JP6110048B2 - 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法 - Google Patents

内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法 Download PDF

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JP6110048B2
JP6110048B2 JP2008557431A JP2008557431A JP6110048B2 JP 6110048 B2 JP6110048 B2 JP 6110048B2 JP 2008557431 A JP2008557431 A JP 2008557431A JP 2008557431 A JP2008557431 A JP 2008557431A JP 6110048 B2 JP6110048 B2 JP 6110048B2
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JP2009528066A (ja
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ダムール，ケヴィン
カーペンター，メリッサ
バン，アンネ
ムーアマン，マーク
ジー． ケリー，オリビア
ジー． ケリー，オリビア
イー． ベートゲ，エマニュエル
イー． ベートゲ，エマニュエル
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ヴィアサイト，インコーポレイテッド
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JP2008557431A 2006-03-02 2007-03-02 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法 Active JP6110048B2 (ja)

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US77864906P 2006-03-02 2006-03-02
US60/778,649 2006-03-02
US83363306P 2006-07-26 2006-07-26
US60/833,633 2006-07-26
US85287806P 2006-10-18 2006-10-18
US60/852,878 2006-10-18
PCT/US2007/005541 WO2007103282A2 (en) 2006-03-02 2007-03-02 Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production

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JP2008557431A Active JP6110048B2 (ja) 2006-03-02 2007-03-02 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
JP2013242867A Pending JP2014079247A (ja) 2006-03-02 2013-11-25 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
JP2015153742A Active JP6339980B2 (ja) 2006-03-02 2015-08-03 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
JP2016096963A Active JP6804866B2 (ja) 2006-03-02 2016-05-13 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
JP2017022606A Active JP6574212B2 (ja) 2006-03-02 2017-02-09 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
JP2018194658A Pending JP2019022517A (ja) 2006-03-02 2018-10-15 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
JP2019214611A Active JP7409839B2 (ja) 2006-03-02 2019-11-27 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
JP2021070464A Active JP7619873B2 (ja) 2006-03-02 2021-04-19 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
JP2022118466A Pending JP2022136183A (ja) 2006-03-02 2022-07-26 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
JP2024002853A Pending JP2024026731A (ja) 2006-03-02 2024-01-11 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法

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JP2015153742A Active JP6339980B2 (ja) 2006-03-02 2015-08-03 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
JP2016096963A Active JP6804866B2 (ja) 2006-03-02 2016-05-13 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
JP2017022606A Active JP6574212B2 (ja) 2006-03-02 2017-02-09 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
JP2018194658A Pending JP2019022517A (ja) 2006-03-02 2018-10-15 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
JP2019214611A Active JP7409839B2 (ja) 2006-03-02 2019-11-27 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
JP2021070464A Active JP7619873B2 (ja) 2006-03-02 2021-04-19 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
JP2022118466A Pending JP2022136183A (ja) 2006-03-02 2022-07-26 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
JP2024002853A Pending JP2024026731A (ja) 2006-03-02 2024-01-11 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法

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US (4) US8129182B2 (enExample)
EP (4) EP4112718A1 (enExample)
JP (10) JP6110048B2 (enExample)
AU (1) AU2007224116B2 (enExample)
CA (2) CA2644468C (enExample)
DK (3) DK1999253T3 (enExample)
NZ (1) NZ571427A (enExample)
SG (2) SG170068A1 (enExample)
WO (1) WO2007103282A2 (enExample)

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US7432104B2 (en) * 2001-08-06 2008-10-07 Bresgen Inc. Methods for the culture of human embryonic stem cells on human feeder cells
