JP5828903B2 - 新規特異的ｈｃｖ ｎｓ３プロテアーゼ阻害剤 - Google Patents

新規特異的ｈｃｖ ｎｓ３プロテアーゼ阻害剤 Download PDF

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Publication number
JP5828903B2
JP5828903B2 JP2013537733A JP2013537733A JP5828903B2 JP 5828903 B2 JP5828903 B2 JP 5828903B2 JP 2013537733 A JP2013537733 A JP 2013537733A JP 2013537733 A JP2013537733 A JP 2013537733A JP 5828903 B2 JP5828903 B2 JP 5828903B2
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Prior art keywords
compound
agent
hcv
drug
compound according
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Japanese (ja)
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JP2013542955A (ja
JP2013542955A5 (enExample
Inventor
ジェローム クルカンベック
ジェローム クルカンベック
フィリップ アルフォン
フィリップ アルフォン
ムーラ ブジディ
ムーラ ブジディ
スティーブン ジェー． コーツ
スティーブン ジェー． コーツ
リチャード アンソニー ウィテカー
リチャード アンソニー ウィテカー
Original Assignee
アールエフエス ファーマ，エルエルシー
アールエフエス ファーマ，エルエルシー
ジェノサイエンス ファーマ
ジェノサイエンス ファーマ
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2013537733A 2010-11-01 2011-10-28 新規特異的ｈｃｖ ｎｓ３プロテアーゼ阻害剤 Expired - Fee Related JP5828903B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40898910P 2010-11-01 2010-11-01
US61/408,989 2010-11-01
PCT/US2011/058404 WO2012061248A2 (en) 2010-11-01 2011-10-28 Novel specific hcv ns3 protease inhibitors

Publications (3)

Publication Number Publication Date
JP2013542955A JP2013542955A (ja) 2013-11-28
JP2013542955A5 JP2013542955A5 (enExample) 2015-02-12
JP5828903B2 true JP5828903B2 (ja) 2015-12-09

Family

ID=46025037

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013537733A Expired - Fee Related JP5828903B2 (ja) 2010-11-01 2011-10-28 新規特異的ｈｃｖ ｎｓ３プロテアーゼ阻害剤

Country Status (10)

Country Link
US (1) US8729014B2 (enExample)
EP (1) EP2635570B1 (enExample)
JP (1) JP5828903B2 (enExample)
CN (1) CN103328466B (enExample)
AU (1) AU2011323658A1 (enExample)
BR (1) BR112013010836A2 (enExample)
CA (1) CA2815855C (enExample)
IL (1) IL225908A0 (enExample)
MX (1) MX2013004906A (enExample)
WO (1) WO2012061248A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103096891A (zh) 2010-06-24 2013-05-08 判米德有限公司 利用羟氯喹或羟氯喹和抗病毒剂的组合治疗丙型肝炎病毒相关疾病
JP5828903B2 (ja) 2010-11-01 2015-12-09 アールエフエス ファーマ，エルエルシー 新規特異的ｈｃｖ ｎｓ３プロテアーゼ阻害剤
EP2723337A1 (en) 2011-06-23 2014-04-30 Panmed Ltd. Treatment of hepatitis c virus
EP2802574A4 (en) 2012-01-12 2015-06-24 Rfs Pharma Llc INHIBITORS OF HCV NS3 PROTEASE
UA119315C2 (uk) 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
ES2735355T3 (es) 2013-03-15 2019-12-18 Gilead Sciences Inc Inhibidores macrocíclicos y bicíclicos de virus de hepatitis C
JP2017513852A (ja) * 2014-04-15 2017-06-01 コクリスタル ファーマ，インコーポレイテッド Ｃ型肝炎ウイルスの強力及び選択的な阻害剤
CN105315261A (zh) * 2014-08-04 2016-02-10 正大天晴药业集团股份有限公司 Hcv ns3蛋白酶抑制剂的钠盐

