JP5907357B2 - 移植臓器生着促進剤 - Google Patents
移植臓器生着促進剤 Download PDFInfo
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- JP5907357B2 JP5907357B2 JP2013538423A JP2013538423A JP5907357B2 JP 5907357 B2 JP5907357 B2 JP 5907357B2 JP 2013538423 A JP2013538423 A JP 2013538423A JP 2013538423 A JP2013538423 A JP 2013538423A JP 5907357 B2 JP5907357 B2 JP 5907357B2
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- JP
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- Prior art keywords
- organ
- iron
- transplantation
- transplanted
- survival
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000000056 organ Anatomy 0.000 title claims description 233
- 230000004083 survival effect Effects 0.000 title claims description 91
- 238000002054 transplantation Methods 0.000 claims description 108
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 40
- 150000002506 iron compounds Chemical class 0.000 claims description 38
- 150000003839 salts Chemical class 0.000 claims description 33
- 150000001875 compounds Chemical class 0.000 claims description 23
- 229910052742 iron Inorganic materials 0.000 claims description 20
- 239000003761 preservation solution Substances 0.000 claims description 19
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 16
- 239000003755 preservative agent Substances 0.000 claims description 16
- 239000003018 immunosuppressive agent Substances 0.000 claims description 15
- 230000002335 preservative effect Effects 0.000 claims description 15
- 230000001737 promoting effect Effects 0.000 claims description 13
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 10
- 229960003444 immunosuppressant agent Drugs 0.000 claims description 9
- 125000002252 acyl group Chemical group 0.000 claims description 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 8
- 230000001861 immunosuppressant effect Effects 0.000 claims description 8
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 7
- JHYAVWJELFKHLM-UHFFFAOYSA-H tetrasodium;2-hydroxypropane-1,2,3-tricarboxylate;iron(2+) Chemical compound [Na+].[Na+].[Na+].[Na+].[Fe+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O JHYAVWJELFKHLM-UHFFFAOYSA-H 0.000 claims description 6
- KXFFQVUPQCREHA-UHFFFAOYSA-K sodium;2-hydroxypropane-1,2,3-tricarboxylate;iron(2+) Chemical compound [Na+].[Fe+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KXFFQVUPQCREHA-UHFFFAOYSA-K 0.000 claims description 5
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 4
- YNVZDODIHZTHOZ-UHFFFAOYSA-K 2-hydroxypropanoate;iron(3+) Chemical compound [Fe+3].CC(O)C([O-])=O.CC(O)C([O-])=O.CC(O)C([O-])=O YNVZDODIHZTHOZ-UHFFFAOYSA-K 0.000 claims description 3
- 229920002307 Dextran Polymers 0.000 claims description 3
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 claims description 3
- 102000008857 Ferritin Human genes 0.000 claims description 3
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- JVOGSHDZLOJKKR-MXFMKSRJSA-I [Na+].[Na+].[Na+].[Mg++].CCc1c(C)c2cc3[n-]c(c(C)c3C=C)c(C)c3nc(C[C@H]3CCC([O-])=O)c(CC([O-])=O)c3[n-]c(cc1n2)c(C)c3C([O-])=O Chemical compound [Na+].[Na+].[Na+].[Mg++].CCc1c(C)c2cc3[n-]c(c(C)c3C=C)c(C)c3nc(C[C@H]3CCC([O-])=O)c(CC([O-])=O)c3[n-]c(cc1n2)c(C)c3C([O-])=O JVOGSHDZLOJKKR-MXFMKSRJSA-I 0.000 claims description 3
- PLKYGPRDCKGEJH-UHFFFAOYSA-N azane;2-hydroxypropane-1,2,3-tricarboxylic acid;iron Chemical compound N.[Fe].OC(=O)CC(O)(C(O)=O)CC(O)=O PLKYGPRDCKGEJH-UHFFFAOYSA-N 0.000 claims description 3
- MDXRFOWKIZPNTA-UHFFFAOYSA-L butanedioate;iron(2+) Chemical compound [Fe+2].[O-]C(=O)CCC([O-])=O MDXRFOWKIZPNTA-UHFFFAOYSA-L 0.000 claims description 3
- FJZZHNSAKKNYJJ-QTNFYWBSSA-N diazanium;(2s)-2-(dicarboxymethylamino)pentanedioate Chemical compound [NH4+].[NH4+].OC(=O)C(C(O)=O)N[C@H](C([O-])=O)CCC([O-])=O FJZZHNSAKKNYJJ-QTNFYWBSSA-N 0.000 claims description 3
- VEPSWGHMGZQCIN-UHFFFAOYSA-H ferric oxalate Chemical compound [Fe+3].[Fe+3].[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O VEPSWGHMGZQCIN-UHFFFAOYSA-H 0.000 claims description 3
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- 150000003278 haem Chemical class 0.000 claims description 3
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 claims description 3
- ATEAWHILRRXHPW-UHFFFAOYSA-J iron(2+);phosphonato phosphate Chemical compound [Fe+2].[Fe+2].[O-]P([O-])(=O)OP([O-])([O-])=O ATEAWHILRRXHPW-UHFFFAOYSA-J 0.000 claims description 3
- PVFSDGKDKFSOTB-UHFFFAOYSA-K iron(3+);triacetate Chemical compound [Fe+3].CC([O-])=O.CC([O-])=O.CC([O-])=O PVFSDGKDKFSOTB-UHFFFAOYSA-K 0.000 claims description 3
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- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims description 3
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- 235000021242 lactoferrin Nutrition 0.000 claims description 3
- BKJXSPNFVILSSW-UHFFFAOYSA-N n'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine;iron Chemical compound [Fe].NCCNCCNCCN BKJXSPNFVILSSW-UHFFFAOYSA-N 0.000 claims description 3
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- SRFKWQSWMOPVQK-UHFFFAOYSA-K sodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxymethyl)amino]acetate;iron(2+) Chemical compound [Na+].[Fe+2].OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O SRFKWQSWMOPVQK-UHFFFAOYSA-K 0.000 claims description 3
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- 239000012581 transferrin Substances 0.000 claims description 3
- LPOSZYSKJWFIQH-UHFFFAOYSA-N 2-aminoacetic acid;iron Chemical compound [Fe].NCC(O)=O LPOSZYSKJWFIQH-UHFFFAOYSA-N 0.000 claims description 2
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Landscapes
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| JP2013538423A JP5907357B2 (ja) | 2011-10-12 | 2012-09-12 | 移植臓器生着促進剤 |
| PCT/JP2012/005782 WO2013054470A1 (fr) | 2011-10-12 | 2012-09-12 | Agent d'amélioration de la survie d'un organe transplanté |
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| TWI571455B (zh) * | 2011-12-07 | 2017-02-21 | Sbi Pharmaceuticals Co Ltd | To prevent alcohol from causing discomfort to the human body of the hangover preventive agent and / or therapeutic agent |
| HUE043511T2 (hu) * | 2012-07-13 | 2019-08-28 | Sbi Pharmaceuticals Co Ltd | Immuntoleranciát kiváltó szer |
| CN107148215A (zh) * | 2014-05-30 | 2017-09-08 | 思佰益药业股份有限公司 | 器官保存液 |
| PL2977056T3 (pl) | 2014-07-11 | 2019-03-29 | Grifols Worldwide Operations Limited | Transferryna do zastosowania w leczeniu zaburzeń neurodegeneracyjnych związanych z czynnikiem indukowanym hipoksją (HIF) |
| WO2016057536A1 (fr) * | 2014-10-06 | 2016-04-14 | Myostar, Llc | Procédés de préparation de tissu de donneur pour une transplantation |
| CN112010772A (zh) * | 2016-01-26 | 2020-12-01 | 赵鸣 | 5-氨基酮戊酸及其衍生物的盐化合物和应用 |
| JPWO2018043240A1 (ja) * | 2016-09-02 | 2019-06-24 | Ｓｂｉファーマ株式会社 | ５−アミノレブリン酸類を含む水性製剤 |
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| JP4590041B2 (ja) | 1998-12-24 | 2010-12-01 | 株式会社林原生物化学研究所 | 臓器保存剤 |
| JP5230042B2 (ja) * | 1999-06-02 | 2013-07-10 | 株式会社ビーエムジー | 動物の細胞または臓器の保存剤およびその保存方法。 |
| JP5008810B2 (ja) | 2000-04-11 | 2012-08-22 | ユニバーシティ オブ サザン カリフォルニア | 抑制性Ｔ細胞を誘導するためにＴＧＦ−βを用いる移植拒絶反応を防止する方法 |
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| WO2002098431A1 (fr) | 2001-06-01 | 2002-12-12 | National Jewish Medical And Research Center | Capteurs oxydants destines au traitement du diabete ou a etre utilises dans une transplantation ou a induire une tolerance immunitaire |
| US20040235162A1 (en) | 2003-03-18 | 2004-11-25 | Kirin Beer Kabushiki Kaisha | Method of preparing immunoregulatory dendritic cells and the use thereof |
| US20050032210A1 (en) | 2003-03-18 | 2005-02-10 | Kirin Beer Kabushiki Kaisha | Method of preparing immuno-regulatory dendritic cells and the use thereof |