US20050266554A1 (en) * 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US8187878B2 (en) 2004-08-13 2012-05-29 University Of Georgia Research Foundation, Inc. Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
JP2009500297A (ja) 2005-06-08 2009-01-08 セントカー・インコーポレーテツド 眼の変性についての細胞療法
ES2687233T3 (es) 2005-10-27 2018-10-24 Viacyte, Inc. Endodermo de intestino proximal dorsal y ventral que expresa PDX-1
EP2420565B1 (en) 2006-02-23 2017-08-30 ViaCyte, Inc. Compositions and methods useful for culturing differentiable cells
US11254916B2 (en) 2006-03-02 2022-02-22 Viacyte, Inc. Methods of making and using PDX1-positive pancreatic endoderm cells
NZ571427A (en) * 2006-03-02 2012-07-27 Viacyte Inc Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
US7695965B2 (en) 2006-03-02 2010-04-13 Cythera, Inc. Methods of producing pancreatic hormones
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
WO2008013664A2 (en) 2006-07-26 2008-01-31 Cythera, Inc. Methods of producing pancreatic hormones
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
WO2009012428A2 (en) * 2007-07-18 2009-01-22 Lifescan, Inc. Differentiation of human embryonic stem cells
CA2694956C (en) * 2007-07-31 2017-12-19 Lifescan, Inc. Pluripotent stem cell differentiation by using human feeder cells
RU2473685C2 (ru) 2007-07-31 2013-01-27 Лайфскен, Инк. Дифференцировка человеческих эмбриональных стволовых клеток
US9005962B2 (en) 2007-08-24 2015-04-14 The University Court Of The University Of Edinburgh Regionalised endoderm cells and uses thereof
CN107574142B (zh) * 2007-11-27 2021-07-06 生命扫描有限公司 人胚胎干细胞的分化
JP2011509076A (ja) 2007-12-28 2011-03-24 ノボ・ノルデイスク・エー／エス 膵臓内分泌細胞の前駆体を介した該細胞のｄｄｒ１媒介性細胞精製
SG154367A1 (en) * 2008-01-31 2009-08-28 Es Cell Int Pte Ltd Method of differentiating stem cells
BRPI0908033A2 (pt) 2008-02-21 2015-08-04 Centocor Ortho Biotech Inc Método placas de superfície modificada e composições para adesão, cultura e desprendimento de célula
US8399251B2 (en) 2008-04-03 2013-03-19 Novo Nordisk A/S Use of the extracellular marker DNER for identification and selection of specific pancreatic cells
US8338170B2 (en) 2008-04-21 2012-12-25 Viacyte, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
US8623648B2 (en) 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
US7939322B2 (en) 2008-04-24 2011-05-10 Centocor Ortho Biotech Inc. Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm
WO2009137844A2 (en) * 2008-05-09 2009-11-12 Vistagen Therapeutics, Inc. Pancreatic endocrine progenitor cells derived from pluripotent stem cells
US20090298178A1 (en) * 2008-06-03 2009-12-03 D Amour Kevin Allen Growth factors for production of definitive endoderm
CN108486040A (zh) * 2008-06-30 2018-09-04 詹森生物科技公司 多能干细胞的分化
CA2729121C (en) 2008-06-30 2019-04-09 Centocor Ortho Biotech Inc. Differentiation of pluripotent stem cells
WO2010014723A1 (en) * 2008-07-29 2010-02-04 The Board Of Regents Of The University Of Texas System Methods and composition related to acetylcholine receptor conjugates
US9683215B2 (en) * 2008-08-22 2017-06-20 President And Fellows Of Harvard College Methods of reprogramming cells
WO2010030641A2 (en) * 2008-09-10 2010-03-18 The Regents Of The University Of Michigan Pancreatic cancer markers
WO2010037784A1 (en) * 2008-09-30 2010-04-08 Novo Nordisk A/S G6pc2-encoded beta cell surface tags
JP2012507289A (ja) 2008-10-31 2012-03-29 ヤンセン バイオテツク，インコーポレーテツド ヒト胚性幹細胞の膵内分泌系への分化
EP2346988B1 (en) * 2008-10-31 2017-05-31 Janssen Biotech, Inc. Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
CN108342353B (zh) 2008-11-04 2022-01-11 韦尔赛特公司 干细胞聚集体悬浮组合物及其分化方法
US8895300B2 (en) 2008-11-04 2014-11-25 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
US8008075B2 (en) 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
EP2356227B1 (en) 2008-11-14 2018-03-28 Viacyte, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells
MX2011005288A (es) 2008-11-20 2011-06-01 Centocor Ortho Biotech Inc Celulas madre pluripotentes en microportadores.
