JP6072058B2 - 顆粒球コロニー刺激因子受容体と結合する方法および組成物 - Google Patents
顆粒球コロニー刺激因子受容体と結合する方法および組成物 Download PDFInfo
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- JP6072058B2 JP6072058B2 JP2014541379A JP2014541379A JP6072058B2 JP 6072058 B2 JP6072058 B2 JP 6072058B2 JP 2014541379 A JP2014541379 A JP 2014541379A JP 2014541379 A JP2014541379 A JP 2014541379A JP 6072058 B2 JP6072058 B2 JP 6072058B2
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- 0 CN(C1=O)N=C(*)C1=C(*)NNC(**)=* Chemical compound CN(C1=O)N=C(*)C1=C(*)NNC(**)=* 0.000 description 11
- NMINNDRUFIEJSN-JCMHNJIXSA-N C/C(/NCCC(CCC(O)=O)=O)=C(\c1ccc(C(F)(F)F)cc1N1c2ccc(C)cc2)/C1=O Chemical compound C/C(/NCCC(CCC(O)=O)=O)=C(\c1ccc(C(F)(F)F)cc1N1c2ccc(C)cc2)/C1=O NMINNDRUFIEJSN-JCMHNJIXSA-N 0.000 description 1
- KJAZFACIPKNEEB-KQWNVCNZSA-N C/C(/NNC(C(CC1)CCC1O)=O)=C(\c1ccc(C(F)(F)F)cc1N1c2cc(C)cc(C)c2)/C1=O Chemical compound C/C(/NNC(C(CC1)CCC1O)=O)=C(\c1ccc(C(F)(F)F)cc1N1c2cc(C)cc(C)c2)/C1=O KJAZFACIPKNEEB-KQWNVCNZSA-N 0.000 description 1
- MGPYOCAAWSWALL-ROMGYVFFSA-N CC(/C1=N/Nc(cccc2C#Cc3c(C)cccc3C)c2O)=NN(CCCC=O)C1=O Chemical compound CC(/C1=N/Nc(cccc2C#Cc3c(C)cccc3C)c2O)=NN(CCCC=O)C1=O MGPYOCAAWSWALL-ROMGYVFFSA-N 0.000 description 1
- PMIAQLYTBNBQBI-UHFFFAOYSA-O CC(C(C([NH2+]c(cc1)ccc1C(O)=O)=O)=NNc(ccc1c2cccc1)c2O)=N Chemical compound CC(C(C([NH2+]c(cc1)ccc1C(O)=O)=O)=NNc(ccc1c2cccc1)c2O)=N PMIAQLYTBNBQBI-UHFFFAOYSA-O 0.000 description 1
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559660P | 2011-11-14 | 2011-11-14 | |
| US61/559,660 | 2011-11-14 | ||
| US201161561510P | 2011-11-18 | 2011-11-18 | |
| US61/561,510 | 2011-11-18 | ||
| PCT/US2012/064706 WO2013074459A1 (en) | 2011-11-14 | 2012-11-12 | Methods and compositions associated with the granulocyte colony-stimulating factor receptor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016253294A Division JP2017095481A (ja) | 2011-11-14 | 2016-12-27 | 顆粒球コロニー刺激因子受容体と結合する方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015504426A JP2015504426A (ja) | 2015-02-12 |
| JP2015504426A5 JP2015504426A5 (https=) | 2015-12-24 |
| JP6072058B2 true JP6072058B2 (ja) | 2017-02-01 |
Family
ID=47258112
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014541379A Active JP6072058B2 (ja) | 2011-11-14 | 2012-11-12 | 顆粒球コロニー刺激因子受容体と結合する方法および組成物 |
| JP2016253294A Pending JP2017095481A (ja) | 2011-11-14 | 2016-12-27 | 顆粒球コロニー刺激因子受容体と結合する方法および組成物 |
| JP2018106998A Pending JP2018150369A (ja) | 2011-11-14 | 2018-06-04 | 顆粒球コロニー刺激因子受容体と結合する方法および組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016253294A Pending JP2017095481A (ja) | 2011-11-14 | 2016-12-27 | 顆粒球コロニー刺激因子受容体と結合する方法および組成物 |
| JP2018106998A Pending JP2018150369A (ja) | 2011-11-14 | 2018-06-04 | 顆粒球コロニー刺激因子受容体と結合する方法および組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US9492430B2 (https=) |
