JP5794744B2 - 安定化された眼用ガラクトマンナン処方物 - Google Patents

安定化された眼用ガラクトマンナン処方物 Download PDF

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Publication number
JP5794744B2
JP5794744B2 JP2013509217A JP2013509217A JP5794744B2 JP 5794744 B2 JP5794744 B2 JP 5794744B2 JP 2013509217 A JP2013509217 A JP 2013509217A JP 2013509217 A JP2013509217 A JP 2013509217A JP 5794744 B2 JP5794744 B2 JP 5794744B2
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Japan
Prior art keywords
formulation
concentration
present
galactomannan
borate
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JP2013509217A
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English (en)
Japanese (ja)
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JP2013525493A (ja
JP2013525493A5 (enExample
Inventor
ホワード アレン ケテルソン，
ホワード アレン ケテルソン，
ジェイムズ ダブリュー． デイビス，
ジェイムズ ダブリュー． デイビス，
デイビッド エル． メドーズ，
デイビッド エル． メドーズ，
Original Assignee
アルコン リサーチ， リミテッド
アルコン リサーチ， リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2013509217A 2010-05-05 2011-05-04 安定化された眼用ガラクトマンナン処方物 Active JP5794744B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33151110P 2010-05-05 2010-05-05
US61/331,511 2010-05-05
PCT/US2011/035165 WO2011140203A2 (en) 2010-05-05 2011-05-04 Stabilized ophthalmic galactomannan formulations

Publications (3)

Publication Number Publication Date
JP2013525493A JP2013525493A (ja) 2013-06-20
JP2013525493A5 JP2013525493A5 (enExample) 2014-05-08
JP5794744B2 true JP5794744B2 (ja) 2015-10-14

Family

ID=44626461

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013509217A Active JP5794744B2 (ja) 2010-05-05 2011-05-04 安定化された眼用ガラクトマンナン処方物

Country Status (16)