CA2744227C (en) 2008-11-20 2018-10-02 Centocor Ortho Biotech Inc. Methods and compositions for cell attachment and cultivation on planar substrates
EP2367931B1 (en) * 2008-12-03 2017-05-31 International Stem Cell Corporation Methods of deriving differentiated cells from stem cells
WO2010085842A1 (en) * 2009-01-27 2010-08-05 Australian Stem Cell Centre Limited Lung epithelial progenitor cells, uses thereof and processes for production
US9109245B2 (en) * 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
JP2011010653A (ja) * 2009-06-05 2011-01-20 Kumamoto Univ 細胞の分化誘導方法
US9388381B2 (en) 2009-07-09 2016-07-12 Massachusetts Institute Of Technology Methods and compositions for increased safety of stem cell-derived populations
EP2456862A4 (en) * 2009-07-20 2013-02-27 Janssen Biotech Inc DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS
RU2540016C2 (ru) 2009-07-20 2015-01-27 Янссен Байотек, Инк. Дифференцировка эмбриональных стволовых клеток человека
EP2456858B1 (en) 2009-07-20 2018-08-29 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
DK2516625T3 (da) 2009-12-23 2024-09-09 Janssen Biotech Inc Differentiering af humane embryonale stamceller
RU2664864C1 (ru) * 2009-12-23 2018-08-23 Янссен Байотек, Инк. Способы увеличения экспрессии ngn3 и nkx6.1 в эндокринных клетках поджелудочной железы
AU2011223900A1 (en) 2010-03-01 2012-09-13 Janssen Biotech, Inc. Methods for purifying cells derived from pluripotent stem cells
AU2011250912A1 (en) 2010-05-12 2012-11-22 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
CN103052393B (zh) * 2010-08-12 2017-11-14 詹森生物科技公司 用胰腺内分泌前体细胞治疗糖尿病
KR101836850B1 (ko) 2010-08-31 2018-03-09 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
WO2012030540A2 (en) 2010-08-31 2012-03-08 Janssen Biotech, Inc. Differentiation of pluripotent stem cells
CN103221536B (zh) 2010-08-31 2016-08-31 詹森生物科技公司 人胚胎干细胞的分化
US20130225443A1 (en) 2010-11-05 2013-08-29 Kyoto University Method of examining polycystic kidney disease and method of screening for therapeutic agent of the disease
CA2816495C (en) * 2010-12-15 2020-10-13 Kadimastem Ltd. Insulin producing cells derived from pluripotent stem cells
US9433557B2 (en) 2011-02-21 2016-09-06 Viacyte, Inc. Loading system for an encapsulation device
WO2012175633A1 (en) 2011-06-21 2012-12-27 Novo Nordisk A/S Efficient induction of definitive endoderm from pluripotent stem cells
RU2705001C2 (ru) * 2011-12-22 2019-11-01 Янссен Байотек, Инк. Дифференцировка эмбриональных стволовых клеток человека в одногормональные инсулинположительные клетки
MX354775B (es) 2012-03-07 2018-03-20 Janssen Biotech Inc Medios definidos para la expansion y el mantenimiento de celulas madre pluripotentes.
US9447378B2 (en) 2012-04-27 2016-09-20 Massachusetts Institute Of Technology Method for differentiating human embryonic stem cells into β-cells for the treatment of type I diabetes
DK2844739T3 (da) 2012-04-30 2019-09-30 Univ Health Network FREMGANGSMÅDER OG SAMMENSÆTNINGER TIL GENERERING AF PANCREATISKE PROGENITORER OG FUNKTIONELLE BETA-CELLER UD FRA hPSC'ER
EP2857500B1 (en) * 2012-05-25 2018-01-31 Saitama Medical University Method for producing pancreatic hormone-producing cell, pancreatic hormone-producing cell, and differentiation/induction promoter
CN104334719B (zh) * 2012-06-08 2018-02-13 詹森生物科技公司 人胚胎干细胞向胰腺内分泌细胞的分化
EP2893000B1 (en) 2012-09-03 2019-04-10 Novo Nordisk A/S Generation of pancreatic endoderm from pluripotent stem cells using small molecules
AU2013248265B2 (en) 2012-11-08 2018-11-01 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
DK2938722T3 (da) 2012-12-31 2022-02-14 Janssen Biotech Inc Suspension og klyngedannelse af humane pluripotente celler til differentiering til endokrine pankreasceller
MX2015008578A (es) 2012-12-31 2015-09-07 Janssen Biotech Inc Diferenciacion de celulas madre embrionarias humanas en celulas endocrinas pancreaticas mediante el uso de relugadores de hb9.