| EP (1) | EP2780322B1 (https=) |
| JP (3) | JP6072058B2 (https=) |
| CN (2) | CN109293551A (https=) |
| WO (1) | WO2013074459A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017095481A (ja) * | 2011-11-14 | 2017-06-01 | リガンド・ファーマシューティカルズ・インコーポレイテッド | 顆粒球コロニー刺激因子受容体と結合する方法および組成物 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9962370B2 (en) | 2013-03-15 | 2018-05-08 | Ligand Pharmaceuticals Incorporated | Methods of treatment associated with the granulocyte colony-stimulating factor receptor |
| WO2020070332A1 (en) * | 2018-10-05 | 2020-04-09 | Ichnos Sciences S.A. | Oxindole compounds for use as map4k1 inhibitors |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19816624A1 (de) | 1998-04-15 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| CN1376150A (zh) * | 1999-07-26 | 2002-10-23 | 盐野义制药株式会社 | 具有血栓形成素受体拮抗作用的药物组合物 |
| CY2010012I2 (el) | 2000-05-25 | 2020-05-29 | Novartis Ag | Μιμητικα θρομβοποιητινης |
| JP2002167378A (ja) * | 2000-09-22 | 2002-06-11 | Ss Pharmaceut Co Ltd | イミダゾール誘導体又はその塩 |
| ATE384076T1 (de) * | 2000-12-21 | 2008-02-15 | Smithkline Beecham Corp | Regulierte aktivierung von zellmembranrezeptoren durch metallchelatisierende agonisten |
| WO2003011287A1 (en) * | 2001-08-03 | 2003-02-13 | Vertex Pharmaceuticals Incorporated | Pyrazolon derivatives as inhibitors of gsk-3 |
| GB0126036D0 (en) | 2001-10-30 | 2001-12-19 | Amedis Pharm Ltd | Silicon compounds |
| WO2003103686A1 (en) | 2002-06-06 | 2003-12-18 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
| TWI324593B (en) | 2002-10-09 | 2010-05-11 | Nissan Chemical Ind Ltd | Pyrazolone compounds and thrombopoietin receptor activator |
| EP1622609A4 (en) * | 2003-04-29 | 2008-09-03 | Smithkline Beecham Corp | METHODS OF TREATING DEGENERATIVE DISEASES / LESIONS |
| MXPA06000441A (es) | 2003-07-17 | 2006-04-05 | Astellas Pharma Inc | Derivado de 2-acilaminotiazole o sal del mismo. |
| KR100776961B1 (ko) | 2003-08-12 | 2007-11-28 | 시오노기세이야쿠가부시키가이샤 | 트롬보포이에틴 수용체 아고니스트 작용을 가지는 화합물 |
| JP2007528423A (ja) * | 2004-03-11 | 2007-10-11 | セコイア、ファーマシューティカルズ、インコーポレイテッド | 耐性防止レトロウイルスプロテアーゼ阻害薬 |
| DE102004012068A1 (de) * | 2004-03-12 | 2005-09-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue alkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel |
| WO2005094805A1 (ja) * | 2004-04-01 | 2005-10-13 | Institute Of Medicinal Molecular Design. Inc. | イミン誘導体及びアミド誘導体 |
| JP2005305836A (ja) * | 2004-04-21 | 2005-11-04 | Tdk Corp | 光記録材料及び光記録媒体 |
| WO2005118551A2 (en) * | 2004-05-28 | 2005-12-15 | Ligand Pharmaceuticals Inc. | Thrombopoietin activity modulating compounds and methods |
| MX2007003377A (es) | 2004-09-23 | 2007-05-10 | Pfizer Prod Inc | Agonistas del receptor de trombopoyetina. |
