JP6034188B2 - 抗微生物剤 - Google Patents
抗微生物剤 Download PDFInfo
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- JP6034188B2 JP6034188B2 JP2012516777A JP2012516777A JP6034188B2 JP 6034188 B2 JP6034188 B2 JP 6034188B2 JP 2012516777 A JP2012516777 A JP 2012516777A JP 2012516777 A JP2012516777 A JP 2012516777A JP 6034188 B2 JP6034188 B2 JP 6034188B2
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
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- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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Landscapes
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| CA2764131C (en) | 2009-06-26 | 2022-05-10 | Katholieke Universiteit Leuven, K.U. Leuven R&D | Antimicrobial agents |
| JP5847081B2 (ja) | 2009-08-24 | 2016-01-20 | カトリック ユニバーシテイト ルーベン ケイ．ユー． ルーベン アール アンド ディー | エンドリシンＯＢＰｇｐＬＹＳ |
| EP3443970B1 (en) | 2010-09-17 | 2020-09-09 | Tecnifar-Indústria Técnica Farmacêutica, S.A. | Antibacterial phage, phage peptides and methods of use thereof |
| EP2468856A1 (en) * | 2010-12-23 | 2012-06-27 | Lysando Aktiengesellschaft | Antimicrobial Agents |
| CN102766196B (zh) * | 2011-05-06 | 2014-10-29 | 上海医药工业研究院 | 一组阳离子抗菌肽及其制备方法和应用 |
| CN103361341B (zh) * | 2012-03-26 | 2015-09-02 | 复旦大学附属华山医院 | 杀菌肽ll-37的基因工程的表达及其制备方法和用途 |
| EP2679232A1 (en) * | 2012-06-29 | 2014-01-01 | Lysando Aktiengesellschaft | Composition for use in Mycobacteria vaccination |
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| EP2679677A1 (en) * | 2012-06-29 | 2014-01-01 | Lysando Aktiengesellschaft | Composition for use in Mycobacteria therapy |
| US11155801B2 (en) * | 2013-08-06 | 2021-10-26 | Trustees Of Dartmouth College | Unglycosylated lysostaphin variant protein |
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| EP2904912A1 (en) * | 2014-02-07 | 2015-08-12 | Hyglos Invest GmbH | Novel high pressure method with endolysin for processing of foods |
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| CA2958421C (en) | 2014-08-29 | 2023-10-17 | Aarhus Universitet | Positively charged co-polymers for use as antimicrobial agents |
| WO2016130024A1 (en) * | 2015-02-13 | 2016-08-18 | Supreme Biotechnologies Limited | Endolysin expression platform |
| US20190125897A1 (en) * | 2016-04-28 | 2019-05-02 | Lysando Ag | Antimicrobial agents against salmonella bacteria |
| WO2018073416A1 (en) | 2016-10-20 | 2018-04-26 | Lysando Ag | New antimicrobial agents against enterococcus bacteria |
| KR20200012844A (ko) * | 2017-04-03 | 2020-02-05 | 사시나파스 컴퍼니 리미티드 | 조작된 그람-음성 엔도리신 |
| CN108018271B (zh) * | 2018-01-31 | 2020-08-11 | 武汉核圣生物技术有限公司 | 单亚基rna聚合酶、其纯化方法及在rna合成中的应用 |
| CN112368376A (zh) * | 2018-03-29 | 2021-02-12 | 康特拉费克特公司 | 溶素-抗微生物肽(amp)多肽构建体、溶素、其分离的编码多核苷酸及其用途 |
| WO2020046747A1 (en) * | 2018-08-23 | 2020-03-05 | Contrafect Corporation | Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof |
| KR20210014673A (ko) * | 2018-05-30 | 2021-02-09 | 뤼산도 아게 | 신규 항균성 단백질 |
| US20220380744A1 (en) * | 2019-10-31 | 2022-12-01 | University Of Maryland, College Park | Method of treating infections by bacteriolytic enzymes and manufacture thereof |
| MX2022010725A (es) * | 2020-03-02 | 2022-09-23 | Unilever Ip Holdings B V | Una composicion efectiva para el cuidado personal anti-acne. |
