JP5767631B2 - バニロイド受容体リガンドとしての置換された芳香族カルボキサミドおよび尿素誘導体 - Google Patents
バニロイド受容体リガンドとしての置換された芳香族カルボキサミドおよび尿素誘導体 Download PDFInfo
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- JP5767631B2 JP5767631B2 JP2012508950A JP2012508950A JP5767631B2 JP 5767631 B2 JP5767631 B2 JP 5767631B2 JP 2012508950 A JP2012508950 A JP 2012508950A JP 2012508950 A JP2012508950 A JP 2012508950A JP 5767631 B2 JP5767631 B2 JP 5767631B2
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- alkyl
- methyl
- pyrazol
- trifluoromethyl
- chlorophenyl
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- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
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- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- GKASDNZWUGIAMG-UHFFFAOYSA-N triethyl orthoformate Chemical compound CCOC(OCC)OCC GKASDNZWUGIAMG-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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| JP6822145B2 (ja) | 2015-01-13 | 2021-01-27 | 日産化学株式会社 | 反応混合物中のスズ化合物の処理方法 |
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| EP3241830A1 (de) | 2016-05-04 | 2017-11-08 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
| CN107805221A (zh) * | 2016-09-09 | 2018-03-16 | 西华大学 | 一种制备1h‑吲唑衍生物的方法 |
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| WO2018224455A1 (en) | 2017-06-07 | 2018-12-13 | Basf Se | Substituted cyclopropyl derivatives |
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| CN110627683A (zh) * | 2018-06-25 | 2019-12-31 | 广东东阳光药业有限公司 | 一种茚满酮中间体的制备方法 |
| CN112409191A (zh) * | 2019-08-23 | 2021-02-26 | 持田制药株式会社 | 光学活性的氨基醇的制备方法 |
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| CN115197146A (zh) * | 2021-04-13 | 2022-10-18 | 西格莱(苏州)生物医药有限公司 | 吲唑类化合物的制备方法 |
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| CN115282134B (zh) * | 2022-07-20 | 2023-06-23 | 天津中医药大学 | 辣椒素在制备治疗脆性x染色体综合征的药物中的应用 |
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| CN117304009A (zh) * | 2023-10-10 | 2023-12-29 | 韶远科技（上海)有限公司 | 一种3-氟-4-甲基-8-氧代-5,6,7,8-四氢萘的制备方法 |
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| AR230994A1 (es) | 1981-08-31 | 1984-08-31 | Pfizer | Procedimiento para preparar compuesto de 3'-substituido-5'-(2-amino-4-piridil)-1',2',4'-triazol |
| JPH06157469A (ja) | 1992-11-13 | 1994-06-03 | Ube Ind Ltd | ピラゾールカルボニルウレア誘導体、その製法及び有害生物防除剤 |
| US6455559B1 (en) | 2001-07-19 | 2002-09-24 | Pharmacia Italia S.P.A. | Phenylacetamido-pyrazole derivatives, process for their preparation and their use as antitumor agents |
| GB0206876D0 (en) * | 2002-03-22 | 2002-05-01 | Merck Sharp & Dohme | Therapeutic agents |
| EP1497270A4 (en) * | 2002-03-27 | 2006-01-04 | Smithkline Beecham Corp | AMID COMPOUNDS AND METHOD FOR THEIR USE |
| WO2005004810A2 (en) | 2003-07-02 | 2005-01-20 | Merck & Co., Inc. | Arylsulfonamide derivatives |
| WO2005048953A2 (en) | 2003-11-13 | 2005-06-02 | Ambit Biosciences Corporation | Amide derivatives as kinase modulators |
| US7838524B2 (en) | 2004-04-30 | 2010-11-23 | Bayer Healthcare Llc | Substituted pyrazolyl urea derivatives useful in the treatment of cancer |
| DE102005037499A1 (de) | 2005-08-09 | 2007-02-15 | Merck Patent Gmbh | Pyrazolderivate |
| JP2009518298A (ja) | 2005-12-01 | 2009-05-07 | バイエル ヘルスケア リミティド ライアビリティ カンパニー | 癌治療に有用な尿素化合物 |
| BRPI0713187A2 (pt) * | 2006-07-20 | 2012-10-16 | Mehmet Kahraman | método de inibir rho-quinase, método de tratamento de doença mediada por rho-quinase, composto e composição farmacêutica |
| ATE509925T1 (de) * | 2006-11-17 | 2011-06-15 | Pfizer | Substituierte bicyclocarbonsäureamidverbindungen |
| TW200833663A (en) * | 2006-12-21 | 2008-08-16 | Astrazeneca Ab | Therapeutic agents |
| WO2008137102A2 (en) | 2007-05-04 | 2008-11-13 | Torreypines Therapeutics, Inc. | Methods of modulating amyloid beta and compounds useful therefor |
| JP2010083763A (ja) * | 2008-09-29 | 2010-04-15 | Mitsui Chemicals Inc | ピラゾール誘導体およびその製造方法、ならびに殺菌剤 |
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| EP2427436B1 (en) | 2013-01-09 |
| HRP20130128T1 (hr) | 2013-03-31 |
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| JP2012526061A (ja) | 2012-10-25 |
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| EP2427436A1 (en) | 2012-03-14 |
| WO2010127855A1 (en) | 2010-11-11 |
| MX2011011800A (es) | 2012-01-27 |
| BRPI1011192A2 (pt) | 2016-03-15 |
| US20110003795A1 (en) | 2011-01-06 |
| CA2758289A1 (en) | 2010-11-11 |
| AU2010244684A1 (en) | 2011-11-03 |
| AU2010244684B2 (en) | 2014-07-03 |
| US8334315B2 (en) | 2012-12-18 |
| TW201120010A (en) | 2011-06-16 |
| AR076753A1 (es) | 2011-07-06 |
| DK2427436T3 (da) | 2013-04-02 |
| ES2402805T3 (es) | 2013-05-09 |
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