JP5890846B2 - ポリフェノールの新規合成方法 - Google Patents

ポリフェノールの新規合成方法 Download PDF

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Publication number
JP5890846B2
JP5890846B2 JP2013551012A JP2013551012A JP5890846B2 JP 5890846 B2 JP5890846 B2 JP 5890846B2 JP 2013551012 A JP2013551012 A JP 2013551012A JP 2013551012 A JP2013551012 A JP 2013551012A JP 5890846 B2 JP5890846 B2 JP 5890846B2
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Japan
Prior art keywords
formula
compound
group
epicatechin
chloride
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JP2013551012A
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English (en)
Japanese (ja)
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JP2014509312A (ja
JP2014509312A5 (enExample
Inventor
スンディープ デュガル
スンディープ デュガル
ディネシュ マハジャン
ディネシュ マハジャン
パンテリス ピーター ジャンヌーシス
パンテリス ピーター ジャンヌーシス
ヴィジャイ シン
ヴィジャイ シン
カマル キショア カプール
カマル キショア カプール
Original Assignee
スファエラ ファーマ ピーティーイー リミテッド
スファエラ ファーマ ピーティーイー リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pyrane Compounds (AREA)
JP2013551012A 2011-01-27 2012-01-24 ポリフェノールの新規合成方法 Expired - Fee Related JP5890846B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN196DE2011 2011-01-27
IN196/DEL/2011 2011-01-27
PCT/IN2012/000052 WO2012101652A2 (en) 2011-01-27 2012-01-24 A novel process for synthesis of polyphenols

Publications (3)

Publication Number Publication Date
JP2014509312A JP2014509312A (ja) 2014-04-17
JP2014509312A5 JP2014509312A5 (enExample) 2015-03-19
JP5890846B2 true JP5890846B2 (ja) 2016-03-22

Family

ID=46581222

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013551012A Expired - Fee Related JP5890846B2 (ja) 2011-01-27 2012-01-24 ポリフェノールの新規合成方法

Country Status (7)

Country Link
US (1) US9428482B2 (enExample)
EP (1) EP2668176B1 (enExample)
JP (1) JP5890846B2 (enExample)
CN (1) CN103582635B (enExample)
ES (1) ES2636441T3 (enExample)
TW (1) TWI697489B (enExample)
WO (1) WO2012101652A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9556140B2 (en) 2013-01-26 2017-01-31 Sphaera Pharma Pvt. Ltd. Approach for synthesis of catechins
WO2014162320A2 (en) 2013-04-04 2014-10-09 Sphaera Pharma Pvt. Ltd. Novel analogues of epicatechin and related polyphenols
CN106714770B (zh) 2014-07-23 2024-04-19 斯法尔制药私人有限公司 羟基类固醇化合物、其中间体、制备方法、组合物及其用途
WO2017221269A1 (en) * 2016-06-21 2017-12-28 Sphaera Pharma Pvt. Ltd., Utility of (+) epicatechin and their analogs
CN105949161B (zh) * 2016-06-28 2018-05-15 温州大学 一种3-芳巯基黄酮化合物的制备方法
CN106946835B (zh) * 2017-04-25 2019-03-01 广州科技职业技术学院 橙皮素酯化物及其制备方法和应用
EP3677577A4 (en) * 2017-08-28 2021-04-28 NBC Meshtec, Inc. POLYPHENOL PRODUCTION PROCESS
JP2022512811A (ja) 2018-10-24 2022-02-07 エピリウム バイオ インコーポレイテッド エピカテキンとカルボキシ－ｎ－複素環式共結晶形成剤とを含む共結晶

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2122608B (en) * 1982-06-01 1985-10-02 Zyma Sa (+)-cyanidan-3-ol derivatives
EP0445819B1 (en) * 1990-03-08 2001-08-22 Fuji Photo Film Co., Ltd. Positive type photoresist composition
US6476241B1 (en) * 2000-09-05 2002-11-05 Mars Incorporated Synthesis of 4α-arylepicatechins
US20060234957A1 (en) * 2003-03-03 2006-10-19 Takanori Tsuda Adiponectin expression promoter
JP5339664B2 (ja) * 2004-02-13 2013-11-13 花王株式会社 Ａｍｐｋ活性化剤
JP2006083105A (ja) * 2004-09-16 2006-03-30 Ito En Ltd 血液流動性改善剤および飲食物
AU2006263557A1 (en) * 2005-06-29 2007-01-04 Mars, Incorporated Preparation of (+)-catechin, (-)-epicatechin, (-)-catechin, (+)-epicatechin, and their 5,7,3',4'-tetra-O-benzyl analogues
US20100204204A1 (en) * 2007-06-06 2010-08-12 University Of South Florida Nutraceutical co-crystal compositions
JP5382676B2 (ja) * 2007-12-07 2014-01-08 国立大学法人名古屋大学 アントシアニジン類の製造方法

Also Published As

Publication number Publication date
CN103582635A (zh) 2014-02-12
JP2014509312A (ja) 2014-04-17
CN103582635B (zh) 2019-02-19
TWI697489B (zh) 2020-07-01
US9428482B2 (en) 2016-08-30
ES2636441T8 (es) 2018-12-14
WO2012101652A3 (en) 2012-12-27
EP2668176B1 (en) 2017-05-17
US20140031421A1 (en) 2014-01-30
EP2668176A4 (en) 2014-08-27
WO2012101652A2 (en) 2012-08-02
ES2636441T3 (es) 2017-10-05
TW201309662A (zh) 2013-03-01
EP2668176A2 (en) 2013-12-04

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