| JP4547174B2 (ja) | 2003-03-18 | 2010-09-22 | 協和発酵キリン株式会社 | 免疫制御性樹状細胞の調製法およびその用途 |
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| EP1785132B1 (fr) * | 2004-09-02 | 2014-04-09 | Cosmo Oil Co., Ltd. | Agents d'amélioration de fonctions constitutionnelles |
| JP4814567B2 (ja) * | 2004-09-02 | 2011-11-16 | コスモ石油株式会社 | 健康機能向上剤 |
| US20070141548A1 (en) * | 2005-03-11 | 2007-06-21 | Jorg Kohl | Organ transplant solutions and method for transplanting organs |
| JP4919453B2 (ja) | 2005-04-07 | 2012-04-18 | 独立行政法人理化学研究所 | 炎症性疾患の予防又は治療剤 |
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| WO2007100154A1 (fr) | 2006-03-03 | 2007-09-07 | Riken | Therapie immunitaire contre une maladie allergique utilisant une cellule dendritique regulatrice |
| JP5150091B2 (ja) | 2006-11-01 | 2013-02-20 | 日本澱粉工業株式会社 | 低酸素状態下での細胞及び心臓保存剤 |
| CN101970643A (zh) | 2007-11-30 | 2011-02-09 | 特拉科斯有限公司 | 用活体外扩增的cd4+cd25+调节性t细胞降低移植物抗宿主病效应的方法 |
| JP2009221128A (ja) | 2008-03-14 | 2009-10-01 | Seizo Fujikawa | 臓器保存液および臓器保存方法 |
| CA2722578C (fr) | 2008-05-14 | 2014-02-11 | Sbi Alapromo Co., Ltd. | Utilisation de l'acide .delta.-aminolevulinique pour traiter la sterilite chez l'homme |
| KR20110036570A (ko) | 2008-06-06 | 2011-04-07 | 베일러 리서치 인스티튜트 | 수지상 세포를 관용원성이 되게 하는 호흡기 합포체 바이러스 |
| JP5295652B2 (ja) * | 2008-06-16 | 2013-09-18 | Ｓｂｉファーマ株式会社 | 光障害の軽減剤 |
| EP3192506A3 (fr) | 2008-10-27 | 2017-10-25 | SBI Pharmaceuticals Co., Ltd. | Agent prophylactique/améliorant pour les maladies d'adulte comprenant de l'acide 5 aminolévulinique, un dérivé d'acide 5 aminolévulinique ou un sel d'acide 5 aminolévulinique ou son dérivé ou de l'acide 5 aminolévulinique en tant qu'ingrédient actif |
| JP2009143939A (ja) | 2009-01-27 | 2009-07-02 | Tsujido Chemical Corp | 治療剤 |
| JP5611548B2 (ja) | 2009-07-08 | 2014-10-22 | Ｓｂｉファーマ株式会社 | ５−アミノレブリン酸若しくはその誘導体、又はそれらの塩を有効成分とするがんの予防・改善剤 |
| JP5954727B2 (ja) | 2009-10-21 | 2016-07-20 | 国立大学法人愛媛大学 | 自己免疫疾患治療に用いる新規抗原としての炭酸脱水酵素ｉ |
| WO2011105394A1 (fr) | 2010-02-23 | 2011-09-01 | 日本化薬株式会社 | Procédé pour produire des dendrocytes régulateurs |
| CN102905702A (zh) | 2010-05-19 | 2013-01-30 | 思佰益药业股份有限公司 | 以5-氨基乙酰丙酸或其衍生物作为有效成分的抗疟药 |
| EP2722041B1 (fr) | 2011-06-16 | 2018-10-24 | SBI Pharmaceuticals Co., Ltd. | Agent thérapeutique pour la rhinite allergique |
| JP5907357B2 (ja) | 2011-10-12 | 2016-04-26 | Ｓｂｉファーマ株式会社 | 移植臓器生着促進剤 |
| HUE043511T2 (hu) * | 2012-07-13 | 2019-08-28 | Sbi Pharmaceuticals Co Ltd | Immuntoleranciát kiváltó szer |
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- 2012-09-12 US US14/350,488 patent/US9314443B2/en active Active
- 2012-09-12 CN CN201280050051.4A patent/CN103930103B/zh active Active
- 2012-09-12 CN CN201610615612.0A patent/CN106110326A/zh active Pending
- 2012-09-12 EP EP12839496.2A patent/EP2767278B1/fr active Active
- 2012-09-12 WO PCT/JP2012/005782 patent/WO2013054470A1/fr active Application Filing
- 2012-09-25 TW TW101135180A patent/TWI543762B/zh active
- 2012-09-25 TW TW105118232A patent/TWI612958B/zh active
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2767278A4 (fr) | 2015-04-08 |
| WO2013054470A1 (fr) | 2013-04-18 |
| TWI612958B (zh) | 2018-02-01 |
| CN103930103B (zh) | 2016-08-24 |
| US20140249217A1 (en) | 2014-09-04 |
| US9937138B2 (en) | 2018-04-10 |
| CN103930103A (zh) | 2014-07-16 |
| CN106110326A (zh) | 2016-11-16 |
| EP2767278B1 (fr) | 2019-11-06 |
| EP2767278A1 (fr) | 2014-08-20 |
| JPWO2013054470A1 (ja) | 2015-03-30 |
| HK1195008A1 (zh) | 2014-10-31 |
| US20160206582A1 (en) | 2016-07-21 |
| TW201325586A (zh) | 2013-07-01 |
| US9314443B2 (en) | 2016-04-19 |
| JP2016106113A (ja) | 2016-06-16 |
| US20160184250A1 (en) | 2016-06-30 |
| TWI543762B (zh) | 2016-08-01 |
| JP6172724B2 (ja) | 2017-08-02 |
| US9901558B2 (en) | 2018-02-27 |
| TW201632178A (zh) | 2016-09-16 |
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