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
KR102084561B1 (ko) 2012-12-31 2020-03-04 얀센 바이오테크 인코포레이티드 췌장 내분비 세포로의 분화를 위한 공기-액체 계면에서의 인간 배아 줄기세포의 배양
USD720469S1 (en) 2013-03-07 2014-12-30 Viacyte, Inc. Cell encapsulation device
JP6234485B2 (ja) 2013-03-07 2017-11-22 ヴィアサイト インコーポレイテッド ３次元大収容力細胞封入デバイスアセンブリー
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
TW201522637A (zh) * 2013-03-15 2015-06-16 Jackson Lab 非胚胎幹細胞之單離及其用途
WO2014165663A1 (en) * 2013-04-03 2014-10-09 Cellular Dynamics International, Inc. Methods and compositions for culturing endoderm progenitor cells in suspension
TW201536799A (zh) 2013-05-24 2015-10-01 Univ Saitama Medical 新穎之胜肽及其用途
AU2014278178B2 (en) 2013-06-11 2021-01-21 President And Fellows Of Harvard College SC-beta cells and compositions and methods for generating the same
WO2014201431A1 (en) 2013-06-14 2014-12-18 Massachusetts Institute Of Technology Articles and methods for stem cell differentiation
DK3039122T3 (da) * 2013-08-30 2019-09-30 Novo Nordisk As Generering af endokrine progenitorceller fra humane pluripotente stamceller under anvendelse af små molekyler
EP3071685B1 (en) * 2013-11-21 2026-07-29 Memorial Sloan-Kettering Cancer Center Specification of functional cranial placode derivatives from human pluripotent stem cells
EP2896688A1 (en) * 2014-01-20 2015-07-22 Centre National de la Recherche Scientifique (CNRS) A method of producing beta pancreatic cells from progenitor cells through the use of hydrogen peroxide
US11051900B2 (en) 2014-04-16 2021-07-06 Viacyte, Inc. Tools and instruments for use with implantable encapsulation devices
SG11201609473XA (en) 2014-05-16 2016-12-29 Janssen Biotech Inc Use of small molecules to enhance mafa expression in pancreatic endocrine cells
ES2985135T3 (es) 2014-12-18 2024-11-04 Harvard College Procedimientos para generar células ß derivadas de células madre y usos de las mismas
US10443042B2 (en) 2014-12-18 2019-10-15 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof
CN107614678B (zh) 2014-12-18 2021-04-30 哈佛学院校长同事会 干细胞来源的β细胞的产生方法及其使用方法
CN107250349A (zh) * 2014-12-19 2017-10-13 詹森生物科技公司 多能干细胞的悬浮培养
ES2840076T3 (es) 2015-04-24 2021-07-06 Univ Copenhagen Aislamiento de células progenitoras pancreáticas bona fide
JP6441256B2 (ja) * 2016-04-13 2018-12-19 バイアサイト インク 幹細胞集合体懸濁液組成物、その分化方法
WO2017180361A1 (en) 2016-04-14 2017-10-19 Janssen Biotech, Inc. Differentiation of pluripotent stem cells to intestinal midgut endoderm cells
EP4595951A3 (en) 2016-11-10 2025-08-27 ViaCyte, Inc. Pdx1 pancreatic endoderm cells in cell delivery devices
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
EP3409239A1 (en) 2017-05-29 2018-12-05 University College Dublin, National University of Ireland, Dublin An implantable active agent encapsulating device
IL313825B2 (en) 2017-06-14 2025-07-01 Vertex Pharma Devices and methods for administering medications
US10391156B2 (en) 2017-07-12 2019-08-27 Viacyte, Inc. University donor cells and related methods
CA2983845C (en) 2017-10-26 2024-01-30 University Of Copenhagen Generation of glucose-responsive beta cells
WO2019099725A1 (en) 2017-11-15 2019-05-23 Semma Therapeutics, Inc. Islet cell manufacturing compositions and methods of use
US11530211B2 (en) 2018-01-18 2022-12-20 Daiichi Sankyo Company, Limited Dihydroindolizinone derivative
WO2019169351A1 (en) 2018-03-02 2019-09-06 Semma Therapeutics, Inc. Methods of enhancing stem cell differentiation into beta cells
WO2019208788A1 (ja) * 2018-04-27 2019-10-31 株式会社カネカ 膵臓β細胞の製造方法
