JP2013518579A5 - - Google Patents
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- JP2013518579A5 JP2013518579A5 JP2012551704A JP2012551704A JP2013518579A5 JP 2013518579 A5 JP2013518579 A5 JP 2013518579A5 JP 2012551704 A JP2012551704 A JP 2012551704A JP 2012551704 A JP2012551704 A JP 2012551704A JP 2013518579 A5 JP2013518579 A5 JP 2013518579A5
- Authority
- JP
- Japan
- Prior art keywords
- alk
- mutant
- nucleic acid
- amino acid
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 claims 165
- 102000039446 nucleic acids Human genes 0.000 claims 127
- 108020004707 nucleic acids Proteins 0.000 claims 127
- 150000007523 nucleic acids Chemical class 0.000 claims 127
- 235000018102 proteins Nutrition 0.000 claims 112
- 108090000623 proteins and genes Proteins 0.000 claims 112
- 102000004169 proteins and genes Human genes 0.000 claims 112
- 125000000539 amino acid group Chemical group 0.000 claims 92
- 208000034951 Genetic Translocation Diseases 0.000 claims 72
- 239000002299 complementary DNA Substances 0.000 claims 37
- 239000000203 mixture Substances 0.000 claims 31
- 235000001014 amino acid Nutrition 0.000 claims 28
- 150000001413 amino acids Chemical class 0.000 claims 28
- 229920001184 polypeptide Polymers 0.000 claims 23
- 102000004196 processed proteins & peptides Human genes 0.000 claims 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims 23
- 229940122531 Anaplastic lymphoma kinase inhibitor Drugs 0.000 claims 18
- 108020004705 Codon Proteins 0.000 claims 18
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 14
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 14
- 206010028980 Neoplasm Diseases 0.000 claims 14
- 235000018417 cysteine Nutrition 0.000 claims 14
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 14
- 102000040430 polynucleotide Human genes 0.000 claims 14
- 108091033319 polynucleotide Proteins 0.000 claims 14
- 239000002157 polynucleotide Substances 0.000 claims 14
- 239000000523 sample Substances 0.000 claims 12
- 101710168331 ALK tyrosine kinase receptor Proteins 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 9
- 230000000694 effects Effects 0.000 claims 9
- 238000000034 method Methods 0.000 claims 6
- 239000003153 chemical reaction reagent Substances 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 102220197961 rs1057519784 Human genes 0.000 claims 5
- 102220198074 rs1057519859 Human genes 0.000 claims 5
- 210000004962 mammalian cell Anatomy 0.000 claims 4
- 210000001519 tissue Anatomy 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- -1 2-methyl-11- (2-methylpropyl) -4-oxo-4,5,6,11,12,13-hexahydro-2H-indazolo [5,4 -A] pyrrolo [3,4-c] carbazol-8-yl [4- (dimethylamino) benzyl] carbamate Chemical class 0.000 claims 2
- QQWUGDVOUVUTOY-UHFFFAOYSA-N 5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine Chemical compound COC1=CC(N2CCC(CC2)N2CCN(C)CC2)=CC=C1NC(N=1)=NC=C(Cl)C=1NC1=CC=CC=C1S(=O)(=O)C(C)C QQWUGDVOUVUTOY-UHFFFAOYSA-N 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims 2
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 2
- 230000009702 cancer cell proliferation Effects 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 238000002474 experimental method Methods 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 230000004614 tumor growth Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 206010073478 Anaplastic large-cell lymphoma Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 201000003803 Inflammatory myofibroblastic tumor Diseases 0.000 claims 1
- 206010067917 Inflammatory myofibroblastic tumour Diseases 0.000 claims 1
- 208000032004 Large-Cell Anaplastic Lymphoma Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 208000002151 Pleural effusion Diseases 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 108700005078 Synthetic Genes Proteins 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 230000035572 chemosensitivity Effects 0.000 claims 1
