JP5985502B2 - 試料の化学、生物学または生化学分析に用いる複合技術による結像のシステムおよび方法 - Google Patents

試料の化学、生物学または生化学分析に用いる複合技術による結像のシステムおよび方法 Download PDF

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JP5985502B2
JP5985502B2 JP2013542590A JP2013542590A JP5985502B2 JP 5985502 B2 JP5985502 B2 JP 5985502B2 JP 2013542590 A JP2013542590 A JP 2013542590A JP 2013542590 A JP2013542590 A JP 2013542590A JP 5985502 B2 JP5985502 B2 JP 5985502B2
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light beam
sample
objective lens
light source
incident light
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JP2013545989A5 (enExample
JP2013545989A (ja
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オザナン，フランソワ
シャザルヴィエル，ジャン−ノエル
ブケーロ，ラバ
アン−ガブリエル ガロパン，エリザベス
アン−ガブリエル ガロパン，エリザベス
シャンタル グージェ−レムリ，アン
シャンタル グージェ−レムリ，アン
シュネリ，サビーヌ
トーアヒア，ラルビ
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Centre National de la Recherche Scientifique
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G01N21/554—Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G02B21/08—Condensers
    • G02B21/082—Condensers for incident illumination only
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6471—Special filters, filter wheel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6491—Measuring fluorescence and transmission; Correcting inner filter effect
    • G01N2021/6493—Measuring fluorescence and transmission; Correcting inner filter effect by alternating fluorescence/transmission or fluorescence/reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
JP2013542590A 2010-12-07 2011-12-07 試料の化学、生物学または生化学分析に用いる複合技術による結像のシステムおよび方法 Expired - Fee Related JP5985502B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1060195 2010-12-07
FR1060195A FR2968402B1 (fr) 2010-12-07 2010-12-07 Systeme et procede d'imagerie multitechniques pour l'analyse chimique, biologique ou biochimique d'un echantillon.
PCT/FR2011/052886 WO2012076810A1 (fr) 2010-12-07 2011-12-07 Systeme et procede d'imagerie multitechniques pour l'analyse chimique, biologique ou biochiimique d'un echantillon.

Publications (3)

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JP2013545989A JP2013545989A (ja) 2013-12-26
JP2013545989A5 JP2013545989A5 (enExample) 2014-12-04
JP5985502B2 true JP5985502B2 (ja) 2016-09-06

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US (1) US9476827B2 (enExample)
EP (1) EP2649431B1 (enExample)
JP (1) JP5985502B2 (enExample)
FR (1) FR2968402B1 (enExample)
WO (1) WO2012076810A1 (enExample)

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JP6488501B2 (ja) * 2013-09-11 2019-03-27 株式会社分光科学研究所 計測方法及び計測装置
US20180267286A1 (en) * 2015-01-27 2018-09-20 Ecole Polytechnique Federale De Lausanne (Epfl) Observation Device with Optical Compensation
US10705022B2 (en) 2016-08-24 2020-07-07 Goodrich Corporation Robust spectroscopy systems
FR3058521B1 (fr) * 2016-11-08 2021-01-08 Univ Montpellier Dispositif et procede de detection de presence de molecules determinees, biocapteur
CN106896095B (zh) * 2017-01-11 2019-08-06 四川大学 复合表面等离子体共振及表面增强拉曼的显微成像技术
WO2020235142A1 (ja) * 2019-05-20 2020-11-26 日本電気株式会社 分光分析装置、分光分析方法及びコンピュータ可読媒体
US12304278B2 (en) * 2022-05-17 2025-05-20 Ford Global Technologies, Llc Air monitoring system for vehicle interior

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US3229564A (en) * 1961-05-12 1966-01-18 Bausch & Lomb Reflectometer
DE2402127C3 (de) * 1974-01-17 1978-04-06 Pluess-Staufer Ag, Oftringen (Schweiz) Vorrichtung zur Messung des Glanzschleiers von Oberflächen
JPH1020203A (ja) * 1996-07-08 1998-01-23 Nikon Corp 顕微鏡装置
US5994707A (en) * 1997-03-18 1999-11-30 Physical Optics Corporation Modular fiber optic fluorometer and method of use thereof
US6548796B1 (en) * 1999-06-23 2003-04-15 Regents Of The University Of Minnesota Confocal macroscope
JP2001185796A (ja) * 1999-12-27 2001-07-06 Hitachi Metals Ltd レーザ装置、その応用装置並びにその使用方法
GB0106342D0 (en) * 2001-03-15 2001-05-02 Renishaw Plc Spectroscopy apparatus and method
JP3741051B2 (ja) * 2001-05-10 2006-02-01 横河電機株式会社 バイオチップ読取装置
JP4954452B2 (ja) * 2004-07-06 2012-06-13 オリンパス株式会社 顕微鏡
DE102004034970A1 (de) * 2004-07-16 2006-02-02 Carl Zeiss Jena Gmbh Lichtrastermikroskop und Verwendung
EP1787157B1 (en) * 2004-07-23 2014-09-24 GE Healthcare Niagara Inc. Apparatus for fluorescent confocal microscopy
JP4520795B2 (ja) * 2004-08-23 2010-08-11 株式会社ミツトヨ 測定器
WO2007070382A2 (en) * 2005-12-09 2007-06-21 Auburn University Simultaneous observation of darkfield images and fluorescence using filter and diaphragm
WO2008047893A1 (fr) * 2006-10-19 2008-04-24 Olympus Corporation Microscope

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Publication number Publication date
WO2012076810A1 (fr) 2012-06-14
FR2968402A1 (fr) 2012-06-08
US9476827B2 (en) 2016-10-25
EP2649431B1 (fr) 2015-03-04
US20130314528A1 (en) 2013-11-28
FR2968402B1 (fr) 2013-02-15
EP2649431A1 (fr) 2013-10-16
JP2013545989A (ja) 2013-12-26

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