CO6870004A2 - Métodos de modulación de un microarn en el tratamiento de la hipertensión arterial pulmonar - Google Patents
Métodos de modulación de un microarn en el tratamiento de la hipertensión arterial pulmonarInfo
- Publication number
- CO6870004A2 CO6870004A2 CO13268130A CO13268130A CO6870004A2 CO 6870004 A2 CO6870004 A2 CO 6870004A2 CO 13268130 A CO13268130 A CO 13268130A CO 13268130 A CO13268130 A CO 13268130A CO 6870004 A2 CO6870004 A2 CO 6870004A2
- Authority
- CO
- Colombia
- Prior art keywords
- microarn
- modulating
- treatment
- methods
- arterial hypertension
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161484091P | 2011-05-09 | 2011-05-09 | |
| US201261605376P | 2012-03-01 | 2012-03-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6870004A2 true CO6870004A2 (es) | 2014-02-20 |
Family
ID=46178572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO13268130A CO6870004A2 (es) | 2011-05-09 | 2013-11-14 | Métodos de modulación de un microarn en el tratamiento de la hipertensión arterial pulmonar |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9267134B2 (es) |
| EP (1) | EP2707485B1 (es) |
| JP (1) | JP6049700B2 (es) |
| KR (1) | KR20140037868A (es) |
| CN (1) | CN103814131A (es) |
| AU (1) | AU2012252165A1 (es) |
| BR (1) | BR112013029016A2 (es) |
| CA (1) | CA2835568A1 (es) |
| CO (1) | CO6870004A2 (es) |
| SG (1) | SG194901A1 (es) |
| WO (1) | WO2012153135A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150131365A (ko) | 2013-03-15 | 2015-11-24 | 미라젠 세러퓨틱스 인코포레이티드 | 브리지드 바이사이클릭 뉴클레오시드 |
| JP6410791B2 (ja) * | 2013-03-15 | 2018-10-24 | ミラゲン セラピューティクス， インコーポレイテッド | Ｍｉｒ−１４５のロックト核酸阻害剤およびその使用 |
| US9840705B2 (en) * | 2013-12-02 | 2017-12-12 | The University Court Of The University Of Glasgow | Materials and methods for treatment of pulmonary arterial hypertension |
| CN106794233B (zh) * | 2014-08-01 | 2021-11-12 | 布里格姆及妇女医院股份有限公司 | 与肺动脉高压的治疗有关的组合物和方法 |
| WO2016114993A1 (en) | 2015-01-13 | 2016-07-21 | Selten Pharma, Inc. | Combination therapy for pulmonary hypertension |
| JP6842779B2 (ja) * | 2016-10-31 | 2021-03-17 | 国立大学法人岐阜大学 | 二本鎖核酸分子、およびその用途 |
| CN115175685A (zh) * | 2019-12-09 | 2022-10-11 | 艾姆皮瑞克公司 | 用于治疗血管生成素样4(angptl4)相关疾病的寡核苷酸 |
| WO2022154636A1 (ko) * | 2021-01-18 | 2022-07-21 | (주)스템메디텍 | Mir 145 억제제를 유효성분으로 포함하는 심근경색증의 치료용 조성물 |
| CN113332306A (zh) * | 2021-04-28 | 2021-09-03 | 武汉华纪元生物技术开发有限公司 | 用于治疗肺动脉高血压的microRNA-30a抑制剂及其应用 |
| GB202215974D0 (en) * | 2022-10-28 | 2022-12-14 | Imperial College Innovations Ltd | Microrna panels for pulmonary hypertension |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6060451A (en) | 1990-06-15 | 2000-05-09 | The National Research Council Of Canada | Thrombin inhibitors based on the amino acid sequence of hirudin |
| AU7404994A (en) | 1993-07-30 | 1995-02-28 | Regents Of The University Of California, The | Endocardial infusion catheter |
| GB9525620D0 (en) | 1995-12-15 | 1996-02-14 | Glaxo Group Ltd | Chemical compounds |
| SE9600216D0 (sv) | 1996-01-18 | 1996-01-18 | Hans Arne Hansson | Styrning av läkningsprocesser |
| EP0918768B1 (en) | 1996-05-31 | 2002-01-09 | C & C Research Laboratories | Aromatic amidine derivatives useful as selective thrombin inhibitors |
| US5985833A (en) | 1996-09-17 | 1999-11-16 | Wisconsin Alumni Research Foundation | Thrombin inhibitor |
| US6416510B1 (en) | 1997-03-13 | 2002-07-09 | Biocardia, Inc. | Drug delivery catheters that attach to tissue and methods for their use |
| US6147109A (en) | 1997-10-14 | 2000-11-14 | The General Hospital Corporation | Upregulation of Type III endothelial cell Nitric Oxide Synthase by HMG-CoA reductase inhibitors |
