BR112013029016A2 - métodos de modulação de micrornas no tratamento da hipertensão arterial pulmonar - Google Patents
métodos de modulação de micrornas no tratamento da hipertensão arterial pulmonarInfo
- Publication number
- BR112013029016A2 BR112013029016A2 BR112013029016A BR112013029016A BR112013029016A2 BR 112013029016 A2 BR112013029016 A2 BR 112013029016A2 BR 112013029016 A BR112013029016 A BR 112013029016A BR 112013029016 A BR112013029016 A BR 112013029016A BR 112013029016 A2 BR112013029016 A2 BR 112013029016A2
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- arterial hypertension
- pulmonary arterial
- modulation methods
- microwave modulation
- Prior art date
Links
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161484091P | 2011-05-09 | 2011-05-09 | |
| US201261605376P | 2012-03-01 | 2012-03-01 | |
| PCT/GB2012/051018 WO2012153135A1 (en) | 2011-05-09 | 2012-05-09 | Methods of modulating micrornas in the treatment of pulmonary arterial hypertension |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013029016A2 true BR112013029016A2 (pt) | 2017-01-17 |
Family
ID=46178572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013029016A BR112013029016A2 (pt) | 2011-05-09 | 2012-05-09 | métodos de modulação de micrornas no tratamento da hipertensão arterial pulmonar |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9267134B2 (https=) |
| EP (1) | EP2707485B1 (https=) |
| JP (1) | JP6049700B2 (https=) |
| KR (1) | KR20140037868A (https=) |
| CN (1) | CN103814131A (https=) |
| AU (1) | AU2012252165A1 (https=) |
| BR (1) | BR112013029016A2 (https=) |
| CA (1) | CA2835568A1 (https=) |
| CO (1) | CO6870004A2 (https=) |
| SG (1) | SG194901A1 (https=) |
| WO (1) | WO2012153135A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2970968T3 (en) | 2013-03-15 | 2018-03-05 | Miragen Therapeutics Inc | CONNECTED BICYCLIC Nucleosides |
| WO2014151835A1 (en) * | 2013-03-15 | 2014-09-25 | Miragen Therapeutics, Inc | Locked nucleic acid inhibitor of mir-145 and uses thereof |
| US9840705B2 (en) * | 2013-12-02 | 2017-12-12 | The University Court Of The University Of Glasgow | Materials and methods for treatment of pulmonary arterial hypertension |
| EP3174550B1 (en) * | 2014-08-01 | 2020-01-29 | The Brigham and Women's Hospital, Inc. | Methods and compositions relating to treatment of pulmonary arterial hypertension |
| CN107427698A (zh) * | 2015-01-13 | 2017-12-01 | 维瓦斯公司 | 肺高血压的组合疗法 |
| CA3041761A1 (en) * | 2016-10-31 | 2018-05-03 | Gifu University | Double-stranded nucleic acid molecule and use thereof |
| CA3164050A1 (en) * | 2019-12-09 | 2021-06-17 | Empirico Inc. | Oligonucleotides for treatment of angiopoietin like 4 (angptl4) related diseases |
| CN116801916A (zh) * | 2021-01-18 | 2023-09-22 | 礼赞伊诺制药株式会社 | 包含miR 145抑制剂作为有效成分的用于治疗心肌梗塞的组合物 |
| CN113332306A (zh) * | 2021-04-28 | 2021-09-03 | 武汉华纪元生物技术开发有限公司 | 用于治疗肺动脉高血压的microRNA-30a抑制剂及其应用 |
| GB202215974D0 (en) * | 2022-10-28 | 2022-12-14 | Imperial College Innovations Ltd | Microrna panels for pulmonary hypertension |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6060451A (en) | 1990-06-15 | 2000-05-09 | The National Research Council Of Canada | Thrombin inhibitors based on the amino acid sequence of hirudin |
| WO1995003843A1 (en) | 1993-07-30 | 1995-02-09 | The Regents Of The University Of California | Endocardial infusion catheter |
| GB9525620D0 (en) | 1995-12-15 | 1996-02-14 | Glaxo Group Ltd | Chemical compounds |
| SE9600216D0 (sv) | 1996-01-18 | 1996-01-18 | Hans Arne Hansson | Styrning av läkningsprocesser |
| CN1079396C (zh) | 1996-05-31 | 2002-02-20 | C&C新药研究所 | 用作选择性凝血酶抑制剂的芳族脒衍生物 |
| US5985833A (en) | 1996-09-17 | 1999-11-16 | Wisconsin Alumni Research Foundation | Thrombin inhibitor |
| US6416510B1 (en) | 1997-03-13 | 2002-07-09 | Biocardia, Inc. | Drug delivery catheters that attach to tissue and methods for their use |
