JP5945568B2 - 粒子特性の測定 - Google Patents
粒子特性の測定 Download PDFInfo
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- JP5945568B2 JP5945568B2 JP2014139417A JP2014139417A JP5945568B2 JP 5945568 B2 JP5945568 B2 JP 5945568B2 JP 2014139417 A JP2014139417 A JP 2014139417A JP 2014139417 A JP2014139417 A JP 2014139417A JP 5945568 B2 JP5945568 B2 JP 5945568B2
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- 239000002245 particle Substances 0.000 title claims description 54
- 238000005259 measurement Methods 0.000 title claims description 22
- 239000007788 liquid Substances 0.000 claims description 89
- 230000003287 optical effect Effects 0.000 claims description 51
- 238000001514 detection method Methods 0.000 claims description 48
- 238000000034 method Methods 0.000 claims description 29
- 238000002296 dynamic light scattering Methods 0.000 claims description 16
- 238000005286 illumination Methods 0.000 claims description 14
- 230000001427 coherent effect Effects 0.000 claims description 12
- 238000001370 static light scattering Methods 0.000 claims description 12
- 230000001678 irradiating effect Effects 0.000 claims description 10
- 238000000691 measurement method Methods 0.000 claims description 10
- 238000011192 particle characterization Methods 0.000 claims description 9
- 230000005855 radiation Effects 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 description 140
- 239000012530 fluid Substances 0.000 description 11
- 230000007246 mechanism Effects 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 238000000149 argon plasma sintering Methods 0.000 description 5
- 239000011521 glass Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 239000002105 nanoparticle Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 230000003068 static effect Effects 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000005314 correlation function Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
- G01N15/0205—Investigating particle size or size distribution by optical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0346—Capillary cells; Microcells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0346—Capillary cells; Microcells
- G01N2021/035—Supports for sample drops
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N2021/4704—Angular selective
- G01N2021/4707—Forward scatter; Low angle scatter
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N2021/4704—Angular selective
- G01N2021/4709—Backscatter
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N2021/4704—Angular selective
- G01N2021/4726—Detecting scatter at 90°
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- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Optical Measuring Cells (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Description
12:下側光学部品
14:上側光学部品
16:入射光ビーム(照射軸線)
18:被検出光ビーム(検出軸線)
18B:後方散乱光
18F:前方散乱光
18S:側方散乱光
22、24:光学部品
30:サンプルキャリヤー
42:毛管キャリヤー
44:毛管カッター(毛管切断機)
Claims (8)
- サンプル液滴中の粒子の特性を測定するための装置であって、
キュべットを保持するためのキュべットホルダーと、