WO2019227198A1 (en) 2018-05-31 2019-12-05 University Health Network (Uhn) Methods and compositions comprising tankyrase inhibitors for generating insulin producing cells
EP3833365A4 (en) 2018-08-10 2022-05-11 Vertex Pharmaceuticals Incorporated Stem cell derived islet differentiation
KR102069635B1 (ko) 2018-09-06 2020-02-24 삼성전기주식회사 코일 부품
US12378572B2 (en) 2018-09-07 2025-08-05 Crispr Therapeutics Ag Universal donor cells
TWI862513B (zh) * 2018-09-19 2024-11-21 日商千紙鶴治療公司 包含胰島素產生細胞之細胞集團、包含該細胞集團之醫藥、其用途及製造方法
EP3953451A1 (en) 2019-04-08 2022-02-16 Novo Nordisk A/S Generation of pancreatic endoderm from stem cell derived definitive endoderm
CA3257300A1 (en) 2019-05-31 2025-06-12 W. L. Gore & Associates, Inc. Cell encapsulation devices with controlled oxygen diffusion distances
EP3975926A1 (en) 2019-05-31 2022-04-06 W.L. Gore & Associates, Inc. A biocompatible membrane composite
AU2020282355B2 (en) 2019-05-31 2023-11-02 Viacyte, Inc. A biocompatible membrane composite
US12310830B2 (en) 2019-05-31 2025-05-27 W. L. Gore & Associates, Inc. Biocompatible membrane composite
US11116798B2 (en) 2019-09-05 2021-09-14 Crispr Therapeutics Ag Universal donor cells
US11104918B2 (en) 2019-09-05 2021-08-31 Crispr Therapeutics Ag Universal donor cells
JP7705448B2 (ja) 2020-07-31 2025-07-09 バーテックス ファーマシューティカルズ インコーポレイテッド 膵内分泌細胞の分化
US11566230B2 (en) 2020-12-31 2023-01-31 Crispr Therapeutics Ag Universal donor cells
JP2024542041A (ja) 2021-11-01 2024-11-13 バーテックス ファーマシューティカルズ インコーポレイテッド 幹細胞由来の膵臓島分化
EP4482465A2 (en) 2022-02-25 2025-01-01 ViaCyte, Inc. Multilayer implantable cell encapsulation devices and methods thereof
WO2024151541A1 (en) 2023-01-09 2024-07-18 Sana Biotechnology, Inc. Type-1 diabetes autoimmune mouse
WO2024243236A2 (en) 2023-05-22 2024-11-28 Sana Biotechnology, Inc. Methods of delivery of islet cells and related methods

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2161804A (en) 1935-11-09 1939-06-13 Baldwin Southwark Corp Hydraulic press
US6165993A (en) 1992-03-23 2000-12-26 University Of Massachusetts Medical Center DNA vaccines against rotavirus infections
US7153684B1 (en) 1992-10-08 2006-12-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5453357A (en) 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5690926A (en) 1992-10-08 1997-11-25 Vanderbilt University Pluripotential embryonic cells and methods of making same
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
US6015671A (en) 1995-06-07 2000-01-18 Indiana University Foundation Myocardial grafts and cellular compositions
US5874301A (en) 1994-11-21 1999-02-23 National Jewish Center For Immunology And Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5731168A (en) * 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
CA2247502A1 (en) 1996-02-28 1997-09-04 Vanderbilt University Compositions and methods of making embryonic stem cells
US5964261A (en) 1996-05-29 1999-10-12 Baxter International Inc. Implantation assembly
JP2001508302A (ja) 1997-01-10 2001-06-26 ライフ テクノロジーズ，インコーポレイテッド 胚性幹細胞血清置換
US6090622A (en) 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
NZ503334A (en) 1997-09-15 2002-05-31 Genetic Immunity Llc A gene delivering complex having a vector with a specific affinity for a foreign genetic material and a second site having a specific affinity for a receptor on an antigen presenting cell
WO1999020740A2 (en) 1997-10-23 1999-04-29 Geron Corporation Methods and materials for the growth of primate-derived primordial stem cells
