IL225908A0 - New specific inhibitors for 3ns hcv protease - Google Patents
New specific inhibitors for 3ns hcv proteaseInfo
- Publication number
- IL225908A0 IL225908A0 IL225908A IL22590813A IL225908A0 IL 225908 A0 IL225908 A0 IL 225908A0 IL 225908 A IL225908 A IL 225908A IL 22590813 A IL22590813 A IL 22590813A IL 225908 A0 IL225908 A0 IL 225908A0
- Authority
- IL
- Israel
- Prior art keywords
- protease inhibitors
- novel specific
- specific hcv
- hcv
- novel
- Prior art date
Links
- 229940124771 HCV-NS3 protease inhibitor Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40898910P | 2010-11-01 | 2010-11-01 | |
| PCT/US2011/058404 WO2012061248A2 (en) | 2010-11-01 | 2011-10-28 | Novel specific hcv ns3 protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL225908A0 true IL225908A0 (en) | 2013-06-27 |
Family
ID=46025037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL225908A IL225908A0 (en) | 2010-11-01 | 2013-04-23 | New specific inhibitors for 3ns hcv protease |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8729014B2 (enExample) |
| EP (1) | EP2635570B1 (enExample) |
| JP (1) | JP5828903B2 (enExample) |
| CN (1) | CN103328466B (enExample) |
| AU (1) | AU2011323658A1 (enExample) |
| BR (1) | BR112013010836A2 (enExample) |
| CA (1) | CA2815855C (enExample) |
| IL (1) | IL225908A0 (enExample) |
| MX (1) | MX2013004906A (enExample) |
| WO (1) | WO2012061248A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011268498A1 (en) | 2010-06-24 | 2013-01-31 | Genoscience Pharma Sas | Treatment of hepatitis C virus related diseases using hydroxychloroquine or a combination of hydroxychloroquine and an anti-viral agent |
| MX2013004906A (es) | 2010-11-01 | 2013-12-06 | Genoscience Pharma | Nuevos inhibidores especificos de la proteasa ns3 de hcv. |
| WO2012176149A1 (en) | 2011-06-23 | 2012-12-27 | Panmed Ltd. | Treatment of hepatitis c virus |
| US9040479B2 (en) | 2012-01-12 | 2015-05-26 | Cocrystal Pharma, Inc. | HCV NS3 protease inhibitors |
| UA119315C2 (uk) | 2012-07-03 | 2019-06-10 | Гіліад Фармассет Елелсі | Інгібітори вірусу гепатиту с |
| JP6511432B2 (ja) | 2013-03-15 | 2019-05-15 | ギリアード サイエンシーズ， インコーポレイテッド | Ｃ型肝炎ウイルスの大環状二環式阻害剤 |
| CN106661004A (zh) * | 2014-04-15 | 2017-05-10 | 共晶制药股份有限公司 | 丙型肝炎病毒的有效和选择性抑制剂 |
| CN105315261A (zh) * | 2014-08-04 | 2016-02-10 | 正大天晴药业集团股份有限公司 | Hcv ns3蛋白酶抑制剂的钠盐 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995000536A1 (en) | 1993-06-22 | 1995-01-05 | Fujisawa Pharmaceutical Co., Ltd. | Peptide compounds |
| NZ335276A (en) | 1996-10-18 | 2000-09-29 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis C virus (HCV) NS3 (Non Structural Protein 3) protease |
| US6767991B1 (en) | 1997-08-11 | 2004-07-27 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C inhibitor peptides |
| AU2001251165A1 (en) | 2000-04-03 | 2001-10-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
| WO2003013571A1 (en) | 2001-08-10 | 2003-02-20 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
| MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| PL215228B1 (pl) | 2002-05-20 | 2013-11-29 | Bristol Myers Squibb Co | Zwiazki tripeptydowe, ich zastosowanie i kompozycja farmaceutyczna je zawierajaca oraz jej zastosowanie |
| BRPI0412502A (pt) | 2003-07-10 | 2006-09-19 | Achillion Pharmaceuticals Inc | derivados de ariltiouréia substituìda úteis como inibidores de replicação viral |
| ES2336009T3 (es) | 2004-01-30 | 2010-04-07 | Medivir Ab | Inhibidores de la ns-3 serina proteasa del vhc. |
