MX2012012826A - Formulaciones de galactomanana oftalmicas estabilizadas. - Google Patents
Formulaciones de galactomanana oftalmicas estabilizadas.Info
- Publication number
- MX2012012826A MX2012012826A MX2012012826A MX2012012826A MX2012012826A MX 2012012826 A MX2012012826 A MX 2012012826A MX 2012012826 A MX2012012826 A MX 2012012826A MX 2012012826 A MX2012012826 A MX 2012012826A MX 2012012826 A MX2012012826 A MX 2012012826A
- Authority
- MX
- Mexico
- Prior art keywords
- formulations
- stabilized ophthalmic
- guar
- galactomannan formulations
- ophthalmic galactomannan
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 5
- 229920000926 Galactomannan Polymers 0.000 title abstract 2
- OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 title 1
- -1 hydroxypropyl Chemical group 0.000 abstract 3
- 244000007835 Cyamopsis tetragonoloba Species 0.000 abstract 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 abstract 2
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 abstract 1
- 239000004327 boric acid Substances 0.000 abstract 1
- 150000002009 diols Chemical class 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 229910001629 magnesium chloride Inorganic materials 0.000 abstract 1
- 239000000600 sorbitol Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33151110P | 2010-05-05 | 2010-05-05 | |
| PCT/US2011/035165 WO2011140203A2 (en) | 2010-05-05 | 2011-05-04 | Stabilized ophthalmic galactomannan formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012012826A true MX2012012826A (es) | 2013-01-28 |
Family
ID=44626461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012012826A MX2012012826A (es) | 2010-05-05 | 2011-05-04 | Formulaciones de galactomanana oftalmicas estabilizadas. |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20110275593A1 (enExample) |
| EP (1) | EP2566447B1 (enExample) |
| JP (1) | JP5794744B2 (enExample) |
| KR (2) | KR20130060228A (enExample) |
| CN (2) | CN102939074A (enExample) |
| AR (1) | AR081015A1 (enExample) |
| AU (1) | AU2011248129B2 (enExample) |
| BR (1) | BR112012028308B1 (enExample) |
| CA (1) | CA2798069C (enExample) |
| ES (1) | ES2809304T3 (enExample) |
| MX (1) | MX2012012826A (enExample) |
| NZ (1) | NZ603345A (enExample) |
| SG (2) | SG10201804305SA (enExample) |
| TW (1) | TWI606841B (enExample) |
| WO (1) | WO2011140203A2 (enExample) |
| ZA (1) | ZA201208199B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2009000985A1 (es) * | 2008-04-26 | 2010-01-15 | Alcon Res Ltd | Composicion oftalmica que comprende entre 0,16 y 0,19% p/v de un galactomanano, alrededor de 0,7% p/v de un borato, cis-diol y menos de 5 ppm de concentracion de cationes divalentes; y su uso para lubricar el ojo. |
| TWI492769B (zh) * | 2009-09-23 | 2015-07-21 | Alcon Res Ltd | 可注射的水性眼用組成物及其使用之方法 |
| TW201336527A (zh) * | 2012-02-10 | 2013-09-16 | Alcon Res Ltd | 具增強的穩定性之水性藥學組成物 |
| UA113434C2 (uk) * | 2012-05-04 | 2017-01-25 | Алкон Рісерч, Лтд. | Офтальмологічна композиція з поліпшеним захистом від зневоднювання й утриманням |
| EP3340982B1 (en) | 2015-08-26 | 2021-12-15 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| KR20190036520A (ko) | 2016-06-27 | 2019-04-04 | 아칠리온 파르마세우티칼스 인코포레이티드 | 의학적 장애를 치료하기 위한 퀴나졸린 및 인돌 화합물 |
| CN115089547A (zh) * | 2016-10-12 | 2022-09-23 | Ps治疗有限公司 | 人工泪液、隐形眼镜和药物载体组合物及其使用方法 |
| US11583496B2 (en) | 2016-10-12 | 2023-02-21 | PS Therapy Inc. | Drug vehicle compositions and methods of use thereof |
| US11260035B2 (en) | 2016-10-12 | 2022-03-01 | Ps Therapies Ltd | Topical compositions and methods of use thereof |
| AU2018227849B2 (en) | 2017-03-01 | 2022-04-28 | Achillion Pharmaceuticals, Inc. | Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders |
| EP3841086B1 (en) | 2018-08-20 | 2025-04-23 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement factor d medical disorders |
| JP7443375B2 (ja) | 2018-09-06 | 2024-03-05 | アキリオン ファーマシューティカルズ， インコーポレーテッド | 医学的障害の治療のための大環状化合物 |
| JP7504088B2 (ja) | 2018-10-16 | 2024-06-21 | ジョージア ステイト ユニバーシティー リサーチ ファウンデーション インコーポレイテッド | 医学的障害の治療のための一酸化炭素プロドラッグ |
| TWI757773B (zh) | 2019-06-28 | 2022-03-11 | 瑞士商愛爾康公司 | 眼用組成物 |
| JP2023515073A (ja) | 2020-02-20 | 2023-04-12 | アキリオン ファーマシューティカルズ， インコーポレーテッド | 補体因子ｄ媒介障害の処置用のヘテロアリール化合物 |
| US20250171423A1 (en) | 2020-09-23 | 2025-05-29 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement mediated disorders |
