AU2010264659B2 - Antimicrobial agents - Google Patents

Antimicrobial agents Download PDF

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Publication number
AU2010264659B2
AU2010264659B2 AU2010264659A AU2010264659A AU2010264659B2 AU 2010264659 B2 AU2010264659 B2 AU 2010264659B2 AU 2010264659 A AU2010264659 A AU 2010264659A AU 2010264659 A AU2010264659 A AU 2010264659A AU 2010264659 B2 AU2010264659 B2 AU 2010264659B2
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AU
Australia
Prior art keywords
fusion protein
amino acid
acid residues
peptide
present
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AU2010264659A
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AU2010264659A1 (en
Inventor
Stefan Miller
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Lysando AG
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Lysando AG
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Assigned to LYSANDO AKTIENGESELLSCHAFT reassignment LYSANDO AKTIENGESELLSCHAFT Amend patent request/document other than specification (104) Assignors: LYSANDO HOLDING AKTIENGESELLSHAFT
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Cosmetics (AREA)
AU2010264659A 2009-06-26 2010-06-28 Antimicrobial agents Active AU2010264659B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09163955.9 2009-06-26
EP09163955 2009-06-26
PCT/EP2010/059152 WO2010149795A1 (en) 2009-06-26 2010-06-28 Antimicrobial agents

Publications (2)

Publication Number Publication Date
AU2010264659A1 AU2010264659A1 (en) 2011-12-15
AU2010264659B2 true AU2010264659B2 (en) 2016-08-04

Family

ID=42537604

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010264659A Active AU2010264659B2 (en) 2009-06-26 2010-06-28 Antimicrobial agents

Country Status (13)

Country Link
US (2) US20120195872A1 (enExample)
EP (2) EP3363896A1 (enExample)
JP (2) JP6034188B2 (enExample)
KR (1) KR101701890B1 (enExample)
CN (1) CN102482655B (enExample)
AU (1) AU2010264659B2 (enExample)
BR (1) BRPI1015203B1 (enExample)
CA (1) CA2765810C (enExample)
EA (1) EA038542B1 (enExample)
IL (1) IL217121B (enExample)
MX (1) MX2011013453A (enExample)
SG (1) SG177704A1 (enExample)
WO (1) WO2010149795A1 (enExample)

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EP3058950B1 (en) 2009-06-26 2020-03-04 Lysando AG Antimicrobial agents
KR101701890B1 (ko) 2009-06-26 2017-02-02 뤼산도 아게 항균제
EP2470648B1 (en) 2009-08-24 2019-04-10 Katholieke Universiteit Leuven K.U. Leuven R&D New endolysin obpgplys
CA3154006C (en) * 2010-09-17 2025-09-09 Technophage, Investigacao E Desenvolvimento Em Biotecnologia S.A. Antibacterial phages, phage peptides and their methods of use
EP2468856A1 (en) * 2010-12-23 2012-06-27 Lysando Aktiengesellschaft Antimicrobial Agents
CN102766196B (zh) * 2011-05-06 2014-10-29 上海医药工业研究院 一组阳离子抗菌肽及其制备方法和应用
CN103361341B (zh) * 2012-03-26 2015-09-02 复旦大学附属华山医院 杀菌肽ll-37的基因工程的表达及其制备方法和用途
EP2679677A1 (en) * 2012-06-29 2014-01-01 Lysando Aktiengesellschaft Composition for use in Mycobacteria therapy
EP2679232A1 (en) * 2012-06-29 2014-01-01 Lysando Aktiengesellschaft Composition for use in Mycobacteria vaccination
US9388400B2 (en) 2012-06-29 2016-07-12 Lysando Ag Composition for use in mycobacteria diagnosis
CN113717964A (zh) * 2013-08-06 2021-11-30 达特茅斯学院理事会 非糖基化溶葡球菌素变体蛋白
WO2015070912A1 (en) 2013-11-14 2015-05-21 Lysando Ag Modified el188 endolysin sequence
WO2015070911A1 (en) 2013-11-14 2015-05-21 Lysando Ag Modified kz144 endolysin sequence
EP2904912A1 (en) * 2014-02-07 2015-08-12 Hyglos Invest GmbH Novel high pressure method with endolysin for processing of foods
WO2015121443A1 (en) 2014-02-14 2015-08-20 Lysando Ag Antimicrobial agents
US10166253B2 (en) 2014-08-29 2019-01-01 Region Midtjylland Positively charged co-polymers for use as antimicrobial agents
WO2016130024A1 (en) * 2015-02-13 2016-08-18 Supreme Biotechnologies Limited Endolysin expression platform
CA3022334A1 (en) * 2016-04-28 2017-11-02 Lysando Ag Antimicrobial agents against salmonella bacteria
CA3041190A1 (en) * 2016-10-20 2018-04-26 Lysando Ag New antimicrobial agents against enterococcus bacteria
CN110651044A (zh) * 2017-04-03 2020-01-03 萨西那帕斯有限公司 工程化的革兰氏阴性细胞内溶素
CN108018271B (zh) * 2018-01-31 2020-08-11 武汉核圣生物技术有限公司 单亚基rna聚合酶、其纯化方法及在rna合成中的应用
MX2020010075A (es) * 2018-03-29 2021-01-08 Contrafect Corp Constructos de polipeptido de lisina-peptido anti-microbiano (amp), lisinas, polinucleotidos aislados que codifican para estas, y sus usos.
AU2019276253A1 (en) * 2018-05-30 2020-11-26 Lysando Ag Novel antimicrobial proteins
AU2019327378A1 (en) * 2018-08-23 2020-10-29 Contrafect Corporation Lysin-antimicrobial peptide (AMP) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof
US20220380744A1 (en) * 2019-10-31 2022-12-01 University Of Maryland, College Park Method of treating infections by bacteriolytic enzymes and manufacture thereof
US20230106068A1 (en) * 2020-03-02 2023-04-06 Conopco, Inc., D/B/A Unilever An effective anti-acne personal care composition
WO2021185948A1 (en) 2020-03-19 2021-09-23 Micreos Human Health B.V. A stabilized protein of interest
EP4289949A4 (en) 2021-02-08 2024-11-06 Wuhan Lysigen Bio-Tech Company Limited BACTERIOPHAGE LYSINE, CHIMERA THEREOF AND ITS APPLICATION
KR102547393B1 (ko) * 2021-04-19 2023-06-23 엠브릭스 주식회사 보툴리늄 독소 전위 도메인 및 엔도라이신을 포함하는 단백질 복합체 및 이를 포함하는 항균 조성물
WO2023168418A1 (en) * 2022-03-03 2023-09-07 Massachusetts Institute Of Technology Cell-wall binding protein specifically targeting cutibacterium acnes
CN114349870B (zh) * 2022-03-21 2022-06-03 天津辅元生物医药科技有限公司 一种兼具防粘连功效的重组抗菌肽及其制备方法和应用
CN114540385B (zh) * 2022-03-21 2023-06-23 齐鲁工业大学 一种利用大肠杆菌产溶葡萄球菌酶的方法
WO2024241070A1 (en) 2023-05-22 2024-11-28 L'oreal Cosmetic composition comprising an endolysin and a polyvinyl alcohol
FR3149209A1 (fr) 2023-06-02 2024-12-06 L'oreal Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et un alcool aromatique
FR3149208A1 (fr) 2023-06-02 2024-12-06 L'oreal Composition cosmétique, notamment aqueuse, comprenant une endolysine et un pullulane
FR3149207A1 (fr) 2023-06-02 2024-12-06 L'oreal Composition cosmétique comprenant une endolysine et un composé de formule (I)
FR3149205A1 (fr) 2023-06-02 2024-12-06 L'oreal Composition cosmétique comprenant une endolysine et un agent de charge organique
FR3149206A1 (fr) 2023-06-02 2024-12-06 L'oreal Composition cosmétique aqueuse comprenant une endolysine et du tréhalose
FR3149204A1 (fr) 2023-06-02 2024-12-06 L'oreal Composition cosmétique comprenant une endolysine et un tensioactif non ionique comprenant un résidu carbohydrate
FR3152395A1 (fr) 2023-08-28 2025-03-07 L'oreal Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et la 4-hydroxyacetophenone
WO2024246325A1 (en) 2023-06-02 2024-12-05 L'oreal Cosmetic composition comprising an endolysin derived from a staphylococcus aureus phage and an aromatic alcohol
FR3149203A1 (fr) 2023-06-02 2024-12-06 L'oreal Composition anhydre comprenant une endolysine et de l’hydroxypropylmethylcellulose et/ou du pullulane
FR3149202A1 (fr) 2023-06-02 2024-12-06 L'oreal Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et une huile.
FR3152396A1 (fr) 2023-08-28 2025-03-07 L'oreal Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et un polyhydroxyalcane
FR3152393A1 (fr) 2023-08-28 2025-03-07 L'oreal Composition cosmétique comprenant une endolysine dérivée d’un phage de Staphylococcus aureus et une charge minérale
FR3152394A1 (fr) 2023-08-28 2025-03-07 L'oreal Composition cosmétique comprenant une endolysine et des particules d’aérogel de silice hydrophobe
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Also Published As

Publication number Publication date
SG177704A1 (en) 2012-02-28
WO2010149795A1 (en) 2010-12-29
CA2765810A1 (en) 2010-12-29
BRPI1015203A2 (pt) 2016-08-02
EP2446028A1 (en) 2012-05-02
EA038542B1 (ru) 2021-09-13
KR101701890B1 (ko) 2017-02-02
CA2765810C (en) 2018-10-16
EP2446028B1 (en) 2018-04-04
BRPI1015203B1 (pt) 2021-06-01
CN102482655B (zh) 2018-04-10
KR20120061802A (ko) 2012-06-13
US11136570B2 (en) 2021-10-05
AU2010264659A1 (en) 2011-12-15
US20190218538A1 (en) 2019-07-18
EP3363896A1 (en) 2018-08-22
CN102482655A (zh) 2012-05-30
JP2017018092A (ja) 2017-01-26
MX2011013453A (es) 2012-04-11
IL217121B (en) 2019-08-29
US20120195872A1 (en) 2012-08-02
EA201270082A1 (ru) 2012-06-29
JP6034188B2 (ja) 2016-11-30
JP2012530510A (ja) 2012-12-06
IL217121A0 (en) 2012-02-29

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