JP6068397B2 - 磁気共鳴イメージング装置 - Google Patents
磁気共鳴イメージング装置 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/029—Measuring or recording blood output from the heart, e.g. minute volume
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
- G01R33/5635—Angiography, e.g. contrast-enhanced angiography [CE-MRA] or time-of-flight angiography [TOF-MRA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/0037—Performing a preliminary scan, e.g. a prescan for identifying a region of interest
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0263—Measuring blood flow using NMR
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7271—Specific aspects of physiological measurement analysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/74—Details of notification to user or communication with user or patient ; user input means
- A61B5/742—Details of notification to user or communication with user or patient ; user input means using visual displays
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/38—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
- G01R33/385—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field using gradient magnetic field coils
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
- G01R33/56366—Perfusion imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/483—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy
- G01R33/4833—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy using spatially selective excitation of the volume of interest, e.g. selecting non-orthogonal or inclined slices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/543—Control of the operation of the MR system, e.g. setting of acquisition parameters prior to or during MR data acquisition, dynamic shimming, use of one or more scout images for scan plane prescription
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5608—Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels
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- Radiology & Medical Imaging (AREA)
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- Molecular Biology (AREA)
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- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
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Description
図2は、磁気共鳴イメージング装置の実施の形態を示す構成図である。
Td1 + ΔT + BBTI = n × RR + td2 ・・・(1)
ΔT + BBTI = TI ・・・(2)
(1)式において、RRはR波とR波の時間間隔(心臓の拍動の1周期の期間に相当)であり、nは1以上の自然数(例えば3まで)である。図4は、n=2の場合に対応する。(2)式において、TIは、心筋の縦緩和時間により決まる物性値であり、一定の値である。
次に磁気共鳴イメージング装置20の動作および作用について説明する。
1.第1の変形例
上述した実施形態では、イメージング領域に流入する血液からの信号を識別するための領域選択励起パルスとして、180°領域選択IRパルスを印加する例を示した。本発明の実施形態は、かかる形態に限定されるものではない。領域選択励起パルスとしては、90°飽和(サチュレーション:saturation)パルスを印加してもよい。
上述した実施形態では、被検体に運動負荷および薬剤負荷のいずれもかけないでイメージングを行う例を示した。本発明の実施形態は、かかる形態に限定されるものではない。運動負荷および薬剤負荷の一方または双方を被検体にかけた上で、イメージングを行ってもよい。さらに、運動負荷および薬剤負荷の一方または双方を被検体にかけたイメージングと、かけないイメージングとをそれぞれ実行し、得られた各血流像を比較できるように、これら血流像を並列表示させることもできる。また、負荷を被検体にかけて収集された血流像データと、負荷を被検体にかけずに収集された血流像データとの差分処理によって、診断用の血流像データを生成して表示させることもできる。そして、このような比較表示や差分表示により、診断を良好に行うことが可能となる。
図4および図5において説明したように、ECG信号の(R波)を同期信号としてパルスシーケンスを設定する例について説明した。本発明の実施形態は、かかる形態に限定されるものではない。前述した脈波同期(PPG: peripheral pulse gating)信号、或いは、心音同期信号を取得し、それに基づいてパルスシーケンスを設定してもよい。
21 静磁場用磁石
22 シムコイル
23 傾斜磁場コイル
24 RFコイル
25 制御系
26 静磁場電源
27 傾斜磁場電源
28 シムコイル電源
29 送信器
30 受信器
31 シーケンスコントローラ
32 コンピュータ
33 入力装置
34 表示装置
35 演算装置
36 記憶装置
37 寝台
38 ECGユニット
40 撮像条件設定部
41 シーケンスコントローラ制御部