| AU2021238683A1 (en) | 2020-03-19 | 2022-10-13 | Micreos Human Health B.V. | A stabilized protein of interest |
| US20250288652A1 (en) | 2021-02-08 | 2025-09-18 | Wuhan Lysigen Bio-Tech Company Limited | Bacteriophage lysine, chimera thereof and application thereof |
| WO2022225267A1 (ko) * | 2021-04-19 | 2022-10-27 | 엠브릭스 주식회사 | 보툴리늄 독소 전위 도메인 및 엔도라이신을 포함하는 단백질 복합체 및 이를 포함하는 항균 조성물 |
| CN119183372A (zh) * | 2022-03-03 | 2024-12-24 | 麻省理工学院 | 特异性靶向痤疮丙酸杆菌的细胞壁结合蛋白 |
| CN114349870B (zh) * | 2022-03-21 | 2022-06-03 | 天津辅元生物医药科技有限公司 | 一种兼具防粘连功效的重组抗菌肽及其制备方法和应用 |
| CN114540385B (zh) * | 2022-03-21 | 2023-06-23 | 齐鲁工业大学 | 一种利用大肠杆菌产溶葡萄球菌酶的方法 |
| WO2024241070A1 (en) | 2023-05-22 | 2024-11-28 | L'oreal | Cosmetic composition comprising an endolysin and a polyvinyl alcohol |
| WO2024246325A1 (en) | 2023-06-02 | 2024-12-05 | L'oreal | Cosmetic composition comprising an endolysin derived from a staphylococcus aureus phage and an aromatic alcohol |
| FR3149207A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine et un composé de formule (I) |
| FR3149203A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition anhydre comprenant une endolysine et de l’hydroxypropylmethylcellulose et/ou du pullulane |
| FR3149204A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine et un tensioactif non ionique comprenant un résidu carbohydrate |
| FR3149209A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et un alcool aromatique |
| FR3149202A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et une huile. |
| FR3149206A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique aqueuse comprenant une endolysine et du tréhalose |
| FR3149205A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine et un agent de charge organique |
| FR3152395A1 (fr) | 2023-08-28 | 2025-03-07 | L'oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et la 4-hydroxyacetophenone |
| FR3149208A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique, notamment aqueuse, comprenant une endolysine et un pullulane |
| FR3152396A1 (fr) | 2023-08-28 | 2025-03-07 | L'oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et un polyhydroxyalcane |
| FR3152393A1 (fr) | 2023-08-28 | 2025-03-07 | L'oreal | Composition cosmétique comprenant une endolysine dérivée d’un phage de Staphylococcus aureus et une charge minérale |
| FR3152394A1 (fr) | 2023-08-28 | 2025-03-07 | L'oreal | Composition cosmétique comprenant une endolysine et des particules d’aérogel de silice hydrophobe |
| WO2025093666A1 (en) | 2023-11-01 | 2025-05-08 | University Of Copenhagen | Treatment of lymphoma |
| CN118421604B (zh) * | 2024-05-27 | 2024-10-22 | 小白鲸(中山)生物医药有限公司 | 一种重组溶葡萄球菌酶突变体及其制备方法和应用 |
| CN119799685A (zh) * | 2024-12-27 | 2025-04-11 | 深圳先进技术研究院 | 一种靶向闪烁梭菌的抗菌蛋白及其制备方法与应用 |
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| BRPI1015203B1 (pt) | 2021-06-01 |
| EP3363896A1 (en) | 2018-08-22 |
| EP2446028A1 (en) | 2012-05-02 |
| IL217121A0 (en) | 2012-02-29 |
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| EA201270082A1 (ru) | 2012-06-29 |
| CA2765810C (en) | 2018-10-16 |
| WO2010149795A1 (en) | 2010-12-29 |
| US20190218538A1 (en) | 2019-07-18 |
| JP2017018092A (ja) | 2017-01-26 |
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