JP6049700B2 - 肺動脈高血圧の治療におけるｍｉｃｒｏＲＮＡの調節方法 - Google Patents

肺動脈高血圧の治療におけるｍｉｃｒｏＲＮＡの調節方法 Download PDF

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JP6049700B2
JP6049700B2 JP2014509823A JP2014509823A JP6049700B2 JP 6049700 B2 JP6049700 B2 JP 6049700B2 JP 2014509823 A JP2014509823 A JP 2014509823A JP 2014509823 A JP2014509823 A JP 2014509823A JP 6049700 B2 JP6049700 B2 JP 6049700B2
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mir
mice
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inhibitor
pharmaceutical composition
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JP2014516027A (ja
JP2014516027A5 (https=
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ベイカー，アンドリュー
マクリーン，マーガレット
マレル，ニコラス
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
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  • Wood Science & Technology (AREA)
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  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2014509823A 2011-05-09 2012-05-09 肺動脈高血圧の治療におけるｍｉｃｒｏＲＮＡの調節方法 Expired - Fee Related JP6049700B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161484091P 2011-05-09 2011-05-09
US61/484,091 2011-05-09
US201261605376P 2012-03-01 2012-03-01
US61/605,376 2012-03-01
PCT/GB2012/051018 WO2012153135A1 (en) 2011-05-09 2012-05-09 Methods of modulating micrornas in the treatment of pulmonary arterial hypertension

Publications (3)

Publication Number Publication Date
JP2014516027A JP2014516027A (ja) 2014-07-07
JP2014516027A5 JP2014516027A5 (https=) 2015-06-11
JP6049700B2 true JP6049700B2 (ja) 2016-12-21

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JP2014509823A Expired - Fee Related JP6049700B2 (ja) 2011-05-09 2012-05-09 肺動脈高血圧の治療におけるｍｉｃｒｏＲＮＡの調節方法

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Country Link
US (1) US9267134B2 (https=)
EP (1) EP2707485B1 (https=)
JP (1) JP6049700B2 (https=)
KR (1) KR20140037868A (https=)
CN (1) CN103814131A (https=)
AU (1) AU2012252165A1 (https=)
BR (1) BR112013029016A2 (https=)
CA (1) CA2835568A1 (https=)
CO (1) CO6870004A2 (https=)
SG (1) SG194901A1 (https=)
WO (1) WO2012153135A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2970968T3 (en) 2013-03-15 2018-03-05 Miragen Therapeutics Inc CONNECTED BICYCLIC Nucleosides
WO2014151835A1 (en) * 2013-03-15 2014-09-25 Miragen Therapeutics, Inc Locked nucleic acid inhibitor of mir-145 and uses thereof
US9840705B2 (en) * 2013-12-02 2017-12-12 The University Court Of The University Of Glasgow Materials and methods for treatment of pulmonary arterial hypertension
EP3174550B1 (en) * 2014-08-01 2020-01-29 The Brigham and Women's Hospital, Inc. Methods and compositions relating to treatment of pulmonary arterial hypertension
CN107427698A (zh) * 2015-01-13 2017-12-01 维瓦斯公司 肺高血压的组合疗法
CA3041761A1 (en) * 2016-10-31 2018-05-03 Gifu University Double-stranded nucleic acid molecule and use thereof
CA3164050A1 (en) * 2019-12-09 2021-06-17 Empirico Inc. Oligonucleotides for treatment of angiopoietin like 4 (angptl4) related diseases
CN116801916A (zh) * 2021-01-18 2023-09-22 礼赞伊诺制药株式会社 包含miR 145抑制剂作为有效成分的用于治疗心肌梗塞的组合物
CN113332306A (zh) * 2021-04-28 2021-09-03 武汉华纪元生物技术开发有限公司 用于治疗肺动脉高血压的microRNA-30a抑制剂及其应用
GB202215974D0 (en) * 2022-10-28 2022-12-14 Imperial College Innovations Ltd Microrna panels for pulmonary hypertension

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WO1995003843A1 (en) 1993-07-30 1995-02-09 The Regents Of The University Of California Endocardial infusion catheter
GB9525620D0 (en) 1995-12-15 1996-02-14 Glaxo Group Ltd Chemical compounds
SE9600216D0 (sv) 1996-01-18 1996-01-18 Hans Arne Hansson Styrning av läkningsprocesser
CN1079396C (zh) 1996-05-31 2002-02-20 C&C新药研究所 用作选择性凝血酶抑制剂的芳族脒衍生物
US5985833A (en) 1996-09-17 1999-11-16 Wisconsin Alumni Research Foundation Thrombin inhibitor
US6416510B1 (en) 1997-03-13 2002-07-09 Biocardia, Inc. Drug delivery catheters that attach to tissue and methods for their use
US6147109A (en) 1997-10-14 2000-11-14 The General Hospital Corporation Upregulation of Type III endothelial cell Nitric Oxide Synthase by HMG-CoA reductase inhibitors
US6749617B1 (en) 1997-11-04 2004-06-15 Scimed Life Systems, Inc. Catheter and implants for the delivery of therapeutic agents to tissues
JP2002516256A (ja) 1998-05-26 2002-06-04 アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド 二環式糖成分を有する新規ヌクレオシド
WO2000018352A2 (en) 1998-09-28 2000-04-06 Merck & Co., Inc. A method for treating inflammatory diseases by administering a thrombin inhibitor
US6838283B2 (en) 1998-09-29 2005-01-04 Isis Pharmaceuticals Inc. Antisense modulation of survivin expression
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US7683036B2 (en) * 2003-07-31 2010-03-23 Regulus Therapeutics Inc. Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
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Also Published As

Publication number Publication date
JP2014516027A (ja) 2014-07-07
CN103814131A (zh) 2014-05-21
KR20140037868A (ko) 2014-03-27
CA2835568A1 (en) 2012-11-15
WO2012153135A1 (en) 2012-11-15
AU2012252165A1 (en) 2013-03-21
BR112013029016A2 (pt) 2017-01-17
EP2707485A1 (en) 2014-03-19
CO6870004A2 (es) 2014-02-20
US9267134B2 (en) 2016-02-23
SG194901A1 (en) 2013-12-30
EP2707485B1 (en) 2016-12-14
US20140163086A1 (en) 2014-06-12

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