- 239000013068 control sample Substances 0.000 claims 1
- 210000003608 fece Anatomy 0.000 claims 1
- 210000004602 germ cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 238000007899 nucleic acid hybridization Methods 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 238000003752 polymerase chain reaction Methods 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000000392 somatic effect Effects 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33746510P | 2010-02-04 | 2010-02-04 | |
| US61/337,465 | 2010-02-04 | ||
| PCT/IB2011/000382 WO2011095894A2 (en) | 2010-02-04 | 2011-02-04 | Identification, assessment, and therapy of cancers with innate or acquired resistance to alk inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518579A JP2013518579A (ja) | 2013-05-23 |
| JP2013518579A5 true JP2013518579A5 (enExample) | 2014-04-03 |
| JP5937017B2 JP5937017B2 (ja) | 2016-06-22 |
Family
ID=44355876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012551704A Expired - Fee Related JP5937017B2 (ja) | 2010-02-04 | 2011-02-04 | Ａｌｋ阻害剤に対する自然耐性または獲得耐性を有する癌の同定、評価および治療法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9018230B2 (enExample) |
| EP (1) | EP2531858B1 (enExample) |
| JP (1) | JP5937017B2 (enExample) |
| KR (1) | KR101843967B1 (enExample) |
| CN (2) | CN103937877B (enExample) |
| AR (1) | AR080361A1 (enExample) |
| AU (1) | AU2011212165B2 (enExample) |
| BR (1) | BR112012019215A2 (enExample) |
| CA (1) | CA2786974C (enExample) |
| ES (1) | ES2660149T3 (enExample) |
| MX (1) | MX336498B (enExample) |
| NZ (1) | NZ601606A (enExample) |
| RU (1) | RU2589834C2 (enExample) |
| SG (1) | SG182766A1 (enExample) |
| TW (1) | TWI518325B (enExample) |
| WO (1) | WO2011095894A2 (enExample) |
| ZA (1) | ZA201205831B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8383793B2 (en) * | 2010-04-15 | 2013-02-26 | St. Jude Children's Research Hospital | Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (ALK) kinase inhibitors |
| WO2012019132A2 (en) * | 2010-08-06 | 2012-02-09 | Cell Signaling Technology, Inc. | Anaplastic lymphoma kinase in kidney cancer |
| JP6205216B2 (ja) * | 2012-09-24 | 2017-09-27 | アークレイ株式会社 | 変異検出用プローブ、変異検出方法、薬効判定方法及び変異検出用キット |
| US9428812B2 (en) * | 2014-04-28 | 2016-08-30 | Insight Genetics, Inc. | Kit comprising primers for amplifying ALK kinase domain nucleic acids |
| EP3186284B1 (en) * | 2014-08-28 | 2022-04-06 | BioAtla, Inc. | Conditionally active chimeric antigen receptors for modified t-cells |
| US20170349953A1 (en) * | 2016-06-01 | 2017-12-07 | Roche Sequencing Solutions, Inc. | Novel mutations in anaplastic lymphoma kinase predicting response to alk inhibitor therapy in lung cancer patients |
| KR101872624B1 (ko) * | 2016-12-27 | 2018-06-28 | (주) 바이오인프라생명과학 | Alk 표적 치료제에 대한 폐암의 치료 반응성을 예측하는 방법 |
| CN107828823A (zh) * | 2017-09-29 | 2018-03-23 | 暨南大学 | 一种评价eml4‑alk抑制剂对肺癌治疗效果的方法 |
| RU2717309C2 (ru) * | 2018-08-01 | 2020-03-20 | Общество с ограниченной ответственностью "ОНКОДИАГНОСТИКА АТЛАС" | Способ определения микросателлитной нестабильности |
| KR102890173B1 (ko) | 2018-11-01 | 2025-11-21 | 일루미나, 인코포레이티드 | 체세포 변이 검출을 위한 방법 및 조성물 |
| IL297442A (en) | 2020-04-22 | 2022-12-01 | Iovance Biotherapeutics Inc | Systems and methods for coordinating production of cells for patient-specific immunotherapy |
| WO2024017352A1 (zh) * | 2022-07-22 | 2024-01-25 | 四川大学 | 用于rdaa阳性疾病的诊断和治疗的方法和试剂盒 |
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| WO2009103061A2 (en) | 2008-02-15 | 2009-08-20 | The Children's Hospital Of Philadelphia | Methods and compositions for identifying, diagnosing, and treating neuroblastoma |
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| EP3133167B1 (en) * | 2009-05-15 | 2018-09-12 | Insight Genetics, Inc. | Methods relating to fusions of alk for diagnosing cancer |
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