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000536A1 (en) 1993-06-22 1995-01-05 Fujisawa Pharmaceutical Co., Ltd. Peptide compounds
UA79749C2 (en) 1996-10-18 2007-07-25 Vertex Pharma Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
US6767991B1 (en) 1997-08-11 2004-07-27 Boehringer Ingelheim (Canada) Ltd. Hepatitis C inhibitor peptides
ATE297946T1 (de) 2000-04-03 2005-07-15 Vertex Pharma Inhibitoren von serin proteasen, speziell der hepatitis-c-virus ns3-protease
EP1425029A4 (en) 2001-08-10 2006-06-07 Palatin Technologies Inc PEPTIDOMIMETICS OF BIOLOGICALLY ACTIVE METALLOPEPTIDES
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
US7041698B2 (en) 2002-05-20 2006-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EA010017B1 (ru) 2003-07-10 2008-06-30 Ачиллион Фармасьютикалз, Инк. Замещённые арилтиомочевины, применимые в качестве ингибиторов репликации вирусов
SI1713823T1 (sl) 2004-01-30 2010-04-30 Medivir Ab Inhibitorji HCV NS-3 serin proteaze
MXPA06013404A (es) 2004-05-20 2007-01-23 Schering Corp Prolinas sustituidas como inhibidores de serina proteasa ns3 de virus de hepatitis c.
US7323447B2 (en) * 2005-02-08 2008-01-29 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
CN100486397C (zh) 2005-04-19 2009-05-06 皇家飞利浦电子股份有限公司 包括红色发射陶瓷发光转换器的照明系统
US7470664B2 (en) 2005-07-20 2008-12-30 Merck & Co., Inc. HCV NS3 protease inhibitors
JP4705984B2 (ja) 2005-08-01 2011-06-22 メルク・シャープ・エンド・ドーム・コーポレイション Ｈｃｖｎｓ３プロテアーゼ阻害剤としての大環状ペプチド
JP2009524681A (ja) 2006-01-27 2009-07-02 フェノミックス コーポレーション Ｃ型肝炎ウイルスセリンプロテアーゼインヒビターおよびそのための使用
CN101495457A (zh) * 2006-07-05 2009-07-29 因特蒙公司 C型肝炎病毒复制的新颖抑制剂
KR20090024834A (ko) * 2006-07-05 2009-03-09 인터뮨, 인크. Ｃ형 간염 바이러스 복제의 신규 억제제
US7635683B2 (en) 2006-08-04 2009-12-22 Enanta Pharmaceuticals, Inc. Quinoxalinyl tripeptide hepatitis C virus inhibitors
JP5035251B2 (ja) 2006-11-24 2012-09-26 株式会社島津製作所 Ｘ線透視撮影装置
US20080287449A1 (en) 2007-04-26 2008-11-20 Deqiang Niu Aza-tripeptide hepatitis c serine protease inhibitors
CN101977621A (zh) 2007-12-05 2011-02-16 益安药业 氟化三肽hcv丝氨酸蛋白酶抑制剂
TWI487522B (zh) 2007-12-21 2015-06-11 賽基艾維洛米斯研究股份有限公司 Ｈｃｖ蛋白酶抑制劑及其用途（一）
US8293705B2 (en) 2007-12-21 2012-10-23 Avila Therapeutics, Inc. HCV protease inhibitors and uses thereof
KR20110005869A (ko) 2008-04-15 2011-01-19 인터뮨, 인크. Ｃ형 간염 바이러스 복제의 신규한 마크로사이클릭 억제제
KR101781789B1 (ko) * 2010-01-27 2017-09-26 에이비 파르마 리미티드. C형 간염 바이러스 억제제로 사용되는 다환 헤테로사이클릭 화합물
JP5828903B2 (ja) 2010-11-01 2015-12-09 アールエフエス ファーマ，エルエルシー 新規特異的ｈｃｖ ｎｓ３プロテアーゼ阻害剤

Also Published As

Publication number Publication date
IL225908A0 (en) 2013-06-27
JP2013542955A (ja) 2013-11-28
CA2815855A1 (en) 2012-05-10
US8729014B2 (en) 2014-05-20
EP2635570A4 (en) 2014-04-16
AU2011323658A1 (en) 2013-05-23
CN103328466A (zh) 2013-09-25
CN103328466B (zh) 2016-08-03
CA2815855C (en) 2016-02-02
WO2012061248A2 (en) 2012-05-10
WO2012061248A3 (en) 2012-08-02
EP2635570B1 (en) 2017-12-13
EP2635570A2 (en) 2013-09-11
MX2013004906A (es) 2013-12-06
US20120129765A1 (en) 2012-05-24
BR112013010836A2 (pt) 2019-09-24
WO2012061248A8 (en) 2013-08-01

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