| CA2583764C (en) | 2004-10-25 | 2009-06-09 | Ligand Pharmaceuticals, Inc. | Thrombopoietin activity modulating compounds and methods |
| WO2007004038A1 (en) | 2005-07-05 | 2007-01-11 | Pfizer Products Inc. | Aminothiazole derivatives as agonists of the thrombopoietin receptor |
| WO2007036769A1 (en) | 2005-07-05 | 2007-04-05 | Pfizer Products Inc. | Aminothiazole derivatives as agonists of the thrombopoietin receptor |
| WO2007008529A2 (en) * | 2005-07-08 | 2007-01-18 | Kalypsys, Inc | Celullar cholesterol absorption modifiers |
| JP2007063443A (ja) * | 2005-08-31 | 2007-03-15 | Tdk Corp | 錯化合物及びこれを用いた光記録媒体 |
| FR2890987B1 (fr) * | 2005-09-19 | 2007-10-26 | Seb Sa | Fer a repasser comportant un dispositif guide cordon perfectionne. |
| WO2007054783A2 (en) | 2005-11-08 | 2007-05-18 | Astellas Pharma Inc. | Compositions and methods for treating thrombocytopenia |
| CA2630234A1 (en) * | 2005-11-23 | 2007-05-31 | Ligand Pharmaceuticals Inc. | Thrombopoietin activity modulating compounds and methods |
| JP4939078B2 (ja) * | 2006-02-24 | 2012-05-23 | キヤノン株式会社 | 現像ローラ、プロセスカートリッジ、電子写真装置 |
| MX2008011666A (es) | 2006-03-15 | 2008-10-17 | Ligand Pharm Inc | Sintesis de compuestos que modulan la actividad de la trombopoyetina. |
| JP5157900B2 (ja) | 2006-06-07 | 2013-03-06 | 日産化学工業株式会社 | 含窒素ヘテロ環化合物及びトロンボポエチンレセプター活性化剤 |
| CA2670345A1 (en) * | 2006-12-01 | 2008-06-12 | Stategics, Inc. | Thrombopoietin mimetics |
| WO2009086303A2 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| CN101514179A (zh) | 2008-02-21 | 2009-08-26 | 上海恒瑞医药有限公司 | 吲哚酮亚乙基肼羰基化合物、其制备方法及其在医药上的应用 |
| US8263642B2 (en) * | 2008-06-25 | 2012-09-11 | Vanderbilt University | Antimicrobial compounds and methods of use thereof |
| WO2013074459A1 (en) * | 2011-11-14 | 2013-05-23 | Ligand Pharmaceuticals, Inc. | Methods and compositions associated with the granulocyte colony-stimulating factor receptor |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017095481A (ja) * | 2011-11-14 | 2017-06-01 | リガンド・ファーマシューティカルズ・インコーポレイテッド | 顆粒球コロニー刺激因子受容体と結合する方法および組成物 |
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| US10736875B2 (en) | 2020-08-11 |
| US11413274B2 (en) | 2022-08-16 |
| WO2013074459A1 (en) | 2013-05-23 |
| US20140296292A1 (en) | 2014-10-02 |
| CN109293551A (zh) | 2019-02-01 |
| US10111859B2 (en) | 2018-10-30 |
| JP2015504426A (ja) | 2015-02-12 |
| JP2018150369A (ja) | 2018-09-27 |
| US20210046045A1 (en) | 2021-02-18 |
| US20160374989A1 (en) | 2016-12-29 |
| CN104039761A (zh) | 2014-09-10 |
| EP2780322B1 (en) | 2018-05-16 |
| EP2780322A1 (en) | 2014-09-24 |
| JP2017095481A (ja) | 2017-06-01 |
| US20180369197A1 (en) | 2018-12-27 |
| US9492430B2 (en) | 2016-11-15 |
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