US6921811B2 (en) 1998-09-22 2005-07-26 Biosurface Engineering Technologies, Inc. Bioactive coating composition and methods
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
DE19852800C1 (de) 1998-11-16 2000-04-13 Univ Albert Ludwigs Freiburg Verfahren zur Herstellung von Antikörpern gegen ein Polypeptid, von dem die kodierende Nukleinsäure bekannt ist
US6326201B1 (en) 1999-02-10 2001-12-04 Curis, Inc. Pancreatic progenitor cells, methods and uses related thereto
US6872389B1 (en) 1999-07-08 2005-03-29 Rhode Island Hospital Liver stem cell
US7005252B1 (en) 2000-03-09 2006-02-28 Wisconsin Alumni Research Foundation Serum free cultivation of primate embryonic stem cells
US7256042B2 (en) 2000-04-27 2007-08-14 Geron Corporation Process for making hepatocytes from pluripotent stem cells
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
JP2004504834A (ja) 2000-08-01 2004-02-19 イスム　リサーチ　ディベロップメント　カンパニー 胚性細胞の定方向分化
AU2002226075A1 (en) 2000-10-23 2002-05-06 University Of Kansas Cadherin peptides for drug delivery and inhibition of tumor metastasis/invasion
CA2435826A1 (en) 2001-01-24 2002-08-01 The Government Of The United States Of America Differentiation of stem cells to pancreatic endocrine cells
TW534580U (en) * 2001-03-29 2003-05-21 Delta Electronics Inc Foldable handle
WO2002092756A2 (en) * 2001-05-15 2002-11-21 Rappaport Family Institute For Research In The Medical Sciences Insulin producing cells derived from human embryonic stem cells
US20050079159A1 (en) 2001-06-13 2005-04-14 Massachusetts Instiute Of Technology In vivo bioreactors
EP1298201A1 (en) 2001-09-27 2003-04-02 Cardion AG Process for the production of cells exhibiting an islet-beta-cell-like state
US20030232430A1 (en) * 2001-11-26 2003-12-18 Advanced Cell Technology Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells
US7157278B2 (en) * 2001-12-04 2007-01-02 Organogenesis, Inc. Cultured cells from pancreatic islets
JP2005511046A (ja) * 2001-12-04 2005-04-28 オーガノジェネシス インコーポレーテッド 膵島由来の培養細胞
GB2399823B (en) 2001-12-07 2006-02-15 Geron Corp Islet cells from primate pluripotent stem cells
US20030138949A1 (en) 2001-12-12 2003-07-24 Anil Bhushan Methods for the regeneration of pancreatic islets and expansion of pancreatic endocrine cells
US20060003446A1 (en) 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
US7763466B2 (en) 2002-05-17 2010-07-27 Mount Sinai School Of Medicine Of New York University Mesoderm and definitive endoderm cell populations
WO2003102171A1 (en) 2002-05-28 2003-12-11 Becton, Dickinson And Company Expansion and transdifferentiation of human acinar cells
BR0311362A (pt) 2002-05-28 2006-10-31 Novocell Inc métodos, composições e fatores de crescimento e de diferenciação para produzir células produtoras de insulina
EP1539928A4 (en) * 2002-09-06 2006-09-06 Amcyte Inc CD56-POSITIVE HUMAN ADULTS PANCREATIC ENDOCRINE PRECURSOR CELLS
AU2003302702B2 (en) 2002-12-05 2008-08-07 Technion Research & Development Foundation Ltd. Cultured human pancreatic islets, and uses thereof
FR2849043B1 (fr) * 2002-12-24 2005-07-08 Gemac Procede de fabrication d'un vecteur de molecules actives applicable dans le domaine de la diffusion de principes actifs et vecteur obtenu
WO2004072251A2 (en) 2003-02-07 2004-08-26 Wisconsin Alumni Research Foundation Directed genetic modifications of human stem cells
US20070154981A1 (en) 2003-02-14 2007-07-05 The Board Of Trustees Of The Leland Stanford Junior University Insulin-producing cells derived from stem cells
