AR066901A1 - Composiciones fodfolipidicas para elcuidado de lentes de contacto y conservacion de composiciones farmaceuticas - Google Patents

Composiciones fodfolipidicas para elcuidado de lentes de contacto y conservacion de composiciones farmaceuticas

Info

Publication number
AR066901A1
AR066901A1 ARP080102006A ARP080102006A AR066901A1 AR 066901 A1 AR066901 A1 AR 066901A1 AR P080102006 A ARP080102006 A AR P080102006A AR P080102006 A ARP080102006 A AR P080102006A AR 066901 A1 AR066901 A1 AR 066901A1
Authority
AR
Argentina
Prior art keywords
group
compositions
synthetic phospholipids
phospholipid
compounds
Prior art date
Application number
ARP080102006A
Other languages
English (en)
Original Assignee
Alcon Mfg Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Mfg Ltd filed Critical Alcon Mfg Ltd
Publication of AR066901A1 publication Critical patent/AR066901A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/143—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
    • A01N57/12—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing acyclic or cycloaliphatic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

Fosfolípidos sintéticos para conservar composiciones farmacéuticas de la contaminacion microbiana. Los fosfolípidos sintéticos tienen disposiciones moleculares unicas donde un grupo fosfato está ligado a una funcionalidad amonio cuaternario por medio de un grupo propenilo sustituido, y la funcionalidad amonio cuaternario está además ligada -a por lo menos una cadena de hidrocarburos larga. Dichas disposiciones moleculares hacen que los fosfolípidos de formula (1) sean altamente solubles en agua, por ejemplo, la longitud de la cadena de hidrocarburos ayuda a mantener la solubilidad y la eficacia de las moléculas para los usos descritos en la presente invencion. Se descubrio que los fosfolípidos sintéticos descritos en esta invencion son particularmente utiles como conservantes antimicrobianos para composiciones oftálmicas, oticas y nasales, especiales composiciones oftálmicas. Estos compuestos también pueden utilizarse para desinfectar lentes de contacto. La invencion se basa en parte en un descubrimiento de que la actividad antimicrobiana de los fosfolípidos sintéticos es afectada por la resistencia ionica de las composiciones en las cuales están contenidos los compuestos. La provision de compuestos que tienen resistencias ionicas limitadas es por ende preferida. Reivindicacion 1: Una composicion farmacéutica estéril que comprende una cantidad eficaz conservante de un compuesto de la siguiente formula (1), donde: R1 y R3 son alquilo (C1-6); R2 se selecciona del grupo formado por hidrogeno y alquilo (C1-16) opcionalmente sustituido con NHC(=O)-(CH2)10CH3 o NHC(=O)-(CH2)12CH3; R4 se selecciona del grupo formado por hidrogeno y CH2CH(Y)CH2N+R1R2R3X, donde R1 R2, y R3 son segun lo definido anteriormente; X es halo; Y se selecciona del grupo formado por OH, O-alquilo (C1-10) y O-alquenilo (C1-10); M se selecciona del grupo formado por sodio y potasio; y un vehículo farmacéuticamente aceptable para el mismo. Reivindicacion 3: La composicion de acuerdo con la reivindicacion 2 donde el compuesto de formula (1) se selecciona del grupo formado por Fosfolípido CDM, Fostolípido PTC y Fosfolípido PTM. Reivindicacion 7: La composicion de acuerdo con la reivindicacion 1, donde la composicion comprende además un ingrediente conservante seleccionado del grupo formado por cloruro de benzalconio, bromuro de benzalconio, policuaternio 1, clorhexidina, cloroburanol, cloruro de cetilpiridinio, un parabeno, un timerosal, dioxido de cloro y N,N-diclorotaurina.
ARP080102006A 2007-05-18 2008-05-12 Composiciones fodfolipidicas para elcuidado de lentes de contacto y conservacion de composiciones farmaceuticas AR066901A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93893907P 2007-05-18 2007-05-18

Publications (1)

Publication Number Publication Date
AR066901A1 true AR066901A1 (es) 2009-09-23

Family

ID=39627450

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080102006A AR066901A1 (es) 2007-05-18 2008-05-12 Composiciones fodfolipidicas para elcuidado de lentes de contacto y conservacion de composiciones farmaceuticas

Country Status (15)

Country Link
US (2) US20080287395A1 (es)
EP (1) EP2155271B1 (es)
JP (1) JP5620264B2 (es)
KR (1) KR20100016091A (es)
CN (1) CN101678140A (es)
AR (1) AR066901A1 (es)
AU (1) AU2008254858B2 (es)
BR (1) BRPI0811188A2 (es)
CA (1) CA2683283A1 (es)
CL (1) CL2008001462A1 (es)
ES (1) ES2627437T3 (es)
MX (1) MX2009011713A (es)
TW (1) TW200904485A (es)
UY (1) UY31094A1 (es)
WO (1) WO2008144494A1 (es)

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TW201010727A (en) * 2008-09-03 2010-03-16 Alcon Res Ltd Pharmaceutical composition having relatively low ionic strength
RU2011130552A (ru) * 2008-12-22 2013-01-27 Алькон Рисерч, Лтд. Композиции местных глазных растворов для доставки эффективных концентраций активного агента в задний сегмент глаза
CN101473832B (zh) * 2009-02-17 2012-05-09 上海斯贝生物科技有限公司 一种新型环保型消毒液
JP2011021002A (ja) * 2009-06-16 2011-02-03 Lion Corp 眼科用組成物
TWI547522B (zh) 2009-07-07 2016-09-01 愛爾康研究有限公司 環氧乙烷環氧丁烷嵌段共聚物組成物
WO2011140203A2 (en) * 2010-05-05 2011-11-10 Alcon Research, Ltd. Stabilized ophthalmic galactomannan formulations
TW201336527A (zh) * 2012-02-10 2013-09-16 Alcon Res Ltd 具增強的穩定性之水性藥學組成物
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CN113729039A (zh) * 2021-08-27 2021-12-03 上海罗克环控节能科技股份有限公司 一种绿色环保消毒液及其制造方法

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Also Published As

Publication number Publication date
AU2008254858B2 (en) 2013-06-20
AU2008254858A1 (en) 2008-11-27
WO2008144494A1 (en) 2008-11-27
JP5620264B2 (ja) 2014-11-05
WO2008144494A8 (en) 2009-12-10
JP2010527933A (ja) 2010-08-19
BRPI0811188A2 (pt) 2014-10-07
ES2627437T3 (es) 2017-07-28
TW200904485A (en) 2009-02-01
EP2155271B1 (en) 2017-03-08
US20150209466A1 (en) 2015-07-30
CA2683283A1 (en) 2008-11-27
KR20100016091A (ko) 2010-02-12
UY31094A1 (es) 2008-07-03
EP2155271A1 (en) 2010-02-24
CN101678140A (zh) 2010-03-24
US20080287395A1 (en) 2008-11-20
MX2009011713A (es) 2009-11-10
CL2008001462A1 (es) 2009-01-02

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Legal Events

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FA Abandonment or withdrawal