サンプル液滴を受容し且つ支持するため構成された表面と、水平方向の入射光ビームを前記表面の上のサンプル液滴を照射するように垂直方向に差し向ける働きをする反射器と、前記表面及び反射器を所定位置に保持するように位置づけされた支持体とを有するサンプルキャリヤーであって、キュべットホルダー内に嵌合させるように形状及び寸法を定めた前記サンプルキャリヤーと、
光源からの空間的に干渉性をもつ光を散乱帯域を横切って散乱させるようにサンプル液滴を透過するように向けられた照射軸線を有する空間的干渉性の光源と、
前記サンプル液滴が前記表面の上に支持されているとき、該サンプル液滴中の粒子によって散乱された光を前記光源の照射軸線に対して所定の角度に方向づけされた所定の散乱光検出軸線に沿って受容するように位置づけされた少なくとも1つの空間的干渉性散乱光の検出器とから成り、該所定の散乱光検出軸線と前記照射軸線とのなす角度は、該検出器が、前記散乱帯域を横切って該角度で散乱された前記空間的干渉性をもつ光を検出することを可能にする角度であり、
前記空間的干渉性の光源は、前記反射器を経て前記サンプル液滴を透過するように向けられた照射軸線を有しており、前記空間的干渉性散乱光の検出器は、前記サンプル液滴中の粒子によって散乱された光を前記反射器を経て受容するように位置づけされていることを特徴とする粒子特性測定装置。
- 前記支持体によって所定位置に保持された下側光学表面と上側光学表面を含む前記サンプルキャリヤーであり、前記反射器は、前記入射光ビームが前記表面の上のサンプル液滴を照射する前に該入射光ビームを前記下側光学表面を通し、前記上側光学表面を通して導く働きをする、請求項1に記載の粒子特性測定装置。
- 前記支持体は、前記水平方向の入射光ビームを前記反射器に向けて通すアパーチャーを有する、請求項1又は2に記載の粒子特性測定装置。
- 前記表面は、透明な光学部品の一部分である、請求項1〜3のいずれか1項に記載の粒子特性測定装置。
- 前記サンプルキャリヤーが外寸12mm×12mmの正方形の断面形状を有する請求項1〜4のいずれか1項に記載の粒子特性測定装置。
- サンプル液滴中の粒子の特性を測定するための粒子特性測定方法であって、
粒子特性測定装置のキュべットホルダー内に嵌合させることができるサンプルキャリヤーの表面にサンプル液滴を接触させて支持する工程と、
水平方向の入射光ビームを前記表面の上のサンプル液滴を照射するように垂直方向に差し向ける働きをする反射器と、前記表面及び反射器を所定位置に保持するように位置づけされた支持体とを有する前記サンプルキャリヤーを準備する工程と、
空間的に干渉性をもつ空間的干渉性光を散乱帯域を横切って散乱させるように前記表面の上に支持されたサンプル液滴を照射軸線に沿って該空間的干渉性光で照射する工程と、
光が前記支持されたサンプル液滴中の粒子によって散乱された後、該散乱光の少なくとも一部分を所定の散乱光検出軸線に沿って検出する検出工程とから成り、
前記照射軸線と検出軸線とは、互いに所定の角度に方向づけし、該所定の角度は、前記散乱帯域を横切って該所定の角度で散乱された光を検出することを可能にする角度にして、
前記反射器を経て前記サンプル液滴を透過するように向けられた前記照射軸線を有しており、光検出器が、前記サンプル液滴中の粒子によって散乱された光を前記反射器を経て受容するように位置づけられることを特徴とする粒子特性測定方法。
- 前記検出工程の結果から所定の角度分解能に関して動的光散乱測定値又は静的光散乱測定値を導出する工程をさらに含む、請求項6に記載の粒子特性測定方法。
- 前記検出工程は、前記表面を透過して実施される、請求項6、7のいずれかに記載の粒子特性測定方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US20913909P | 2009-03-04 | 2009-03-04 | |
US61/209,139 | 2009-03-04 |
Related Parent Applications (1)
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JP2011552527A Division JP2012519839A (ja) | 2009-03-04 | 2010-03-04 | 粒子特性の測定 |
Publications (2)
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JP2014186039A JP2014186039A (ja) | 2014-10-02 |
JP5945568B2 true JP5945568B2 (ja) | 2016-07-05 |
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JP2011552527A Ceased JP2012519839A (ja) | 2009-03-04 | 2010-03-04 | 粒子特性の測定 |
JP2014139417A Active JP5945568B2 (ja) | 2009-03-04 | 2014-07-07 | 粒子特性の測定 |
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Country Status (4)
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EP (1) | EP2404154B1 (ja) |
JP (2) | JP2012519839A (ja) |
CN (1) | CN102341690B (ja) |
WO (1) | WO2010100502A1 (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2480596A (en) * | 2010-01-29 | 2011-11-30 | Kenneth John Cunningham | Disposable light scattering cuvette for liquid sample held by surface tension |
WO2012045846A1 (en) * | 2010-10-08 | 2012-04-12 | Hecus X-Ray Systems Gmbh | Apparatus and method for supporting a liquid sample for measuring scattering of electromagnetic radiation |
JP6592765B2 (ja) * | 2015-04-30 | 2019-10-23 | トライボテックス株式会社 | 粒子計数装置 |
