JP6023082B2 - 精神神経性の疾病を処置するためのプロスタグランジンを含む組成物 - Google Patents

精神神経性の疾病を処置するためのプロスタグランジンを含む組成物 Download PDF

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JP6023082B2
JP6023082B2 JP2013549683A JP2013549683A JP6023082B2 JP 6023082 B2 JP6023082 B2 JP 6023082B2 JP 2013549683 A JP2013549683 A JP 2013549683A JP 2013549683 A JP2013549683 A JP 2013549683A JP 6023082 B2 JP6023082 B2 JP 6023082B2
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JP2014502974A5 (enExample
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ジー. マストロナルディ,ファブリツィオ
ジー. マストロナルディ,ファブリツィオ
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インセプタム リサーチ アンド セラピューティクス,インク.
インセプタム リサーチ アンド セラピューティクス,インク.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47064-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
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    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013549683A 2011-01-24 2012-01-24 精神神経性の疾病を処置するためのプロスタグランジンを含む組成物 Expired - Fee Related JP6023082B2 (ja)

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US201161435546P 2011-01-24 2011-01-24
US61/435,546 2011-01-24
PCT/CA2012/050037 WO2012100347A1 (en) 2011-01-24 2012-01-24 Compositions comprising a prostaglandin for treating neuropsychiatric conditions

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JP2014502974A JP2014502974A (ja) 2014-02-06
JP2014502974A5 JP2014502974A5 (enExample) 2015-02-05
JP6023082B2 true JP6023082B2 (ja) 2016-11-09

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US (2) US9259409B2 (enExample)
EP (1) EP2667875A4 (enExample)
JP (1) JP6023082B2 (enExample)
CA (1) CA2860453C (enExample)
WO (1) WO2012100347A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG187770A1 (en) 2010-08-12 2013-03-28 Univ Nanyang Tech A liposomal formulation for ocular drug delivery
WO2012100347A1 (en) * 2011-01-24 2012-08-02 Inceptum Research & Therapeutics, Inc. Compositions comprising a prostaglandin for treating neuropsychiatric conditions
BR112014002712A8 (pt) * 2011-08-05 2017-06-20 Sucampo Ag método para tratamento da esquizofrenia
CN103664726A (zh) * 2012-08-31 2014-03-26 南京华狮化工有限公司 氘代比马前列素或其衍生物、它们的制备方法及其应用
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
US9956195B2 (en) 2014-01-07 2018-05-01 Nanyang Technological University Stable liposomal formulations for ocular drug delivery
US20180000771A1 (en) * 2015-01-13 2018-01-04 Kyoto University Agent for preventing and/or treating amyotrophic lateral sclerosis
AU2017363147B2 (en) * 2016-11-17 2023-09-14 Biojiva Llc Isotopically modified components and therapeutic uses thereof
US20200206309A1 (en) * 2017-07-27 2020-07-02 The Mclean Hospital Corporation METHODS AND COMPOSITIONS RELATED TO THE TREATMENT OF NURR1- AND PPARy-MEDIATED CONDITIONS
EP3870292A4 (en) 2018-10-26 2022-11-09 The Research Foundation for The State University of New York COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA
US12109194B2 (en) 2021-02-05 2024-10-08 Biojiva Llc Synergistic combination therapy for treating ALS

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60146826A (ja) * 1983-12-30 1985-08-02 Hisanobu Kaitani 向精神病薬
JPH0761944B2 (ja) * 1989-11-22 1995-07-05 株式会社アールテック・ウエノ 脳機能改善処置剤
JPH07291867A (ja) * 1994-04-28 1995-11-07 Sagami Chem Res Center 神経成長因子産生促進剤
JPH08277222A (ja) * 1995-04-05 1996-10-22 Green Cross Corp:The 神経疾患の予防治療剤
US6043224A (en) 1996-09-05 2000-03-28 The Massachusetts Institute Of Technology Compositions and methods for treatment of neurological disorders and neurodegenerative diseases
CA2255024A1 (en) * 1997-03-14 1998-09-24 Susumu Matsuda Protective agents for cells constituting nervous system
JPH11228417A (ja) * 1998-02-06 1999-08-24 Teijin Ltd 神経障害治療剤
SE9803761D0 (sv) * 1998-11-04 1998-11-04 Synphora Ab Method to avoid increased iridial pigmentation during prostaglandin treatment
US6191154B1 (en) * 1998-11-27 2001-02-20 Case Western Reserve University Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
JP2000351733A (ja) * 1999-04-09 2000-12-19 Osaka Bioscience Institute 神経栄養因子様低分子化合物
CA2378315A1 (en) * 1999-08-05 2001-02-15 Teijin Limited Neuropathy therapeutic agent
JP4000505B2 (ja) 1999-12-01 2007-10-31 第一三共株式会社 緑内障を治療するための併用剤
GB0014356D0 (en) 2000-06-12 2000-08-02 Colover Jack Treatment of multiple sclerosis
US20030018079A1 (en) 2000-11-13 2003-01-23 Richardson Helene Treatment
US20040122100A1 (en) 2001-03-16 2004-06-24 Shuh Narumiya Remedies for post-traumatic stress disorder
JP4261912B2 (ja) * 2001-04-19 2009-05-13 テイカ製薬株式会社 薬剤および薬剤キット
JP4300347B2 (ja) * 2002-01-29 2009-07-22 参天製薬株式会社 ブナゾシンとプロスタグランジン類からなる緑内障治療剤
IL147921A0 (en) * 2002-01-31 2002-08-14 Abdulrazik Mohammad A method for treating central nervous system disorders by ocular dosing
JP4482726B2 (ja) * 2002-08-29 2010-06-16 参天製薬株式会社 Rhoキナーゼ阻害剤とプロスタグランジン類からなる緑内障治療剤
CN1214794C (zh) 2003-09-08 2005-08-17 秦正红 前列腺素a1在制备治疗脑缺血性中风疾病的药物中的用途
ATE404560T1 (de) * 2004-05-26 2008-08-15 Pfizer Indazol- und indolonderivative und deren verwendung als pharmazeutika
CA2576279A1 (en) * 2004-11-08 2006-05-18 Nitromed, Inc. Nitrosated and nitrosylated compounds, compositions and methods for the treatment of ophthalmic disorders
EP1841433B1 (en) * 2005-01-27 2011-11-30 Sucampo AG Composition for treating central nervous system disorders
EP2377531A2 (en) * 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
US20090062561A1 (en) 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched latanoprost
CN101176735A (zh) 2007-12-03 2008-05-14 苏州大学 一种治疗缺血性脑损伤的组合制剂
JP5222608B2 (ja) * 2008-03-31 2013-06-26 カゴメ株式会社 抗不安作用剤
WO2012100347A1 (en) * 2011-01-24 2012-08-02 Inceptum Research & Therapeutics, Inc. Compositions comprising a prostaglandin for treating neuropsychiatric conditions

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WO2012100347A1 (en) 2012-08-02
CA2860453C (en) 2020-04-28
JP2014502974A (ja) 2014-02-06
EP2667875A1 (en) 2013-12-04
CA2860453A1 (en) 2012-08-02
US9259409B2 (en) 2016-02-16
US20160113942A1 (en) 2016-04-28
US20130309330A1 (en) 2013-11-21
EP2667875A4 (en) 2014-07-30

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