JP5854371B2 - カルシウム拮抗薬/アンジオテンシンii受容体拮抗薬含有医薬製剤 - Google Patents

カルシウム拮抗薬/アンジオテンシンii受容体拮抗薬含有医薬製剤 Download PDF

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Publication number
JP5854371B2
JP5854371B2 JP2014540902A JP2014540902A JP5854371B2 JP 5854371 B2 JP5854371 B2 JP 5854371B2 JP 2014540902 A JP2014540902 A JP 2014540902A JP 2014540902 A JP2014540902 A JP 2014540902A JP 5854371 B2 JP5854371 B2 JP 5854371B2
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mass
disintegrant
angiotensin
antagonist
receptor antagonist
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JPWO2014058046A1 (ja
Inventor
友紀子 田中
友紀子 田中
一郎 原
一郎 原
祐幸 樋口
祐幸 樋口
智也 小野下
智也 小野下
晶子 寺本
晶子 寺本
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Ajinomoto Co Inc
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Ajinomoto Co Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/44221,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014540902A 2012-10-12 2013-10-11 カルシウム拮抗薬/アンジオテンシンii受容体拮抗薬含有医薬製剤 Active JP5854371B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2014540902A JP5854371B2 (ja) 2012-10-12 2013-10-11 カルシウム拮抗薬/アンジオテンシンii受容体拮抗薬含有医薬製剤

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2012226983 2012-10-12
JP2012226983 2012-10-12
PCT/JP2013/077729 WO2014058046A1 (ja) 2012-10-12 2013-10-11 カルシウム拮抗薬/アンジオテンシンii受容体拮抗薬含有医薬製剤
JP2014540902A JP5854371B2 (ja) 2012-10-12 2013-10-11 カルシウム拮抗薬/アンジオテンシンii受容体拮抗薬含有医薬製剤

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JP2014182380A Division JP6231959B2 (ja) 2012-10-12 2014-09-08 カルシウム拮抗薬/アンジオテンシンii受容体拮抗薬含有医薬製剤

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JP5854371B2 true JP5854371B2 (ja) 2016-02-09
JPWO2014058046A1 JPWO2014058046A1 (ja) 2016-09-05

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JP2014182380A Active JP6231959B2 (ja) 2012-10-12 2014-09-08 カルシウム拮抗薬/アンジオテンシンii受容体拮抗薬含有医薬製剤

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JP (2) JP5854371B2 (ko)
KR (2) KR20160128449A (ko)
TW (1) TWI586353B (ko)
WO (1) WO2014058046A1 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112017015788B1 (pt) 2015-01-26 2023-05-16 Daiichi Sankyo Company, Limited Composição sólida, e, método de fabricação para uma composição sólida
JP5897196B1 (ja) 2015-10-05 2016-03-30 大同化成工業株式会社 糖又は糖アルコール、膨潤型結合剤、崩壊剤及び高吸収性賦形剤を含む複合化造粒物及びその製造方法
CN106236753A (zh) * 2016-08-29 2016-12-21 许昌恒生制药有限公司 一种用于治疗高血压的盐酸马尼地平和缬沙坦复方片剂及其制备方法
KR101769293B1 (ko) * 2016-09-30 2017-08-30 주식회사 종근당 칸데사르탄 및 암로디핀을 포함하는 단일층으로 이루어진 복합제
JP2018172361A (ja) * 2016-10-14 2018-11-08 大原薬品工業株式会社 光安定性を改善した、デュロキセチンを含有する固形製剤
KR20220002147A (ko) 2020-06-30 2022-01-06 한국원자력의학원 니솔디핀을 유효성분으로 함유하는 방사선 민감성 증진용 조성물

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3110794B2 (ja) * 1991-06-05 2000-11-20 ユーシービージャパン株式会社 1,4−ジヒドロピリジン誘導体を含有する製剤
JP2003104888A (ja) * 2001-09-28 2003-04-09 Taiyo Yakuhin Kogyo Kk ジヒドロピリジン誘導体の錠剤
JP2008044871A (ja) * 2006-08-11 2008-02-28 Ajinomoto Co Inc 心血管疾患予防・治療剤
JP2008081512A (ja) * 2006-04-19 2008-04-10 Ajinomoto Co Inc 固体分散体のフィルムコーティング方法
JP2008133258A (ja) * 2006-08-08 2008-06-12 Shin Etsu Chem Co Ltd 腸溶性固体分散体の固形製剤及びその製造方法
JP2009521526A (ja) * 2005-12-27 2009-06-04 ハンミ ファーム. シーオー., エルティーディー. カンシル酸アムロジピン及びシンバスタチンを含む複合製剤及びその製造方法
WO2012063498A2 (ja) * 2010-11-12 2012-05-18 富士化学工業株式会社 新規なエキセメスタン固体分散体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101252863B1 (ko) * 2004-04-08 2013-04-09 교와 핫꼬 기린 가부시키가이샤 안정성이 향상된 고형 제제 및 그 제조 방법
WO2007001067A2 (en) * 2005-06-27 2007-01-04 Daiichi Sankyo Company, Limited Solid dosage form comprising an angiotensin ii receptor antagonist and a calcium channel blocker
KR101434316B1 (ko) * 2006-04-19 2014-08-28 아지노모토 가부시키가이샤 고체 분산체의 필름 코팅방법
US20080051438A1 (en) * 2006-08-11 2008-02-28 Shinobu Nagahama Preventive/Therapeutic Compositions Useful for Treating Cardiovascular Diseases
KR101778050B1 (ko) * 2012-10-12 2017-09-13 이에이 파마 가부시키가이샤 칼슘 길항약/안지오텐신 ii 수용체 길항약 함유 의약 제제의 제조 방법

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3110794B2 (ja) * 1991-06-05 2000-11-20 ユーシービージャパン株式会社 1,4−ジヒドロピリジン誘導体を含有する製剤
JP2003104888A (ja) * 2001-09-28 2003-04-09 Taiyo Yakuhin Kogyo Kk ジヒドロピリジン誘導体の錠剤
JP2009521526A (ja) * 2005-12-27 2009-06-04 ハンミ ファーム. シーオー., エルティーディー. カンシル酸アムロジピン及びシンバスタチンを含む複合製剤及びその製造方法
JP2008081512A (ja) * 2006-04-19 2008-04-10 Ajinomoto Co Inc 固体分散体のフィルムコーティング方法
JP2008133258A (ja) * 2006-08-08 2008-06-12 Shin Etsu Chem Co Ltd 腸溶性固体分散体の固形製剤及びその製造方法
JP2008044871A (ja) * 2006-08-11 2008-02-28 Ajinomoto Co Inc 心血管疾患予防・治療剤
WO2012063498A2 (ja) * 2010-11-12 2012-05-18 富士化学工業株式会社 新規なエキセメスタン固体分散体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6014048862; 薬学雑誌 vol.124, no.1, 2004, p.19-23 *

Also Published As

Publication number Publication date
KR20150068993A (ko) 2015-06-22
WO2014058046A1 (ja) 2014-04-17
KR101725462B1 (ko) 2017-04-11
JP2015007116A (ja) 2015-01-15
TWI586353B (zh) 2017-06-11
JP6231959B2 (ja) 2017-11-15
JPWO2014058046A1 (ja) 2016-09-05
TW201427661A (zh) 2014-07-16
KR20160128449A (ko) 2016-11-07

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