EP3350574B1 (en) * | 2015-09-16 | 2021-12-15 | Thermo Electron Scientific Instruments LLC | Image analysis system and method |
CN108431582A (zh) * | 2015-12-28 | 2018-08-21 | Kbf企划株式会社 | 凝胶粒子测定方法及其装置 |
EP3309536A1 (en) | 2016-10-11 | 2018-04-18 | Malvern Panalytical Limited | Particle characterisation instrument |
WO2018110468A1 (ja) * | 2016-12-14 | 2018-06-21 | 株式会社堀場製作所 | 粒子物性測定装置 |
Family Cites Families (20)
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JPS5973753A (ja) * | 1982-10-21 | 1984-04-26 | Toshiba Corp | 超微量分光光度計 |
DE3344387A1 (de) * | 1983-12-08 | 1985-06-20 | Hoechst Ag, 6230 Frankfurt | Photometerkopf fuer kleine messvolumina |
JPH0448245A (ja) * | 1990-06-15 | 1992-02-18 | Canon Inc | 粒子測定装置 |
JPH05340885A (ja) * | 1992-06-08 | 1993-12-24 | Matsushita Electric Ind Co Ltd | パーティクル検査方法 |
JP2910596B2 (ja) * | 1994-12-27 | 1999-06-23 | 株式会社島津製作所 | 粒度分布測定装置 |
DE19725211C1 (de) | 1997-06-15 | 1998-06-04 | Alv Laser Vertriebsgesellschaf | Faserdetektor zur Detektion des Streulichtes oder des Fluoreszenzlichtes einer flüssigen Suspension |
KR19990011927A (ko) * | 1997-07-25 | 1999-02-18 | 윤종용 | 광학적 입자 농도 측정기 및 그의 측정 방법 |
JP3475097B2 (ja) * | 1998-11-06 | 2003-12-08 | 株式会社堀場製作所 | 粒径分布測定装置 |
WO2001014855A1 (en) * | 1999-08-20 | 2001-03-01 | Charles William Robertson | Liquid photometer using surface tension to contain sample |
JP4002173B2 (ja) * | 2002-12-13 | 2007-10-31 | 株式会社栃木ニコン | テラヘルツ分光装置 |
US20070224087A1 (en) * | 2004-07-08 | 2007-09-27 | Zhong Ding | Airborne material collection and detection method and apparatus |
US7375815B2 (en) * | 2004-10-12 | 2008-05-20 | Agilent Technologies, Inc. | Optical devices, systems and method for producing a collimated light path |
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JP2007170984A (ja) * | 2005-12-22 | 2007-07-05 | Shimadzu Corp | 試料セル及び該試料セルを用いた分光光度計 |
EP2027452B1 (en) * | 2006-05-12 | 2017-06-28 | Carl Stuart Limited | Microvolume analysis system |
JP2008039539A (ja) * | 2006-08-04 | 2008-02-21 | Shimadzu Corp | 光散乱検出装置 |
CN101523191B (zh) * | 2006-10-06 | 2012-06-06 | 株式会社岛津制作所 | 分光光度计 |
JP2008116314A (ja) * | 2006-11-02 | 2008-05-22 | Seikoh Giken Co Ltd | 微少量液体測定装置 |
-
2010
- 2010-03-04 JP JP2011552527A patent/JP2012519839A/ja not_active Ceased
- 2010-03-04 EP EP10707345.4A patent/EP2404154B1/en active Active
- 2010-03-04 CN CN2010800107028A patent/CN102341690B/zh active Active
- 2010-03-04 WO PCT/GB2010/050383 patent/WO2010100502A1/en active Application Filing
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2014
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Also Published As
Publication number | Publication date |
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JP2012519839A (ja) | 2012-08-30 |
CN102341690B (zh) | 2013-10-09 |
CN102341690A (zh) | 2012-02-01 |
WO2010100502A1 (en) | 2010-09-10 |
JP2014186039A (ja) | 2014-10-02 |
EP2404154A1 (en) | 2012-01-11 |
EP2404154B1 (en) | 2020-11-11 |
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