JP5937017B2 - Ａｌｋ阻害剤に対する自然耐性または獲得耐性を有する癌の同定、評価および治療法 - Google Patents

Ａｌｋ阻害剤に対する自然耐性または獲得耐性を有する癌の同定、評価および治療法 Download PDF

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JP5937017B2
JP5937017B2 JP2012551704A JP2012551704A JP5937017B2 JP 5937017 B2 JP5937017 B2 JP 5937017B2 JP 2012551704 A JP2012551704 A JP 2012551704A JP 2012551704 A JP2012551704 A JP 2012551704A JP 5937017 B2 JP5937017 B2 JP 5937017B2
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alk
cancer
mutation
nucleic acid
marker
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JP2013518579A5 (enExample
JP2013518579A (ja
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博行 間野
博行 間野
エル チョイ，ヨン
エル チョイ，ヨン
学 曽田
学 曽田
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Jichi Medical University
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012551704A 2010-02-04 2011-02-04 Ａｌｋ阻害剤に対する自然耐性または獲得耐性を有する癌の同定、評価および治療法 Expired - Fee Related JP5937017B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33746510P 2010-02-04 2010-02-04
US61/337,465 2010-02-04
PCT/IB2011/000382 WO2011095894A2 (en) 2010-02-04 2011-02-04 Identification, assessment, and therapy of cancers with innate or acquired resistance to alk inhibitors

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JP2013518579A JP2013518579A (ja) 2013-05-23
JP2013518579A5 JP2013518579A5 (enExample) 2014-04-03
JP5937017B2 true JP5937017B2 (ja) 2016-06-22

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US (1) US9018230B2 (enExample)
EP (1) EP2531858B1 (enExample)
JP (1) JP5937017B2 (enExample)
KR (1) KR101843967B1 (enExample)
CN (2) CN103937877B (enExample)
AR (1) AR080361A1 (enExample)
AU (1) AU2011212165B2 (enExample)
BR (1) BR112012019215A2 (enExample)
CA (1) CA2786974C (enExample)
ES (1) ES2660149T3 (enExample)
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NZ (1) NZ601606A (enExample)
RU (1) RU2589834C2 (enExample)
SG (1) SG182766A1 (enExample)
TW (1) TWI518325B (enExample)
WO (1) WO2011095894A2 (enExample)
ZA (1) ZA201205831B (enExample)

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JP6205216B2 (ja) * 2012-09-24 2017-09-27 アークレイ株式会社 変異検出用プローブ、変異検出方法、薬効判定方法及び変異検出用キット
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US20170349953A1 (en) * 2016-06-01 2017-12-07 Roche Sequencing Solutions, Inc. Novel mutations in anaplastic lymphoma kinase predicting response to alk inhibitor therapy in lung cancer patients
KR101872624B1 (ko) * 2016-12-27 2018-06-28 (주) 바이오인프라생명과학 Alk 표적 치료제에 대한 폐암의 치료 반응성을 예측하는 방법
CN107828823A (zh) * 2017-09-29 2018-03-23 暨南大学 一种评价eml4‑alk抑制剂对肺癌治疗效果的方法
RU2717309C2 (ru) * 2018-08-01 2020-03-20 Общество с ограниченной ответственностью "ОНКОДИАГНОСТИКА АТЛАС" Способ определения микросателлитной нестабильности
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WO2011095894A3 (en) 2012-03-01
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CA2786974A1 (en) 2011-08-11
BR112012019215A2 (pt) 2016-10-25
EP2531858A4 (en) 2013-08-07
HK1197922A1 (zh) 2015-02-27
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WO2011095894A2 (en) 2011-08-11
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CN102844664A (zh) 2012-12-26
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US20130203810A1 (en) 2013-08-08
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ES2660149T3 (es) 2018-03-21
EP2531858B1 (en) 2018-01-10
KR20120130329A (ko) 2012-11-30
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US9018230B2 (en) 2015-04-28
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