JP5847156B2 - 肝細胞がんの処置方法 - Google Patents

肝細胞がんの処置方法 Download PDF

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Publication number
JP5847156B2
JP5847156B2 JP2013501523A JP2013501523A JP5847156B2 JP 5847156 B2 JP5847156 B2 JP 5847156B2 JP 2013501523 A JP2013501523 A JP 2013501523A JP 2013501523 A JP2013501523 A JP 2013501523A JP 5847156 B2 JP5847156 B2 JP 5847156B2
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composition
hcc
individual
nanoparticles
taxane
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JP2013523656A5 (enExample
JP2013523656A (ja
Inventor
ワイニー イーオ，
ワイニー イーオ，
ナタリー ウォン，
ナタリー ウォン，
Original Assignee
アブラクシス バイオサイエンス， エルエルシー
アブラクシス バイオサイエンス， エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013501523A 2010-03-26 2011-03-25 肝細胞がんの処置方法 Active JP5847156B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31815310P 2010-03-26 2010-03-26
US61/318,153 2010-03-26
PCT/US2011/030037 WO2011119988A1 (en) 2010-03-26 2011-03-25 Methods of treatment of hepatocellular carcinoma

Related Child Applications (1)

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JP2015091142A Division JP2015134825A (ja) 2010-03-26 2015-04-28 肝細胞がんの処置方法

Publications (3)

Publication Number Publication Date
JP2013523656A JP2013523656A (ja) 2013-06-17
JP2013523656A5 JP2013523656A5 (enExample) 2014-05-08
JP5847156B2 true JP5847156B2 (ja) 2016-01-20

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JP2013501523A Active JP5847156B2 (ja) 2010-03-26 2011-03-25 肝細胞がんの処置方法
JP2015091142A Pending JP2015134825A (ja) 2010-03-26 2015-04-28 肝細胞がんの処置方法

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US (3) US9370494B2 (enExample)
EP (2) EP2898884B1 (enExample)
JP (2) JP5847156B2 (enExample)
KR (1) KR101786142B1 (enExample)
CN (2) CN103052385B (enExample)
AU (1) AU2011230512B2 (enExample)
BR (1) BR112012024349A2 (enExample)
CA (2) CA3051495A1 (enExample)
DK (1) DK2552438T3 (enExample)
ES (2) ES2675212T3 (enExample)
HR (1) HRP20160609T1 (enExample)
HU (1) HUE027749T2 (enExample)
IL (2) IL221886A (enExample)
LT (1) LT2552438T (enExample)
MX (2) MX346861B (enExample)
NZ (1) NZ602382A (enExample)
PL (1) PL2552438T3 (enExample)
PT (1) PT2552438T (enExample)
TW (1) TWI495467B (enExample)
WO (1) WO2011119988A1 (enExample)

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Also Published As

Publication number Publication date
HRP20160609T1 (hr) 2016-09-23
AU2011230512B2 (en) 2016-09-15
ES2580135T3 (es) 2016-08-19
NZ602382A (en) 2014-11-28
CA2793536C (en) 2019-10-01
MX2012010936A (es) 2012-10-10
AU2011230512A1 (en) 2012-10-04
KR20130062922A (ko) 2013-06-13
JP2015134825A (ja) 2015-07-27
BR112012024349A2 (pt) 2016-05-24
EP2552438A4 (en) 2013-09-04
US20140079787A1 (en) 2014-03-20
CN104784121A (zh) 2015-07-22
TW201138765A (en) 2011-11-16
DK2552438T3 (en) 2016-07-04
US20130115296A1 (en) 2013-05-09
US9370494B2 (en) 2016-06-21
CN103052385A (zh) 2013-04-17
HK1212926A1 (en) 2016-06-24
EP2898884B1 (en) 2018-05-09
WO2011119988A1 (en) 2011-09-29
LT2552438T (lt) 2016-09-26
KR101786142B1 (ko) 2017-10-17
US20160374952A1 (en) 2016-12-29
CA3051495A1 (en) 2011-09-29
PT2552438T (pt) 2016-07-07
TWI495467B (zh) 2015-08-11
EP2898884A1 (en) 2015-07-29
ES2675212T3 (es) 2018-07-09
JP2013523656A (ja) 2013-06-17
HUE027749T2 (en) 2016-10-28
IL221886A (en) 2016-08-31
IL247171B (en) 2019-02-28
CN103052385B (zh) 2015-05-27
EP2552438A1 (en) 2013-02-06
CA2793536A1 (en) 2011-09-29
MX359413B (es) 2018-09-27
PL2552438T3 (pl) 2016-12-30
EP2552438B1 (en) 2016-05-11
HK1181665A1 (zh) 2013-11-15
MX346861B (es) 2017-04-04

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