JP6084924B2 - β−アミロイドパシーまたはα−シヌクレオパシーを治療するための２−（Ｒ２−チオ）−１０−［３−（４−Ｒ１−ピペラジン−１−イル）プロピル］−１０Ｈ−フェノチアジン、およびβ−アミロイドパシーまたはα−シヌクレオパシーの診断または事前診断のための方法 - Google Patents

β−アミロイドパシーまたはα−シヌクレオパシーを治療するための２−（Ｒ２−チオ）−１０−［３−（４−Ｒ１−ピペラジン−１−イル）プロピル］−１０Ｈ−フェノチアジン、およびβ−アミロイドパシーまたはα−シヌクレオパシーの診断または事前診断のための方法 Download PDF

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JP6084924B2
JP6084924B2 JP2013527544A JP2013527544A JP6084924B2 JP 6084924 B2 JP6084924 B2 JP 6084924B2 JP 2013527544 A JP2013527544 A JP 2013527544A JP 2013527544 A JP2013527544 A JP 2013527544A JP 6084924 B2 JP6084924 B2 JP 6084924B2
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パーンケ，イエンス
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イムンゲネテイクス・アーゲー
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    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
    • C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A—HUMAN NECESSITIES
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    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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JP2013527544A 2010-09-07 2011-08-30 β−アミロイドパシーまたはα−シヌクレオパシーを治療するための２−（Ｒ２−チオ）−１０−［３−（４−Ｒ１−ピペラジン−１−イル）プロピル］−１０Ｈ−フェノチアジン、およびβ−アミロイドパシーまたはα−シヌクレオパシーの診断または事前診断のための方法 Active JP6084924B2 (ja)

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DE102010044561 2010-09-07
DE102010044561.4 2010-09-07
PCT/EP2011/064893 WO2012031941A2 (de) 2010-09-07 2011-08-30 2-(R²-THIO)-10-[3-(4-R1-PIPERAZIN-1-YL)PROPYL]-10H-PHENOTHIAZINE ZUR BEHANDLUNG EINER β-AMYLOIDOPATHIE ODER ALPHA-SYNUCLEOPATHIE SOWIE VERFAHREN ZU DEREN DIAGNOSE ODER PRÄDIAGNOSE

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JP2016131781A Active JP6426663B2 (ja) 2010-09-07 2016-07-01 β−アミロイドパシーまたはα−シヌクレオパシーを治療するための２−（Ｒ２−チオ）−１０−［３−（４−Ｒ１−ピペラジン−１−イル）プロピル］−１０Ｈ−フェノチアジン、およびβ−アミロイドパシーまたはα−シヌクレオパシーの診断または事前診断のための方法

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US (3) US20130184268A1 (enExample)
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BR (1) BR112013005472A2 (enExample)
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AU2017301966B2 (en) 2016-07-25 2022-09-22 TauRx Therapeutics Management Ltd Administration and dosage of diaminophenothiazines
EP3826639B1 (en) 2018-07-26 2024-08-21 WisTa Laboratories Ltd. Optimised dosage of diaminophenothiazines in populations
EP4121546A1 (en) * 2020-03-16 2023-01-25 Doublerainbow Biosciences Inc. Etoposide glycosides, methods of making, and uses thereof as an anti-cancer drug
EP4460311A1 (en) * 2022-01-04 2024-11-13 Immungenetics AG Specific dosage of phenothiazine compounds for use in treatment or prevention of alzheimer's dementia
CA3268498A1 (en) * 2022-10-18 2024-04-25 Immungenetics Ag IDENTIFICATION OF A SUBJECT SUFFERING FROM ALZHEIMER'S DISEASE OR PRESENTING A RISK OF DEVELOPING ALZHEIMER'S DISEASE

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CH365379A (de) * 1956-04-18 1962-11-15 Sandoz Ag Verfahren zur Herstellung von neuen, in 3-Stellung mit einer einwertigen Schwefelfunktion substituierten Phenothiazinen
BE568701A (enExample) * 1957-06-18
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DK1470818T3 (da) * 2003-04-25 2006-11-20 Neuro3D Anvendelse af Piperazin-phenothiazin-derivater til fremstilling af et medikament med neurobeskyttende og/eller neurotrofiske effekter på CNS og/eller PNS
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GB0701970D0 (en) * 2007-02-01 2007-03-14 Wilson Stuart Treatment of protein aggregation diseases
WO2008133884A2 (en) * 2007-04-23 2008-11-06 Combinatorx, Incorporated Methods and compositions for the treatment of neurodegenerative disorders
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PT2282779E (pt) * 2008-04-29 2013-05-28 Pharnext Novas abordagens terapêuticas para o tratamento da doença de alzheimer e doenças relacionadas através de uma modulação de resposta ao stresse celular
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JP2017019776A (ja) 2017-01-26
US20130184268A1 (en) 2013-07-18
RU2013110018A (ru) 2014-10-20
CN103237802B (zh) 2017-06-09
DE102010062810B4 (de) 2014-03-13
EP2693216B1 (de) 2018-09-12
EP2693216A1 (de) 2014-02-05
JP2013537881A (ja) 2013-10-07
PL2693216T3 (pl) 2019-04-30
ES2701453T3 (es) 2019-02-22
CA2811454C (en) 2017-03-28
ES2605705T3 (es) 2017-03-15
DE102010062810A1 (de) 2012-03-08
EP2614060B1 (de) 2016-08-31
WO2012031941A3 (de) 2012-09-20
MX2013002612A (es) 2013-08-01
PL2614060T3 (pl) 2017-05-31
EP3097914A2 (de) 2016-11-30
CA2870626A1 (en) 2012-03-15
RU2016118021A (ru) 2018-11-01
CN103237802A (zh) 2013-08-07
WO2012031941A2 (de) 2012-03-15
US20150374711A1 (en) 2015-12-31
BR112013005472A2 (pt) 2020-11-10
CA2870626C (en) 2018-08-14
JP6426663B2 (ja) 2018-11-21
EP3097914A3 (de) 2016-12-28
US9370523B2 (en) 2016-06-21
DK2614060T3 (da) 2017-01-02
EP2614060A2 (de) 2013-07-17
US20150024418A1 (en) 2015-01-22
RU2587154C2 (ru) 2016-06-20
RU2016118021A3 (enExample) 2020-02-26
DE102011053114A1 (de) 2012-03-08
CA2811454A1 (en) 2012-03-15
CN106243060A (zh) 2016-12-21
MX357521B (es) 2018-07-12
DK2693216T3 (en) 2019-01-14

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