| US6749617B1 (en) | 1997-11-04 | 2004-06-15 | Scimed Life Systems, Inc. | Catheter and implants for the delivery of therapeutic agents to tissues |
| UA61997C2 (en) | 1998-05-26 | 2003-12-15 | Icn Pharmaceuticals | Nucleosides with bicyclic sugar constituent, oligonucleotide and antiviral pharmaceutical composition |
| WO2000018352A2 (en) | 1998-09-28 | 2000-04-06 | Merck & Co., Inc. | A method for treating inflammatory diseases by administering a thrombin inhibitor |
| US6838283B2 (en) | 1998-09-29 | 2005-01-04 | Isis Pharmaceuticals Inc. | Antisense modulation of survivin expression |
| US6693187B1 (en) | 2000-10-17 | 2004-02-17 | Lievre Cornu Llc | Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge |
| US7683036B2 (en) * | 2003-07-31 | 2010-03-23 | Regulus Therapeutics Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding RNAs |
| US20070203445A1 (en) | 2004-02-26 | 2007-08-30 | V-Kardia Pty Ltd | Isolating cardiac circulation |
| EP1735037B1 (en) | 2004-02-26 | 2015-05-20 | Osprey Medical Inc. | Isolating cardiac circulation |
| US7722596B2 (en) | 2004-02-26 | 2010-05-25 | Osprey Medical, Inc. | Regional cardiac tissue treatment |
| WO2006089340A2 (en) | 2005-02-23 | 2006-08-31 | V-Kardia Pty Ltd | Polynucleotide delivery to cardiac tissue |
| PL1969125T3 (pl) | 2005-12-12 | 2012-11-30 | Univ North Carolina Chapel Hill | Mikrorna, które regulują proliferację i różnicowanie komórek mięśniowych |
| EP2279267A4 (en) | 2008-03-27 | 2012-01-18 | Vascular Biosciences Inc | METHOD FOR IDENTIFICATION OF NEW THERAPEUTIC CANDIDATES VIA GENE EXPRESSION ANALYSIS IN VASCULAR DISEASES |
| WO2010104796A2 (en) | 2009-03-09 | 2010-09-16 | The J. David Gladstone Institutes | Methods of modulating smooth muscle cell proliferation and differentiation |
| CN101843632B (zh) * | 2009-03-24 | 2012-07-04 | 复旦大学附属华山医院 | miR-145在制备治疗炎症药物中的应用 |
| EA022757B1 (ru) * | 2009-06-08 | 2016-02-29 | Мираджен Терапьютикс | МОТИВЫ ХИМИЧЕСКИХ МОДИФИКАЦИЙ ДЛЯ ИНГИБИТОРОВ И МИМЕТИКОВ мкРНК |
| RU2012129900A (ru) * | 2009-12-15 | 2014-01-27 | Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем | Регуляция микро-рнк при ишемии и ишемически-реперфузионном повреждении |
| CN102382824A (zh) | 2010-09-01 | 2012-03-21 | 中国科学院上海药物研究所 | 人miR-145反义核酸及其应用 |
-
2012
- 2012-05-09 JP JP2014509823A patent/JP6049700B2/ja not_active Expired - Fee Related
- 2012-05-09 AU AU2012252165A patent/AU2012252165A1/en not_active Abandoned
- 2012-05-09 US US14/116,724 patent/US9267134B2/en not_active Expired - Fee Related
- 2012-05-09 KR KR1020137032530A patent/KR20140037868A/ko not_active Application Discontinuation
- 2012-05-09 SG SG2013083480A patent/SG194901A1/en unknown
- 2012-05-09 EP EP12724369.9A patent/EP2707485B1/en not_active Not-in-force
- 2012-05-09 BR BR112013029016A patent/BR112013029016A2/pt not_active IP Right Cessation
- 2012-05-09 WO PCT/GB2012/051018 patent/WO2012153135A1/en active Application Filing
- 2012-05-09 CA CA2835568A patent/CA2835568A1/en not_active Abandoned
- 2012-05-09 CN CN201280034183.8A patent/CN103814131A/zh active Pending
-
2013
- 2013-11-14 CO CO13268130A patent/CO6870004A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20140163086A1 (en) | 2014-06-12 |
| KR20140037868A (ko) | 2014-03-27 |
| EP2707485A1 (en) | 2014-03-19 |
| SG194901A1 (en) | 2013-12-30 |
| WO2012153135A1 (en) | 2012-11-15 |
| AU2012252165A1 (en) | 2013-03-21 |
| CN103814131A (zh) | 2014-05-21 |
| US9267134B2 (en) | 2016-02-23 |
| JP2014516027A (ja) | 2014-07-07 |
| JP6049700B2 (ja) | 2016-12-21 |
| BR112013029016A2 (pt) | 2017-01-17 |
| EP2707485B1 (en) | 2016-12-14 |
| CA2835568A1 (en) | 2012-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |