CN103582635B - 用于合成多酚的方法 - Google Patents

用于合成多酚的方法 Download PDF

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Publication number
CN103582635B
CN103582635B CN201280010653.7A CN201280010653A CN103582635B CN 103582635 B CN103582635 B CN 103582635B CN 201280010653 A CN201280010653 A CN 201280010653A CN 103582635 B CN103582635 B CN 103582635B
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compound
formula
solvent
acid
method described
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CN103582635A (zh
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松迪普·杜加尔
迪内希·马哈詹
潘泰利斯·彼得·詹努西斯
维贾伊·辛格
卡马尔·基肖尔·卡普尔
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Sphaera Pharma Pte Ltd
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Sphaera Pharma Pte Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201280010653.7A 2011-01-27 2012-01-24 用于合成多酚的方法 Active CN103582635B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN196DE2011 2011-01-27
IN196/DEL/2011 2011-01-27
PCT/IN2012/000052 WO2012101652A2 (en) 2011-01-27 2012-01-24 A novel process for synthesis of polyphenols

Publications (2)

Publication Number Publication Date
CN103582635A CN103582635A (zh) 2014-02-12
CN103582635B true CN103582635B (zh) 2019-02-19

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Country Status (7)

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US (1) US9428482B2 (enExample)
EP (1) EP2668176B1 (enExample)
JP (1) JP5890846B2 (enExample)
CN (1) CN103582635B (enExample)
ES (1) ES2636441T3 (enExample)
TW (1) TWI697489B (enExample)
WO (1) WO2012101652A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9556140B2 (en) 2013-01-26 2017-01-31 Sphaera Pharma Pvt. Ltd. Approach for synthesis of catechins
WO2014162320A2 (en) 2013-04-04 2014-10-09 Sphaera Pharma Pvt. Ltd. Novel analogues of epicatechin and related polyphenols
CN106714770B (zh) 2014-07-23 2024-04-19 斯法尔制药私人有限公司 羟基类固醇化合物、其中间体、制备方法、组合物及其用途
WO2017221269A1 (en) * 2016-06-21 2017-12-28 Sphaera Pharma Pvt. Ltd., Utility of (+) epicatechin and their analogs
CN105949161B (zh) * 2016-06-28 2018-05-15 温州大学 一种3-芳巯基黄酮化合物的制备方法
CN106946835B (zh) * 2017-04-25 2019-03-01 广州科技职业技术学院 橙皮素酯化物及其制备方法和应用
EP3677577A4 (en) * 2017-08-28 2021-04-28 NBC Meshtec, Inc. POLYPHENOL PRODUCTION PROCESS
JP2022512811A (ja) 2018-10-24 2022-02-07 エピリウム バイオ インコーポレイテッド エピカテキンとカルボキシ－ｎ－複素環式共結晶形成剤とを含む共結晶

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GB2122608B (en) * 1982-06-01 1985-10-02 Zyma Sa (+)-cyanidan-3-ol derivatives
EP0445819B1 (en) * 1990-03-08 2001-08-22 Fuji Photo Film Co., Ltd. Positive type photoresist composition
US6476241B1 (en) * 2000-09-05 2002-11-05 Mars Incorporated Synthesis of 4α-arylepicatechins
US20060234957A1 (en) * 2003-03-03 2006-10-19 Takanori Tsuda Adiponectin expression promoter
JP5339664B2 (ja) * 2004-02-13 2013-11-13 花王株式会社 Ａｍｐｋ活性化剤
JP2006083105A (ja) * 2004-09-16 2006-03-30 Ito En Ltd 血液流動性改善剤および飲食物
AU2006263557A1 (en) * 2005-06-29 2007-01-04 Mars, Incorporated Preparation of (+)-catechin, (-)-epicatechin, (-)-catechin, (+)-epicatechin, and their 5,7,3',4'-tetra-O-benzyl analogues
US20100204204A1 (en) * 2007-06-06 2010-08-12 University Of South Florida Nutraceutical co-crystal compositions
JP5382676B2 (ja) * 2007-12-07 2014-01-08 国立大学法人名古屋大学 アントシアニジン類の製造方法

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
A Zanarotti.SYNTHESIS OF A FLAV-3-EN-3-OL VIA CINNAMYLPHENOL.《Tetrahedron Letters》.1982,第23卷(第38期),第3963-3964页. *
A.C. Waiss et al..Synthesis of flav-2-enes and flav-3-enes.《Chemistry and Industry》.1968,第743-744页. *
ANTHOCYANINS AND RELATED COMPOUNDS-V FORMATION OF BISFLAVENYLIDENES FROM FLAVONES BY REDUCTIVE DIMERIZATION;B.J.Bergot et al.;《Tetrahedron》;19651231;第21卷;第657-661页 *
Flavonoid binding to human serum albumin;Alessandro Bolli et al.;《Biochemical and Biophysical Research Communications》;20100627;第398卷;第444-449页 *
J. G. Sweeny et al..SYNTHESIS OF ANTHOCYANIDINS-I THE OXIDATIVE GENERATION OF FLAVYLIUM CATIONS USING BENZOQUINONES.《Tetrahedron》.1977,第33卷第2923-2926页. *
Rapid characterization of wood extractives in Wood by thermal desorption-gas Chromatography in the presence of Tetramethylammonium acetate;Hiroaki Yokoi et, al;《Journal of Analytical and Applied Pyrolysis》;20031231;第67卷;第191-200页 *
Selective Monomethylation of Quercetin;Zhong-Hua Zhou et. al.;《Synthesis》;20101021(第23期);第3980-3986页 *
SYNTHESIS OF A FLAV-3-EN-3-OL VIA CINNAMYLPHENOL;A Zanarotti;《Tetrahedron Letters》;19821231;第23卷(第38期);第3963-3964页 *
SYNTHESIS OF ANTHOCYANIDINS-I THE OXIDATIVE GENERATION OF FLAVYLIUM CATIONS USING BENZOQUINONES;J. G. Sweeny et al.;《Tetrahedron》;19771231;第33卷;第2923-2926页 *
Synthesis of flav-2-enes and flav-3-enes;A.C. Waiss et al.;《Chemistry and Industry》;19680608;第743-744页 *

Also Published As

Publication number Publication date
CN103582635A (zh) 2014-02-12
JP2014509312A (ja) 2014-04-17
TWI697489B (zh) 2020-07-01
JP5890846B2 (ja) 2016-03-22
US9428482B2 (en) 2016-08-30
ES2636441T8 (es) 2018-12-14
WO2012101652A3 (en) 2012-12-27
EP2668176B1 (en) 2017-05-17
US20140031421A1 (en) 2014-01-30
EP2668176A4 (en) 2014-08-27
WO2012101652A2 (en) 2012-08-02
ES2636441T3 (es) 2017-10-05
TW201309662A (zh) 2013-03-01
EP2668176A2 (en) 2013-12-04

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