JP6096117B2 - 抗ｃｄ４８抗体およびその使用 - Google Patents

抗ｃｄ４８抗体およびその使用 Download PDF

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Publication number
JP6096117B2
JP6096117B2 JP2013530383A JP2013530383A JP6096117B2 JP 6096117 B2 JP6096117 B2 JP 6096117B2 JP 2013530383 A JP2013530383 A JP 2013530383A JP 2013530383 A JP2013530383 A JP 2013530383A JP 6096117 B2 JP6096117 B2 JP 6096117B2
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Japan
Prior art keywords
antibody
human
antigen
seq
antibodies
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Expired - Fee Related
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JP2013530383A
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English (en)
Japanese (ja)
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JP2013542194A (ja
JP2013542194A5 (https=
Inventor
ブレンダン・ジェイ・クラソン
アナ・コスティク
シュンバオ・デュアン
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Publication of JP2013542194A5 publication Critical patent/JP2013542194A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2013530383A 2010-09-27 2011-09-26 抗ｃｄ４８抗体およびその使用 Expired - Fee Related JP6096117B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US38674610P 2010-09-27 2010-09-27
US61/386,746 2010-09-27
US201161475280P 2011-04-14 2011-04-14
US61/475,280 2011-04-14
US201161515490P 2011-08-05 2011-08-05
US61/515,490 2011-08-05
PCT/US2011/053193 WO2012047567A1 (en) 2010-09-27 2011-09-26 Anti-cd48 antibodies and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016210605A Division JP2017036324A (ja) 2010-09-27 2016-10-27 抗ｃｄ４８抗体およびその使用

Publications (3)

Publication Number Publication Date
JP2013542194A JP2013542194A (ja) 2013-11-21
JP2013542194A5 JP2013542194A5 (https=) 2014-11-13
JP6096117B2 true JP6096117B2 (ja) 2017-03-15

Family

ID=45870888

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013530383A Expired - Fee Related JP6096117B2 (ja) 2010-09-27 2011-09-26 抗ｃｄ４８抗体およびその使用
JP2016210605A Pending JP2017036324A (ja) 2010-09-27 2016-10-27 抗ｃｄ４８抗体およびその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016210605A Pending JP2017036324A (ja) 2010-09-27 2016-10-27 抗ｃｄ４８抗体およびその使用

Country Status (19)

Country Link
US (1) US9228014B2 (https=)
EP (1) EP2621952A1 (https=)
JP (2) JP6096117B2 (https=)
KR (1) KR20140014067A (https=)
CN (1) CN103261226B (https=)
AR (1) AR083044A1 (https=)
AU (1) AU2011312623B2 (https=)
BR (1) BR112013007314A2 (https=)
CA (1) CA2812748A1 (https=)
CL (1) CL2013000843A1 (https=)
EA (1) EA030437B1 (https=)
IL (1) IL225484A (https=)
MX (1) MX348417B (https=)
MY (1) MY165273A (https=)
NZ (1) NZ608660A (https=)
PH (1) PH12013500564A1 (https=)
SG (1) SG189089A1 (https=)
TW (1) TWI507416B (https=)
WO (1) WO2012047567A1 (https=)

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AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
WO2016036252A2 (en) * 2014-09-05 2016-03-10 Aimm Therapeutics B.V. Hepatitis c virus specific antibody
DK3270965T3 (da) 2015-03-18 2020-06-08 Seattle Genetics Inc Cd48-antistoffer og konjugater deraf
TWI870789B (zh) 2015-08-04 2025-01-21 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
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JP6805884B2 (ja) 2017-02-28 2020-12-23 住友ゴム工業株式会社 二輪自動用空気入りタイヤ
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MX2020006639A (es) 2017-12-22 2020-09-14 Regeneron Pharma Sistema y metodo para caracterizar las impurezas de un producto farmaceutico.
BR112020013336A2 (pt) 2018-01-31 2020-12-01 Regeneron Pharmaceuticals, Inc. produto farmacêutico proteico, métodos para caracterizar as impurezas do produto farmacêutico proteico de alto peso molecular intermediário, para produção de um anticorpo, e para caracterizar as impurezas de fármaco com variação de carga, anticorpo, e, sistema para caracterizar impurezas de fármaco de alto peso molecular intermediário.
TW202311746A (zh) 2018-02-02 2023-03-16 美商再生元醫藥公司 用於表徵蛋白質二聚合之系統及方法
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US12259355B2 (en) 2018-03-19 2025-03-25 Regeneron Pharmaceuticals, Inc. Microchip capillary electrophoresis assays and reagents
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Publication number Publication date
EA201370081A1 (ru) 2013-12-30
IL225484A (en) 2017-07-31
NZ608660A (en) 2015-03-27
US9228014B2 (en) 2016-01-05
PH12013500564A1 (en) 2021-06-02
TWI507416B (zh) 2015-11-11
CN103261226A (zh) 2013-08-21
EA030437B1 (ru) 2018-08-31
JP2017036324A (ja) 2017-02-16
EP2621952A1 (en) 2013-08-07
AR083044A1 (es) 2013-01-30
TW201305206A (zh) 2013-02-01
BR112013007314A2 (pt) 2017-03-21
MX348417B (es) 2017-06-12
CA2812748A1 (en) 2012-04-12
JP2013542194A (ja) 2013-11-21
WO2012047567A1 (en) 2012-04-12
KR20140014067A (ko) 2014-02-05
US20120076790A1 (en) 2012-03-29
SG189089A1 (en) 2013-05-31
AU2011312623B2 (en) 2016-12-15
CL2013000843A1 (es) 2014-03-07
IL225484A0 (en) 2013-06-27
CN103261226B (zh) 2016-06-15
MY165273A (en) 2018-03-20
AU2011312623A1 (en) 2013-05-02
MX2013003468A (es) 2013-05-31

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