Country Link
US (2) US20110275593A1 (enExample)
EP (1) EP2566447B1 (enExample)
JP (1) JP5794744B2 (enExample)
KR (2) KR20130060228A (enExample)
CN (2) CN102939074A (enExample)
AR (1) AR081015A1 (enExample)
AU (1) AU2011248129B2 (enExample)
BR (1) BR112012028308B1 (enExample)
CA (1) CA2798069C (enExample)
ES (1) ES2809304T3 (enExample)
MX (1) MX2012012826A (enExample)
NZ (1) NZ603345A (enExample)
SG (2) SG10201804305SA (enExample)
TW (1) TWI606841B (enExample)
WO (1) WO2011140203A2 (enExample)
ZA (1) ZA201208199B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2009000985A1 (es) * 2008-04-26 2010-01-15 Alcon Res Ltd Composicion oftalmica que comprende entre 0,16 y 0,19% p/v de un galactomanano, alrededor de 0,7% p/v de un borato, cis-diol y menos de 5 ppm de concentracion de cationes divalentes; y su uso para lubricar el ojo.
TWI492769B (zh) * 2009-09-23 2015-07-21 Alcon Res Ltd 可注射的水性眼用組成物及其使用之方法
TW201336527A (zh) * 2012-02-10 2013-09-16 Alcon Res Ltd 具增強的穩定性之水性藥學組成物
UA113434C2 (uk) * 2012-05-04 2017-01-25 Алкон Рісерч, Лтд. Офтальмологічна композиція з поліпшеним захистом від зневоднювання й утриманням
EP3340982B1 (en) 2015-08-26 2021-12-15 Achillion Pharmaceuticals, Inc. Compounds for treatment of immune and inflammatory disorders
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
KR20190036520A (ko) 2016-06-27 2019-04-04 아칠리온 파르마세우티칼스 인코포레이티드 의학적 장애를 치료하기 위한 퀴나졸린 및 인돌 화합물
CN115089547A (zh) * 2016-10-12 2022-09-23 Ps治疗有限公司 人工泪液、隐形眼镜和药物载体组合物及其使用方法
US11583496B2 (en) 2016-10-12 2023-02-21 PS Therapy Inc. Drug vehicle compositions and methods of use thereof
US11260035B2 (en) 2016-10-12 2022-03-01 Ps Therapies Ltd Topical compositions and methods of use thereof
AU2018227849B2 (en) 2017-03-01 2022-04-28 Achillion Pharmaceuticals, Inc. Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders
EP3841086B1 (en) 2018-08-20 2025-04-23 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement factor d medical disorders
JP7443375B2 (ja) 2018-09-06 2024-03-05 アキリオン ファーマシューティカルズ， インコーポレーテッド 医学的障害の治療のための大環状化合物
JP7504088B2 (ja) 2018-10-16 2024-06-21 ジョージア ステイト ユニバーシティー リサーチ ファウンデーション インコーポレイテッド 医学的障害の治療のための一酸化炭素プロドラッグ
TWI757773B (zh) 2019-06-28 2022-03-11 瑞士商愛爾康公司 眼用組成物
JP2023515073A (ja) 2020-02-20 2023-04-12 アキリオン ファーマシューティカルズ， インコーポレーテッド 補体因子ｄ媒介障害の処置用のヘテロアリール化合物
US20250171423A1 (en) 2020-09-23 2025-05-29 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement mediated disorders
WO2025186703A1 (en) 2024-03-04 2025-09-12 Alcon Inc. Carbamoylphenylboronic acid-containing acrylic monomers and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8028A (en) * 1851-04-08 Hokse-poweb
US4136173A (en) * 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
DE3827561C1 (enExample) * 1988-08-13 1989-12-28 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
US5505953A (en) * 1992-05-06 1996-04-09 Alcon Laboratories, Inc. Use of borate-polyol complexes in ophthalmic compositions
DE69839355T2 (de) * 1997-07-29 2009-06-04 Alcon Laboratories, Inc., Fort Worth Ophthalmische Zusammensetzungen enthaltend Galaktomannanpolymere und Borat
GB9808461D0 (en) * 1998-04-22 1998-06-17 Innovative Tech Ltd Solid borate-diol interaction products
US7084130B2 (en) * 2001-12-11 2006-08-01 Alcon, Inc. Intraocular irrigating solution having improved flow characteristics
TWI336257B (en) * 2003-06-13 2011-01-21 Alcon Inc Ophthalmic compositions containing a synergistic combination of three polymers
WO2008036855A2 (en) * 2006-09-21 2008-03-27 Alcon Research, Ltd. Self-preserved aqueous pharmaceutical compositions
TWI434926B (zh) 2006-12-11 2014-04-21 Alcon Res Ltd 眼用組成物中聚氧化乙烯-聚氧化丁烯（ｐｅｏ-ｐｂｏ）嵌段共聚物之使用
TW200904485A (en) * 2007-05-18 2009-02-01 Alcon Res Ltd Phospholipid compositions for contact lens care and preservation of pharmaceutical compositions
CL2009000985A1 (es) * 2008-04-26 2010-01-15 Alcon Res Ltd Composicion oftalmica que comprende entre 0,16 y 0,19% p/v de un galactomanano, alrededor de 0,7% p/v de un borato, cis-diol y menos de 5 ppm de concentracion de cationes divalentes; y su uso para lubricar el ojo.
WO2010091287A1 (en) 2009-02-05 2010-08-12 Alcon Research, Ltd. Process for purifying guar

Also Published As

Publication number Publication date
US20130244971A1 (en) 2013-09-19
SG10201804305SA (en) 2018-06-28
BR112012028308B1 (pt) 2021-09-28
NZ603345A (en) 2014-12-24
BR112012028308A2 (pt) 2016-11-01
WO2011140203A2 (en) 2011-11-10
EP2566447B1 (en) 2020-07-15
MX2012012826A (es) 2013-01-28
CA2798069C (en) 2016-07-05
CN106389325A (zh) 2017-02-15
KR20130060228A (ko) 2013-06-07
AU2011248129B2 (en) 2014-10-09
US20110275593A1 (en) 2011-11-10
ES2809304T3 (es) 2021-03-03
JP2013525493A (ja) 2013-06-20
TWI606841B (zh) 2017-12-01
WO2011140203A3 (en) 2012-04-19
AU2011248129A1 (en) 2012-11-29
KR20180001587A (ko) 2018-01-04
CN102939074A (zh) 2013-02-20
EP2566447A2 (en) 2013-03-13
US8846641B2 (en) 2014-09-30
TW201141524A (en) 2011-12-01
SG185422A1 (en) 2012-12-28
ZA201208199B (en) 2014-01-29
AR081015A1 (es) 2012-05-30
CA2798069A1 (en) 2011-11-10

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