42 k空間データベース
43 血流像作成部
44 画像データベース
45 血流情報作成部
P 被検体
Claims (3)
- 心臓の大動脈から分岐する複数の冠動脈のうち所定の冠動脈の少なくとも一部を含む領域であって、右冠動脈、左冠動脈主幹部、左旋回枝、または、左前下行枝である特定の血管を選択的に標識化するように方向及び幅が調整された領域と、心室内の領域とに対して、心筋を含むイメージング領域に流入する血液を識別表示させるための領域選択励起パルスであって、前記イメージング領域に流入する血液の縦磁化を反転させる領域選択励起パルスを印加し、イメージングデータを前記イメージング領域から非造影で収集するイメージングデータ収集部と、
前記イメージングデータに基づいて、心筋の血流像データを生成する血流情報生成部と
を備えていることを特徴とする磁気共鳴イメージング装置。 - 前記イメージングデータ収集部は、前記大動脈から分岐する少なくとも1つの冠動脈への出口を含む領域に対して、前記領域選択励起パルスを印加するように構成される請求項1記載の磁気共鳴イメージング装置。
- 前記イメージングデータ収集部は、右冠動脈、左冠動脈主幹部、左回旋枝、および、左前下行枝のうちの1つを含むが他の3つを含まない領域に対して、前記領域選択励起パルスを印加するように構成される請求項1記載の磁気共鳴イメージング装置。
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JP2014139700A Active JP6068397B2 (ja) | 2009-09-18 | 2014-07-07 | 磁気共鳴イメージング装置 |
JP2014139701A Active JP5855176B2 (ja) | 2009-09-18 | 2014-07-07 | 磁気共鳴イメージング装置 |
JP2014139699A Active JP5788574B2 (ja) | 2009-09-18 | 2014-07-07 | 磁気共鳴イメージング装置 |
JP2015198566A Pending JP2016027891A (ja) | 2009-09-18 | 2015-10-06 | 磁気共鳴イメージング装置 |
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EP (1) | EP2299286B1 (ja) |
JP (6) | JP5613438B2 (ja) |
CN (2) | CN102018511A (ja) |
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JP5582739B2 (ja) * | 2008-09-09 | 2014-09-03 | 株式会社東芝 | 磁気共鳴イメージング装置および磁気共鳴イメージング装置の制御方法 |
CN102018511A (zh) * | 2009-09-18 | 2011-04-20 | 株式会社东芝 | 磁共振成像装置以及磁共振成像方法 |
US8581582B2 (en) | 2009-09-18 | 2013-11-12 | Kabushiki Kaisha Toshiba | MRI non-contrast time-slip angiography using variably positioned cine sub-sequence |
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US9271658B2 (en) | 2011-01-10 | 2016-03-01 | East Carolina University | Methods, systems and computer program products for non-invasive determination of blood flow distribution using speckle imaging techniques and hemodynamic modeling |
US9226673B2 (en) * | 2011-01-10 | 2016-01-05 | East Carolina University | Methods, systems and computer program products for non-invasive determination of blood flow distribution using speckle imaging techniques and hemodynamic modeling |
US9435871B2 (en) * | 2011-01-17 | 2016-09-06 | Hitachi Medical Corporation | Magnetic resonance imaging apparatus and fluid-enhanced image acquisition method |
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CN102707251B (zh) * | 2011-12-12 | 2015-04-15 | 中国科学院深圳先进技术研究院 | 计算space序列信号的方法和系统及主动脉信号的采集方法 |
JP6173673B2 (ja) * | 2011-12-14 | 2017-08-02 | 東芝メディカルシステムズ株式会社 | 磁気共鳴イメージング装置 |
US9858687B2 (en) * | 2012-01-17 | 2018-01-02 | Emory University | Systems, methods, and computer readable storage media storing instructions for generating an image integrating functional, physiological and anatomical images |
US8768034B2 (en) | 2012-03-20 | 2014-07-01 | Siemens Medical Solutions Usa, Inc. | Motion compensated MR imaging system |
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WO2013168809A1 (ja) * | 2012-05-11 | 2013-11-14 | 株式会社東芝 | 磁気共鳴イメージング装置及び画像処理装置 |
US8548778B1 (en) * | 2012-05-14 | 2013-10-01 | Heartflow, Inc. | Method and system for providing information from a patient-specific model of blood flow |
US9579041B2 (en) | 2012-05-24 | 2017-02-28 | Toshiba Medical Systems Corporation | Semi-automated non-contrast magnetic resonance angiography (MRA) |
JP5806175B2 (ja) * | 2012-07-06 | 2015-11-10 | ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー | ラベリング領域決定装置および磁気共鳴装置並びにプログラム |
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