129A2 (en) 2006-01-12 2007-08-02 Merck & Co., Inc. Fluorinated arylamide derivatives
MY160690A (en) 2008-01-18 2017-03-15 Eisai R&D Man Co Ltd Condensed aminodihydrothiazine derivative
EP2303881A2 (en) * 2008-07-14 2011-04-06 Gilead Sciences, Inc. Fused heterocyclyc inhibitors of histone deacetylase and/or cyclin-dependent kinases
US8198269B2 (en) 2008-09-30 2012-06-12 Eisai R&D Management Co., Ltd. Fused aminodihydrothiazine derivative
AR077277A1 (es) 2009-07-09 2011-08-17 Lilly Co Eli Compuestos de biciclo (1,3)tiazin-2-amina formulacion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de la enfermedad de alzheimer
GB0912777D0 (en) 2009-07-22 2009-08-26 Eisai London Res Lab Ltd Fused aminodihydropyrimidone derivatives
GB0912778D0 (en) 2009-07-22 2009-08-26 Eisai London Res Lab Ltd Fused aminodihydro-oxazine derivatives
JP5696355B2 (ja) * 2009-11-18 2015-04-08 セントラル硝子株式会社 芳香族ジフルオロメチル化合物の製造方法
US8673894B2 (en) 2010-05-07 2014-03-18 Hoffmann-La Roche Inc. 2,5,6,7-tetrahydro-[1,4]oxazepin-3-ylamine or 2,3,6,7-tetrahydro-[1,4]oxazepin-5-ylamine compounds
JP5679855B2 (ja) 2011-02-14 2015-03-04 国立大学法人群馬大学 ジフルオロメチル化ヘテロアリール化合物の製造方法

Also Published As

Publication number Publication date
US20150087836A1 (en) 2015-03-26
RU2014142545A (ru) 2016-06-27
IN2014DN08922A (enExample) 2015-05-22
MX2014012683A (es) 2015-01-16
EP2841423B1 (en) 2016-11-30
JP2015514676A (ja) 2015-05-21
US9227942B2 (en) 2016-01-05
SG11201406589PA (en) 2014-11-27
IL235161A0 (en) 2014-12-31
HUE030534T2 (hu) 2017-05-29
BR112014026474A2 (pt) 2017-06-27
EP2841423A4 (en) 2015-09-09
WO2013162065A1 (en) 2013-10-31
CN104245680B (zh) 2016-11-23
CA2871264A1 (en) 2013-10-31
CN104245680A (zh) 2014-12-24
EP2841423A1 (en) 2015-03-04
ES2615304T3 (es) 2017-06-06

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