JP5912273B2 - 抗ウイルス剤及びその製造方法 - Google Patents
抗ウイルス剤及びその製造方法 Download PDFInfo
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- JP5912273B2 JP5912273B2 JP2011061283A JP2011061283A JP5912273B2 JP 5912273 B2 JP5912273 B2 JP 5912273B2 JP 2011061283 A JP2011061283 A JP 2011061283A JP 2011061283 A JP2011061283 A JP 2011061283A JP 5912273 B2 JP5912273 B2 JP 5912273B2
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- BMMGVYCKOGBVEV-UHFFFAOYSA-N oxo(oxoceriooxy)cerium Chemical compound [Ce]=O.O=[Ce]=O BMMGVYCKOGBVEV-UHFFFAOYSA-N 0.000 description 1
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- 238000002360 preparation method Methods 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
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- FZHAPNGMFPVSLP-UHFFFAOYSA-N silanamine Chemical compound [SiH3]N FZHAPNGMFPVSLP-UHFFFAOYSA-N 0.000 description 1
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Description
(実施例1)
0.5mmolのHAuCl4・4H2Oを100mlの水に溶解(5mmol/l)させ、70℃に加温してNaOH水溶液でpH4.8に調製した。その水溶液に基体としてのジルコニア粉末を5g加えて1時間攪拌した。その後、混合物を固液分離し、減圧乾燥して、窒素雰囲気下、200℃で4時間乾燥、粉砕し金ナノ微粒子担持抗ウイルス剤を得た。得た抗ウイルス剤のTEM画像を図2に示す。画像解析で分析した結果、金ナノ微粒子の平均粒子径は4.4nmであった。
実施例1において、NaOH水溶液でpH4.8に調製する代わりに、pH5.5に調製し、ジルコニア粉末の代わりにチタニア粉末を5g加えた以外は実施例1と同じ手順でサンプルを調製した。このときの金ナノ微粒子の平均粒径は4.0nmであった。
実施例1において、NaOH水溶液でpH4.8に調製する代わりに、pH5.0に調製し、ジルコニア粉末の代わりにγ-アルミナ粉末を5g加えた以外は実施例1と同じ手順でサンプルを調製した。このときの金ナノ微粒子の平均粒径は3.6nmであった。
実施例1において、NaOH水溶液でpH6.0に調製する代わりに、pH4.0に調製し、ジルコニア粉末の代わりにセリア粉末を5g加えた以外は実施例1と同じ手順でサンプル調製した。このときの金ナノ微粒子の平均粒径は3.8nmであった。
実施例1において、NaOH水溶液でpH4.8に調製する代わりに、pH8.0に調製し、ジルコニア粉末の代わりに酸化コバルト(II,III)粉末を5g加えた以外は実施例1と同じ手段でサンプルを調製した。このときの金ナノ微粒子の平均粒径は4.5nmであった。
5mmolのHAuCl4・4H2Oを50mlの水に溶解させた水溶液(100mmol/l)にハイドロキシアパタイト(サンギ製SP-1)10gを加えて1時間攪拌した。その後、混合物を固液分離し、100℃で4時間乾燥、粉砕し金担持ハイドロキシアパタイトを得た。なお、本比較例1のような含浸法で形成された金粒子の形状は接合界面周縁部のない球体状になる。
ウイルス吸着性を評価した。対象ウイルスとして、MDCK細胞を用いて培養し、精製したインフルエンザウイルス(influenza A/北九州/159/93(H3N2))を用いた。各物質と接触させたインフルエンザウイルスの赤血球凝集反応(HA)の力価(HA価)を定法により判定した。
次に、上記のウイルスを用いて、各物質と接触させたインフルエンザウイルスに対する不活化効果を定法により判定した。
さらに、別の実施例として、抗ウイルス剤を担持した繊維構造体の実施例および比較例を作成し、ウイルスに対する不活化効果を調べた。
反応性ホットメルト接着剤として積水フーラー株式会社製のTL-0511を、ノードソン株式会社製ALTA400シグレチャースプレーガンより糸状に吐出させ、粘着性を有する繊維構造体を作製した。次に、実施例1の抗ウイルス剤を接触させて、粘着性を有する反応性ホットメルト接着剤からなる繊維構造体の繊維表面に付着させ、湿度60%、50℃の環境で4時間反応させて反応性ホットメルト接着剤を硬化させ、抗ウイルス性を有する繊維構造体を得た。
無機微粒子として、チタニア微粒子をメタノールに対して10.0質量%、シランモノマーとして3−メタクリロキシプロピルトリメトキシシランを無機微粒子に対して5.0質量%加えてpHを3.0に塩酸で調製した後、ビーズミルにより平均粒子径18nmに粉砕分散した。その後、凍結乾燥機により固液分離して120℃で加熱し、シランモノマーをチタニア微粒子の表面に脱水縮合反応により化学結合させて被覆を形成した。得られた表面処理されたチタニア微粒子をメタノールに10.0質量%に調製し、ビーズミルにより平均粒子径16nmに再度粉砕分散した。
実施例1の抗ウイルス剤を混合しない以外は実施例6と同じ方法で作成したホットメルト不織布を比較例2とした。
表面に何も担持しないPET製不織布を比較例3とした。
実施例6および実施例7の抗ウイルス性フィルター(抗ウイルス性繊維構造体)並びに比較例2、3を4cm×4cmにカットし、プラスチックシャーレにいれ、ウイルス液0.1 mlを滴下し、室温で60分間作用させた。このとき試験品の上面をPPフィルム(4cm×4cm)で覆うことで、ウイルス液と試験品の接触面積を一定にし、試験を行った。60分間作用させたのち、20mg/mlのブイヨン蛋白液を900μlを添加し、ピペッティングによりウイルスを洗い出した。その後、各反応サンプルが10-2〜10-5になるまでMEM希釈液にて希釈を行った(10倍段階希釈)。シャーレに培養したMDCK細胞にサンプル液100μLを接種した。90分間静置しウイルスを細胞へ吸着させた後、0.7%寒天培地を重層し、48時間、34℃、5%CO2インキュベータにて培養後、ホルマリン固定、メチレンブルー染色を行い形成されたプラック数をカウントして、ウイルスの感染価(PFU/0.1ml,Log10);(PFU:plaque-forming units)を算出した。その測定結果を表3に示す。
2 接合界面周縁部(エッジ部)
10 金ナノ微粒子
20 基体
100 本実施形態の抗ウイルス剤
Claims (2)
- pHが4.0〜8.0の金化合物水溶液を無機微粒子からなる基体と接触させ、
前記金化合物水溶液と接触させた前記基体を100〜200℃で加熱乾燥することにより前記基体の表面に接合界面周縁部を有する状態で金ナノ微粒子を接合することを含む抗ウイルス剤の製造方法。 - 前記無機微粒子が金属酸化物からなることを特徴とする請求項1に記載の抗ウイルス剤の製造方法。
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