JP5788890B2 - テトラヒドロキノリン誘導体及びその薬学的使用 - Google Patents

テトラヒドロキノリン誘導体及びその薬学的使用 Download PDF

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Publication number
JP5788890B2
JP5788890B2 JP2012537377A JP2012537377A JP5788890B2 JP 5788890 B2 JP5788890 B2 JP 5788890B2 JP 2012537377 A JP2012537377 A JP 2012537377A JP 2012537377 A JP2012537377 A JP 2012537377A JP 5788890 B2 JP5788890 B2 JP 5788890B2
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Prior art keywords
methyl
tetrahydro
acetyl
quinolinyl
methylethyl
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JP2012537377A
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Japanese (ja)
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JP2013510120A (ja
JP2013510120A5 (enExample
Inventor
デモント，エマニュエル，ヒューバート
ガートン，ニール，スチュアート
ゴスミニ，ロマン，リュック，マリー
ヘイホウ，トーマス，ジョージ，クリストファー
シール，ジョナサン
ウィルソン，デヴィッド，マシュー
ウッドロー，マイケル，デヴィッド
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グラクソスミスクライン エルエルシー
グラクソスミスクライン エルエルシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
JP2012537377A 2009-11-05 2010-11-03 テトラヒドロキノリン誘導体及びその薬学的使用 Expired - Fee Related JP5788890B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0919431.7 2009-11-05
GBGB0919431.7A GB0919431D0 (en) 2009-11-05 2009-11-05 Novel compounds
PCT/EP2010/066693 WO2011054841A1 (en) 2009-11-05 2010-11-03 Tetrahydroquinoline derivatives and their pharmaceutical use

Publications (3)

Publication Number Publication Date
JP2013510120A JP2013510120A (ja) 2013-03-21
JP2013510120A5 JP2013510120A5 (enExample) 2013-11-07
JP5788890B2 true JP5788890B2 (ja) 2015-10-07

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JP2012537377A Expired - Fee Related JP5788890B2 (ja) 2009-11-05 2010-11-03 テトラヒドロキノリン誘導体及びその薬学的使用

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Country Link
US (1) US8697725B2 (enExample)
EP (1) EP2496557B1 (enExample)
JP (1) JP5788890B2 (enExample)
ES (1) ES2449470T3 (enExample)
GB (1) GB0919431D0 (enExample)
WO (1) WO2011054841A1 (enExample)

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Also Published As

Publication number Publication date
US8697725B2 (en) 2014-04-15
US20120208798A1 (en) 2012-08-16
JP2013510120A (ja) 2013-03-21
WO2011054841A1 (en) 2011-05-12
EP2496557B1 (en) 2013-12-18
EP2496557A1 (en) 2012-09-12
GB0919431D0 (en) 2009-12-23
ES2449470T3 (es) 2014-03-19

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