| US6147109A (en) | 1997-10-14 | 2000-11-14 | The General Hospital Corporation | Upregulation of Type III endothelial cell Nitric Oxide Synthase by HMG-CoA reductase inhibitors |
| US6749617B1 (en) | 1997-11-04 | 2004-06-15 | Scimed Life Systems, Inc. | Catheter and implants for the delivery of therapeutic agents to tissues |
| JP2002516256A (ja) | 1998-05-26 | 2002-06-04 | アイ・シー・エヌ・フアーマシユーテイカルズ・インコーポレイテツド | 二環式糖成分を有する新規ヌクレオシド |
| WO2000018352A2 (en) | 1998-09-28 | 2000-04-06 | Merck & Co., Inc. | A method for treating inflammatory diseases by administering a thrombin inhibitor |
| US6838283B2 (en) | 1998-09-29 | 2005-01-04 | Isis Pharmaceuticals Inc. | Antisense modulation of survivin expression |
| US6693187B1 (en) | 2000-10-17 | 2004-02-17 | Lievre Cornu Llc | Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge |
| US7683036B2 (en) * | 2003-07-31 | 2010-03-23 | Regulus Therapeutics Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding RNAs |
| US20070203445A1 (en) | 2004-02-26 | 2007-08-30 | V-Kardia Pty Ltd | Isolating cardiac circulation |
| US20060148742A1 (en) | 2004-02-26 | 2006-07-06 | Kaye David M | Polynucleotide delivery to cardiac tissue |
| US7722596B2 (en) | 2004-02-26 | 2010-05-25 | Osprey Medical, Inc. | Regional cardiac tissue treatment |
| WO2005082440A1 (en) | 2004-02-26 | 2005-09-09 | V-Kardia Pty Ltd | Isolating cardiac circulation |
| KR101485071B1 (ko) | 2005-12-12 | 2015-01-26 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 마이크로 ｒｎａ를 이용한 근육 세포 증식 및 분화 조절방법과 근육 세포 치료방법 및 유전자 발현 억제방법그리고 마이크로 ｒｎａ 분자의 발현용 벡터와 이를 이용한키트 및 미오사이트 |
| WO2009121031A1 (en) * | 2008-03-27 | 2009-10-01 | Vascular Biosciences, Inc. | Methods of novel therapeutic candidate identification through gene expression analysis in vascular-related diseases |
| WO2010104796A2 (en) | 2009-03-09 | 2010-09-16 | The J. David Gladstone Institutes | Methods of modulating smooth muscle cell proliferation and differentiation |
| CN101843632B (zh) * | 2009-03-24 | 2012-07-04 | 复旦大学附属华山医院 | miR-145在制备治疗炎症药物中的应用 |
| SG176716A1 (en) * | 2009-06-08 | 2012-01-30 | Miragen Therapeutics | CHEMICAL MODIFICATION MOTIFS FOR miRNA INHIBITORS AND MIMETICS |
| AU2010340062A1 (en) * | 2009-12-15 | 2012-07-12 | Board Of Regents, The University Of Texas System | Micro-RNA regulation in ischemia and ischemia-reperfusion injury |
| CN102382824A (zh) | 2010-09-01 | 2012-03-21 | 中国科学院上海药物研究所 | 人miR-145反义核酸及其应用 |
-
2012
- 2012-05-09 AU AU2012252165A patent/AU2012252165A1/en not_active Abandoned
- 2012-05-09 BR BR112013029016A patent/BR112013029016A2/pt not_active IP Right Cessation
- 2012-05-09 JP JP2014509823A patent/JP6049700B2/ja not_active Expired - Fee Related
- 2012-05-09 WO PCT/GB2012/051018 patent/WO2012153135A1/en not_active Ceased
- 2012-05-09 SG SG2013083480A patent/SG194901A1/en unknown
- 2012-05-09 CA CA2835568A patent/CA2835568A1/en not_active Abandoned
- 2012-05-09 US US14/116,724 patent/US9267134B2/en not_active Expired - Fee Related
- 2012-05-09 CN CN201280034183.8A patent/CN103814131A/zh active Pending
- 2012-05-09 EP EP12724369.9A patent/EP2707485B1/en not_active Not-in-force
- 2012-05-09 KR KR1020137032530A patent/KR20140037868A/ko not_active Withdrawn
-
2013
- 2013-11-14 CO CO13268130A patent/CO6870004A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014516027A (ja) | 2014-07-07 |
| CN103814131A (zh) | 2014-05-21 |
| KR20140037868A (ko) | 2014-03-27 |
| CA2835568A1 (en) | 2012-11-15 |
| WO2012153135A1 (en) | 2012-11-15 |
| AU2012252165A1 (en) | 2013-03-21 |
| JP6049700B2 (ja) | 2016-12-21 |
| EP2707485A1 (en) | 2014-03-19 |
| CO6870004A2 (es) | 2014-02-20 |
| US9267134B2 (en) | 2016-02-23 |
| SG194901A1 (en) | 2013-12-30 |
| EP2707485B1 (en) | 2016-12-14 |
| US20140163086A1 (en) | 2014-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |