BRPI1015203B1 - Proteína de fusão composta por uma endolisina e uma extensão de peptídeo anfifática, usos da mesma e composição farmacêutica que compreende a dita proteína - Google Patents
Proteína de fusão composta por uma endolisina e uma extensão de peptídeo anfifática, usos da mesma e composição farmacêutica que compreende a dita proteína Download PDFInfo
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- BRPI1015203B1 BRPI1015203B1 BRPI1015203-2A BRPI1015203A BRPI1015203B1 BR PI1015203 B1 BRPI1015203 B1 BR PI1015203B1 BR PI1015203 A BRPI1015203 A BR PI1015203A BR PI1015203 B1 BRPI1015203 B1 BR PI1015203B1
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- fusion protein
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
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- Oncology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09163955.9 | 2009-06-26 | ||
| EP09163955 | 2009-06-26 | ||
| PCT/EP2010/059152 WO2010149795A1 (en) | 2009-06-26 | 2010-06-28 | Antimicrobial agents |
Publications (2)
| Publication Number | Publication Date |
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| BRPI1015203A2 BRPI1015203A2 (pt) | 2016-08-02 |
| BRPI1015203B1 true BRPI1015203B1 (pt) | 2021-06-01 |
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| BRPI1015203-2A BRPI1015203B1 (pt) | 2009-06-26 | 2010-06-28 | Proteína de fusão composta por uma endolisina e uma extensão de peptídeo anfifática, usos da mesma e composição farmacêutica que compreende a dita proteína |
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| US (2) | US20120195872A1 (enExample) |
| EP (2) | EP3363896A1 (enExample) |
| JP (2) | JP6034188B2 (enExample) |
| KR (1) | KR101701890B1 (enExample) |
| CN (1) | CN102482655B (enExample) |
| AU (1) | AU2010264659B2 (enExample) |
| BR (1) | BRPI1015203B1 (enExample) |
| CA (1) | CA2765810C (enExample) |
| EA (1) | EA038542B1 (enExample) |
| IL (1) | IL217121B (enExample) |
| MX (1) | MX2011013453A (enExample) |
| SG (1) | SG177704A1 (enExample) |
| WO (1) | WO2010149795A1 (enExample) |
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| EP3058950B1 (en) | 2009-06-26 | 2020-03-04 | Lysando AG | Antimicrobial agents |
| KR101701890B1 (ko) | 2009-06-26 | 2017-02-02 | 뤼산도 아게 | 항균제 |
| EP2470648B1 (en) | 2009-08-24 | 2019-04-10 | Katholieke Universiteit Leuven K.U. Leuven R&D | New endolysin obpgplys |
| CA3154006C (en) * | 2010-09-17 | 2025-09-09 | Technophage, Investigacao E Desenvolvimento Em Biotecnologia S.A. | Antibacterial phages, phage peptides and their methods of use |
| EP2468856A1 (en) * | 2010-12-23 | 2012-06-27 | Lysando Aktiengesellschaft | Antimicrobial Agents |
| CN102766196B (zh) * | 2011-05-06 | 2014-10-29 | 上海医药工业研究院 | 一组阳离子抗菌肽及其制备方法和应用 |
| CN103361341B (zh) * | 2012-03-26 | 2015-09-02 | 复旦大学附属华山医院 | 杀菌肽ll-37的基因工程的表达及其制备方法和用途 |
| EP2679677A1 (en) * | 2012-06-29 | 2014-01-01 | Lysando Aktiengesellschaft | Composition for use in Mycobacteria therapy |
| EP2679232A1 (en) * | 2012-06-29 | 2014-01-01 | Lysando Aktiengesellschaft | Composition for use in Mycobacteria vaccination |
| US9388400B2 (en) | 2012-06-29 | 2016-07-12 | Lysando Ag | Composition for use in mycobacteria diagnosis |
| CN113717964A (zh) * | 2013-08-06 | 2021-11-30 | 达特茅斯学院理事会 | 非糖基化溶葡球菌素变体蛋白 |
| WO2015070912A1 (en) | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified el188 endolysin sequence |
| WO2015070911A1 (en) | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified kz144 endolysin sequence |
| EP2904912A1 (en) * | 2014-02-07 | 2015-08-12 | Hyglos Invest GmbH | Novel high pressure method with endolysin for processing of foods |
| WO2015121443A1 (en) | 2014-02-14 | 2015-08-20 | Lysando Ag | Antimicrobial agents |
| US10166253B2 (en) | 2014-08-29 | 2019-01-01 | Region Midtjylland | Positively charged co-polymers for use as antimicrobial agents |
| WO2016130024A1 (en) * | 2015-02-13 | 2016-08-18 | Supreme Biotechnologies Limited | Endolysin expression platform |
| CA3022334A1 (en) * | 2016-04-28 | 2017-11-02 | Lysando Ag | Antimicrobial agents against salmonella bacteria |
| CA3041190A1 (en) * | 2016-10-20 | 2018-04-26 | Lysando Ag | New antimicrobial agents against enterococcus bacteria |
| CN110651044A (zh) * | 2017-04-03 | 2020-01-03 | 萨西那帕斯有限公司 | 工程化的革兰氏阴性细胞内溶素 |
| CN108018271B (zh) * | 2018-01-31 | 2020-08-11 | 武汉核圣生物技术有限公司 | 单亚基rna聚合酶、其纯化方法及在rna合成中的应用 |
| MX2020010075A (es) * | 2018-03-29 | 2021-01-08 | Contrafect Corp | Constructos de polipeptido de lisina-peptido anti-microbiano (amp), lisinas, polinucleotidos aislados que codifican para estas, y sus usos. |
| AU2019276253A1 (en) * | 2018-05-30 | 2020-11-26 | Lysando Ag | Novel antimicrobial proteins |
| AU2019327378A1 (en) * | 2018-08-23 | 2020-10-29 | Contrafect Corporation | Lysin-antimicrobial peptide (AMP) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof |
| US20220380744A1 (en) * | 2019-10-31 | 2022-12-01 | University Of Maryland, College Park | Method of treating infections by bacteriolytic enzymes and manufacture thereof |
| US20230106068A1 (en) * | 2020-03-02 | 2023-04-06 | Conopco, Inc., D/B/A Unilever | An effective anti-acne personal care composition |
| WO2021185948A1 (en) | 2020-03-19 | 2021-09-23 | Micreos Human Health B.V. | A stabilized protein of interest |
| EP4289949A4 (en) | 2021-02-08 | 2024-11-06 | Wuhan Lysigen Bio-Tech Company Limited | BACTERIOPHAGE LYSINE, CHIMERA THEREOF AND ITS APPLICATION |
| KR102547393B1 (ko) * | 2021-04-19 | 2023-06-23 | 엠브릭스 주식회사 | 보툴리늄 독소 전위 도메인 및 엔도라이신을 포함하는 단백질 복합체 및 이를 포함하는 항균 조성물 |
| WO2023168418A1 (en) * | 2022-03-03 | 2023-09-07 | Massachusetts Institute Of Technology | Cell-wall binding protein specifically targeting cutibacterium acnes |
| CN114349870B (zh) * | 2022-03-21 | 2022-06-03 | 天津辅元生物医药科技有限公司 | 一种兼具防粘连功效的重组抗菌肽及其制备方法和应用 |
| CN114540385B (zh) * | 2022-03-21 | 2023-06-23 | 齐鲁工业大学 | 一种利用大肠杆菌产溶葡萄球菌酶的方法 |
| WO2024241070A1 (en) | 2023-05-22 | 2024-11-28 | L'oreal | Cosmetic composition comprising an endolysin and a polyvinyl alcohol |
| FR3149209A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et un alcool aromatique |
| FR3149208A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique, notamment aqueuse, comprenant une endolysine et un pullulane |
| FR3149207A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine et un composé de formule (I) |
| FR3149205A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine et un agent de charge organique |
| FR3149206A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique aqueuse comprenant une endolysine et du tréhalose |
| FR3149204A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine et un tensioactif non ionique comprenant un résidu carbohydrate |
| FR3152395A1 (fr) | 2023-08-28 | 2025-03-07 | L'oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et la 4-hydroxyacetophenone |
