BR112013005472A2 - 2-(r tio) 10 3 (4 r1 piperazina 1 il) propil 10h fenotiazina para tratar um amiloidopatia ou um alfa sinucleopatia ou um alfa-sinucleopatia, e método para seu diagnóstico ou pré diagnóstico - Google Patents
2-(r tio) 10 3 (4 r1 piperazina 1 il) propil 10h fenotiazina para tratar um amiloidopatia ou um alfa sinucleopatia ou um alfa-sinucleopatia, e método para seu diagnóstico ou pré diagnóstico Download PDFInfo
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102010044561 | 2010-09-07 | ||
| DE102010044561.4 | 2010-09-07 | ||
| PCT/EP2011/064893 WO2012031941A2 (de) | 2010-09-07 | 2011-08-30 | 2-(R²-THIO)-10-[3-(4-R1-PIPERAZIN-1-YL)PROPYL]-10H-PHENOTHIAZINE ZUR BEHANDLUNG EINER β-AMYLOIDOPATHIE ODER ALPHA-SYNUCLEOPATHIE SOWIE VERFAHREN ZU DEREN DIAGNOSE ODER PRÄDIAGNOSE |
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| BR112013005472A2 true BR112013005472A2 (pt) | 2020-11-10 |
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| BR112013005472-7A BR112013005472A2 (pt) | 2010-09-07 | 2011-08-30 | 2-(r tio) 10 3 (4 r1 piperazina 1 il) propil 10h fenotiazina para tratar um amiloidopatia ou um alfa sinucleopatia ou um alfa-sinucleopatia, e método para seu diagnóstico ou pré diagnóstico |
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| KR20230058533A (ko) | 2016-07-25 | 2023-05-03 | 위스타 레보레이토리스 리미티드 | 디아미노페노티아진 (diaminophenothiazines)의 투여 및 투여량 (dosage) |
| EP4364801B1 (en) | 2018-07-26 | 2025-11-12 | TauRx Therapeutics Management Ltd. | Optimised dosage of diaminophenothiazines in populations |
| CN115279915A (zh) * | 2020-03-16 | 2022-11-01 | 德瑞生物医药股份有限公司 | 依托泊苷糖苷、其制备方法及其作为抗癌药物的用途 |
| JP2025501408A (ja) * | 2022-01-04 | 2025-01-17 | イムヌジェネティクス アーゲー | アルツハイマー型認知症の処置又は予防における使用のための特定の投与量のフェノチアジン化合物 |
| CN119998661A (zh) * | 2022-10-18 | 2025-05-13 | 免疫基因股份公司 | 鉴别患有阿尔茨海默氏痴呆或处于发展阿尔茨海默氏痴呆的风险的受试者 |
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| CH365379A (de) * | 1956-04-18 | 1962-11-15 | Sandoz Ag | Verfahren zur Herstellung von neuen, in 3-Stellung mit einer einwertigen Schwefelfunktion substituierten Phenothiazinen |
| BE568701A (enExample) * | 1957-06-18 | |||
| US3621097A (en) * | 1970-03-30 | 1971-11-16 | Jan Marcel Didier Aron Samuel | Method and compositions for treatment of mental illness |
| US4471116A (en) * | 1982-07-28 | 1984-09-11 | Hoffmann-La Roche Inc. | Substituted (10H-phenothiazin-10-L)-propyl-1-piperazines |
| US6566368B2 (en) * | 1994-04-22 | 2003-05-20 | Pentech Pharmaceuticals, Inc. | Apomorphine-containing dosage form for ameliorating male erectile dysfunction |
| WO1996004915A1 (en) * | 1994-08-08 | 1996-02-22 | Albert Einstein College Of Medicine Of Yeshiva University | Methods for treating and/or preventing alzheimer's disease using phenothiazines and/or thioxanthenes |
| DE4430091A1 (de) * | 1994-08-25 | 1996-02-29 | Bayer Ag | Verwendung von N-substituierten Phenothiazinen |
| DK1470818T3 (da) * | 2003-04-25 | 2006-11-20 | Neuro3D | Anvendelse af Piperazin-phenothiazin-derivater til fremstilling af et medikament med neurobeskyttende og/eller neurotrofiske effekter på CNS og/eller PNS |
| DE102005014142B4 (de) * | 2005-03-23 | 2006-11-09 | Hennig Arzneimittel Gmbh & Co. Kg | Pelletförmige Retardzubereitung gegen Schwindel |
| WO2007062862A2 (en) * | 2005-12-02 | 2007-06-07 | Ludwig Maximilians Universität München | Use of calmodulin inhibitors for the treatment of neurodegenerative disorders |
| PT3121169T (pt) * | 2006-07-11 | 2022-05-13 | Wista Lab Ltd | Processos de síntese e/ou purificação de compostos diaminofenotiazínio |
| PL2064228T3 (pl) * | 2006-11-10 | 2013-01-31 | Cara Therapeutics Inc | Syntetyczne amidy peptydowe |
| GB0701970D0 (en) * | 2007-02-01 | 2007-03-14 | Wilson Stuart | Treatment of protein aggregation diseases |
| TW200848063A (en) * | 2007-04-23 | 2008-12-16 | Combinatorx Inc | Methods and compositions for the treatment of neurodegenerative disorders |
| EA021731B1 (ru) * | 2008-04-29 | 2015-08-31 | Фарнекст | Новые композиции для лечения болезни альцгеймера |
| BRPI0911874A2 (pt) * | 2008-04-29 | 2018-05-22 | Pharnext | composições combinadas para o tratamento da doença de alzheimer e doenças relacionadas com zonisamida e acamprosato |
| EP2282779B1 (en) * | 2008-04-29 | 2013-03-13 | Pharnext | New therapeutic approaches for treating alzheimer disease and related disorders through a modulation of cell stress response |
| CN102573847A (zh) * | 2009-05-14 | 2012-07-11 | 总医院公司 | 治疗退化性及缺血性疾病的方法和组合物 |
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