| CN1984922A (zh) | 2004-05-20 | 2007-06-20 | 先灵公司 | 用作丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的取代脯氨酸 |
| US7323447B2 (en) * | 2005-02-08 | 2008-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CN100486397C (zh) | 2005-04-19 | 2009-05-06 | 皇家飞利浦电子股份有限公司 | 包括红色发射陶瓷发光转换器的照明系统 |
| AR057456A1 (es) | 2005-07-20 | 2007-12-05 | Merck & Co Inc | Inhibidores de la proteasa ns3 del vhc |
| US8278322B2 (en) | 2005-08-01 | 2012-10-02 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
| WO2007089618A2 (en) | 2006-01-27 | 2007-08-09 | Phenomix Corporation | Hepatitis c serine protease inhibitors and uses therefor |
| CN101495457A (zh) * | 2006-07-05 | 2009-07-29 | 因特蒙公司 | C型肝炎病毒复制的新颖抑制剂 |
| RU2008152171A (ru) * | 2006-07-05 | 2010-08-10 | Интермьюн, Инк. (Us) | Новые ингибиторы вирусной репликации гепатита с |
| US7635683B2 (en) | 2006-08-04 | 2009-12-22 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl tripeptide hepatitis C virus inhibitors |
| US7988358B2 (en) | 2006-11-24 | 2011-08-02 | Shimadzu Corporation | X-ray fluoroscopic apparatus |
| WO2008134397A1 (en) | 2007-04-26 | 2008-11-06 | Enanta Pharmaceuticals, Inc. | Aza-tripeptide hepatitis c serine protease inhibitors |
| CA2708150A1 (en) * | 2007-12-05 | 2009-06-18 | Enanta Pharmaceuticals, Inc. | Fluorinated tripeptide hcv serine protease inhibitors |
| US8293705B2 (en) | 2007-12-21 | 2012-10-23 | Avila Therapeutics, Inc. | HCV protease inhibitors and uses thereof |
| CN104557880A (zh) | 2007-12-21 | 2015-04-29 | 阿维拉制药公司 | Hcv蛋白酶抑制剂和其用途 |
| WO2009142842A2 (en) | 2008-04-15 | 2009-11-26 | Intermune, Inc. | Novel macrocyclic inhibitors of hepatitis c virus replication |
| CA2788155C (en) | 2010-01-27 | 2018-04-24 | AB Pharma Ltd. | Polyheterocyclic compounds highly potent as hcv inhibitors |
| MX2013004906A (es) | 2010-11-01 | 2013-12-06 | Genoscience Pharma | Nuevos inhibidores especificos de la proteasa ns3 de hcv. |
-
2011
- 2011-10-28 MX MX2013004906A patent/MX2013004906A/es active IP Right Grant
- 2011-10-28 CA CA2815855A patent/CA2815855C/en not_active Expired - Fee Related
- 2011-10-28 CN CN201180063866.1A patent/CN103328466B/zh not_active Expired - Fee Related
- 2011-10-28 WO PCT/US2011/058404 patent/WO2012061248A2/en not_active Ceased
- 2011-10-28 EP EP11838590.5A patent/EP2635570B1/en not_active Not-in-force
- 2011-10-28 JP JP2013537733A patent/JP5828903B2/ja not_active Expired - Fee Related
- 2011-10-28 US US13/284,641 patent/US8729014B2/en not_active Expired - Fee Related
- 2011-10-28 AU AU2011323658A patent/AU2011323658A1/en not_active Abandoned
- 2011-10-28 BR BR112013010836A patent/BR112013010836A2/pt not_active IP Right Cessation
-
2013
- 2013-04-23 IL IL225908A patent/IL225908A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20120129765A1 (en) | 2012-05-24 |
| WO2012061248A8 (en) | 2013-08-01 |
| AU2011323658A1 (en) | 2013-05-23 |
| EP2635570A2 (en) | 2013-09-11 |
| WO2012061248A3 (en) | 2012-08-02 |
| EP2635570B1 (en) | 2017-12-13 |
| CN103328466A (zh) | 2013-09-25 |
| CA2815855C (en) | 2016-02-02 |
| EP2635570A4 (en) | 2014-04-16 |
| JP5828903B2 (ja) | 2015-12-09 |
| JP2013542955A (ja) | 2013-11-28 |
| US8729014B2 (en) | 2014-05-20 |
| BR112013010836A2 (pt) | 2019-09-24 |
| CN103328466B (zh) | 2016-08-03 |
| WO2012061248A2 (en) | 2012-05-10 |
| CA2815855A1 (en) | 2012-05-10 |
| MX2013004906A (es) | 2013-12-06 |
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