| WO2024246325A1 (en) | 2023-06-02 | 2024-12-05 | L'oreal | Cosmetic composition comprising an endolysin derived from a staphylococcus aureus phage and an aromatic alcohol |
| FR3149203A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition anhydre comprenant une endolysine et de l’hydroxypropylmethylcellulose et/ou du pullulane |
| FR3149202A1 (fr) | 2023-06-02 | 2024-12-06 | L'oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et une huile. |
| FR3152396A1 (fr) | 2023-08-28 | 2025-03-07 | L'oreal | Composition cosmétique comprenant une endolysine dérivée de phage de Staphylococcus aureus et un polyhydroxyalcane |
| FR3152393A1 (fr) | 2023-08-28 | 2025-03-07 | L'oreal | Composition cosmétique comprenant une endolysine dérivée d’un phage de Staphylococcus aureus et une charge minérale |
| FR3152394A1 (fr) | 2023-08-28 | 2025-03-07 | L'oreal | Composition cosmétique comprenant une endolysine et des particules d’aérogel de silice hydrophobe |
| WO2025093666A1 (en) | 2023-11-01 | 2025-05-08 | University Of Copenhagen | Treatment of lymphoma |
| CN118421604B (zh) * | 2024-05-27 | 2024-10-22 | 小白鲸(中山)生物医药有限公司 | 一种重组溶葡萄球菌酶突变体及其制备方法和应用 |
| CN119799685A (zh) * | 2024-12-27 | 2025-04-11 | 深圳先进技术研究院 | 一种靶向闪烁梭菌的抗菌蛋白及其制备方法与应用 |
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| US7566447B2 (en) | 2003-05-15 | 2009-07-28 | Iogenetics, Llc | Biocides |
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| WO2005108563A2 (en) | 2004-04-19 | 2005-11-17 | University Of Chicago | Peptidoglycan-hydrolyzing protein encoded by bacteriophage n4 |
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| DE102006061002A1 (de) | 2006-12-22 | 2008-06-26 | Profos Ag | Verfahren und Mittel zur Anreicherung, Entfernung und zum Nachweis von gram-positiven Bakterien |
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| AU2009273845B2 (en) | 2008-07-24 | 2016-02-04 | The United State Of America, As Represented By The Secretary Of Agriculture | Triple acting antimicrobials that are refractory to resistance development |
| EP2157100A1 (en) * | 2008-08-19 | 2010-02-24 | Profos AG | Artificial peptidoglycan lysing enzymes and peptidoglycan binding proteins |
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| DE102010014867A1 (de) * | 2009-04-17 | 2010-11-18 | Sms Siemag Ag | Verfahren zum Bereitstellen mindestens einer Arbeitswalze zum Walzen eines Walzguts |
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| SG177704A1 (en) | 2012-02-28 |
| WO2010149795A1 (en) | 2010-12-29 |
| CA2765810A1 (en) | 2010-12-29 |
| BRPI1015203A2 (pt) | 2016-08-02 |
| EP2446028A1 (en) | 2012-05-02 |
| EA038542B1 (ru) | 2021-09-13 |
| KR101701890B1 (ko) | 2017-02-02 |
| CA2765810C (en) | 2018-10-16 |
| EP2446028B1 (en) | 2018-04-04 |
| AU2010264659B2 (en) | 2016-08-04 |
| CN102482655B (zh) | 2018-04-10 |
| KR20120061802A (ko) | 2012-06-13 |
| US11136570B2 (en) | 2021-10-05 |
| AU2010264659A1 (en) | 2011-12-15 |
| US20190218538A1 (en) | 2019-07-18 |
| EP3363896A1 (en) | 2018-08-22 |
| CN102482655A (zh) | 2012-05-30 |
| JP2017018092A (ja) | 2017-01-26 |
| MX2011013453A (es) | 2012-04-11 |
| IL217121B (en) | 2019-08-29 |
| US20120195872A1 (en) | 2012-08-02 |
| EA201270082A1 (ru) | 2012-06-29 |
| JP6034188B2 (ja) | 2016-11-30 |
| JP2012530510A (ja) | 2012-12-06 |
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