US20030224411A1 (en) 2003-03-13 2003-12-04 Stanton Lawrence W. Genes that are up- or down-regulated during differentiation of human embryonic stem cells
US20040229350A1 (en) 2003-05-12 2004-11-18 Nikolai Strelchenko Morula derived embryonic stem cells
KR20060010820A (ko) 2003-05-20 2006-02-02 도꾸리쯔교세이호징 리가가쿠 겐큐소 내배엽계 줄기세포의 제조
WO2005017131A2 (en) 2003-08-14 2005-02-24 THE GOUVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT F HEALTH AND HUMAN SERVICES Methods for the differentiation of human stem cells
US20050170502A1 (en) 2003-09-30 2005-08-04 Regents Of The University Of California Methods for maintaining hepatocytes in culture and for differentiating embryonic stem cells along a hepatocyte lineage
WO2005059095A2 (en) * 2003-12-10 2005-06-30 The General Hospital Corporation Expansion and differentiation of islet progenitor cells
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US8647873B2 (en) * 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
EP2722387B1 (en) 2003-12-23 2019-12-11 Viacyte, Inc. Definitive endoderm
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
US8586357B2 (en) 2003-12-23 2013-11-19 Viacyte, Inc. Markers of definitive endoderm
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
JP4848355B2 (ja) 2004-02-27 2011-12-28 アンスティテュ・キュリ 臨床診療における新規増殖マーカーおよび癌の予後または診断のためのそれらの用途
JP2008500809A (ja) 2004-03-09 2008-01-17 ライフスキャン・インコーポレイテッド インスリン産生細胞を発生させるための方法
WO2005097980A2 (en) 2004-03-26 2005-10-20 Geron Corporation New protocols for making hepatocytes from embryonic stem cells
KR20070029681A (ko) 2004-04-01 2007-03-14 위스콘신 얼럼나이 리서어치 화운데이션 줄기 세포의 내배엽 및 이자 혈통으로의 분화
CN103103158B (zh) * 2004-04-27 2016-08-03 韦尔赛特公司 细胞培养基
CA2966883A1 (en) 2004-07-09 2006-02-16 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
CN102586170B (zh) 2004-07-09 2019-11-29 维亚希特公司 前原条和中内胚层细胞
US8187878B2 (en) 2004-08-13 2012-05-29 University Of Georgia Research Foundation, Inc. Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors
EP1797171A1 (en) 2004-09-29 2007-06-20 Cellartis AB Methods for the generation of hepatocyte-like cells from human blastocyst-derived stem (hbs)
AU2006210955A1 (en) * 2005-01-31 2006-08-10 Es Cell International Pte Ltd. Directed differentiation of embryonic stem cells and uses thereof
CN100425694C (zh) 2005-04-15 2008-10-15 北京大学 诱导胚胎干细胞向胰腺细胞分化的方法
WO2007002210A2 (en) 2005-06-20 2007-01-04 Bresagen, Inc. Embryonic stem cell culture compositions and methods of use thereof
ES2687233T3 (es) 2005-10-27 2018-10-24 Viacyte, Inc. Endodermo de intestino proximal dorsal y ventral que expresa PDX-1
GB0602063D0 (en) 2006-02-02 2006-03-15 Univ Manchester Cell Culture
NZ571427A (en) * 2006-03-02 2012-07-27 Viacyte Inc Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
US7695965B2 (en) 2006-03-02 2010-04-13 Cythera, Inc. Methods of producing pancreatic hormones
WO2008013664A2 (en) 2006-07-26 2008-01-31 Cythera, Inc. Methods of producing pancreatic hormones
US8772020B2 (en) 2006-08-01 2014-07-08 The Regents Of The University Of California Fermentation system having strainer assembly
US20080241250A1 (en) 2006-11-08 2008-10-02 Emans Pieter J In vivo bioreactors and methods of making and using same
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
DK2993226T3 (da) * 2008-06-03 2021-02-22 Viacyte Inc Vækstfaktorer til fremstilling af en definitiv endoderm
US11586805B2 (en) 2021-07-26 2023-02-21 Atlassian Pty Ltd. Machine-learning-based natural language processing techniques for low-latency document summarization

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