| WO2025186703A1 (en) | 2024-03-04 | 2025-09-12 | Alcon Inc. | Carbamoylphenylboronic acid-containing acrylic monomers and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8028A (en) * | 1851-04-08 | Hokse-poweb | ||
| US4136173A (en) * | 1977-01-31 | 1979-01-23 | American Home Products Corp. | Mixed xanthan gum and locust beam gum therapeutic compositions |
| DE3827561C1 (enExample) * | 1988-08-13 | 1989-12-28 | Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De | |
| US5505953A (en) * | 1992-05-06 | 1996-04-09 | Alcon Laboratories, Inc. | Use of borate-polyol complexes in ophthalmic compositions |
| DE69839355T2 (de) * | 1997-07-29 | 2009-06-04 | Alcon Laboratories, Inc., Fort Worth | Ophthalmische Zusammensetzungen enthaltend Galaktomannanpolymere und Borat |
| GB9808461D0 (en) * | 1998-04-22 | 1998-06-17 | Innovative Tech Ltd | Solid borate-diol interaction products |
| US7084130B2 (en) * | 2001-12-11 | 2006-08-01 | Alcon, Inc. | Intraocular irrigating solution having improved flow characteristics |
| TWI336257B (en) * | 2003-06-13 | 2011-01-21 | Alcon Inc | Ophthalmic compositions containing a synergistic combination of three polymers |
| WO2008036855A2 (en) * | 2006-09-21 | 2008-03-27 | Alcon Research, Ltd. | Self-preserved aqueous pharmaceutical compositions |
| TWI434926B (zh) | 2006-12-11 | 2014-04-21 | Alcon Res Ltd | 眼用組成物中聚氧化乙烯-聚氧化丁烯（ｐｅｏ-ｐｂｏ）嵌段共聚物之使用 |
| TW200904485A (en) * | 2007-05-18 | 2009-02-01 | Alcon Res Ltd | Phospholipid compositions for contact lens care and preservation of pharmaceutical compositions |
| CL2009000985A1 (es) * | 2008-04-26 | 2010-01-15 | Alcon Res Ltd | Composicion oftalmica que comprende entre 0,16 y 0,19% p/v de un galactomanano, alrededor de 0,7% p/v de un borato, cis-diol y menos de 5 ppm de concentracion de cationes divalentes; y su uso para lubricar el ojo. |
| WO2010091287A1 (en) | 2009-02-05 | 2010-08-12 | Alcon Research, Ltd. | Process for purifying guar |
-
2011
- 2011-05-04 SG SG10201804305SA patent/SG10201804305SA/en unknown
- 2011-05-04 TW TW100115587A patent/TWI606841B/zh active
- 2011-05-04 CN CN2011800292803A patent/CN102939074A/zh active Pending
- 2011-05-04 EP EP11720357.0A patent/EP2566447B1/en active Active
- 2011-05-04 NZ NZ603345A patent/NZ603345A/en not_active IP Right Cessation
- 2011-05-04 CA CA2798069A patent/CA2798069C/en active Active
- 2011-05-04 US US13/100,439 patent/US20110275593A1/en not_active Abandoned
- 2011-05-04 JP JP2013509217A patent/JP5794744B2/ja active Active
- 2011-05-04 SG SG2012081386A patent/SG185422A1/en unknown
- 2011-05-04 KR KR1020127031590A patent/KR20130060228A/ko not_active Ceased
- 2011-05-04 KR KR1020177037138A patent/KR20180001587A/ko not_active Ceased
- 2011-05-04 CN CN201610986410.7A patent/CN106389325A/zh active Pending
- 2011-05-04 ES ES11720357T patent/ES2809304T3/es active Active
- 2011-05-04 MX MX2012012826A patent/MX2012012826A/es active IP Right Grant
- 2011-05-04 BR BR112012028308-1A patent/BR112012028308B1/pt active IP Right Grant
- 2011-05-04 WO PCT/US2011/035165 patent/WO2011140203A2/en not_active Ceased
- 2011-05-04 AU AU2011248129A patent/AU2011248129B2/en active Active
- 2011-05-05 AR ARP110101556A patent/AR081015A1/es unknown
-
2012
- 2012-10-31 ZA ZA2012/08199A patent/ZA201208199B/en unknown
-
2013
- 2013-05-13 US US13/892,429 patent/US8846641B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20130244971A1 (en) | 2013-09-19 |
| SG10201804305SA (en) | 2018-06-28 |
| BR112012028308B1 (pt) | 2021-09-28 |
| NZ603345A (en) | 2014-12-24 |
| BR112012028308A2 (pt) | 2016-11-01 |
| WO2011140203A2 (en) | 2011-11-10 |
| EP2566447B1 (en) | 2020-07-15 |
| CA2798069C (en) | 2016-07-05 |
| CN106389325A (zh) | 2017-02-15 |
| KR20130060228A (ko) | 2013-06-07 |
| AU2011248129B2 (en) | 2014-10-09 |
| US20110275593A1 (en) | 2011-11-10 |
| ES2809304T3 (es) | 2021-03-03 |
| JP2013525493A (ja) | 2013-06-20 |
| TWI606841B (zh) | 2017-12-01 |
| WO2011140203A3 (en) | 2012-04-19 |
| AU2011248129A1 (en) | 2012-11-29 |
| KR20180001587A (ko) | 2018-01-04 |
| CN102939074A (zh) | 2013-02-20 |
| EP2566447A2 (en) | 2013-03-13 |
| US8846641B2 (en) | 2014-09-30 |
| TW201141524A (en) | 2011-12-01 |
| SG185422A1 (en) | 2012-12-28 |
| JP5794744B2 (ja) | 2015-10-14 |
| ZA201208199B (en) | 2014-01-29 |
| AR081015A1 (es) | 2012-05-30 |
| CA2798069A1 (en) | 2011-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |